Applying predator-prey theory to modelling immune-mediated, within-host interspecific parasite interactions
Identifieur interne : 002877 ( Main/Exploration ); précédent : 002876; suivant : 002878Applying predator-prey theory to modelling immune-mediated, within-host interspecific parasite interactions
Auteurs : Andy Fenton [Royaume-Uni] ; Sarah E. Perkins [États-Unis]Source :
- Parasitology [ 0031-1820 ] ; 2010-05.
Abstract
Predator-prey models are often applied to the interactions between host immunity and parasite growth. A key component of these models is the immune system's functional response, the relationship between immune activity and parasite load. Typically, models assume a simple, linear functional response. However, based on the mechanistic interactions between parasites and immunity we argue that alternative forms are more likely, resulting in very different predictions, ranging from parasite exclusion to chronic infection. By extending this framework to consider multiple infections we show that combinations of parasites eliciting different functional responses greatly affect community stability. Indeed, some parasites may stabilize other species that would be unstable if infecting alone. Therefore hosts' immune systems may have adapted to tolerate certain parasites, rather than clear them and risk erratic parasite dynamics. We urge for more detailed empirical information relating immune activity to parasite load to enable better predictions of the dynamic consequences of immune-mediated interspecific interactions within parasite communities.
Url:
DOI: 10.1017/S0031182009991788
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000E94
- to stream Istex, to step Curation: 000E94
- to stream Istex, to step Checkpoint: 000B30
- to stream Main, to step Merge: 002916
- to stream Main, to step Curation: 002877
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Applying predator-prey theory to modelling immune-mediated, within-host interspecific parasite interactions</title><author><name sortKey="Fenton, Andy" sort="Fenton, Andy" uniqKey="Fenton A" first="Andy" last="Fenton">Andy Fenton</name></author><author><name sortKey="Perkins, Sarah E" sort="Perkins, Sarah E" uniqKey="Perkins S" first="Sarah E." last="Perkins">Sarah E. Perkins</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:71A94FDC916CAE4A6452A66AECFE98E032FDC841</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1017/S0031182009991788</idno><idno type="url">https://api.istex.fr/ark:/67375/6GQ-VWP29H3Q-H/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000E94</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000E94</idno><idno type="wicri:Area/Istex/Curation">000E94</idno><idno type="wicri:Area/Istex/Checkpoint">000B30</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000B30</idno><idno type="wicri:doubleKey">0031-1820:2010:Fenton A:applying:predator:prey</idno><idno type="wicri:Area/Main/Merge">002916</idno><idno type="wicri:Area/Main/Curation">002877</idno><idno type="wicri:Area/Main/Exploration">002877</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Applying predator-prey theory to modelling immune-mediated, within-host interspecific parasite interactions</title><author><name sortKey="Fenton, Andy" sort="Fenton, Andy" uniqKey="Fenton A" first="Andy" last="Fenton">Andy Fenton</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Biological Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZB</wicri:regionArea><wicri:noRegion>Liverpool L69 7ZB</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Royaume-Uni</country></affiliation></author><author><name sortKey="Perkins, Sarah E" sort="Perkins, Sarah E" uniqKey="Perkins S" first="Sarah E." last="Perkins">Sarah E. Perkins</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Infectious Disease Dynamics, 208 Mueller Lab, Penn State University, State College, PA, 16803</wicri:regionArea><wicri:noRegion>16803</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Parasitology</title><title level="j" type="abbrev">Parasitology</title><idno type="ISSN">0031-1820</idno><idno type="eISSN">1469-8161</idno><imprint><publisher>Cambridge University Press</publisher><pubPlace>Cambridge, UK</pubPlace><date type="published" when="2010-05">2010-05</date><biblScope unit="volume">137</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1027">1027</biblScope><biblScope unit="page" to="1038">1038</biblScope></imprint><idno type="ISSN">0031-1820</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0031-1820</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Predator-prey models are often applied to the interactions between host immunity and parasite growth. A key component of these models is the immune system's functional response, the relationship between immune activity and parasite load. Typically, models assume a simple, linear functional response. However, based on the mechanistic interactions between parasites and immunity we argue that alternative forms are more likely, resulting in very different predictions, ranging from parasite exclusion to chronic infection. By extending this framework to consider multiple infections we show that combinations of parasites eliciting different functional responses greatly affect community stability. Indeed, some parasites may stabilize other species that would be unstable if infecting alone. Therefore hosts' immune systems may have adapted to tolerate certain parasites, rather than clear them and risk erratic parasite dynamics. We urge for more detailed empirical information relating immune activity to parasite load to enable better predictions of the dynamic consequences of immune-mediated interspecific interactions within parasite communities.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li><li>États-Unis</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Fenton, Andy" sort="Fenton, Andy" uniqKey="Fenton A" first="Andy" last="Fenton">Andy Fenton</name></noRegion><name sortKey="Fenton, Andy" sort="Fenton, Andy" uniqKey="Fenton A" first="Andy" last="Fenton">Andy Fenton</name></country><country name="États-Unis"><noRegion><name sortKey="Perkins, Sarah E" sort="Perkins, Sarah E" uniqKey="Perkins S" first="Sarah E." last="Perkins">Sarah E. Perkins</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002877 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002877 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:71A94FDC916CAE4A6452A66AECFE98E032FDC841
|texte= Applying predator-prey theory to modelling immune-mediated, within-host interspecific parasite interactions
}}
| This area was generated with Dilib version V0.6.33. |  |