SrasV1, PascalFrancis, Corpus, bibRecord, 000924

Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong

Identifieur interne : 000924 ( PascalFrancis/Corpus ); précédent : 000923; suivant : 000925

Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong

Auteurs : S. S. C. Chim ; S. K. W. Tsui ; K. C. A. Chan ; T. C. C. Au ; E. C. W. Hung ; Y. K. Tong ; R. W. K. Chiu ; E. K. O. Ng ; P. K. S. Chan ; C. M. Chu ; J. J. Y. Sung ; J. S. Tam ; K. P. Fung ; M. M. Y. Waye ; C. Y. Lee ; K. Y. Yuen ; Y. M. D. Lo

Source :

Lancet : (British edition) [ 0140-6736 ] ; 2003.

RBID : Pascal:04-0125308

Descripteurs français

Pascal (Inist)
- Infection, Appareil respiratoire, Aigu, Hong Kong, Prévalence, Pullulation, Coronavirus, Génomique, Mécanisme action, Homme.

English descriptors

KwdEn :
- Acute, Coronavirus, Genomics, Hong Kong, Human, Infection, Mechanism of action, Outbreak, Prevalence, Respiratory system.

Abstract

Severe acute respiratory syndrome (SARS) is a global health concern. In Hong Kong, two major outbreaks, one hospital based and the other In the Amoy Gardens apartments, were identified. The frequency of diarrhoea, admission to intensive care, and mortality differed significantly between the two outbreaks. We did genomic sequencing for viral isolates from five Amoy Gardens patients. The virus sequence was identical in four of these five patients. The sequence data from one hospital case and the four identical community cases had only three nucleotide differences. Alterations in the SARS coronavirus genome are unlikely to have caused the distinctive clinical features of the Amoy Gardens patients, and these results highlight the Importance of non-viral genomic factors in this outbreak.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A02	`01`			`@0 LANCAO`
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A11	`01`	`1`		`@1 CHIM (S. S. C.)`
A11	`02`	`1`		`@1 TSUI (S. K. W.)`
A11	`03`	`1`		`@1 CHAN (K. C. A.)`
A11	`04`	`1`		`@1 AU (T. C. C.)`
A11	`05`	`1`		`@1 HUNG (E. C. W.)`
A11	`06`	`1`		`@1 TONG (Y. K.)`
A11	`07`	`1`		`@1 CHIU (R. W. K.)`
A11	`08`	`1`		`@1 NG (E. K. O.)`
A11	`09`	`1`		`@1 CHAN (P. K. S.)`
A11	`10`	`1`		`@1 CHU (C. M.)`
A11	`11`	`1`		`@1 SUNG (J. J. Y.)`
A11	`12`	`1`		`@1 TAM (J. S.)`
A11	`13`	`1`		`@1 FUNG (K. P.)`
A11	`14`	`1`		`@1 WAYE (M. M. Y.)`
A11	`15`	`1`		`@1 LEE (C. Y.)`
A11	`16`	`1`		`@1 YUEN (K. Y.)`
A11	`17`	`1`		`@1 LO (Y. M. D.)`
A14	`01`			`@1 Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital @3 HKG @Z 1 aut. @Z 3 aut. @Z 6 aut. @Z 7 aut. @Z 8 aut. @Z 17 aut.`
A14	`02`			`@1 Department of Biochemistry, Chinese University of Hong Kong, Prince of Wales Hospital @3 HKG @Z 2 aut. @Z 4 aut. @Z 13 aut. @Z 14 aut. @Z 15 aut.`
A14	`03`			`@1 Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital @3 HKG @Z 5 aut.`
A14	`04`			`@1 Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital @3 HKG @Z 9 aut. @Z 12 aut.`
A14	`05`			`@1 Department of Medicine, United Christian Hospital @3 HKG @Z 10 aut.`
A14	`06`			`@1 Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital @3 HKG @Z 11 aut.`
A14	`07`			`@1 Department of Microbiology, Queen Mary Hospital, University of Hong Kong @3 HKG @Z 16 aut.`
A17	`01`	`1`		`@1 CUHK Molecular SARS Research Group @3 HKG`
A20				`@1 1807-1808`
A21				`@1 2003`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 5004 @5 354000116007080090`
A44				`@0 0000 @1 © 2004 INIST-CNRS. All rights reserved.`
A45				`@0 5 ref.`
A47	`01`	`1`		`@0 04-0125308`
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A61				`@0 A`
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A66	`01`			`@0 GBR`
C01	`01`		`ENG`	@0 Severe acute respiratory syndrome (SARS) is a global health concern. In Hong Kong, two major outbreaks, one hospital based and the other In the Amoy Gardens apartments, were identified. The frequency of diarrhoea, admission to intensive care, and mortality differed significantly between the two outbreaks. We did genomic sequencing for viral isolates from five Amoy Gardens patients. The virus sequence was identical in four of these five patients. The sequence data from one hospital case and the four identical community cases had only three nucleotide differences. Alterations in the SARS coronavirus genome are unlikely to have caused the distinctive clinical features of the Amoy Gardens patients, and these results highlight the Importance of non-viral genomic factors in this outbreak.
C02	`01`	`X`		`@0 002B05B02E`
C03	`01`	`X`	`FRE`	`@0 Infection @2 NM @5 01`
C03	`01`	`X`	`ENG`	`@0 Infection @2 NM @5 01`
C03	`01`	`X`	`SPA`	`@0 Infección @2 NM @5 01`
C03	`02`	`X`	`FRE`	`@0 Appareil respiratoire @5 02`
C03	`02`	`X`	`ENG`	`@0 Respiratory system @5 02`
C03	`02`	`X`	`SPA`	`@0 Aparato respiratorio @5 02`
C03	`03`	`X`	`FRE`	`@0 Aigu @5 03`
C03	`03`	`X`	`ENG`	`@0 Acute @5 03`
C03	`03`	`X`	`SPA`	`@0 Agudo @5 03`
C03	`04`	`X`	`FRE`	`@0 Hong Kong @2 NG @5 04`
C03	`04`	`X`	`ENG`	`@0 Hong Kong @2 NG @5 04`
C03	`04`	`X`	`SPA`	`@0 Hong Kong @2 NG @5 04`
C03	`05`	`X`	`FRE`	`@0 Prévalence @5 05`
C03	`05`	`X`	`ENG`	`@0 Prevalence @5 05`
C03	`05`	`X`	`SPA`	`@0 Prevalencia @5 05`
C03	`06`	`X`	`FRE`	`@0 Pullulation @5 06`
C03	`06`	`X`	`ENG`	`@0 Outbreak @5 06`
C03	`06`	`X`	`SPA`	`@0 Pululación @5 06`
C03	`07`	`X`	`FRE`	`@0 Coronavirus @2 NW @5 07`
C03	`07`	`X`	`ENG`	`@0 Coronavirus @2 NW @5 07`
C03	`07`	`X`	`SPA`	`@0 Coronavirus @2 NW @5 07`
C03	`08`	`X`	`FRE`	`@0 Génomique @5 08`
C03	`08`	`X`	`ENG`	`@0 Genomics @5 08`
C03	`08`	`X`	`SPA`	`@0 Genómica @5 08`
C03	`09`	`X`	`FRE`	`@0 Mécanisme action @5 09`
C03	`09`	`X`	`ENG`	`@0 Mechanism of action @5 09`
C03	`09`	`X`	`SPA`	`@0 Mecanismo acción @5 09`
C03	`10`	`X`	`FRE`	`@0 Homme @5 11`
C03	`10`	`X`	`ENG`	`@0 Human @5 11`
C03	`10`	`X`	`SPA`	`@0 Hombre @5 11`
C07	`01`	`X`	`FRE`	`@0 Chine @2 NG`
C07	`01`	`X`	`ENG`	`@0 China @2 NG`
C07	`01`	`X`	`SPA`	`@0 China @2 NG`
C07	`02`	`X`	`FRE`	`@0 Asie @2 NG`
C07	`02`	`X`	`ENG`	`@0 Asia @2 NG`
C07	`02`	`X`	`SPA`	`@0 Asia @2 NG`
C07	`03`	`X`	`FRE`	`@0 Coronaviridae @2 NW`
C07	`03`	`X`	`ENG`	`@0 Coronaviridae @2 NW`
C07	`03`	`X`	`SPA`	`@0 Coronaviridae @2 NW`
C07	`04`	`X`	`FRE`	`@0 Nidovirales @2 NW`
C07	`04`	`X`	`ENG`	`@0 Nidovirales @2 NW`
C07	`04`	`X`	`SPA`	`@0 Nidovirales @2 NW`
C07	`05`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`05`	`X`	`ENG`	`@0 Virus @2 NW`
C07	`05`	`X`	`SPA`	`@0 Virus @2 NW`
C07	`06`	`X`	`FRE`	`@0 Appareil respiratoire pathologie @5 37`
C07	`06`	`X`	`ENG`	`@0 Respiratory disease @5 37`
C07	`06`	`X`	`SPA`	`@0 Aparato respiratorio patología @5 37`
C07	`07`	`X`	`FRE`	`@0 Virose @2 NM @5 53`
C07	`07`	`X`	`ENG`	`@0 Viral disease @2 NM @5 53`
C07	`07`	`X`	`SPA`	`@0 Virosis @2 NM @5 53`
N21				`@1 082`
N82				`@1 PSI`

Format Inist (serveur)

NO :	PASCAL 04-0125308 INIST
ET :	Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong
AU :	CHIM (S. S. C.); TSUI (S. K. W.); CHAN (K. C. A.); AU (T. C. C.); HUNG (E. C. W.); TONG (Y. K.); CHIU (R. W. K.); NG (E. K. O.); CHAN (P. K. S.); CHU (C. M.); SUNG (J. J. Y.); TAM (J. S.); FUNG (K. P.); WAYE (M. M. Y.); LEE (C. Y.); YUEN (K. Y.); LO (Y. M. D.)
AF :	Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital/Hong-Kong (1 aut., 3 aut., 6 aut., 7 aut., 8 aut., 17 aut.); Department of Biochemistry, Chinese University of Hong Kong, Prince of Wales Hospital/Hong-Kong (2 aut., 4 aut., 13 aut., 14 aut., 15 aut.); Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital/Hong-Kong (5 aut.); Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital/Hong-Kong (9 aut., 12 aut.); Department of Medicine, United Christian Hospital/Hong-Kong (10 aut.); Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital/Hong-Kong (11 aut.); Department of Microbiology, Queen Mary Hospital, University of Hong Kong/Hong-Kong (16 aut.)
DT :	Publication en série; Correspondance, lettre; Niveau analytique
SO :	Lancet : (British edition); ISSN 0140-6736; Coden LANCAO; Royaume-Uni; Da. 2003; Vol. 362; No. 9398; Pp. 1807-1808; Bibl. 5 ref.
LA :	Anglais
EA :	Severe acute respiratory syndrome (SARS) is a global health concern. In Hong Kong, two major outbreaks, one hospital based and the other In the Amoy Gardens apartments, were identified. The frequency of diarrhoea, admission to intensive care, and mortality differed significantly between the two outbreaks. We did genomic sequencing for viral isolates from five Amoy Gardens patients. The virus sequence was identical in four of these five patients. The sequence data from one hospital case and the four identical community cases had only three nucleotide differences. Alterations in the SARS coronavirus genome are unlikely to have caused the distinctive clinical features of the Amoy Gardens patients, and these results highlight the Importance of non-viral genomic factors in this outbreak.
CC :	002B05B02E
FD :	Infection; Appareil respiratoire; Aigu; Hong Kong; Prévalence; Pullulation; Coronavirus; Génomique; Mécanisme action; Homme
FG :	Chine; Asie; Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie; Virose
ED :	Infection; Respiratory system; Acute; Hong Kong; Prevalence; Outbreak; Coronavirus; Genomics; Mechanism of action; Human
EG :	China; Asia; Coronaviridae; Nidovirales; Virus; Respiratory disease; Viral disease
SD :	Infección; Aparato respiratorio; Agudo; Hong Kong; Prevalencia; Pululación; Coronavirus; Genómica; Mecanismo acción; Hombre
LO :	INIST-5004.354000116007080090
ID :	04-0125308

Links to Exploration step

Pascal:04-0125308

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong</title>
<author><name sortKey="Chim, S S C" sort="Chim, S S C" uniqKey="Chim S" first="S. S. C." last="Chim">S. S. C. Chim</name>
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<author><name sortKey="Hung, E C W" sort="Hung, E C W" uniqKey="Hung E" first="E. C. W." last="Hung">E. C. W. Hung</name>
<affiliation><inist:fA14 i1="03"><s1>Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital</s1>
<s3>HKG</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Tong, Y K" sort="Tong, Y K" uniqKey="Tong Y" first="Y. K." last="Tong">Y. K. Tong</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital</s1>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
</affiliation>
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<author><name sortKey="Chiu, R W K" sort="Chiu, R W K" uniqKey="Chiu R" first="R. W. K." last="Chiu">R. W. K. Chiu</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital</s1>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>17 aut.</sZ>
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</affiliation>
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<author><name sortKey="Ng, E K O" sort="Ng, E K O" uniqKey="Ng E" first="E. K. O." last="Ng">E. K. O. Ng</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital</s1>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Chan, P K S" sort="Chan, P K S" uniqKey="Chan P" first="P. K. S." last="Chan">P. K. S. Chan</name>
<affiliation><inist:fA14 i1="04"><s1>Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital</s1>
<s3>HKG</s3>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Chu, C M" sort="Chu, C M" uniqKey="Chu C" first="C. M." last="Chu">C. M. Chu</name>
<affiliation><inist:fA14 i1="05"><s1>Department of Medicine, United Christian Hospital</s1>
<s3>HKG</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Sung, J J Y" sort="Sung, J J Y" uniqKey="Sung J" first="J. J. Y." last="Sung">J. J. Y. Sung</name>
<affiliation><inist:fA14 i1="06"><s1>Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital</s1>
<s3>HKG</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Tam, J S" sort="Tam, J S" uniqKey="Tam J" first="J. S." last="Tam">J. S. Tam</name>
<affiliation><inist:fA14 i1="04"><s1>Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital</s1>
<s3>HKG</s3>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Fung, K P" sort="Fung, K P" uniqKey="Fung K" first="K. P." last="Fung">K. P. Fung</name>
<affiliation><inist:fA14 i1="02"><s1>Department of Biochemistry, Chinese University of Hong Kong, Prince of Wales Hospital</s1>
<s3>HKG</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Waye, M M Y" sort="Waye, M M Y" uniqKey="Waye M" first="M. M. Y." last="Waye">M. M. Y. Waye</name>
<affiliation><inist:fA14 i1="02"><s1>Department of Biochemistry, Chinese University of Hong Kong, Prince of Wales Hospital</s1>
<s3>HKG</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Lee, C Y" sort="Lee, C Y" uniqKey="Lee C" first="C. Y." last="Lee">C. Y. Lee</name>
<affiliation><inist:fA14 i1="02"><s1>Department of Biochemistry, Chinese University of Hong Kong, Prince of Wales Hospital</s1>
<s3>HKG</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Yuen, K Y" sort="Yuen, K Y" uniqKey="Yuen K" first="K. Y." last="Yuen">K. Y. Yuen</name>
<affiliation><inist:fA14 i1="07"><s1>Department of Microbiology, Queen Mary Hospital, University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Lo, Y M D" sort="Lo, Y M D" uniqKey="Lo Y" first="Y. M. D." last="Lo">Y. M. D. Lo</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital</s1>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Lancet : (British edition)</title>
<title level="j" type="abbreviated">Lancet : (Br. ed.)</title>
<idno type="ISSN">0140-6736</idno>
<imprint><date when="2003">2003</date>
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<idno type="ISSN">0140-6736</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute</term>
<term>Coronavirus</term>
<term>Genomics</term>
<term>Hong Kong</term>
<term>Human</term>
<term>Infection</term>
<term>Mechanism of action</term>
<term>Outbreak</term>
<term>Prevalence</term>
<term>Respiratory system</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Infection</term>
<term>Appareil respiratoire</term>
<term>Aigu</term>
<term>Hong Kong</term>
<term>Prévalence</term>
<term>Pullulation</term>
<term>Coronavirus</term>
<term>Génomique</term>
<term>Mécanisme action</term>
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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is a global health concern. In Hong Kong, two major outbreaks, one hospital based and the other In the Amoy Gardens apartments, were identified. The frequency of diarrhoea, admission to intensive care, and mortality differed significantly between the two outbreaks. We did genomic sequencing for viral isolates from five Amoy Gardens patients. The virus sequence was identical in four of these five patients. The sequence data from one hospital case and the four identical community cases had only three nucleotide differences. Alterations in the SARS coronavirus genome are unlikely to have caused the distinctive clinical features of the Amoy Gardens patients, and these results highlight the Importance of non-viral genomic factors in this outbreak.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0140-6736</s0>
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<fA02 i1="01"><s0>LANCAO</s0>
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<fA03 i2="1"><s0>Lancet : (Br. ed.)</s0>
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<fA05><s2>362</s2>
</fA05>
<fA06><s2>9398</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>CHIM (S. S. C.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>TSUI (S. K. W.)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>CHAN (K. C. A.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>AU (T. C. C.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>HUNG (E. C. W.)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>TONG (Y. K.)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>CHIU (R. W. K.)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>NG (E. K. O.)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>CHAN (P. K. S.)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>CHU (C. M.)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>SUNG (J. J. Y.)</s1>
</fA11>
<fA11 i1="12" i2="1"><s1>TAM (J. S.)</s1>
</fA11>
<fA11 i1="13" i2="1"><s1>FUNG (K. P.)</s1>
</fA11>
<fA11 i1="14" i2="1"><s1>WAYE (M. M. Y.)</s1>
</fA11>
<fA11 i1="15" i2="1"><s1>LEE (C. Y.)</s1>
</fA11>
<fA11 i1="16" i2="1"><s1>YUEN (K. Y.)</s1>
</fA11>
<fA11 i1="17" i2="1"><s1>LO (Y. M. D.)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital</s1>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>17 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Biochemistry, Chinese University of Hong Kong, Prince of Wales Hospital</s1>
<s3>HKG</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital</s1>
<s3>HKG</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital</s1>
<s3>HKG</s3>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Department of Medicine, United Christian Hospital</s1>
<s3>HKG</s3>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital</s1>
<s3>HKG</s3>
<sZ>11 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>Department of Microbiology, Queen Mary Hospital, University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>16 aut.</sZ>
</fA14>
<fA17 i1="01" i2="1"><s1>CUHK Molecular SARS Research Group</s1>
<s3>HKG</s3>
</fA17>
<fA20><s1>1807-1808</s1>
</fA20>
<fA21><s1>2003</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>5004</s2>
<s5>354000116007080090</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2004 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>5 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>04-0125308</s0>
</fA47>
<fA60><s1>P</s1>
<s3>CR</s3>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Lancet : (British edition)</s0>
</fA64>
<fA66 i1="01"><s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Severe acute respiratory syndrome (SARS) is a global health concern. In Hong Kong, two major outbreaks, one hospital based and the other In the Amoy Gardens apartments, were identified. The frequency of diarrhoea, admission to intensive care, and mortality differed significantly between the two outbreaks. We did genomic sequencing for viral isolates from five Amoy Gardens patients. The virus sequence was identical in four of these five patients. The sequence data from one hospital case and the four identical community cases had only three nucleotide differences. Alterations in the SARS coronavirus genome are unlikely to have caused the distinctive clinical features of the Amoy Gardens patients, and these results highlight the Importance of non-viral genomic factors in this outbreak.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B05B02E</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Infection</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Infection</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Infección</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Appareil respiratoire</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Respiratory system</s0>
<s5>02</s5>
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<s5>02</s5>
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<fC03 i1="03" i2="X" l="FRE"><s0>Aigu</s0>
<s5>03</s5>
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<s5>03</s5>
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<fC03 i1="03" i2="X" l="SPA"><s0>Agudo</s0>
<s5>03</s5>
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<fC03 i1="04" i2="X" l="FRE"><s0>Hong Kong</s0>
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<s5>04</s5>
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<fC03 i1="04" i2="X" l="ENG"><s0>Hong Kong</s0>
<s2>NG</s2>
<s5>04</s5>
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<fC03 i1="04" i2="X" l="SPA"><s0>Hong Kong</s0>
<s2>NG</s2>
<s5>04</s5>
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<fC03 i1="05" i2="X" l="FRE"><s0>Prévalence</s0>
<s5>05</s5>
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<fC03 i1="05" i2="X" l="ENG"><s0>Prevalence</s0>
<s5>05</s5>
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<s5>05</s5>
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<fC03 i1="06" i2="X" l="FRE"><s0>Pullulation</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Outbreak</s0>
<s5>06</s5>
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<fC03 i1="06" i2="X" l="SPA"><s0>Pululación</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>07</s5>
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<fC03 i1="07" i2="X" l="SPA"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>07</s5>
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<fC03 i1="08" i2="X" l="FRE"><s0>Génomique</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Genomics</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Genómica</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Mécanisme action</s0>
<s5>09</s5>
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<fC03 i1="09" i2="X" l="ENG"><s0>Mechanism of action</s0>
<s5>09</s5>
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<s5>09</s5>
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<s5>11</s5>
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<s5>11</s5>
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<s5>11</s5>
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<fC07 i1="01" i2="X" l="FRE"><s0>Chine</s0>
<s2>NG</s2>
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<fC07 i1="01" i2="X" l="ENG"><s0>China</s0>
<s2>NG</s2>
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<fC07 i1="01" i2="X" l="SPA"><s0>China</s0>
<s2>NG</s2>
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<fC07 i1="02" i2="X" l="SPA"><s0>Asia</s0>
<s2>NG</s2>
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<fC07 i1="03" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
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<fC07 i1="03" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
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<fC07 i1="03" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
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<fC07 i1="04" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
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<fC07 i1="04" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
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<s2>NW</s2>
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<s5>37</s5>
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<fC07 i1="06" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>37</s5>
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<s5>37</s5>
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<fC07 i1="07" i2="X" l="FRE"><s0>Virose</s0>
<s2>NM</s2>
<s5>53</s5>
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<s2>NM</s2>
<s5>53</s5>
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<fC07 i1="07" i2="X" l="SPA"><s0>Virosis</s0>
<s2>NM</s2>
<s5>53</s5>
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<fN21><s1>082</s1>
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<fN82><s1>PSI</s1>
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<server><NO>PASCAL 04-0125308 INIST</NO>
<ET>Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong</ET>
<AU>CHIM (S. S. C.); TSUI (S. K. W.); CHAN (K. C. A.); AU (T. C. C.); HUNG (E. C. W.); TONG (Y. K.); CHIU (R. W. K.); NG (E. K. O.); CHAN (P. K. S.); CHU (C. M.); SUNG (J. J. Y.); TAM (J. S.); FUNG (K. P.); WAYE (M. M. Y.); LEE (C. Y.); YUEN (K. Y.); LO (Y. M. D.)</AU>
<AF>Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital/Hong-Kong (1 aut., 3 aut., 6 aut., 7 aut., 8 aut., 17 aut.); Department of Biochemistry, Chinese University of Hong Kong, Prince of Wales Hospital/Hong-Kong (2 aut., 4 aut., 13 aut., 14 aut., 15 aut.); Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital/Hong-Kong (5 aut.); Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital/Hong-Kong (9 aut., 12 aut.); Department of Medicine, United Christian Hospital/Hong-Kong (10 aut.); Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital/Hong-Kong (11 aut.); Department of Microbiology, Queen Mary Hospital, University of Hong Kong/Hong-Kong (16 aut.)</AF>
<DT>Publication en série; Correspondance, lettre; Niveau analytique</DT>
<SO>Lancet : (British edition); ISSN 0140-6736; Coden LANCAO; Royaume-Uni; Da. 2003; Vol. 362; No. 9398; Pp. 1807-1808; Bibl. 5 ref.</SO>
<LA>Anglais</LA>
<EA>Severe acute respiratory syndrome (SARS) is a global health concern. In Hong Kong, two major outbreaks, one hospital based and the other In the Amoy Gardens apartments, were identified. The frequency of diarrhoea, admission to intensive care, and mortality differed significantly between the two outbreaks. We did genomic sequencing for viral isolates from five Amoy Gardens patients. The virus sequence was identical in four of these five patients. The sequence data from one hospital case and the four identical community cases had only three nucleotide differences. Alterations in the SARS coronavirus genome are unlikely to have caused the distinctive clinical features of the Amoy Gardens patients, and these results highlight the Importance of non-viral genomic factors in this outbreak.</EA>
<CC>002B05B02E</CC>
<FD>Infection; Appareil respiratoire; Aigu; Hong Kong; Prévalence; Pullulation; Coronavirus; Génomique; Mécanisme action; Homme</FD>
<FG>Chine; Asie; Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie; Virose</FG>
<ED>Infection; Respiratory system; Acute; Hong Kong; Prevalence; Outbreak; Coronavirus; Genomics; Mechanism of action; Human</ED>
<EG>China; Asia; Coronaviridae; Nidovirales; Virus; Respiratory disease; Viral disease</EG>
<SD>Infección; Aparato respiratorio; Agudo; Hong Kong; Prevalencia; Pululación; Coronavirus; Genómica; Mecanismo acción; Hombre</SD>
<LO>INIST-5004.354000116007080090</LO>
<ID>04-0125308</ID>
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Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong

Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong

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