Celastrol inhibits dengue virus replication via up-regulating type I interferon and downstream interferon-stimulated responses.
Identifieur interne : 000E65 ( Main/Exploration ); précédent : 000E64; suivant : 000E66Celastrol inhibits dengue virus replication via up-regulating type I interferon and downstream interferon-stimulated responses.
Auteurs : Jung-Sheng Yu [Taïwan] ; Chin-Kai Tseng [Taïwan] ; Chun-Kuang Lin [Taïwan] ; Yao-Chin Hsu [Taïwan] ; Yu-Hsuan Wu [Taïwan] ; Ching-Liang Hsieh [Taïwan] ; Jin-Ching Lee [Taïwan]Source :
- Antiviral research [ 1872-9096 ] ; 2017.
Descripteurs français
- KwdFr :
- Activation de la transcription (), Analyse de survie, Animaux, Animaux allaités, Antiviraux (administration et posologie), Antiviraux (pharmacologie), Antiviraux (usage thérapeutique), Dengue (traitement médicamenteux), Dengue (virologie), Interférence par ARN, Interféron alpha (génétique), Interféron de type I (génétique), Modèles animaux de maladie humaine, Régulation positive, Réplication de l'ADN (), Réplication virale (), Souris, Souris de lignée ICR, Triterpènes (administration et posologie), Triterpènes (pharmacologie), Triterpènes (usage thérapeutique), Virus de la dengue (), Virus de la dengue (physiologie).
- MESH :
- administration et posologie : Antiviraux, Triterpènes.
- génétique : Interféron alpha, Interféron de type I.
- pharmacologie : Antiviraux, Triterpènes.
- physiologie : Virus de la dengue.
- traitement médicamenteux : Dengue.
- usage thérapeutique : Antiviraux, Triterpènes.
- virologie : Dengue.
- Activation de la transcription, Analyse de survie, Animaux, Animaux allaités, Interférence par ARN, Modèles animaux de maladie humaine, Régulation positive, Réplication de l'ADN, Réplication virale, Souris, Souris de lignée ICR, Virus de la dengue.
English descriptors
- KwdEn :
- Animals, Animals, Suckling, Antiviral Agents (administration & dosage), Antiviral Agents (pharmacology), Antiviral Agents (therapeutic use), DNA Replication (drug effects), Dengue (drug therapy), Dengue (virology), Dengue Virus (drug effects), Dengue Virus (physiology), Disease Models, Animal, Interferon Type I (genetics), Interferon-alpha (genetics), Mice, Mice, Inbred ICR, RNA Interference, Survival Analysis, Transcriptional Activation (drug effects), Triterpenes (administration & dosage), Triterpenes (pharmacology), Triterpenes (therapeutic use), Up-Regulation, Virus Replication (drug effects).
- MESH :
- chemical , administration & dosage : Antiviral Agents, Triterpenes.
- chemical , genetics : Interferon Type I, Interferon-alpha.
- chemical , pharmacology : Antiviral Agents, Triterpenes.
- chemical , therapeutic use : Antiviral Agents, Triterpenes.
- drug effects : DNA Replication, Dengue Virus, Transcriptional Activation, Virus Replication.
- drug therapy : Dengue.
- physiology : Dengue Virus.
- virology : Dengue.
- Animals, Animals, Suckling, Disease Models, Animal, Mice, Mice, Inbred ICR, RNA Interference, Survival Analysis, Up-Regulation.
Abstract
Tripterygium wilfordii (lei gong teng; Thunder of God Vine), a member of the Celastraceae family, is a medicinal plant used to treat a range of illnesses. Celastrol is a quinone methide triterpene and the most abundant bioactive constituent isolated from the root extracts of T. wilfordii. Previous studies have shown that celastrol exhibits antiviral activity against HIV and SARS-CoV. To date, no investigations of the anti-DENV activity of celastrol have been reported. This work aimed to investigate the anti-DENV effect and possible mechanism of celastrol in vitro and in vivo.
DOI: 10.1016/j.antiviral.2016.11.010
PubMed: 27847245
Affiliations:
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Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Chinese Medicine, Chi Mei Medical Center, Tainan 71004, Taiwan; Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 40402</wicri:regionArea><wicri:noRegion>Taichung 40402</wicri:noRegion></affiliation></author><author><name sortKey="Tseng, Chin Kai" sort="Tseng, Chin Kai" uniqKey="Tseng C" first="Chin-Kai" last="Tseng">Chin-Kai Tseng</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Center of Infectious Disease and Signaling Research, College of Medicine, National Cheng Kung University, Tainan, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 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médicamenteux)</term><term>Dengue (virologie)</term><term>Interférence par ARN</term><term>Interféron alpha (génétique)</term><term>Interféron de type I (génétique)</term><term>Modèles animaux de maladie humaine</term><term>Régulation positive</term><term>Réplication de l'ADN ()</term><term>Réplication virale ()</term><term>Souris</term><term>Souris de lignée ICR</term><term>Triterpènes (administration et posologie)</term><term>Triterpènes (pharmacologie)</term><term>Triterpènes (usage thérapeutique)</term><term>Virus de la dengue ()</term><term>Virus de la dengue (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiviral Agents</term><term>Triterpenes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Interferon Type I</term><term>Interferon-alpha</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Triterpenes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term><term>Triterpenes</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antiviraux</term><term>Triterpènes</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>DNA Replication</term><term>Dengue Virus</term><term>Transcriptional Activation</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dengue</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Interféron alpha</term><term>Interféron de type I</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Triterpènes</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus de la dengue</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Dengue Virus</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Dengue</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term><term>Triterpènes</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Dengue</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Dengue</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Animals, Suckling</term><term>Disease Models, Animal</term><term>Mice</term><term>Mice, Inbred ICR</term><term>RNA Interference</term><term>Survival Analysis</term><term>Up-Regulation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activation de la transcription</term><term>Analyse de survie</term><term>Animaux</term><term>Animaux allaités</term><term>Interférence par ARN</term><term>Modèles animaux de maladie humaine</term><term>Régulation positive</term><term>Réplication de l'ADN</term><term>Réplication virale</term><term>Souris</term><term>Souris de lignée ICR</term><term>Virus de la dengue</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Tripterygium wilfordii (lei gong teng; Thunder of God Vine), a member of the Celastraceae family, is a medicinal plant used to treat a range of illnesses. Celastrol is a quinone methide triterpene and the most abundant bioactive constituent isolated from the root extracts of T. wilfordii. Previous studies have shown that celastrol exhibits antiviral activity against HIV and SARS-CoV. To date, no investigations of the anti-DENV activity of celastrol have been reported. This work aimed to investigate the anti-DENV effect and possible mechanism of celastrol in vitro and in vivo.</div></front></TEI><affiliations><list><country><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Yu, Jung Sheng" sort="Yu, Jung Sheng" uniqKey="Yu J" first="Jung-Sheng" last="Yu">Jung-Sheng Yu</name></noRegion><name sortKey="Hsieh, Ching Liang" sort="Hsieh, Ching Liang" uniqKey="Hsieh C" first="Ching-Liang" last="Hsieh">Ching-Liang Hsieh</name><name sortKey="Hsu, Yao Chin" sort="Hsu, Yao Chin" uniqKey="Hsu Y" first="Yao-Chin" last="Hsu">Yao-Chin Hsu</name><name sortKey="Lee, Jin Ching" sort="Lee, Jin Ching" uniqKey="Lee J" first="Jin-Ching" last="Lee">Jin-Ching Lee</name><name sortKey="Lin, Chun Kuang" sort="Lin, Chun Kuang" uniqKey="Lin C" first="Chun-Kuang" last="Lin">Chun-Kuang Lin</name><name sortKey="Tseng, Chin Kai" sort="Tseng, Chin Kai" uniqKey="Tseng C" first="Chin-Kai" last="Tseng">Chin-Kai Tseng</name><name sortKey="Wu, Yu Hsuan" sort="Wu, Yu Hsuan" uniqKey="Wu Y" first="Yu-Hsuan" last="Wu">Yu-Hsuan Wu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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