Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus.
Identifieur interne : 001904 ( Main/Exploration ); précédent : 001903; suivant : 001905Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus.
Auteurs : Sivakoteswara Rao Mandadapu [États-Unis] ; Pathum M. Weerawarna ; Allan M. Prior ; Roxanne Adeline Z. Uy ; Sridhar Aravapalli ; Kevin R. Alliston ; Gerald H. Lushington ; Yunjeong Kim ; Duy H. Hua ; Kyeong-Ok Chang ; William C. GroutasSource :
- Bioorganic & medicinal chemistry letters [ 1464-3405 ] ; 2013.
Descripteurs français
- KwdFr :
- Composés macrocycliques (), Composés macrocycliques (pharmacologie), Composés macrocycliques (synthèse chimique), Conception de médicament, Conformation moléculaire, Coronavirus (enzymologie), Inhibiteurs de protéases (), Inhibiteurs de protéases (pharmacologie), Inhibiteurs de protéases (synthèse chimique), Modèles moléculaires, Norovirus (enzymologie), Peptide hydrolases (métabolisme), Picornaviridae (enzymologie), Relation dose-effet des médicaments, Relation structure-activité.
- MESH :
- enzymologie : Coronavirus, Norovirus, Picornaviridae.
- métabolisme : Peptide hydrolases.
- pharmacologie : Composés macrocycliques, Inhibiteurs de protéases.
- synthèse chimique : Composés macrocycliques, Inhibiteurs de protéases.
- Composés macrocycliques, Conception de médicament, Conformation moléculaire, Inhibiteurs de protéases, Modèles moléculaires, Relation dose-effet des médicaments, Relation structure-activité.
English descriptors
- KwdEn :
- Coronavirus (enzymology), Dose-Response Relationship, Drug, Drug Design, Macrocyclic Compounds (chemical synthesis), Macrocyclic Compounds (chemistry), Macrocyclic Compounds (pharmacology), Models, Molecular, Molecular Conformation, Norovirus (enzymology), Peptide Hydrolases (metabolism), Picornaviridae (enzymology), Protease Inhibitors (chemical synthesis), Protease Inhibitors (chemistry), Protease Inhibitors (pharmacology), Structure-Activity Relationship.
- MESH :
- chemical , chemical synthesis : Macrocyclic Compounds, Protease Inhibitors.
- chemical , chemistry : Macrocyclic Compounds, Protease Inhibitors.
- enzymology : Coronavirus, Norovirus, Picornaviridae.
- chemical , metabolism : Peptide Hydrolases.
- chemical , pharmacology : Macrocyclic Compounds, Protease Inhibitors.
- Dose-Response Relationship, Drug, Drug Design, Models, Molecular, Molecular Conformation, Structure-Activity Relationship.
Abstract
The design, synthesis, and in vitro evaluation of the first macrocyclic inhibitor of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus are reported. The in vitro inhibitory activity (50% effective concentration) of the macrocyclic inhibitor toward enterovirus 3C protease (CVB3 Nancy strain), and coronavirus (SARS-CoV) and norovirus 3C-like proteases, was determined to be 1.8, 15.5 and 5.1 μM, respectively.
DOI: 10.1016/j.bmcl.2013.05.021
PubMed: 23727045
Affiliations:
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Le document en format XML
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The in vitro inhibitory activity (50% effective concentration) of the macrocyclic inhibitor toward enterovirus 3C protease (CVB3 Nancy strain), and coronavirus (SARS-CoV) and norovirus 3C-like proteases, was determined to be 1.8, 15.5 and 5.1 μM, respectively.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Kansas</li></region></list><tree><noCountry><name sortKey="Alliston, Kevin R" sort="Alliston, Kevin R" uniqKey="Alliston K" first="Kevin R" last="Alliston">Kevin R. Alliston</name><name sortKey="Aravapalli, Sridhar" sort="Aravapalli, Sridhar" uniqKey="Aravapalli S" first="Sridhar" last="Aravapalli">Sridhar Aravapalli</name><name sortKey="Chang, Kyeong Ok" sort="Chang, Kyeong Ok" uniqKey="Chang K" first="Kyeong-Ok" last="Chang">Kyeong-Ok Chang</name><name sortKey="Groutas, William C" sort="Groutas, William C" uniqKey="Groutas W" first="William C" last="Groutas">William C. Groutas</name><name sortKey="Hua, Duy H" sort="Hua, Duy H" uniqKey="Hua D" first="Duy H" last="Hua">Duy H. Hua</name><name sortKey="Kim, Yunjeong" sort="Kim, Yunjeong" uniqKey="Kim Y" first="Yunjeong" last="Kim">Yunjeong Kim</name><name sortKey="Lushington, Gerald H" sort="Lushington, Gerald H" uniqKey="Lushington G" first="Gerald H" last="Lushington">Gerald H. Lushington</name><name sortKey="Prior, Allan M" sort="Prior, Allan M" uniqKey="Prior A" first="Allan M" last="Prior">Allan M. Prior</name><name sortKey="Uy, Roxanne Adeline Z" sort="Uy, Roxanne Adeline Z" uniqKey="Uy R" first="Roxanne Adeline Z" last="Uy">Roxanne Adeline Z. Uy</name><name sortKey="Weerawarna, Pathum M" sort="Weerawarna, Pathum M" uniqKey="Weerawarna P" first="Pathum M" last="Weerawarna">Pathum M. Weerawarna</name></noCountry><country name="États-Unis"><region name="Kansas"><name sortKey="Mandadapu, Sivakoteswara Rao" sort="Mandadapu, Sivakoteswara Rao" uniqKey="Mandadapu S" first="Sivakoteswara Rao" last="Mandadapu">Sivakoteswara Rao Mandadapu</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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