Antibody response and viraemia during the course of severe acute respiratory syndrome (SARS)-associated coronavirus infection
Identifieur interne : 005B76 ( Main/Curation ); précédent : 005B75; suivant : 005B77Antibody response and viraemia during the course of severe acute respiratory syndrome (SARS)-associated coronavirus infection
Auteurs : WEIJUN CHEN [République populaire de Chine] ; ZUYUAN XU [République populaire de Chine] ; JINGSONG MU [République populaire de Chine] ; LING YANG [République populaire de Chine] ; HAIXUE GAN [République populaire de Chine] ; FENG MU [République populaire de Chine] ; BAOXING FAN [République populaire de Chine] ; BO HE [République populaire de Chine] ; SHENGYONG HUANG [République populaire de Chine] ; BO YOU [République populaire de Chine] ; YONGKUI YANG [République populaire de Chine] ; XIANGJUN TANG [République populaire de Chine] ; LING QIU [République populaire de Chine] ; YAN QIU [République populaire de Chine] ; JIE WEN [République populaire de Chine] ; JIANQIU FANG [République populaire de Chine] ; JIAN WANG [République populaire de Chine]Source :
- Journal of medical microbiology [ 0022-2615 ] ; 2004.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
To understand the time-course of viraemia and antibody responses to severe acute respiratory syndrome-associated coronavirus (SARS-CoV), RT-PCR and ELISA were used to assay 376 blood samples from 135 SARS patients at various stages of the illness, including samples from patients who were in their early convalescent phase. The results showed that IgM antibodies decreased and became undetectable 11 weeks into the recovery phase. IgG antibodies, however, remained detectable for a period beyond 11 weeks and were found in 100 % of patients in the early convalescent phase. SARS-CoV viraemia mainly appeared 1 week after the onset of illness and then decreased over a period of 1 month, becoming undetectable in the blood samples of the convalescent patients. At the peak of viraemia, viral RNA was detectable in 75 % of blood samples from patients who were clinically diagnosed with SARS 1 or 2 weeks before the test.
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Pascal:04-0283140Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Antibody response and viraemia during the course of severe acute respiratory syndrome (SARS)-associated coronavirus infection</title>
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<author><name sortKey="Zuyuan Xu" sort="Zuyuan Xu" uniqKey="Zuyuan Xu" last="Zuyuan Xu">ZUYUAN XU</name>
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<country>République populaire de Chine</country>
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<author><name sortKey="Ling Yang" sort="Ling Yang" uniqKey="Ling Yang" last="Ling Yang">LING YANG</name>
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<country>République populaire de Chine</country>
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<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
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<author><name sortKey="Haixue Gan" sort="Haixue Gan" uniqKey="Haixue Gan" last="Haixue Gan">HAIXUE GAN</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Beijing BGI-GBI Biotech Co. Ltd</s1>
<s2>Beijing 101300</s2>
<s3>CHN</s3>
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<country>République populaire de Chine</country>
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<author><name sortKey="Feng Mu" sort="Feng Mu" uniqKey="Feng Mu" last="Feng Mu">FENG MU</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Beijing Genomics Institute, Chinese Academy of Sciences</s1>
<s2>Beijing 101300</s2>
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<country>République populaire de Chine</country>
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<country>République populaire de Chine</country>
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<author><name sortKey="Baoxing Fan" sort="Baoxing Fan" uniqKey="Baoxing Fan" last="Baoxing Fan">BAOXING FAN</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Beijing 301 Hospital</s1>
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<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
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<author><name sortKey="Bo He" sort="Bo He" uniqKey="Bo He" last="Bo He">BO HE</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Beijing BGI-GBI Biotech Co. Ltd</s1>
<s2>Beijing 101300</s2>
<s3>CHN</s3>
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<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
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</author>
<author><name sortKey="Shengyong Huang" sort="Shengyong Huang" uniqKey="Shengyong Huang" last="Shengyong Huang">SHENGYONG HUANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Beijing BGI-GBI Biotech Co. Ltd</s1>
<s2>Beijing 101300</s2>
<s3>CHN</s3>
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<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
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</author>
<author><name sortKey="Bo You" sort="Bo You" uniqKey="Bo You" last="Bo You">BO YOU</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Beijing BGI-GBI Biotech Co. Ltd</s1>
<s2>Beijing 101300</s2>
<s3>CHN</s3>
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<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
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</author>
<author><name sortKey="Yongkui Yang" sort="Yongkui Yang" uniqKey="Yongkui Yang" last="Yongkui Yang">YONGKUI YANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Beijing BGI-GBI Biotech Co. Ltd</s1>
<s2>Beijing 101300</s2>
<s3>CHN</s3>
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<country>République populaire de Chine</country>
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</author>
<author><name sortKey="Xiangjun Tang" sort="Xiangjun Tang" uniqKey="Xiangjun Tang" last="Xiangjun Tang">XIANGJUN TANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Beijing BGI-GBI Biotech Co. Ltd</s1>
<s2>Beijing 101300</s2>
<s3>CHN</s3>
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<placeName><settlement type="city">Pékin</settlement>
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<author><name sortKey="Ling Qiu" sort="Ling Qiu" uniqKey="Ling Qiu" last="Ling Qiu">LING QIU</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Beijing Union Hospital</s1>
<s2>Beijing 100730</s2>
<s3>CHN</s3>
<sZ>13 aut.</sZ>
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<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
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<author><name sortKey="Yan Qiu" sort="Yan Qiu" uniqKey="Yan Qiu" last="Yan Qiu">YAN QIU</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Beijing Red Cross Blood Center</s1>
<s2>Beijing 100088</s2>
<s3>CHN</s3>
<sZ>14 aut.</sZ>
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<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
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<author><name sortKey="Jie Wen" sort="Jie Wen" uniqKey="Jie Wen" last="Jie Wen">JIE WEN</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Beijing Genomics Institute, Chinese Academy of Sciences</s1>
<s2>Beijing 101300</s2>
<s3>CHN</s3>
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<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
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<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Beijing BGI-GBI Biotech Co. Ltd</s1>
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<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
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<author><name sortKey="Jianqiu Fang" sort="Jianqiu Fang" uniqKey="Jianqiu Fang" last="Jianqiu Fang">JIANQIU FANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Beijing Genomics Institute, Chinese Academy of Sciences</s1>
<s2>Beijing 101300</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
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<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
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<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Beijing BGI-GBI Biotech Co. Ltd</s1>
<s2>Beijing 101300</s2>
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<country>République populaire de Chine</country>
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<author><name sortKey="Jian Wang" sort="Jian Wang" uniqKey="Jian Wang" last="Jian Wang">JIAN WANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Beijing Genomics Institute, Chinese Academy of Sciences</s1>
<s2>Beijing 101300</s2>
<s3>CHN</s3>
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<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Beijing BGI-GBI Biotech Co. Ltd</s1>
<s2>Beijing 101300</s2>
<s3>CHN</s3>
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<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
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</analytic>
<series><title level="j" type="main">Journal of medical microbiology</title>
<title level="j" type="abbreviated">J. med. microbiol.</title>
<idno type="ISSN">0022-2615</idno>
<imprint><date when="2004">2004</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of medical microbiology</title>
<title level="j" type="abbreviated">J. med. microbiol.</title>
<idno type="ISSN">0022-2615</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibody</term>
<term>Coronavirus</term>
<term>Microbiology</term>
<term>Severe acute respiratory syndrome</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Coronavirus</term>
<term>Anticorps</term>
<term>Microbiologie</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">To understand the time-course of viraemia and antibody responses to severe acute respiratory syndrome-associated coronavirus (SARS-CoV), RT-PCR and ELISA were used to assay 376 blood samples from 135 SARS patients at various stages of the illness, including samples from patients who were in their early convalescent phase. The results showed that IgM antibodies decreased and became undetectable 11 weeks into the recovery phase. IgG antibodies, however, remained detectable for a period beyond 11 weeks and were found in 100 % of patients in the early convalescent phase. SARS-CoV viraemia mainly appeared 1 week after the onset of illness and then decreased over a period of 1 month, becoming undetectable in the blood samples of the convalescent patients. At the peak of viraemia, viral RNA was detectable in 75 % of blood samples from patients who were clinically diagnosed with SARS 1 or 2 weeks before the test.</div>
</front>
</TEI>
</record>
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