Advancing translational research with next‐generation protein microarrays
Identifieur interne : 001186 ( Main/Exploration ); précédent : 001185; suivant : 001187Advancing translational research with next‐generation protein microarrays
Auteurs : Xiaobo Yu [République populaire de Chine, États-Unis] ; Brianne Petritis [États-Unis] ; Joshua Labaer [États-Unis]Source :
- PROTEOMICS [ 1615-9853 ] ; 2016-04.
Abstract
Protein microarrays are a high‐throughput technology used increasingly in translational research, seeking to apply basic science findings to enhance human health. In addition to assessing protein levels, posttranslational modifications, and signaling pathways in patient samples, protein microarrays have aided in the identification of potential protein biomarkers of disease and infection. In this perspective, the different types of full‐length protein microarrays that are used in translational research are reviewed. Specific studies employing these microarrays are presented to highlight their potential in finding solutions to real clinical problems. Finally, the criteria that should be considered when developing next‐generation protein microarrays are provided.
Url:
DOI: 10.1002/pmic.201500374
Affiliations:
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Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, AZ, Tempe</wicri:regionArea><wicri:noRegion>Tempe</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">PROTEOMICS</title><title level="j" type="sub">Protein arrays</title><title level="j" type="alt">PROTEOMICS</title><idno type="ISSN">1615-9853</idno><idno type="eISSN">1615-9861</idno><imprint><biblScope unit="vol">16</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1238">1238</biblScope><biblScope unit="page" to="1250">1250</biblScope><biblScope unit="page-count">13</biblScope><date type="published" when="2016-04">2016-04</date></imprint><idno type="ISSN">1615-9853</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1615-9853</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Protein microarrays are a high‐throughput technology used increasingly in translational research, seeking to apply basic science findings to enhance human health. In addition to assessing protein levels, posttranslational modifications, and signaling pathways in patient samples, protein microarrays have aided in the identification of potential protein biomarkers of disease and infection. In this perspective, the different types of full‐length protein microarrays that are used in translational research are reviewed. Specific studies employing these microarrays are presented to highlight their potential in finding solutions to real clinical problems. Finally, the criteria that should be considered when developing next‐generation protein microarrays are provided.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Yu, Xiaobo" sort="Yu, Xiaobo" uniqKey="Yu X" first="Xiaobo" last="Yu">Xiaobo Yu</name></noRegion><name sortKey="Yu, Xiaobo" sort="Yu, Xiaobo" uniqKey="Yu X" first="Xiaobo" last="Yu">Xiaobo Yu</name></country><country name="États-Unis"><noRegion><name sortKey="Yu, Xiaobo" sort="Yu, Xiaobo" uniqKey="Yu X" first="Xiaobo" last="Yu">Xiaobo Yu</name></noRegion><name sortKey="Labaer, Joshua" sort="Labaer, Joshua" uniqKey="Labaer J" first="Joshua" last="Labaer">Joshua Labaer</name><name sortKey="Petritis, Brianne" sort="Petritis, Brianne" uniqKey="Petritis B" first="Brianne" last="Petritis">Brianne Petritis</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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