Relationship between Structural Characteristics and Plant Sources along with Pharmacology Research of Quassinoids.
Identifieur interne : 000B00 ( Main/Exploration ); précédent : 000A99; suivant : 000B01Relationship between Structural Characteristics and Plant Sources along with Pharmacology Research of Quassinoids.
Auteurs : Zheng Li ; Jing-Ya Ruan ; Fan Sun ; Jie-Jing Yan ; Jian-Li Wang ; Zi-Xin Zhang ; Yi Zhang ; Tao WangSource :
- Chemical & pharmaceutical bulletin [ 1347-5223 ] ; 2019.
Descripteurs français
- KwdFr :
- Antinéoplasiques d'origine végétale (), Antinéoplasiques d'origine végétale (isolement et purification), Antinéoplasiques d'origine végétale (pharmacologie), Antiprotozoaires (), Antiprotozoaires (isolement et purification), Antiprotozoaires (pharmacologie), Antiviraux (), Antiviraux (isolement et purification), Antiviraux (pharmacologie), Humains, Plantes (), Plantes (métabolisme), Plasmodium falciparum (), Quassinoïdes (), Quassinoïdes (isolement et purification), Quassinoïdes (pharmacologie), Relation structure-activité, Survie cellulaire (), Virus de la mosaïque du tabac ().
- MESH :
- isolement et purification : Antinéoplasiques d'origine végétale, Antiprotozoaires, Antiviraux, Quassinoïdes.
- métabolisme : Plantes.
- pharmacologie : Antinéoplasiques d'origine végétale, Antiprotozoaires, Antiviraux, Quassinoïdes.
- Antinéoplasiques d'origine végétale, Antiprotozoaires, Antiviraux, Humains, Plantes, Plasmodium falciparum, Quassinoïdes, Relation structure-activité, Survie cellulaire, Virus de la mosaïque du tabac.
English descriptors
- KwdEn :
- Antineoplastic Agents, Phytogenic (chemistry), Antineoplastic Agents, Phytogenic (isolation & purification), Antineoplastic Agents, Phytogenic (pharmacology), Antiprotozoal Agents (chemistry), Antiprotozoal Agents (isolation & purification), Antiprotozoal Agents (pharmacology), Antiviral Agents (chemistry), Antiviral Agents (isolation & purification), Antiviral Agents (pharmacology), Cell Survival (drug effects), Humans, Plants (chemistry), Plants (metabolism), Plasmodium falciparum (drug effects), Quassins (chemistry), Quassins (isolation & purification), Quassins (pharmacology), Structure-Activity Relationship, Tobacco Mosaic Virus (drug effects).
- MESH :
- chemical , chemistry : Antineoplastic Agents, Phytogenic, Antiprotozoal Agents, Antiviral Agents, Quassins.
- chemical , isolation & purification : Antineoplastic Agents, Phytogenic, Antiprotozoal Agents, Antiviral Agents, Quassins.
- chemical , pharmacology : Antineoplastic Agents, Phytogenic, Antiprotozoal Agents, Antiviral Agents, Quassins.
- chemistry : Plants.
- drug effects : Cell Survival, Plasmodium falciparum, Tobacco Mosaic Virus.
- metabolism : Plants.
- Humans, Structure-Activity Relationship.
Abstract
Quassinoids, one kind of triterpenoids with multiple bioactivities such as anti-cancer, anti-malarial, anti-oxidative, anti-microbial, anti-diabetic, anti-viral, and anti-inflammatory effects, have drawn much attention in recent years. Between 2004 and 2018, the structural characteristics and plant sources of 190 quassinoids were reported. Herein, the structure-activity relationships (SARs) of quassinoids along with the anti-cancer mechanisms of four representative quassinoids, eurycomanone, bruceine D, dehydrobruceine B, and brusatol are discussed. This review might be useful for further research and development of quassinoids.
DOI: 10.1248/cpb.c18-00958
PubMed: 31257321
Affiliations:
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Chinese Medicine, Tianjin University of Traditional Chinese Medicine.</nlm:affiliation><wicri:noCountry code="subField">Tianjin University of Traditional Chinese Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Sun, Fan" sort="Sun, Fan" uniqKey="Sun F" first="Fan" last="Sun">Fan Sun</name><affiliation><nlm:affiliation>Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine.</nlm:affiliation><wicri:noCountry code="subField">Tianjin University of Traditional Chinese Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Yan, Jie Jing" sort="Yan, Jie Jing" uniqKey="Yan J" first="Jie-Jing" last="Yan">Jie-Jing Yan</name><affiliation><nlm:affiliation>Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine.</nlm:affiliation><wicri:noCountry code="subField">Tianjin University of Traditional Chinese Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Wang, Jian Li" sort="Wang, Jian Li" uniqKey="Wang J" first="Jian-Li" last="Wang">Jian-Li Wang</name><affiliation><nlm:affiliation>Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine.</nlm:affiliation><wicri:noCountry code="subField">Tianjin University of Traditional Chinese Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Zhang, Zi Xin" sort="Zhang, Zi Xin" uniqKey="Zhang Z" first="Zi-Xin" last="Zhang">Zi-Xin Zhang</name><affiliation><nlm:affiliation>Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine.</nlm:affiliation><wicri:noCountry code="subField">Tianjin University of Traditional Chinese Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Zhang, Yi" sort="Zhang, Yi" uniqKey="Zhang Y" first="Yi" last="Zhang">Yi Zhang</name><affiliation><nlm:affiliation>Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine.</nlm:affiliation><wicri:noCountry code="subField">Tianjin University of Traditional Chinese Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Wang, Tao" sort="Wang, Tao" uniqKey="Wang T" first="Tao" last="Wang">Tao Wang</name><affiliation><nlm:affiliation>Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine.</nlm:affiliation><wicri:noCountry code="subField">Tianjin University of Traditional Chinese Medicine</wicri:noCountry></affiliation></author></analytic><series><title level="j">Chemical & pharmaceutical bulletin</title><idno type="eISSN">1347-5223</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antineoplastic Agents, Phytogenic (chemistry)</term><term>Antineoplastic Agents, Phytogenic (isolation & purification)</term><term>Antineoplastic Agents, Phytogenic (pharmacology)</term><term>Antiprotozoal Agents (chemistry)</term><term>Antiprotozoal Agents (isolation & purification)</term><term>Antiprotozoal Agents (pharmacology)</term><term>Antiviral Agents (chemistry)</term><term>Antiviral Agents (isolation & purification)</term><term>Antiviral Agents (pharmacology)</term><term>Cell Survival (drug effects)</term><term>Humans</term><term>Plants (chemistry)</term><term>Plants (metabolism)</term><term>Plasmodium falciparum (drug effects)</term><term>Quassins (chemistry)</term><term>Quassins (isolation & purification)</term><term>Quassins (pharmacology)</term><term>Structure-Activity Relationship</term><term>Tobacco Mosaic Virus (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antinéoplasiques d'origine végétale ()</term><term>Antinéoplasiques d'origine végétale (isolement et purification)</term><term>Antinéoplasiques d'origine végétale (pharmacologie)</term><term>Antiprotozoaires ()</term><term>Antiprotozoaires (isolement et purification)</term><term>Antiprotozoaires (pharmacologie)</term><term>Antiviraux ()</term><term>Antiviraux (isolement et purification)</term><term>Antiviraux (pharmacologie)</term><term>Humains</term><term>Plantes ()</term><term>Plantes (métabolisme)</term><term>Plasmodium falciparum ()</term><term>Quassinoïdes ()</term><term>Quassinoïdes (isolement et purification)</term><term>Quassinoïdes (pharmacologie)</term><term>Relation structure-activité</term><term>Survie cellulaire ()</term><term>Virus de la mosaïque du tabac ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antineoplastic Agents, Phytogenic</term><term>Antiprotozoal Agents</term><term>Antiviral Agents</term><term>Quassins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antineoplastic Agents, Phytogenic</term><term>Antiprotozoal Agents</term><term>Antiviral Agents</term><term>Quassins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antineoplastic Agents, Phytogenic</term><term>Antiprotozoal Agents</term><term>Antiviral Agents</term><term>Quassins</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Plants</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Survival</term><term>Plasmodium falciparum</term><term>Tobacco Mosaic Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Antinéoplasiques d'origine végétale</term><term>Antiprotozoaires</term><term>Antiviraux</term><term>Quassinoïdes</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Plants</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Plantes</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antinéoplasiques d'origine végétale</term><term>Antiprotozoaires</term><term>Antiviraux</term><term>Quassinoïdes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Structure-Activity Relationship</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Antinéoplasiques d'origine végétale</term><term>Antiprotozoaires</term><term>Antiviraux</term><term>Humains</term><term>Plantes</term><term>Plasmodium falciparum</term><term>Quassinoïdes</term><term>Relation structure-activité</term><term>Survie cellulaire</term><term>Virus de la mosaïque du tabac</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Quassinoids, one kind of triterpenoids with multiple bioactivities such as anti-cancer, anti-malarial, anti-oxidative, anti-microbial, anti-diabetic, anti-viral, and anti-inflammatory effects, have drawn much attention in recent years. Between 2004 and 2018, the structural characteristics and plant sources of 190 quassinoids were reported. Herein, the structure-activity relationships (SARs) of quassinoids along with the anti-cancer mechanisms of four representative quassinoids, eurycomanone, bruceine D, dehydrobruceine B, and brusatol are discussed. This review might be useful for further research and development of quassinoids.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Li, Zheng" sort="Li, Zheng" uniqKey="Li Z" first="Zheng" last="Li">Zheng Li</name><name sortKey="Ruan, Jing Ya" sort="Ruan, Jing Ya" uniqKey="Ruan J" first="Jing-Ya" last="Ruan">Jing-Ya Ruan</name><name sortKey="Sun, Fan" sort="Sun, Fan" uniqKey="Sun F" first="Fan" last="Sun">Fan Sun</name><name sortKey="Wang, Jian Li" sort="Wang, Jian Li" uniqKey="Wang J" first="Jian-Li" last="Wang">Jian-Li Wang</name><name sortKey="Wang, Tao" sort="Wang, Tao" uniqKey="Wang T" first="Tao" last="Wang">Tao Wang</name><name sortKey="Yan, Jie Jing" sort="Yan, Jie Jing" uniqKey="Yan J" first="Jie-Jing" last="Yan">Jie-Jing Yan</name><name sortKey="Zhang, Yi" sort="Zhang, Yi" uniqKey="Zhang Y" first="Yi" last="Zhang">Yi Zhang</name><name sortKey="Zhang, Zi Xin" sort="Zhang, Zi Xin" uniqKey="Zhang Z" first="Zi-Xin" last="Zhang">Zi-Xin Zhang</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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