Group A Rotaviruses in Chinese Bats: Genetic Composition, Serology, and Evidence for Bat-to-Human Transmission and Reassortment.
Identifieur interne : 000E25 ( Main/Exploration ); précédent : 000E24; suivant : 000E26Group A Rotaviruses in Chinese Bats: Genetic Composition, Serology, and Evidence for Bat-to-Human Transmission and Reassortment.
Auteurs : Biao He [République populaire de Chine] ; Xiaohong Huang [République populaire de Chine] ; Fuqiang Zhang [République populaire de Chine] ; Weilong Tan [République populaire de Chine] ; Jelle Matthijnssens [Belgique] ; Shaomin Qin [République populaire de Chine] ; Lin Xu [République populaire de Chine] ; Zihan Zhao [République populaire de Chine] ; Ling'En Yang [République populaire de Chine] ; Quanxi Wang [République populaire de Chine] ; Tingsong Hu [République populaire de Chine] ; Xiaolei Bao [République populaire de Chine] ; Jianmin Wu [Oman] ; Changchun Tu [Oman]Source :
- Journal of virology [ 1098-5514 ] ; 2017.
Descripteurs français
- KwdFr :
- ARN viral (génétique), Animaux, Anticorps antiviraux (sang), Canal anal (virologie), Chine, Chiroptera (virologie), Enfant d'âge préscolaire, Génome viral, Génotype, Humains, Infections à rotavirus (immunologie), Infections à rotavirus (médecine vétérinaire), Infections à rotavirus (transmission), Infections à rotavirus (virologie), Intestins (virologie), Phylogénie, Rotavirus (), Rotavirus (génétique), Rotavirus (immunologie), Rotavirus (isolement et purification), Réservoirs d'agents pathogènes (virologie), Variation génétique, Virus recombinants, Zoonoses.
- MESH :
- génétique : ARN viral, Rotavirus.
- immunologie : Infections à rotavirus, Rotavirus.
- isolement et purification : Rotavirus.
- médecine vétérinaire : Infections à rotavirus.
- sang : Anticorps antiviraux.
- virologie : Canal anal, Chiroptera, Infections à rotavirus, Intestins, Réservoirs d'agents pathogènes.
- Animaux, Chine, Enfant d'âge préscolaire, Génome viral, Génotype, Humains, Infections à rotavirus, Phylogénie, Rotavirus, Variation génétique, Virus recombinants, Zoonoses.
English descriptors
- KwdEn :
- Anal Canal (virology), Animals, Antibodies, Viral (blood), Child, Preschool, China, Chiroptera (virology), Disease Reservoirs (virology), Genetic Variation, Genome, Viral, Genotype, Humans, Intestines (virology), Phylogeny, RNA, Viral (genetics), Reassortant Viruses, Rotavirus (classification), Rotavirus (genetics), Rotavirus (immunology), Rotavirus (isolation & purification), Rotavirus Infections (immunology), Rotavirus Infections (transmission), Rotavirus Infections (veterinary), Rotavirus Infections (virology), Zoonoses.
- MESH :
- chemical , blood : Antibodies, Viral.
- chemical , genetics : RNA, Viral.
- classification : Rotavirus.
- genetics : Rotavirus.
- immunology : Rotavirus, Rotavirus Infections.
- isolation & purification : Rotavirus.
- transmission : Rotavirus Infections.
- veterinary : Rotavirus Infections.
- virology : Anal Canal, Chiroptera, Disease Reservoirs, Intestines, Rotavirus Infections.
- Animals, Child, Preschool, China, Genetic Variation, Genome, Viral, Genotype, Humans, Phylogeny, Reassortant Viruses, Zoonoses.
Abstract
Bats are natural reservoirs for many pathogenic viruses, and increasing evidence supports the notion that bats can also harbor group A rotaviruses (RVAs), important causative agents of diarrhea in children and young animals. Currently, 8 RVA strains possessing completely novel genotype constellations or genotypes possibly originating from other mammals have been identified from African and Chinese bats. However, all the data were mainly based on detection of RVA RNA, present only during acute infections, which does not permit assessment of the true exposure of a bat population to RVA. To systematically investigate the genetic diversity of RVAs, 547 bat anal swabs or gut samples along with 448 bat sera were collected from five South Chinese provinces. Specific reverse transcription-PCR (RT-PCR) screening found four RVA strains. Strain GLRL1 possessed a completely novel genotype constellation, whereas the other three possessed a constellation consistent with the MSLH14-like genotype, a newly characterized group of viruses widely prevalent in Chinese insectivorous bats. Among the latter, strain LZHP2 provided strong evidence of cross-species transmission of RVAs from bats to humans, whereas strains YSSK5 and BSTM70 were likely reassortants between typical MSLH14-like RVAs and human RVAs. RVA-specific antibodies were detected in 10.7% (48/448) of bat sera by an indirect immunofluorescence assay (IIFA). Bats in Guangxi and Yunnan had a higher RVA-specific antibody prevalence than those from Fujian and Zhejiang provinces. These observations provide evidence for cross-species transmission of MSLH14-like bat RVAs to humans, highlighting the impact of bats as reservoirs of RVAs on public health.IMPORTANCE Bat viruses, such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), Ebola, Hendra, and Nipah viruses, are important pathogens causing outbreaks of severe emerging infectious diseases. However, little is known about bat viruses capable of causing gastroenteritis in humans, even though 8 group A viruses (RVAs) have been identified from bats so far. In this study, another 4 RVA strains were identified, with one providing strong evidence for zoonotic transmission from bats to humans. Serological investigation has also indicated that RVA infection in bats is far more prevalent than expected based on the detection of viral RNA.
DOI: 10.1128/JVI.02493-16
PubMed: 28381569
Affiliations:
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Le document en format XML
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<author><name sortKey="Zhao, Zihan" sort="Zhao, Zihan" uniqKey="Zhao Z" first="Zihan" last="Zhao">Zihan Zhao</name>
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<author><name sortKey="Wang, Quanxi" sort="Wang, Quanxi" uniqKey="Wang Q" first="Quanxi" last="Wang">Quanxi Wang</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anal Canal (virology)</term>
<term>Animals</term>
<term>Antibodies, Viral (blood)</term>
<term>Child, Preschool</term>
<term>China</term>
<term>Chiroptera (virology)</term>
<term>Disease Reservoirs (virology)</term>
<term>Genetic Variation</term>
<term>Genome, Viral</term>
<term>Genotype</term>
<term>Humans</term>
<term>Intestines (virology)</term>
<term>Phylogeny</term>
<term>RNA, Viral (genetics)</term>
<term>Reassortant Viruses</term>
<term>Rotavirus (classification)</term>
<term>Rotavirus (genetics)</term>
<term>Rotavirus (immunology)</term>
<term>Rotavirus (isolation & purification)</term>
<term>Rotavirus Infections (immunology)</term>
<term>Rotavirus Infections (transmission)</term>
<term>Rotavirus Infections (veterinary)</term>
<term>Rotavirus Infections (virology)</term>
<term>Zoonoses</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (génétique)</term>
<term>Animaux</term>
<term>Anticorps antiviraux (sang)</term>
<term>Canal anal (virologie)</term>
<term>Chine</term>
<term>Chiroptera (virologie)</term>
<term>Enfant d'âge préscolaire</term>
<term>Génome viral</term>
<term>Génotype</term>
<term>Humains</term>
<term>Infections à rotavirus (immunologie)</term>
<term>Infections à rotavirus (médecine vétérinaire)</term>
<term>Infections à rotavirus (transmission)</term>
<term>Infections à rotavirus (virologie)</term>
<term>Intestins (virologie)</term>
<term>Phylogénie</term>
<term>Rotavirus ()</term>
<term>Rotavirus (génétique)</term>
<term>Rotavirus (immunologie)</term>
<term>Rotavirus (isolement et purification)</term>
<term>Réservoirs d'agents pathogènes (virologie)</term>
<term>Variation génétique</term>
<term>Virus recombinants</term>
<term>Zoonoses</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Rotavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Rotavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN viral</term>
<term>Rotavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infections à rotavirus</term>
<term>Rotavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Rotavirus</term>
<term>Rotavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Rotavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Rotavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Infections à rotavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term>
</keywords>
<keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Rotavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Rotavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Canal anal</term>
<term>Chiroptera</term>
<term>Infections à rotavirus</term>
<term>Intestins</term>
<term>Réservoirs d'agents pathogènes</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Anal Canal</term>
<term>Chiroptera</term>
<term>Disease Reservoirs</term>
<term>Intestines</term>
<term>Rotavirus Infections</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Child, Preschool</term>
<term>China</term>
<term>Genetic Variation</term>
<term>Genome, Viral</term>
<term>Genotype</term>
<term>Humans</term>
<term>Phylogeny</term>
<term>Reassortant Viruses</term>
<term>Zoonoses</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Chine</term>
<term>Enfant d'âge préscolaire</term>
<term>Génome viral</term>
<term>Génotype</term>
<term>Humains</term>
<term>Infections à rotavirus</term>
<term>Phylogénie</term>
<term>Rotavirus</term>
<term>Variation génétique</term>
<term>Virus recombinants</term>
<term>Zoonoses</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Bats are natural reservoirs for many pathogenic viruses, and increasing evidence supports the notion that bats can also harbor group A rotaviruses (RVAs), important causative agents of diarrhea in children and young animals. Currently, 8 RVA strains possessing completely novel genotype constellations or genotypes possibly originating from other mammals have been identified from African and Chinese bats. However, all the data were mainly based on detection of RVA RNA, present only during acute infections, which does not permit assessment of the true exposure of a bat population to RVA. To systematically investigate the genetic diversity of RVAs, 547 bat anal swabs or gut samples along with 448 bat sera were collected from five South Chinese provinces. Specific reverse transcription-PCR (RT-PCR) screening found four RVA strains. Strain GLRL1 possessed a completely novel genotype constellation, whereas the other three possessed a constellation consistent with the MSLH14-like genotype, a newly characterized group of viruses widely prevalent in Chinese insectivorous bats. Among the latter, strain LZHP2 provided strong evidence of cross-species transmission of RVAs from bats to humans, whereas strains YSSK5 and BSTM70 were likely reassortants between typical MSLH14-like RVAs and human RVAs. RVA-specific antibodies were detected in 10.7% (48/448) of bat sera by an indirect immunofluorescence assay (IIFA). Bats in Guangxi and Yunnan had a higher RVA-specific antibody prevalence than those from Fujian and Zhejiang provinces. These observations provide evidence for cross-species transmission of MSLH14-like bat RVAs to humans, highlighting the impact of bats as reservoirs of RVAs on public health.<b>IMPORTANCE</b>
Bat viruses, such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), Ebola, Hendra, and Nipah viruses, are important pathogens causing outbreaks of severe emerging infectious diseases. However, little is known about bat viruses capable of causing gastroenteritis in humans, even though 8 group A viruses (RVAs) have been identified from bats so far. In this study, another 4 RVA strains were identified, with one providing strong evidence for zoonotic transmission from bats to humans. Serological investigation has also indicated that RVA infection in bats is far more prevalent than expected based on the detection of viral RNA.</div>
</front>
</TEI>
<affiliations><list><country><li>Belgique</li>
<li>Oman</li>
<li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="He, Biao" sort="He, Biao" uniqKey="He B" first="Biao" last="He">Biao He</name>
</noRegion>
<name sortKey="Bao, Xiaolei" sort="Bao, Xiaolei" uniqKey="Bao X" first="Xiaolei" last="Bao">Xiaolei Bao</name>
<name sortKey="Hu, Tingsong" sort="Hu, Tingsong" uniqKey="Hu T" first="Tingsong" last="Hu">Tingsong Hu</name>
<name sortKey="Huang, Xiaohong" sort="Huang, Xiaohong" uniqKey="Huang X" first="Xiaohong" last="Huang">Xiaohong Huang</name>
<name sortKey="Qin, Shaomin" sort="Qin, Shaomin" uniqKey="Qin S" first="Shaomin" last="Qin">Shaomin Qin</name>
<name sortKey="Tan, Weilong" sort="Tan, Weilong" uniqKey="Tan W" first="Weilong" last="Tan">Weilong Tan</name>
<name sortKey="Wang, Quanxi" sort="Wang, Quanxi" uniqKey="Wang Q" first="Quanxi" last="Wang">Quanxi Wang</name>
<name sortKey="Xu, Lin" sort="Xu, Lin" uniqKey="Xu L" first="Lin" last="Xu">Lin Xu</name>
<name sortKey="Yang, Ling En" sort="Yang, Ling En" uniqKey="Yang L" first="Ling'En" last="Yang">Ling'En Yang</name>
<name sortKey="Zhang, Fuqiang" sort="Zhang, Fuqiang" uniqKey="Zhang F" first="Fuqiang" last="Zhang">Fuqiang Zhang</name>
<name sortKey="Zhao, Zihan" sort="Zhao, Zihan" uniqKey="Zhao Z" first="Zihan" last="Zhao">Zihan Zhao</name>
</country>
<country name="Belgique"><noRegion><name sortKey="Matthijnssens, Jelle" sort="Matthijnssens, Jelle" uniqKey="Matthijnssens J" first="Jelle" last="Matthijnssens">Jelle Matthijnssens</name>
</noRegion>
</country>
<country name="Oman"><noRegion><name sortKey="Wu, Jianmin" sort="Wu, Jianmin" uniqKey="Wu J" first="Jianmin" last="Wu">Jianmin Wu</name>
</noRegion>
<name sortKey="Tu, Changchun" sort="Tu, Changchun" uniqKey="Tu C" first="Changchun" last="Tu">Changchun Tu</name>
</country>
</tree>
</affiliations>
</record>
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