Radiological and pulmonary function outcomes of children with SARS.
Identifieur interne : 005176 ( Main/Curation ); précédent : 005175; suivant : 005177Radiological and pulmonary function outcomes of children with SARS.
Auteurs : A M Li ; H K So ; W. Chu ; P C Ng ; K L Hon ; W K Chiu ; C W Leung ; Y S Yau ; W K Mo ; T F FokSource :
- Pediatric pulmonology [ 8755-6863 ] ; 2004.
Descripteurs français
- KwdFr :
- Adolescent, Enfant, Facteurs temps, Femelle, Humains, Indice de gravité médicale, Mâle, Poumon (imagerie diagnostique), Poumon (physiopathologie), Résultat thérapeutique, Syndrome respiratoire aigu sévère (imagerie diagnostique), Syndrome respiratoire aigu sévère (physiopathologie), Tests de la fonction respiratoire, Tomodensitométrie, Virus du SRAS, Études de suivi.
- MESH :
- imagerie diagnostique : Poumon, Syndrome respiratoire aigu sévère.
- physiopathologie : Poumon, Syndrome respiratoire aigu sévère.
- Adolescent, Enfant, Facteurs temps, Femelle, Humains, Indice de gravité médicale, Mâle, Résultat thérapeutique, Tests de la fonction respiratoire, Tomodensitométrie, Virus du SRAS, Études de suivi.
English descriptors
- KwdEn :
- Adolescent, Child, Female, Follow-Up Studies, Humans, Lung (diagnostic imaging), Lung (physiopathology), Male, Respiratory Function Tests, SARS Virus, Severe Acute Respiratory Syndrome (diagnostic imaging), Severe Acute Respiratory Syndrome (physiopathology), Severity of Illness Index, Time Factors, Tomography, X-Ray Computed, Treatment Outcome.
- MESH :
- diagnostic imaging : Lung, Severe Acute Respiratory Syndrome.
- physiopathology : Lung, Severe Acute Respiratory Syndrome.
- Adolescent, Child, Female, Follow-Up Studies, Humans, Male, Respiratory Function Tests, SARS Virus, Severity of Illness Index, Time Factors, Tomography, X-Ray Computed, Treatment Outcome.
Abstract
We examined the radiological and pulmonary function outcomes of children affected with severe acute respiratory syndrome (SARS) at 6 months from diagnosis. Twenty-one female and 26 male Chinese patients (median age, 13.6 years; interquartile range, 9.9-16.0) were studied. In each subject, high-resolution computed tomography (HRCT) of the thorax and pulmonary function were assessed. All children were asymptomatic and had a normal clinical examination. Mild pulmonary abnormalities were detected on HRCT in 16 (34.0%) subjects, including residual ground-glass opacification (n = 5), air trapping (n = 8), and a combination of ground-glass changes and air trapping (n = 3). The need for oxygen supplementation (P = 0.02) and lymphopenia during the course of illness (P = 0.012) were significant risk factors in predicting abnormal HRCT. There were no significant lung function differences between those with and without HRCT abnormalities. Despite complete clinical resolution, a considerable proportion of children affected with SARS had abnormal HRCT findings at 6 months. These abnormalities were more prevalent in those with severe disease. It is important that careful follow-up be carried out to assess the clinical significance and persistence of such abnormalities.
DOI: 10.1002/ppul.20078
PubMed: 15514972
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A M Li<affiliation><nlm:affiliation>Department of Paediatrics, Prince of Wales Hospital, Shatin Hong Kong.</nlm:affiliation><wicri:noCountry code="subField">Shatin Hong Kong</wicri:noCountry></affiliation>Le document en format XML
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Chu</name></author><author><name sortKey="Ng, P C" sort="Ng, P C" uniqKey="Ng P" first="P C" last="Ng">P C Ng</name></author><author><name sortKey="Hon, K L" sort="Hon, K L" uniqKey="Hon K" first="K L" last="Hon">K L Hon</name></author><author><name sortKey="Chiu, W K" sort="Chiu, W K" uniqKey="Chiu W" first="W K" last="Chiu">W K Chiu</name></author><author><name sortKey="Leung, C W" sort="Leung, C W" uniqKey="Leung C" first="C W" last="Leung">C W Leung</name></author><author><name sortKey="Yau, Y S" sort="Yau, Y S" uniqKey="Yau Y" first="Y S" last="Yau">Y S Yau</name></author><author><name sortKey="Mo, W K" sort="Mo, W K" uniqKey="Mo W" first="W K" last="Mo">W K Mo</name></author><author><name sortKey="Fok, T F" sort="Fok, T F" uniqKey="Fok T" first="T F" last="Fok">T F Fok</name></author></analytic><series><title level="j">Pediatric pulmonology</title><idno type="ISSN">8755-6863</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Lung (diagnostic imaging)</term><term>Lung (physiopathology)</term><term>Male</term><term>Respiratory Function Tests</term><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome (diagnostic imaging)</term><term>Severe Acute Respiratory Syndrome (physiopathology)</term><term>Severity of Illness Index</term><term>Time Factors</term><term>Tomography, X-Ray Computed</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Enfant</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Indice de gravité médicale</term><term>Mâle</term><term>Poumon (imagerie diagnostique)</term><term>Poumon (physiopathologie)</term><term>Résultat thérapeutique</term><term>Syndrome respiratoire aigu sévère (imagerie diagnostique)</term><term>Syndrome respiratoire aigu sévère (physiopathologie)</term><term>Tests de la fonction respiratoire</term><term>Tomodensitométrie</term><term>Virus du SRAS</term><term>Études de suivi</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Lung</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Poumon</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Poumon</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lung</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Respiratory Function Tests</term><term>SARS Virus</term><term>Severity of Illness Index</term><term>Time Factors</term><term>Tomography, X-Ray Computed</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Enfant</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Indice de gravité médicale</term><term>Mâle</term><term>Résultat thérapeutique</term><term>Tests de la fonction respiratoire</term><term>Tomodensitométrie</term><term>Virus du SRAS</term><term>Études de suivi</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We examined the radiological and pulmonary function outcomes of children affected with severe acute respiratory syndrome (SARS) at 6 months from diagnosis. Twenty-one female and 26 male Chinese patients (median age, 13.6 years; interquartile range, 9.9-16.0) were studied. In each subject, high-resolution computed tomography (HRCT) of the thorax and pulmonary function were assessed. All children were asymptomatic and had a normal clinical examination. Mild pulmonary abnormalities were detected on HRCT in 16 (34.0%) subjects, including residual ground-glass opacification (n = 5), air trapping (n = 8), and a combination of ground-glass changes and air trapping (n = 3). The need for oxygen supplementation (P = 0.02) and lymphopenia during the course of illness (P = 0.012) were significant risk factors in predicting abnormal HRCT. There were no significant lung function differences between those with and without HRCT abnormalities. Despite complete clinical resolution, a considerable proportion of children affected with SARS had abnormal HRCT findings at 6 months. These abnormalities were more prevalent in those with severe disease. It is important that careful follow-up be carried out to assess the clinical significance and persistence of such abnormalities.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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