Relationship between Structural Characteristics and Plant Sources along with Pharmacology Research of Quassinoids.
Identifieur interne : 000891 ( PubMed/Corpus ); précédent : 000890; suivant : 000892Relationship between Structural Characteristics and Plant Sources along with Pharmacology Research of Quassinoids.
Auteurs : Zheng Li ; Jing-Ya Ruan ; Fan Sun ; Jie-Jing Yan ; Jian-Li Wang ; Zi-Xin Zhang ; Yi Zhang ; Tao WangSource :
- Chemical & pharmaceutical bulletin [ 1347-5223 ] ; 2019.
English descriptors
- KwdEn :
- Antineoplastic Agents, Phytogenic (chemistry), Antineoplastic Agents, Phytogenic (isolation & purification), Antineoplastic Agents, Phytogenic (pharmacology), Antiprotozoal Agents (chemistry), Antiprotozoal Agents (isolation & purification), Antiprotozoal Agents (pharmacology), Antiviral Agents (chemistry), Antiviral Agents (isolation & purification), Antiviral Agents (pharmacology), Cell Survival (drug effects), Humans, Plants (chemistry), Plants (metabolism), Plasmodium falciparum (drug effects), Quassins (chemistry), Quassins (isolation & purification), Quassins (pharmacology), Structure-Activity Relationship, Tobacco Mosaic Virus (drug effects).
- MESH :
- chemical , chemistry : Antineoplastic Agents, Phytogenic, Antiprotozoal Agents, Antiviral Agents, Quassins.
- chemical , isolation & purification : Antineoplastic Agents, Phytogenic, Antiprotozoal Agents, Antiviral Agents, Quassins.
- chemical , pharmacology : Antineoplastic Agents, Phytogenic, Antiprotozoal Agents, Antiviral Agents, Quassins.
- chemistry : Plants.
- drug effects : Cell Survival, Plasmodium falciparum, Tobacco Mosaic Virus.
- metabolism : Plants.
- Humans, Structure-Activity Relationship.
Abstract
Quassinoids, one kind of triterpenoids with multiple bioactivities such as anti-cancer, anti-malarial, anti-oxidative, anti-microbial, anti-diabetic, anti-viral, and anti-inflammatory effects, have drawn much attention in recent years. Between 2004 and 2018, the structural characteristics and plant sources of 190 quassinoids were reported. Herein, the structure-activity relationships (SARs) of quassinoids along with the anti-cancer mechanisms of four representative quassinoids, eurycomanone, bruceine D, dehydrobruceine B, and brusatol are discussed. This review might be useful for further research and development of quassinoids.
DOI: 10.1248/cpb.c18-00958
PubMed: 31257321
Links to Exploration step
pubmed:31257321Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Relationship between Structural Characteristics and Plant Sources along with Pharmacology Research of Quassinoids.</title><author><name sortKey="Li, Zheng" sort="Li, Zheng" uniqKey="Li Z" first="Zheng" last="Li">Zheng Li</name><affiliation><nlm:affiliation>Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Ruan, Jing Ya" sort="Ruan, Jing Ya" uniqKey="Ruan J" first="Jing-Ya" last="Ruan">Jing-Ya Ruan</name><affiliation><nlm:affiliation>Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Sun, Fan" sort="Sun, Fan" uniqKey="Sun F" first="Fan" last="Sun">Fan Sun</name><affiliation><nlm:affiliation>Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Yan, Jie Jing" sort="Yan, Jie Jing" uniqKey="Yan J" first="Jie-Jing" last="Yan">Jie-Jing Yan</name><affiliation><nlm:affiliation>Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Jian Li" sort="Wang, Jian Li" uniqKey="Wang J" first="Jian-Li" last="Wang">Jian-Li Wang</name><affiliation><nlm:affiliation>Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Zi Xin" sort="Zhang, Zi Xin" uniqKey="Zhang Z" first="Zi-Xin" last="Zhang">Zi-Xin Zhang</name><affiliation><nlm:affiliation>Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Yi" sort="Zhang, Yi" uniqKey="Zhang Y" first="Yi" last="Zhang">Yi Zhang</name><affiliation><nlm:affiliation>Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Tao" sort="Wang, Tao" uniqKey="Wang T" first="Tao" last="Wang">Tao Wang</name><affiliation><nlm:affiliation>Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31257321</idno><idno type="pmid">31257321</idno><idno type="doi">10.1248/cpb.c18-00958</idno><idno type="wicri:Area/PubMed/Corpus">000891</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000891</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Relationship between Structural Characteristics and Plant Sources along with Pharmacology Research of Quassinoids.</title><author><name sortKey="Li, Zheng" sort="Li, Zheng" uniqKey="Li Z" first="Zheng" last="Li">Zheng Li</name><affiliation><nlm:affiliation>Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Ruan, Jing Ya" sort="Ruan, Jing Ya" uniqKey="Ruan J" first="Jing-Ya" last="Ruan">Jing-Ya Ruan</name><affiliation><nlm:affiliation>Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Sun, Fan" sort="Sun, Fan" uniqKey="Sun F" first="Fan" last="Sun">Fan Sun</name><affiliation><nlm:affiliation>Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Yan, Jie Jing" sort="Yan, Jie Jing" uniqKey="Yan J" first="Jie-Jing" last="Yan">Jie-Jing Yan</name><affiliation><nlm:affiliation>Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Jian Li" sort="Wang, Jian Li" uniqKey="Wang J" first="Jian-Li" last="Wang">Jian-Li Wang</name><affiliation><nlm:affiliation>Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Zi Xin" sort="Zhang, Zi Xin" uniqKey="Zhang Z" first="Zi-Xin" last="Zhang">Zi-Xin Zhang</name><affiliation><nlm:affiliation>Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Yi" sort="Zhang, Yi" uniqKey="Zhang Y" first="Yi" last="Zhang">Yi Zhang</name><affiliation><nlm:affiliation>Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Tao" sort="Wang, Tao" uniqKey="Wang T" first="Tao" last="Wang">Tao Wang</name><affiliation><nlm:affiliation>Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Chemical & pharmaceutical bulletin</title><idno type="eISSN">1347-5223</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antineoplastic Agents, Phytogenic (chemistry)</term><term>Antineoplastic Agents, Phytogenic (isolation & purification)</term><term>Antineoplastic Agents, Phytogenic (pharmacology)</term><term>Antiprotozoal Agents (chemistry)</term><term>Antiprotozoal Agents (isolation & purification)</term><term>Antiprotozoal Agents (pharmacology)</term><term>Antiviral Agents (chemistry)</term><term>Antiviral Agents (isolation & purification)</term><term>Antiviral Agents (pharmacology)</term><term>Cell Survival (drug effects)</term><term>Humans</term><term>Plants (chemistry)</term><term>Plants (metabolism)</term><term>Plasmodium falciparum (drug effects)</term><term>Quassins (chemistry)</term><term>Quassins (isolation & purification)</term><term>Quassins (pharmacology)</term><term>Structure-Activity Relationship</term><term>Tobacco Mosaic Virus (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antineoplastic Agents, Phytogenic</term><term>Antiprotozoal Agents</term><term>Antiviral Agents</term><term>Quassins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antineoplastic Agents, Phytogenic</term><term>Antiprotozoal Agents</term><term>Antiviral Agents</term><term>Quassins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antineoplastic Agents, Phytogenic</term><term>Antiprotozoal Agents</term><term>Antiviral Agents</term><term>Quassins</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Plants</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Survival</term><term>Plasmodium falciparum</term><term>Tobacco Mosaic Virus</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Plants</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Structure-Activity Relationship</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Quassinoids, one kind of triterpenoids with multiple bioactivities such as anti-cancer, anti-malarial, anti-oxidative, anti-microbial, anti-diabetic, anti-viral, and anti-inflammatory effects, have drawn much attention in recent years. Between 2004 and 2018, the structural characteristics and plant sources of 190 quassinoids were reported. Herein, the structure-activity relationships (SARs) of quassinoids along with the anti-cancer mechanisms of four representative quassinoids, eurycomanone, bruceine D, dehydrobruceine B, and brusatol are discussed. This review might be useful for further research and development of quassinoids.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31257321</PMID><DateCompleted><Year>2019</Year><Month>07</Month><Day>03</Day></DateCompleted><DateRevised><Year>2019</Year><Month>07</Month><Day>03</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1347-5223</ISSN><JournalIssue CitedMedium="Internet"><Volume>67</Volume><Issue>7</Issue><PubDate><Year>2019</Year></PubDate></JournalIssue><Title>Chemical & pharmaceutical bulletin</Title><ISOAbbreviation>Chem. Pharm. Bull.</ISOAbbreviation></Journal><ArticleTitle>Relationship between Structural Characteristics and Plant Sources along with Pharmacology Research of Quassinoids.</ArticleTitle><Pagination><MedlinePgn>654-665</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1248/cpb.c18-00958</ELocationID><Abstract><AbstractText>Quassinoids, one kind of triterpenoids with multiple bioactivities such as anti-cancer, anti-malarial, anti-oxidative, anti-microbial, anti-diabetic, anti-viral, and anti-inflammatory effects, have drawn much attention in recent years. Between 2004 and 2018, the structural characteristics and plant sources of 190 quassinoids were reported. Herein, the structure-activity relationships (SARs) of quassinoids along with the anti-cancer mechanisms of four representative quassinoids, eurycomanone, bruceine D, dehydrobruceine B, and brusatol are discussed. This review might be useful for further research and development of quassinoids.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Zheng</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ruan</LastName><ForeName>Jing-Ya</ForeName><Initials>JY</Initials><AffiliationInfo><Affiliation>Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Fan</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yan</LastName><ForeName>Jie-Jing</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Jian-Li</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Zi-Xin</ForeName><Initials>ZX</Initials><AffiliationInfo><Affiliation>Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Yi</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Tao</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Japan</Country><MedlineTA>Chem Pharm Bull (Tokyo)</MedlineTA><NlmUniqueID>0377775</NlmUniqueID><ISSNLinking>0009-2363</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000972">Antineoplastic Agents, Phytogenic</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000981">Antiprotozoal Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D036702">Quassins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000972" MajorTopicYN="N">Antineoplastic Agents, Phytogenic</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000981" MajorTopicYN="N">Antiprotozoal Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002470" MajorTopicYN="N">Cell Survival</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010944" MajorTopicYN="N">Plants</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010963" MajorTopicYN="N">Plasmodium falciparum</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D036702" MajorTopicYN="N">Quassins</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013329" MajorTopicYN="N">Structure-Activity Relationship</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014027" MajorTopicYN="N">Tobacco Mosaic Virus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">anti-cancer mechanism</Keyword><Keyword MajorTopicYN="N">plant source</Keyword><Keyword MajorTopicYN="N">quassinoid</Keyword><Keyword MajorTopicYN="N">structural characteristic</Keyword><Keyword MajorTopicYN="N">structure–activity relationship (SAR)</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>7</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>7</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>7</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31257321</ArticleId><ArticleId IdType="doi">10.1248/cpb.c18-00958</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000891 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000891 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:31257321
|texte= Relationship between Structural Characteristics and Plant Sources along with Pharmacology Research of Quassinoids.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:31257321" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |