SrasV1, Ncbi, Merge, bibRecord, 002D33

Celastrol inhibits dengue virus replication via up-regulating type I interferon and downstream interferon-stimulated responses.

Identifieur interne : 002D33 ( Ncbi/Merge ); précédent : 002D32; suivant : 002D34

Celastrol inhibits dengue virus replication via up-regulating type I interferon and downstream interferon-stimulated responses.

Auteurs : Jung-Sheng Yu [Taïwan] ; Chin-Kai Tseng [Taïwan] ; Chun-Kuang Lin [Taïwan] ; Yao-Chin Hsu [Taïwan] ; Yu-Hsuan Wu [Taïwan] ; Ching-Liang Hsieh [Taïwan] ; Jin-Ching Lee [Taïwan]

Source :

Antiviral research [ 1872-9096 ] ; 2017.

RBID : pubmed:27847245

Descripteurs français

KwdFr :
- Activation de la transcription (), Analyse de survie, Animaux, Animaux allaités, Antiviraux (administration et posologie), Antiviraux (pharmacologie), Antiviraux (usage thérapeutique), Dengue (traitement médicamenteux), Dengue (virologie), Interférence par ARN, Interféron alpha (génétique), Interféron de type I (génétique), Modèles animaux de maladie humaine, Régulation positive, Réplication de l'ADN (), Réplication virale (), Souris, Souris de lignée ICR, Triterpènes (administration et posologie), Triterpènes (pharmacologie), Triterpènes (usage thérapeutique), Virus de la dengue (), Virus de la dengue (physiologie).
MESH :
- administration et posologie : Antiviraux, Triterpènes.
- génétique : Interféron alpha, Interféron de type I.
- pharmacologie : Antiviraux, Triterpènes.
- physiologie : Virus de la dengue.
- traitement médicamenteux : Dengue.
- usage thérapeutique : Antiviraux, Triterpènes.
- virologie : Dengue.
- Activation de la transcription, Analyse de survie, Animaux, Animaux allaités, Interférence par ARN, Modèles animaux de maladie humaine, Régulation positive, Réplication de l'ADN, Réplication virale, Souris, Souris de lignée ICR, Virus de la dengue.

English descriptors

KwdEn :
- Animals, Animals, Suckling, Antiviral Agents (administration & dosage), Antiviral Agents (pharmacology), Antiviral Agents (therapeutic use), DNA Replication (drug effects), Dengue (drug therapy), Dengue (virology), Dengue Virus (drug effects), Dengue Virus (physiology), Disease Models, Animal, Interferon Type I (genetics), Interferon-alpha (genetics), Mice, Mice, Inbred ICR, RNA Interference, Survival Analysis, Transcriptional Activation (drug effects), Triterpenes (administration & dosage), Triterpenes (pharmacology), Triterpenes (therapeutic use), Up-Regulation, Virus Replication (drug effects).
MESH :
- chemical , administration & dosage : Antiviral Agents, Triterpenes.
- chemical , genetics : Interferon Type I, Interferon-alpha.
- chemical , pharmacology : Antiviral Agents, Triterpenes.
- chemical , therapeutic use : Antiviral Agents, Triterpenes.
- drug effects : DNA Replication, Dengue Virus, Transcriptional Activation, Virus Replication.
- drug therapy : Dengue.
- physiology : Dengue Virus.
- virology : Dengue.
- Animals, Animals, Suckling, Disease Models, Animal, Mice, Mice, Inbred ICR, RNA Interference, Survival Analysis, Up-Regulation.

Abstract

Tripterygium wilfordii (lei gong teng; Thunder of God Vine), a member of the Celastraceae family, is a medicinal plant used to treat a range of illnesses. Celastrol is a quinone methide triterpene and the most abundant bioactive constituent isolated from the root extracts of T. wilfordii. Previous studies have shown that celastrol exhibits antiviral activity against HIV and SARS-CoV. To date, no investigations of the anti-DENV activity of celastrol have been reported. This work aimed to investigate the anti-DENV effect and possible mechanism of celastrol in vitro and in vivo.

DOI: 10.1016/j.antiviral.2016.11.010
PubMed: 27847245

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to stream PubMed, to step Corpus: 000B88
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pubmed:27847245

Le document en format XML

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<front><div type="abstract" xml:lang="en">Tripterygium wilfordii (lei gong teng; Thunder of God Vine), a member of the Celastraceae family, is a medicinal plant used to treat a range of illnesses. Celastrol is a quinone methide triterpene and the most abundant bioactive constituent isolated from the root extracts of T. wilfordii. Previous studies have shown that celastrol exhibits antiviral activity against HIV and SARS-CoV. To date, no investigations of the anti-DENV activity of celastrol have been reported. This work aimed to investigate the anti-DENV effect and possible mechanism of celastrol in vitro and in vivo.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27847245</PMID>
<DateCompleted><Year>2017</Year>
<Month>12</Month>
<Day>12</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>07</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-9096</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>137</Volume>
<PubDate><Year>2017</Year>
<Month>01</Month>
</PubDate>
</JournalIssue>
<Title>Antiviral research</Title>
<ISOAbbreviation>Antiviral Res.</ISOAbbreviation>
</Journal>
<ArticleTitle>Celastrol inhibits dengue virus replication via up-regulating type I interferon and downstream interferon-stimulated responses.</ArticleTitle>
<Pagination><MedlinePgn>49-57</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0166-3542(16)30435-1</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.antiviral.2016.11.010</ELocationID>
<Abstract><AbstractText Label="ETHNOPHARMACOLOGICAL RELEVANCE AND AIM OF THE STUDY">Tripterygium wilfordii (lei gong teng; Thunder of God Vine), a member of the Celastraceae family, is a medicinal plant used to treat a range of illnesses. Celastrol is a quinone methide triterpene and the most abundant bioactive constituent isolated from the root extracts of T. wilfordii. Previous studies have shown that celastrol exhibits antiviral activity against HIV and SARS-CoV. To date, no investigations of the anti-DENV activity of celastrol have been reported. This work aimed to investigate the anti-DENV effect and possible mechanism of celastrol in vitro and in vivo.</AbstractText>
<AbstractText Label="METHODS">A four-serotype DENV infection system was performed to determine the anti-DENV effect of celastrol by detecting DENV RNA replication and protein synthesis. The precise anti-DENV replication mechanism of celastrol was clarified using specific RNA silencing and specific inhibitor. In addition, the therapeutic efficacy of celastrol was evaluated by monitoring survival rates and clinical scores in a DENV-infected Institute of Cancer Research (ICR) suckling mouse model.</AbstractText>
<AbstractText Label="RESULTS">Celastrol inhibited DENV-1, -2, -3, and -4 RNA replication with EC<sub>50</sub>
 values of 0.19 ± 0.09, 0.12 ± 0.11, 0.16 ± 0.14, and 0.17 ± 0.08 μM, respectively. This antiviral effect of celastrol was associated with celastrol-induced interferon-α (IFN-α) expression and was attenuated by a specific inhibitor of the JAK-STAT signaling pathway downstream of IFN-α or specific shRNA. Furthermore, celastrol protected ICR suckling mice against life-threatening DENV infection.</AbstractText>
<AbstractText Label="CONCLUSION">Celastrol represents a potential anti-DENV agent that induces IFN-α expression and stimulates a downstream antiviral response, making the therapy a promising drug or dietary supplement for the treatment of DENV-infected patients.</AbstractText>
<CopyrightInformation>Copyright © 2016 Elsevier B.V. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yu</LastName>
<ForeName>Jung-Sheng</ForeName>
<Initials>JS</Initials>
<AffiliationInfo><Affiliation>Department of Chinese Medicine, Chi Mei Medical Center, Tainan 71004, Taiwan; Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tseng</LastName>
<ForeName>Chin-Kai</ForeName>
<Initials>CK</Initials>
<AffiliationInfo><Affiliation>Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Center of Infectious Disease and Signaling Research, College of Medicine, National Cheng Kung University, Tainan, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lin</LastName>
<ForeName>Chun-Kuang</ForeName>
<Initials>CK</Initials>
<AffiliationInfo><Affiliation>Doctoral Degree Program in Marine Biotechnology, College of Marine Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hsu</LastName>
<ForeName>Yao-Chin</ForeName>
<Initials>YC</Initials>
<AffiliationInfo><Affiliation>Department of Chinese Medicine, Chi Mei Medical Center, Tainan 71004, Taiwan.</Affiliation>
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</ArticleIdList>
<ReferenceList><Reference><Citation>Science. 1997 Sep 12;277(5332):1630-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9287210</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS Negl Trop Dis. 2012;6(5):e1638</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22563516</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Rev Immunol. 2002 Sep;2(9):675-87</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12209136</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Br J Pharmacol. 2014 Jan;171(1):237-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24117426</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS Pathog. 2011 Feb;7(2):e1001297</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21379341</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Gen Virol. 2007 Feb;88(Pt 2):365-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17251552</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Bioorg Med Chem Lett. 2010 Mar 15;20(6):1873-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20167482</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Antiviral Res. 2015 Apr;116:1-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25614455</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS Negl Trop Dis. 2011 Jan 04;5(1):e926</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21245912</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 1999 Jan;73(1):783-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9847388</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochem Biophys Res Commun. 2010 Jul 16;398(1):140-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20599745</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>JAKSTAT. 2013 Oct 1;2(4):e27521</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24498542</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2005 May;79(9):5414-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15827155</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Infect Dis. 2015 Dec 15;212(12):2011-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26063222</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS Pathog. 2012;8(6):e1002780</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22761576</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2000 Jun;74(11):4957-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10799569</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>BMB Rep. 2015 Mar;48(3):172-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25059279</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Ethnopharmacol. 2015 Aug 22;172:254-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26116162</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Immunol. 2013 Oct 15;191(8):4194-201</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24043884</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nature. 2013 Apr 25;496(7446):504-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23563266</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Antiviral Res. 2013 Nov;100(2):500-19</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24076358</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2010 Aug;84(16):8332-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20534863</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Lancet. 2006 Mar 11;367(9513):859-69</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16530580</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>F1000Res. 2015 Nov 25;4:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26918141</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>BMC Microbiol. 2007 Jan 30;7:9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17263893</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Immunol. 2016 Feb 1;196(3):1218-26</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26712948</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Arch Virol. 2012 Apr;157(4):681-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22249364</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Immunol. 2006 Mar 1;176(5):2825-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16493039</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2004 Mar;78(6):2701-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14990690</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):E3206-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25049377</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Adv Pharmacol. 2000;47:113-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10582086</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>mBio. 2015 May 12;6(3):e00553-15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25968648</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Toxicol Appl Pharmacol. 2014 Oct 1;280(1):42-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25064159</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>PLoS Pathog. 2013 Mar;9(3):e1003265</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23555265</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Rev Immunol. 2015 Dec;15(12):745-59</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26603900</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Infect Dis. 2008 May 15;197(10):1459-67</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18444802</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Sci Transl Med. 2015 Dec 16;7(318):318le4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26676605</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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Celastrol inhibits dengue virus replication via up-regulating type I interferon and downstream interferon-stimulated responses.

Celastrol inhibits dengue virus replication via up-regulating type I interferon and downstream interferon-stimulated responses.

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