SrasV1, PubMed, Checkpoint, bibRecord, 001144

Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus.

Identifieur interne : 001144 ( PubMed/Checkpoint ); précédent : 001143; suivant : 001145

Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus.

Auteurs : Sivakoteswara Rao Mandadapu [États-Unis] ; Pathum M. Weerawarna ; Allan M. Prior ; Roxanne Adeline Z. Uy ; Sridhar Aravapalli ; Kevin R. Alliston ; Gerald H. Lushington ; Yunjeong Kim ; Duy H. Hua ; Kyeong-Ok Chang ; William C. Groutas

Source :

Bioorganic & medicinal chemistry letters [ 1464-3405 ] ; 2013.

RBID : pubmed:23727045

Descripteurs français

KwdFr :
- Composés macrocycliques (), Composés macrocycliques (pharmacologie), Composés macrocycliques (synthèse chimique), Conception de médicament, Conformation moléculaire, Coronavirus (enzymologie), Inhibiteurs de protéases (), Inhibiteurs de protéases (pharmacologie), Inhibiteurs de protéases (synthèse chimique), Modèles moléculaires, Norovirus (enzymologie), Peptide hydrolases (métabolisme), Picornaviridae (enzymologie), Relation dose-effet des médicaments, Relation structure-activité.
MESH :
- enzymologie : Coronavirus, Norovirus, Picornaviridae.
- métabolisme : Peptide hydrolases.
- pharmacologie : Composés macrocycliques, Inhibiteurs de protéases.
- synthèse chimique : Composés macrocycliques, Inhibiteurs de protéases.
- Composés macrocycliques, Conception de médicament, Conformation moléculaire, Inhibiteurs de protéases, Modèles moléculaires, Relation dose-effet des médicaments, Relation structure-activité.

English descriptors

KwdEn :
- Coronavirus (enzymology), Dose-Response Relationship, Drug, Drug Design, Macrocyclic Compounds (chemical synthesis), Macrocyclic Compounds (chemistry), Macrocyclic Compounds (pharmacology), Models, Molecular, Molecular Conformation, Norovirus (enzymology), Peptide Hydrolases (metabolism), Picornaviridae (enzymology), Protease Inhibitors (chemical synthesis), Protease Inhibitors (chemistry), Protease Inhibitors (pharmacology), Structure-Activity Relationship.
MESH :
- chemical , chemical synthesis : Macrocyclic Compounds, Protease Inhibitors.
- chemical , chemistry : Macrocyclic Compounds, Protease Inhibitors.
- enzymology : Coronavirus, Norovirus, Picornaviridae.
- chemical , metabolism : Peptide Hydrolases.
- chemical , pharmacology : Macrocyclic Compounds, Protease Inhibitors.
- Dose-Response Relationship, Drug, Drug Design, Models, Molecular, Molecular Conformation, Structure-Activity Relationship.

Abstract

The design, synthesis, and in vitro evaluation of the first macrocyclic inhibitor of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus are reported. The in vitro inhibitory activity (50% effective concentration) of the macrocyclic inhibitor toward enterovirus 3C protease (CVB3 Nancy strain), and coronavirus (SARS-CoV) and norovirus 3C-like proteases, was determined to be 1.8, 15.5 and 5.1 μM, respectively.

DOI: 10.1016/j.bmcl.2013.05.021
PubMed: 23727045

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 001189
to stream PubMed, to step Curation: 001189

Links to Exploration step

pubmed:23727045

Le document en format XML

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<front><div type="abstract" xml:lang="en">The design, synthesis, and in vitro evaluation of the first macrocyclic inhibitor of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus are reported. The in vitro inhibitory activity (50% effective concentration) of the macrocyclic inhibitor toward enterovirus 3C protease (CVB3 Nancy strain), and coronavirus (SARS-CoV) and norovirus 3C-like proteases, was determined to be 1.8, 15.5 and 5.1 μM, respectively.</div>
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<name sortKey="Hua, Duy H" sort="Hua, Duy H" uniqKey="Hua D" first="Duy H" last="Hua">Duy H. Hua</name>
<name sortKey="Kim, Yunjeong" sort="Kim, Yunjeong" uniqKey="Kim Y" first="Yunjeong" last="Kim">Yunjeong Kim</name>
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Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus.

Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus.

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