Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong
Identifieur interne : 006399 ( Main/Curation ); précédent : 006398; suivant : 006400Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong
Auteurs : S. S. C. Chim [Hong Kong] ; S. K. W. Tsui [Hong Kong] ; K. C. A. Chan [Hong Kong] ; T. C. C. Au [Hong Kong] ; E. C. W. Hung [Hong Kong] ; Y. K. Tong [Hong Kong] ; R. W. K. Chiu [Hong Kong] ; E. K. O. Ng [Hong Kong] ; P. K. S. Chan [Hong Kong] ; C. M. Chu [Hong Kong] ; J. J. Y. Sung [Hong Kong] ; J. S. Tam [Hong Kong] ; K. P. Fung [Hong Kong] ; M. M. Y. Waye [Hong Kong] ; C. Y. Lee [Hong Kong] ; K. Y. Yuen [Hong Kong] ; Y. M. D. Lo [Hong Kong]Source :
- Lancet : (British edition) [ 0140-6736 ] ; 2003.
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Abstract
Severe acute respiratory syndrome (SARS) is a global health concern. In Hong Kong, two major outbreaks, one hospital based and the other In the Amoy Gardens apartments, were identified. The frequency of diarrhoea, admission to intensive care, and mortality differed significantly between the two outbreaks. We did genomic sequencing for viral isolates from five Amoy Gardens patients. The virus sequence was identical in four of these five patients. The sequence data from one hospital case and the four identical community cases had only three nucleotide differences. Alterations in the SARS coronavirus genome are unlikely to have caused the distinctive clinical features of the Amoy Gardens patients, and these results highlight the Importance of non-viral genomic factors in this outbreak.
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Hung</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital</s1><s3>HKG</s3><sZ>5 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital</wicri:noRegion><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Tong, Y K" sort="Tong, Y K" uniqKey="Tong Y" first="Y. K." last="Tong">Y. K. Tong</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital</wicri:noRegion><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Chiu, R W K" sort="Chiu, R W K" uniqKey="Chiu R" first="R. W. K." last="Chiu">R. W. K. Chiu</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital</wicri:noRegion><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Ng, E K O" sort="Ng, E K O" uniqKey="Ng E" first="E. K. O." last="Ng">E. K. O. Ng</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital</wicri:noRegion><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Chan, P K S" sort="Chan, P K S" uniqKey="Chan P" first="P. K. S." last="Chan">P. K. S. 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Y." last="Sung">J. J. Y. Sung</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital</s1><s3>HKG</s3><sZ>11 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital</wicri:noRegion><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Tam, J S" sort="Tam, J S" uniqKey="Tam J" first="J. S." last="Tam">J. S. Tam</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital</s1><s3>HKG</s3><sZ>9 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital</wicri:noRegion><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Fung, K P" sort="Fung, K P" uniqKey="Fung K" first="K. P." last="Fung">K. P. Fung</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Biochemistry, Chinese University of Hong Kong, Prince of Wales Hospital</s1><s3>HKG</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Biochemistry, Chinese University of Hong Kong, Prince of Wales Hospital</wicri:noRegion><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Waye, M M Y" sort="Waye, M M Y" uniqKey="Waye M" first="M. M. Y." last="Waye">M. M. Y. Waye</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Biochemistry, Chinese University of Hong Kong, Prince of Wales Hospital</s1><s3>HKG</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Biochemistry, Chinese University of Hong Kong, Prince of Wales Hospital</wicri:noRegion><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Lee, C Y" sort="Lee, C Y" uniqKey="Lee C" first="C. Y." last="Lee">C. Y. Lee</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Biochemistry, Chinese University of Hong Kong, Prince of Wales Hospital</s1><s3>HKG</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Biochemistry, Chinese University of Hong Kong, Prince of Wales Hospital</wicri:noRegion><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Yuen, K Y" sort="Yuen, K Y" uniqKey="Yuen K" first="K. Y." last="Yuen">K. Y. Yuen</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Microbiology, Queen Mary Hospital, University of Hong Kong</s1><s3>HKG</s3><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Microbiology, Queen Mary Hospital, University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Lo, Y M D" sort="Lo, Y M D" uniqKey="Lo Y" first="Y. M. D." last="Lo">Y. M. D. Lo</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital</wicri:noRegion><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">04-0125308</idno><date when="2003">2003</date><idno type="stanalyst">PASCAL 04-0125308 INIST</idno><idno type="RBID">Pascal:04-0125308</idno><idno type="wicri:Area/PascalFrancis/Corpus">000924</idno><idno type="wicri:Area/PascalFrancis/Curation">000066</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000962</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000962</idno><idno type="wicri:doubleKey">0140-6736:2003:Chim S:genomic:characterisation:of</idno><idno type="wicri:Area/Main/Merge">006911</idno><idno type="wicri:Area/Main/Curation">006399</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong</title><author><name sortKey="Chim, S S C" sort="Chim, S S C" uniqKey="Chim S" first="S. S. C." last="Chim">S. S. C. Chim</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital</wicri:noRegion><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Tsui, S K W" sort="Tsui, S K W" uniqKey="Tsui S" first="S. K. W." last="Tsui">S. K. W. Tsui</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Biochemistry, Chinese University of Hong Kong, Prince of Wales Hospital</s1><s3>HKG</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Biochemistry, Chinese University of Hong Kong, Prince of Wales Hospital</wicri:noRegion><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Chan, K C A" sort="Chan, K C A" uniqKey="Chan K" first="K. C. A." last="Chan">K. C. A. Chan</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital</wicri:noRegion><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Au, T C C" sort="Au, T C C" uniqKey="Au T" first="T. C. C." last="Au">T. C. C. Au</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Biochemistry, Chinese University of Hong Kong, Prince of Wales Hospital</s1><s3>HKG</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Biochemistry, Chinese University of Hong Kong, Prince of Wales Hospital</wicri:noRegion><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Hung, E C W" sort="Hung, E C W" uniqKey="Hung E" first="E. C. W." last="Hung">E. C. W. Hung</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital</s1><s3>HKG</s3><sZ>5 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital</wicri:noRegion><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Tong, Y K" sort="Tong, Y K" uniqKey="Tong Y" first="Y. K." last="Tong">Y. K. Tong</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital</wicri:noRegion><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Chiu, R W K" sort="Chiu, R W K" uniqKey="Chiu R" first="R. W. K." last="Chiu">R. W. K. Chiu</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital</wicri:noRegion><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Ng, E K O" sort="Ng, E K O" uniqKey="Ng E" first="E. K. O." last="Ng">E. K. O. Ng</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital</wicri:noRegion><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Chan, P K S" sort="Chan, P K S" uniqKey="Chan P" first="P. K. S." last="Chan">P. K. S. Chan</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital</s1><s3>HKG</s3><sZ>9 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital</wicri:noRegion><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Chu, C M" sort="Chu, C M" uniqKey="Chu C" first="C. M." last="Chu">C. M. Chu</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Medicine, United Christian Hospital</s1><s3>HKG</s3><sZ>10 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Medicine, United Christian Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Sung, J J Y" sort="Sung, J J Y" uniqKey="Sung J" first="J. J. Y." last="Sung">J. J. Y. Sung</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital</s1><s3>HKG</s3><sZ>11 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital</wicri:noRegion><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Tam, J S" sort="Tam, J S" uniqKey="Tam J" first="J. S." last="Tam">J. S. Tam</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital</s1><s3>HKG</s3><sZ>9 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital</wicri:noRegion><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Fung, K P" sort="Fung, K P" uniqKey="Fung K" first="K. P." last="Fung">K. P. Fung</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Biochemistry, Chinese University of Hong Kong, Prince of Wales Hospital</s1><s3>HKG</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Biochemistry, Chinese University of Hong Kong, Prince of Wales Hospital</wicri:noRegion><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Waye, M M Y" sort="Waye, M M Y" uniqKey="Waye M" first="M. M. Y." last="Waye">M. M. Y. Waye</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Biochemistry, Chinese University of Hong Kong, Prince of Wales Hospital</s1><s3>HKG</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Biochemistry, Chinese University of Hong Kong, Prince of Wales Hospital</wicri:noRegion><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Lee, C Y" sort="Lee, C Y" uniqKey="Lee C" first="C. Y." last="Lee">C. Y. Lee</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Biochemistry, Chinese University of Hong Kong, Prince of Wales Hospital</s1><s3>HKG</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Biochemistry, Chinese University of Hong Kong, Prince of Wales Hospital</wicri:noRegion><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Yuen, K Y" sort="Yuen, K Y" uniqKey="Yuen K" first="K. Y." last="Yuen">K. Y. Yuen</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Microbiology, Queen Mary Hospital, University of Hong Kong</s1><s3>HKG</s3><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Microbiology, Queen Mary Hospital, University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Lo, Y M D" sort="Lo, Y M D" uniqKey="Lo Y" first="Y. M. D." last="Lo">Y. M. D. Lo</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital</wicri:noRegion><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Lancet : (British edition)</title><title level="j" type="abbreviated">Lancet : (Br. ed.)</title><idno type="ISSN">0140-6736</idno><imprint><date when="2003">2003</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Lancet : (British edition)</title><title level="j" type="abbreviated">Lancet : (Br. ed.)</title><idno type="ISSN">0140-6736</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute</term><term>Coronavirus</term><term>Genomics</term><term>Hong Kong</term><term>Human</term><term>Infection</term><term>Mechanism of action</term><term>Outbreak</term><term>Prevalence</term><term>Respiratory system</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Infection</term><term>Appareil respiratoire</term><term>Aigu</term><term>Hong Kong</term><term>Prévalence</term><term>Pullulation</term><term>Coronavirus</term><term>Génomique</term><term>Mécanisme action</term><term>Homme</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Hong Kong</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is a global health concern. In Hong Kong, two major outbreaks, one hospital based and the other In the Amoy Gardens apartments, were identified. The frequency of diarrhoea, admission to intensive care, and mortality differed significantly between the two outbreaks. We did genomic sequencing for viral isolates from five Amoy Gardens patients. The virus sequence was identical in four of these five patients. The sequence data from one hospital case and the four identical community cases had only three nucleotide differences. Alterations in the SARS coronavirus genome are unlikely to have caused the distinctive clinical features of the Amoy Gardens patients, and these results highlight the Importance of non-viral genomic factors in this outbreak.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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