Radiological and pulmonary function outcomes of children with SARS.
Identifieur interne : 002A73 ( PubMed/Corpus ); précédent : 002A72; suivant : 002A74Radiological and pulmonary function outcomes of children with SARS.
Auteurs : A M Li ; H K So ; W. Chu ; P C Ng ; K L Hon ; W K Chiu ; C W Leung ; Y S Yau ; W K Mo ; T F FokSource :
- Pediatric pulmonology [ 8755-6863 ] ; 2004.
English descriptors
- KwdEn :
- Adolescent, Child, Female, Follow-Up Studies, Humans, Lung (diagnostic imaging), Lung (physiopathology), Male, Respiratory Function Tests, SARS Virus, Severe Acute Respiratory Syndrome (diagnostic imaging), Severe Acute Respiratory Syndrome (physiopathology), Severity of Illness Index, Time Factors, Tomography, X-Ray Computed, Treatment Outcome.
- MESH :
- diagnostic imaging : Lung, Severe Acute Respiratory Syndrome.
- physiopathology : Lung, Severe Acute Respiratory Syndrome.
- Adolescent, Child, Female, Follow-Up Studies, Humans, Male, Respiratory Function Tests, SARS Virus, Severity of Illness Index, Time Factors, Tomography, X-Ray Computed, Treatment Outcome.
Abstract
We examined the radiological and pulmonary function outcomes of children affected with severe acute respiratory syndrome (SARS) at 6 months from diagnosis. Twenty-one female and 26 male Chinese patients (median age, 13.6 years; interquartile range, 9.9-16.0) were studied. In each subject, high-resolution computed tomography (HRCT) of the thorax and pulmonary function were assessed. All children were asymptomatic and had a normal clinical examination. Mild pulmonary abnormalities were detected on HRCT in 16 (34.0%) subjects, including residual ground-glass opacification (n = 5), air trapping (n = 8), and a combination of ground-glass changes and air trapping (n = 3). The need for oxygen supplementation (P = 0.02) and lymphopenia during the course of illness (P = 0.012) were significant risk factors in predicting abnormal HRCT. There were no significant lung function differences between those with and without HRCT abnormalities. Despite complete clinical resolution, a considerable proportion of children affected with SARS had abnormal HRCT findings at 6 months. These abnormalities were more prevalent in those with severe disease. It is important that careful follow-up be carried out to assess the clinical significance and persistence of such abnormalities.
DOI: 10.1002/ppul.20078
PubMed: 15514972
Links to Exploration step
pubmed:15514972Le document en format XML
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Chu</name></author><author><name sortKey="Ng, P C" sort="Ng, P C" uniqKey="Ng P" first="P C" last="Ng">P C Ng</name></author><author><name sortKey="Hon, K L" sort="Hon, K L" uniqKey="Hon K" first="K L" last="Hon">K L Hon</name></author><author><name sortKey="Chiu, W K" sort="Chiu, W K" uniqKey="Chiu W" first="W K" last="Chiu">W K Chiu</name></author><author><name sortKey="Leung, C W" sort="Leung, C W" uniqKey="Leung C" first="C W" last="Leung">C W Leung</name></author><author><name sortKey="Yau, Y S" sort="Yau, Y S" uniqKey="Yau Y" first="Y S" last="Yau">Y S Yau</name></author><author><name sortKey="Mo, W K" sort="Mo, W K" uniqKey="Mo W" first="W K" last="Mo">W K Mo</name></author><author><name sortKey="Fok, T F" sort="Fok, T F" uniqKey="Fok T" first="T F" last="Fok">T F Fok</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:15514972</idno><idno type="pmid">15514972</idno><idno type="doi">10.1002/ppul.20078</idno><idno type="wicri:Area/PubMed/Corpus">002A73</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002A73</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Radiological and pulmonary function outcomes of children with SARS.</title><author><name sortKey="Li, A M" sort="Li, A M" uniqKey="Li A" first="A M" last="Li">A M Li</name><affiliation><nlm:affiliation>Department of Paediatrics, Prince of Wales Hospital, Shatin Hong Kong.</nlm:affiliation></affiliation></author><author><name sortKey="So, H K" sort="So, H K" uniqKey="So H" first="H K" last="So">H K So</name></author><author><name sortKey="Chu, W" sort="Chu, W" uniqKey="Chu W" first="W" last="Chu">W. Chu</name></author><author><name sortKey="Ng, P C" sort="Ng, P C" uniqKey="Ng P" first="P C" last="Ng">P C Ng</name></author><author><name sortKey="Hon, K L" sort="Hon, K L" uniqKey="Hon K" first="K L" last="Hon">K L Hon</name></author><author><name sortKey="Chiu, W K" sort="Chiu, W K" uniqKey="Chiu W" first="W K" last="Chiu">W K Chiu</name></author><author><name sortKey="Leung, C W" sort="Leung, C W" uniqKey="Leung C" first="C W" last="Leung">C W Leung</name></author><author><name sortKey="Yau, Y S" sort="Yau, Y S" uniqKey="Yau Y" first="Y S" last="Yau">Y S Yau</name></author><author><name sortKey="Mo, W K" sort="Mo, W K" uniqKey="Mo W" first="W K" last="Mo">W K Mo</name></author><author><name sortKey="Fok, T F" sort="Fok, T F" uniqKey="Fok T" first="T F" last="Fok">T F Fok</name></author></analytic><series><title level="j">Pediatric pulmonology</title><idno type="ISSN">8755-6863</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Lung (diagnostic imaging)</term><term>Lung (physiopathology)</term><term>Male</term><term>Respiratory Function Tests</term><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome (diagnostic imaging)</term><term>Severe Acute Respiratory Syndrome (physiopathology)</term><term>Severity of Illness Index</term><term>Time Factors</term><term>Tomography, X-Ray Computed</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Lung</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lung</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Respiratory Function Tests</term><term>SARS Virus</term><term>Severity of Illness Index</term><term>Time Factors</term><term>Tomography, X-Ray Computed</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We examined the radiological and pulmonary function outcomes of children affected with severe acute respiratory syndrome (SARS) at 6 months from diagnosis. Twenty-one female and 26 male Chinese patients (median age, 13.6 years; interquartile range, 9.9-16.0) were studied. In each subject, high-resolution computed tomography (HRCT) of the thorax and pulmonary function were assessed. All children were asymptomatic and had a normal clinical examination. Mild pulmonary abnormalities were detected on HRCT in 16 (34.0%) subjects, including residual ground-glass opacification (n = 5), air trapping (n = 8), and a combination of ground-glass changes and air trapping (n = 3). The need for oxygen supplementation (P = 0.02) and lymphopenia during the course of illness (P = 0.012) were significant risk factors in predicting abnormal HRCT. There were no significant lung function differences between those with and without HRCT abnormalities. Despite complete clinical resolution, a considerable proportion of children affected with SARS had abnormal HRCT findings at 6 months. These abnormalities were more prevalent in those with severe disease. It is important that careful follow-up be carried out to assess the clinical significance and persistence of such abnormalities.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15514972</PMID><DateCompleted><Year>2005</Year><Month>03</Month><Day>29</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>24</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">8755-6863</ISSN><JournalIssue CitedMedium="Print"><Volume>38</Volume><Issue>6</Issue><PubDate><Year>2004</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Pediatric pulmonology</Title><ISOAbbreviation>Pediatr. Pulmonol.</ISOAbbreviation></Journal><ArticleTitle>Radiological and pulmonary function outcomes of children with SARS.</ArticleTitle><Pagination><MedlinePgn>427-33</MedlinePgn></Pagination><Abstract><AbstractText>We examined the radiological and pulmonary function outcomes of children affected with severe acute respiratory syndrome (SARS) at 6 months from diagnosis. Twenty-one female and 26 male Chinese patients (median age, 13.6 years; interquartile range, 9.9-16.0) were studied. In each subject, high-resolution computed tomography (HRCT) of the thorax and pulmonary function were assessed. All children were asymptomatic and had a normal clinical examination. Mild pulmonary abnormalities were detected on HRCT in 16 (34.0%) subjects, including residual ground-glass opacification (n = 5), air trapping (n = 8), and a combination of ground-glass changes and air trapping (n = 3). The need for oxygen supplementation (P = 0.02) and lymphopenia during the course of illness (P = 0.012) were significant risk factors in predicting abnormal HRCT. There were no significant lung function differences between those with and without HRCT abnormalities. Despite complete clinical resolution, a considerable proportion of children affected with SARS had abnormal HRCT findings at 6 months. These abnormalities were more prevalent in those with severe disease. It is important that careful follow-up be carried out to assess the clinical significance and persistence of such abnormalities.</AbstractText><CopyrightInformation>Copyright 2004 Wiley-Liss, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Li</LastName><ForeName>A M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Department of Paediatrics, Prince of Wales Hospital, Shatin Hong Kong.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>So</LastName><ForeName>H K</ForeName><Initials>HK</Initials></Author><Author ValidYN="Y"><LastName>Chu</LastName><ForeName>W</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Ng</LastName><ForeName>P C</ForeName><Initials>PC</Initials></Author><Author ValidYN="Y"><LastName>Hon</LastName><ForeName>K L</ForeName><Initials>KL</Initials></Author><Author ValidYN="Y"><LastName>Chiu</LastName><ForeName>W K</ForeName><Initials>WK</Initials></Author><Author ValidYN="Y"><LastName>Leung</LastName><ForeName>C W</ForeName><Initials>CW</Initials></Author><Author ValidYN="Y"><LastName>Yau</LastName><ForeName>Y S</ForeName><Initials>YS</Initials></Author><Author ValidYN="Y"><LastName>Mo</LastName><ForeName>W K</ForeName><Initials>WK</Initials></Author><Author ValidYN="Y"><LastName>Fok</LastName><ForeName>T F</ForeName><Initials>TF</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Pediatr Pulmonol</MedlineTA><NlmUniqueID>8510590</NlmUniqueID><ISSNLinking>1099-0496</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012129" MajorTopicYN="N">Respiratory Function Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="Y">SARS Virus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014057" MajorTopicYN="N">Tomography, X-Ray Computed</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2004</Year><Month>10</Month><Day>30</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2005</Year><Month>3</Month><Day>30</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2004</Year><Month>10</Month><Day>30</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15514972</ArticleId><ArticleId IdType="doi">10.1002/ppul.20078</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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