Association of human-leukocyte-antigen class I (B*0703) and class II (DRB1*0301) genotypes with susceptibility and resistance to the development of severe acute respiratory syndrome.
Identifieur interne : 005453 ( Main/Curation ); précédent : 005452; suivant : 005454Association of human-leukocyte-antigen class I (B*0703) and class II (DRB1*0301) genotypes with susceptibility and resistance to the development of severe acute respiratory syndrome.
Auteurs : Margaret H L. Ng [République populaire de Chine] ; Kin-Mang Lau ; Libby Li ; Suk-Hang Cheng ; Wing Y. Chan ; Pak K. Hui ; Benny Zee ; Chi-Bon Leung ; Joseph J Y. SungSource :
- The Journal of infectious diseases [ 0022-1899 ] ; 2004.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Antigènes HLA-B (génétique), Antigènes HLA-DR (génétique), Chaines HLA-DRB1, Dépistage génétique, Femelle, Fréquence d'allèle, Génotype, Humains, Indice de gravité médicale, Mâle, Prédisposition génétique à une maladie, Sujet âgé, Susceptibilité à une maladie, Syndrome respiratoire aigu sévère (génétique), Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (physiopathologie), Virus du SRAS (pathogénicité).
- MESH :
- génétique : Antigènes HLA-B, Antigènes HLA-DR, Syndrome respiratoire aigu sévère.
- immunologie : Syndrome respiratoire aigu sévère.
- pathogénicité : Virus du SRAS.
- physiopathologie : Syndrome respiratoire aigu sévère.
- Adulte, Adulte d'âge moyen, Chaines HLA-DRB1, Dépistage génétique, Femelle, Fréquence d'allèle, Génotype, Humains, Indice de gravité médicale, Mâle, Prédisposition génétique à une maladie, Sujet âgé, Susceptibilité à une maladie.
English descriptors
- KwdEn :
- Adult, Aged, Disease Susceptibility, Female, Gene Frequency, Genetic Predisposition to Disease, Genetic Testing, Genotype, HLA-B Antigens (genetics), HLA-DR Antigens (genetics), HLA-DRB1 Chains, Humans, Male, Middle Aged, SARS Virus (pathogenicity), Severe Acute Respiratory Syndrome (genetics), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (physiopathology), Severity of Illness Index.
- MESH :
- chemical , genetics : HLA-B Antigens, HLA-DR Antigens.
- genetics : Severe Acute Respiratory Syndrome.
- immunology : Severe Acute Respiratory Syndrome.
- pathogenicity : SARS Virus.
- physiopathology : Severe Acute Respiratory Syndrome.
- Adult, Aged, Disease Susceptibility, Female, Gene Frequency, Genetic Predisposition to Disease, Genetic Testing, Genotype, HLA-DRB1 Chains, Humans, Male, Middle Aged, Severity of Illness Index.
Abstract
Severe acute respiratory syndrome (SARS) is a public health concern worldwide. By studying the human leukocyte antigen (HLA) types A, B, DR, and DQ alleles in 90 Chinese patients with serologically confirmed SARS infections, we identified a strong association between HLA-B*0703 (OR, 4.08; 95% CI, 2.03-8.18; P=.00072 [Bonferroni-corrected P value, P(c) <.0022]) and -DRB1*0301 (OR, 0.06; 95%, 0.01-0.47; P=.00008 [after Bonferroni correction, P<.0042]) and the development of SARS. Moreover, the frequency of B*0703 and B60 coinheritance (9.6%; 95% CI, 4.6%-19.0%) in our SARS group was significantly higher (P=3x10(-9)) than that expected in the general population (0.4%). These genetic data will critically affect both the study of the pathogenesis of SARS and the design of vaccination programs.
DOI: 10.1086/421523
PubMed: 15243926
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<term>Aged</term>
<term>Disease Susceptibility</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genetic Predisposition to Disease</term>
<term>Genetic Testing</term>
<term>Genotype</term>
<term>HLA-B Antigens (genetics)</term>
<term>HLA-DR Antigens (genetics)</term>
<term>HLA-DRB1 Chains</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>SARS Virus (pathogenicity)</term>
<term>Severe Acute Respiratory Syndrome (genetics)</term>
<term>Severe Acute Respiratory Syndrome (immunology)</term>
<term>Severe Acute Respiratory Syndrome (physiopathology)</term>
<term>Severity of Illness Index</term>
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<term>Adulte d'âge moyen</term>
<term>Antigènes HLA-B (génétique)</term>
<term>Antigènes HLA-DR (génétique)</term>
<term>Chaines HLA-DRB1</term>
<term>Dépistage génétique</term>
<term>Femelle</term>
<term>Fréquence d'allèle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Indice de gravité médicale</term>
<term>Mâle</term>
<term>Prédisposition génétique à une maladie</term>
<term>Sujet âgé</term>
<term>Susceptibilité à une maladie</term>
<term>Syndrome respiratoire aigu sévère (génétique)</term>
<term>Syndrome respiratoire aigu sévère (immunologie)</term>
<term>Syndrome respiratoire aigu sévère (physiopathologie)</term>
<term>Virus du SRAS (pathogénicité)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>HLA-B Antigens</term>
<term>HLA-DR Antigens</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes HLA-B</term>
<term>Antigènes HLA-DR</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus du SRAS</term>
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<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Disease Susceptibility</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genetic Predisposition to Disease</term>
<term>Genetic Testing</term>
<term>Genotype</term>
<term>HLA-DRB1 Chains</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Severity of Illness Index</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Chaines HLA-DRB1</term>
<term>Dépistage génétique</term>
<term>Femelle</term>
<term>Fréquence d'allèle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Indice de gravité médicale</term>
<term>Mâle</term>
<term>Prédisposition génétique à une maladie</term>
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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is a public health concern worldwide. By studying the human leukocyte antigen (HLA) types A, B, DR, and DQ alleles in 90 Chinese patients with serologically confirmed SARS infections, we identified a strong association between HLA-B*0703 (OR, 4.08; 95% CI, 2.03-8.18; P=.00072 [Bonferroni-corrected P value, P(c) <.0022]) and -DRB1*0301 (OR, 0.06; 95%, 0.01-0.47; P=.00008 [after Bonferroni correction, P<.0042]) and the development of SARS. Moreover, the frequency of B*0703 and B60 coinheritance (9.6%; 95% CI, 4.6%-19.0%) in our SARS group was significantly higher (P=3x10(-9)) than that expected in the general population (0.4%). These genetic data will critically affect both the study of the pathogenesis of SARS and the design of vaccination programs.</div>
</front>
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