Relationship between Structural Characteristics and Plant Sources along with Pharmacology Research of Quassinoids.
Identifieur interne : 000891 ( PubMed/Corpus ); précédent : 000890; suivant : 000892Relationship between Structural Characteristics and Plant Sources along with Pharmacology Research of Quassinoids.
Auteurs : Zheng Li ; Jing-Ya Ruan ; Fan Sun ; Jie-Jing Yan ; Jian-Li Wang ; Zi-Xin Zhang ; Yi Zhang ; Tao WangSource :
- Chemical & pharmaceutical bulletin [ 1347-5223 ] ; 2019.
English descriptors
- KwdEn :
- Antineoplastic Agents, Phytogenic (chemistry), Antineoplastic Agents, Phytogenic (isolation & purification), Antineoplastic Agents, Phytogenic (pharmacology), Antiprotozoal Agents (chemistry), Antiprotozoal Agents (isolation & purification), Antiprotozoal Agents (pharmacology), Antiviral Agents (chemistry), Antiviral Agents (isolation & purification), Antiviral Agents (pharmacology), Cell Survival (drug effects), Humans, Plants (chemistry), Plants (metabolism), Plasmodium falciparum (drug effects), Quassins (chemistry), Quassins (isolation & purification), Quassins (pharmacology), Structure-Activity Relationship, Tobacco Mosaic Virus (drug effects).
- MESH :
- chemical , chemistry : Antineoplastic Agents, Phytogenic, Antiprotozoal Agents, Antiviral Agents, Quassins.
- chemical , isolation & purification : Antineoplastic Agents, Phytogenic, Antiprotozoal Agents, Antiviral Agents, Quassins.
- chemical , pharmacology : Antineoplastic Agents, Phytogenic, Antiprotozoal Agents, Antiviral Agents, Quassins.
- chemistry : Plants.
- drug effects : Cell Survival, Plasmodium falciparum, Tobacco Mosaic Virus.
- metabolism : Plants.
- Humans, Structure-Activity Relationship.
Abstract
Quassinoids, one kind of triterpenoids with multiple bioactivities such as anti-cancer, anti-malarial, anti-oxidative, anti-microbial, anti-diabetic, anti-viral, and anti-inflammatory effects, have drawn much attention in recent years. Between 2004 and 2018, the structural characteristics and plant sources of 190 quassinoids were reported. Herein, the structure-activity relationships (SARs) of quassinoids along with the anti-cancer mechanisms of four representative quassinoids, eurycomanone, bruceine D, dehydrobruceine B, and brusatol are discussed. This review might be useful for further research and development of quassinoids.
DOI: 10.1248/cpb.c18-00958
PubMed: 31257321
Links to Exploration step
pubmed:31257321Le document en format XML
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<term>Cell Survival (drug effects)</term>
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<front><div type="abstract" xml:lang="en">Quassinoids, one kind of triterpenoids with multiple bioactivities such as anti-cancer, anti-malarial, anti-oxidative, anti-microbial, anti-diabetic, anti-viral, and anti-inflammatory effects, have drawn much attention in recent years. Between 2004 and 2018, the structural characteristics and plant sources of 190 quassinoids were reported. Herein, the structure-activity relationships (SARs) of quassinoids along with the anti-cancer mechanisms of four representative quassinoids, eurycomanone, bruceine D, dehydrobruceine B, and brusatol are discussed. This review might be useful for further research and development of quassinoids.</div>
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