SrasV1, Main, Merge, bibRecord, 006044

Antibody response and viraemia during the course of severe acute respiratory syndrome (SARS)-associated coronavirus infection

Identifieur interne : 006044 ( Main/Merge ); précédent : 006043; suivant : 006045

Antibody response and viraemia during the course of severe acute respiratory syndrome (SARS)-associated coronavirus infection

Source :

Journal of medical microbiology [ 0022-2615 ] ; 2004.

RBID : Pascal:04-0283140

Descripteurs français

Pascal (Inist)
- Coronavirus, Anticorps, Microbiologie, Syndrome respiratoire aigu sévère.

English descriptors

KwdEn :
- Antibody, Coronavirus, Microbiology, Severe acute respiratory syndrome.

Abstract

To understand the time-course of viraemia and antibody responses to severe acute respiratory syndrome-associated coronavirus (SARS-CoV), RT-PCR and ELISA were used to assay 376 blood samples from 135 SARS patients at various stages of the illness, including samples from patients who were in their early convalescent phase. The results showed that IgM antibodies decreased and became undetectable 11 weeks into the recovery phase. IgG antibodies, however, remained detectable for a period beyond 11 weeks and were found in 100 % of patients in the early convalescent phase. SARS-CoV viraemia mainly appeared 1 week after the onset of illness and then decreased over a period of 1 month, becoming undetectable in the blood samples of the convalescent patients. At the peak of viraemia, viral RNA was detectable in 75 % of blood samples from patients who were clinically diagnosed with SARS 1 or 2 weeks before the test.

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Pascal:04-0283140

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Antibody response and viraemia during the course of severe acute respiratory syndrome (SARS)-associated coronavirus infection</title>
<author><name sortKey="Weijun Chen" sort="Weijun Chen" uniqKey="Weijun Chen" last="Weijun Chen">WEIJUN CHEN</name>
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<author><name sortKey="Zuyuan Xu" sort="Zuyuan Xu" uniqKey="Zuyuan Xu" last="Zuyuan Xu">ZUYUAN XU</name>
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<s2>Beijing 101300</s2>
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<country>République populaire de Chine</country>
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<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Beijing BGI-GBI Biotech Co. Ltd</s1>
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<country>République populaire de Chine</country>
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</affiliation>
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<author><name sortKey="Feng Mu" sort="Feng Mu" uniqKey="Feng Mu" last="Feng Mu">FENG MU</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Beijing Genomics Institute, Chinese Academy of Sciences</s1>
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<country>République populaire de Chine</country>
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</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Beijing BGI-GBI Biotech Co. Ltd</s1>
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<author><name sortKey="Baoxing Fan" sort="Baoxing Fan" uniqKey="Baoxing Fan" last="Baoxing Fan">BAOXING FAN</name>
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</author>
<author><name sortKey="Bo He" sort="Bo He" uniqKey="Bo He" last="Bo He">BO HE</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Beijing BGI-GBI Biotech Co. Ltd</s1>
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<s3>CHN</s3>
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</author>
<author><name sortKey="Shengyong Huang" sort="Shengyong Huang" uniqKey="Shengyong Huang" last="Shengyong Huang">SHENGYONG HUANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Beijing BGI-GBI Biotech Co. Ltd</s1>
<s2>Beijing 101300</s2>
<s3>CHN</s3>
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<country>République populaire de Chine</country>
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</affiliation>
</author>
<author><name sortKey="Bo You" sort="Bo You" uniqKey="Bo You" last="Bo You">BO YOU</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Beijing BGI-GBI Biotech Co. Ltd</s1>
<s2>Beijing 101300</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
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<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
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</author>
<author><name sortKey="Yongkui Yang" sort="Yongkui Yang" uniqKey="Yongkui Yang" last="Yongkui Yang">YONGKUI YANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Beijing BGI-GBI Biotech Co. Ltd</s1>
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<author><name sortKey="Xiangjun Tang" sort="Xiangjun Tang" uniqKey="Xiangjun Tang" last="Xiangjun Tang">XIANGJUN TANG</name>
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<author><name sortKey="Ling Qiu" sort="Ling Qiu" uniqKey="Ling Qiu" last="Ling Qiu">LING QIU</name>
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<country>République populaire de Chine</country>
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<author><name sortKey="Yan Qiu" sort="Yan Qiu" uniqKey="Yan Qiu" last="Yan Qiu">YAN QIU</name>
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<sZ>14 aut.</sZ>
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<country>République populaire de Chine</country>
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<author><name sortKey="Jie Wen" sort="Jie Wen" uniqKey="Jie Wen" last="Jie Wen">JIE WEN</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Beijing Genomics Institute, Chinese Academy of Sciences</s1>
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<s3>CHN</s3>
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<country>République populaire de Chine</country>
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<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Beijing BGI-GBI Biotech Co. Ltd</s1>
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<author><name sortKey="Jianqiu Fang" sort="Jianqiu Fang" uniqKey="Jianqiu Fang" last="Jianqiu Fang">JIANQIU FANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Beijing Genomics Institute, Chinese Academy of Sciences</s1>
<s2>Beijing 101300</s2>
<s3>CHN</s3>
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<country>République populaire de Chine</country>
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</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Beijing BGI-GBI Biotech Co. Ltd</s1>
<s2>Beijing 101300</s2>
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</author>
<author><name sortKey="Jian Wang" sort="Jian Wang" uniqKey="Jian Wang" last="Jian Wang">JIAN WANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Beijing Genomics Institute, Chinese Academy of Sciences</s1>
<s2>Beijing 101300</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
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<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Beijing BGI-GBI Biotech Co. Ltd</s1>
<s2>Beijing 101300</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
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<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of medical microbiology</title>
<title level="j" type="abbreviated">J. med. microbiol.</title>
<idno type="ISSN">0022-2615</idno>
<imprint><date when="2004">2004</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of medical microbiology</title>
<title level="j" type="abbreviated">J. med. microbiol.</title>
<idno type="ISSN">0022-2615</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibody</term>
<term>Coronavirus</term>
<term>Microbiology</term>
<term>Severe acute respiratory syndrome</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Coronavirus</term>
<term>Anticorps</term>
<term>Microbiologie</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">To understand the time-course of viraemia and antibody responses to severe acute respiratory syndrome-associated coronavirus (SARS-CoV), RT-PCR and ELISA were used to assay 376 blood samples from 135 SARS patients at various stages of the illness, including samples from patients who were in their early convalescent phase. The results showed that IgM antibodies decreased and became undetectable 11 weeks into the recovery phase. IgG antibodies, however, remained detectable for a period beyond 11 weeks and were found in 100 % of patients in the early convalescent phase. SARS-CoV viraemia mainly appeared 1 week after the onset of illness and then decreased over a period of 1 month, becoming undetectable in the blood samples of the convalescent patients. At the peak of viraemia, viral RNA was detectable in 75 % of blood samples from patients who were clinically diagnosed with SARS 1 or 2 weeks before the test.</div>
</front>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<settlement><li>Pékin</li>
</settlement>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Weijun Chen" sort="Weijun Chen" uniqKey="Weijun Chen" last="Weijun Chen">WEIJUN CHEN</name>
</noRegion>
<name sortKey="Baoxing Fan" sort="Baoxing Fan" uniqKey="Baoxing Fan" last="Baoxing Fan">BAOXING FAN</name>
<name sortKey="Bo He" sort="Bo He" uniqKey="Bo He" last="Bo He">BO HE</name>
<name sortKey="Bo You" sort="Bo You" uniqKey="Bo You" last="Bo You">BO YOU</name>
<name sortKey="Feng Mu" sort="Feng Mu" uniqKey="Feng Mu" last="Feng Mu">FENG MU</name>
<name sortKey="Feng Mu" sort="Feng Mu" uniqKey="Feng Mu" last="Feng Mu">FENG MU</name>
<name sortKey="Haixue Gan" sort="Haixue Gan" uniqKey="Haixue Gan" last="Haixue Gan">HAIXUE GAN</name>
<name sortKey="Jian Wang" sort="Jian Wang" uniqKey="Jian Wang" last="Jian Wang">JIAN WANG</name>
<name sortKey="Jian Wang" sort="Jian Wang" uniqKey="Jian Wang" last="Jian Wang">JIAN WANG</name>
<name sortKey="Jianqiu Fang" sort="Jianqiu Fang" uniqKey="Jianqiu Fang" last="Jianqiu Fang">JIANQIU FANG</name>
<name sortKey="Jianqiu Fang" sort="Jianqiu Fang" uniqKey="Jianqiu Fang" last="Jianqiu Fang">JIANQIU FANG</name>
<name sortKey="Jie Wen" sort="Jie Wen" uniqKey="Jie Wen" last="Jie Wen">JIE WEN</name>
<name sortKey="Jie Wen" sort="Jie Wen" uniqKey="Jie Wen" last="Jie Wen">JIE WEN</name>
<name sortKey="Jingsong Mu" sort="Jingsong Mu" uniqKey="Jingsong Mu" last="Jingsong Mu">JINGSONG MU</name>
<name sortKey="Ling Qiu" sort="Ling Qiu" uniqKey="Ling Qiu" last="Ling Qiu">LING QIU</name>
<name sortKey="Ling Yang" sort="Ling Yang" uniqKey="Ling Yang" last="Ling Yang">LING YANG</name>
<name sortKey="Ling Yang" sort="Ling Yang" uniqKey="Ling Yang" last="Ling Yang">LING YANG</name>
<name sortKey="Shengyong Huang" sort="Shengyong Huang" uniqKey="Shengyong Huang" last="Shengyong Huang">SHENGYONG HUANG</name>
<name sortKey="Weijun Chen" sort="Weijun Chen" uniqKey="Weijun Chen" last="Weijun Chen">WEIJUN CHEN</name>
<name sortKey="Xiangjun Tang" sort="Xiangjun Tang" uniqKey="Xiangjun Tang" last="Xiangjun Tang">XIANGJUN TANG</name>
<name sortKey="Yan Qiu" sort="Yan Qiu" uniqKey="Yan Qiu" last="Yan Qiu">YAN QIU</name>
<name sortKey="Yongkui Yang" sort="Yongkui Yang" uniqKey="Yongkui Yang" last="Yongkui Yang">YONGKUI YANG</name>
<name sortKey="Zuyuan Xu" sort="Zuyuan Xu" uniqKey="Zuyuan Xu" last="Zuyuan Xu">ZUYUAN XU</name>
<name sortKey="Zuyuan Xu" sort="Zuyuan Xu" uniqKey="Zuyuan Xu" last="Zuyuan Xu">ZUYUAN XU</name>
</country>
</tree>
</affiliations>
</record>

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Antibody response and viraemia during the course of severe acute respiratory syndrome (SARS)-associated coronavirus infection

Antibody response and viraemia during the course of severe acute respiratory syndrome (SARS)-associated coronavirus infection

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