Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains
Identifieur interne : 004413 ( Main/Curation ); précédent : 004412; suivant : 004414Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains
Auteurs : Marie-Pierre Egloff [France] ; Hélène Malet [France] ; Akos Putics [Allemagne] ; Maarit Heinonen [Finlande] ; Hélène Dutartre [France] ; Antoine Frangeui [France] ; Arnaud Gruez [France] ; Valérie Campanacci [France] ; Christian Cambillau [France] ; John Ziebuhr [Allemagne, Royaume-Uni] ; Tero Ahola [Finlande] ; Bruno Canard [France]Source :
- Journal of virology [ 0022-538X ] ; 2006.
Descripteurs français
- KwdFr :
- Adénosine diphosphate ribose (), Adénosine diphosphate ribose (analogues et dérivés), Adénosine diphosphate ribose (métabolisme), Cristallographie, Données de séquences moléculaires, Histone (), Histone (métabolisme), Modèles moléculaires, Poly adénosine diphosphate ribose (métabolisme), Poly(ADP-ribose) polymerases (métabolisme), Relation structure-activité, Séquence d'acides aminés, Virus de l'hépatite E (), Virus de l'hépatite E (métabolisme), Virus de la forêt de Semliki (), Virus de la forêt de Semliki (métabolisme), Virus du SRAS (), Virus du SRAS (métabolisme).
- MESH :
- analogues et dérivés : Adénosine diphosphate ribose.
- métabolisme : Adénosine diphosphate ribose, Histone, Poly adénosine diphosphate ribose, Poly(ADP-ribose) polymerases, Virus de l'hépatite E, Virus de la forêt de Semliki, Virus du SRAS.
- Pascal (Inist)
English descriptors
- KwdEn :
- ADP, Adenosine Diphosphate Ribose (analogs & derivatives), Adenosine Diphosphate Ribose (chemistry), Adenosine Diphosphate Ribose (metabolism), Amino Acid Sequence, Crystallography, Hepatitis E virus (chemistry), Hepatitis E virus (metabolism), Histones (chemistry), Histones (metabolism), Microbiology, Models, Molecular, Molecular Sequence Data, Poly Adenosine Diphosphate Ribose (metabolism), Poly(ADP-ribose) Polymerases (metabolism), SARS Virus (chemistry), SARS Virus (metabolism), Semliki forest virus (chemistry), Semliki forest virus (metabolism), Structure-Activity Relationship, Virology.
- MESH :
- chemical , analogs & derivatives : Adenosine Diphosphate Ribose.
- chemical , chemistry : Adenosine Diphosphate Ribose, Histones.
- chemical , metabolism : Adenosine Diphosphate Ribose, Histones, Poly Adenosine Diphosphate Ribose, Poly(ADP-ribose) Polymerases.
- chemistry : Hepatitis E virus, SARS Virus, Semliki forest virus.
- metabolism : Hepatitis E virus, SARS Virus, Semliki forest virus.
- Amino Acid Sequence, Crystallography, Models, Molecular, Molecular Sequence Data, Structure-Activity Relationship.
Abstract
Macro domains constitute a protein module family found associated with specific histones and proteins involved in chromatin metabolism. In addition, a small number of animal RNA viruses, such as corona- and toroviruses, alphaviruses, and hepatitis E virus, encode macro domains for which, however, structural and functional information is extremely limited. Here, we characterized the macro domains from hepatitis E virus, Semliki Forest virus, and severe acute respiratory syndrome coronavirus (SARS-CoV). The crystal structure of the SARS-CoV macro domain was determined at 1.8-Å resolution in complex with ADP-ribose. Information derived from structural, mutational, and sequence analyses suggests a close phylogenetic and, most probably, functional relationship between viral and cellular macro domain homologs. The data revealed that viral macro domains have relatively poor ADP-ribose 1"-phosphohydrolase activities (which were previously proposed to be their biologically relevant function) but bind efficiently free and poly(ADP-ribose) polymerase 1-bound poly-(ADP-ribose) in vitro. Collectively, these results suggest to further evaluate the role of viral macro domains in host response to viral infection.
Url:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000467
- to stream PascalFrancis, to step Curation: Pour aller vers cette notice dans l'étape Curation :000523
- to stream PascalFrancis, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000431
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :004632
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002125
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :002125
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001F86
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :001621
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :001621
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001621
- to stream Hal, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000146
- to stream Hal, to step Curation: Pour aller vers cette notice dans l'étape Curation :000146
- to stream Hal, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000171
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :003E62
Links to Exploration step
Pascal:06-0412132Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains</title>
<author><name sortKey="Egloff, Marie Pierre" sort="Egloff, Marie Pierre" uniqKey="Egloff M" first="Marie-Pierre" last="Egloff">Marie-Pierre Egloff</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Malet, Helene" sort="Malet, Helene" uniqKey="Malet H" first="Hélène" last="Malet">Hélène Malet</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Putics, Akos" sort="Putics, Akos" uniqKey="Putics A" first="Akos" last="Putics">Akos Putics</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Virology and Immunology, University of Wilrzburg, Versbacher Strasse 7</s1>
<s2>97078 Würzburg</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Basse-Franconie</region>
<settlement type="city">Wurtzbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Heinonen, Maarit" sort="Heinonen, Maarit" uniqKey="Heinonen M" first="Maarit" last="Heinonen">Maarit Heinonen</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Program in Cellular Biotechnology, Institute of Biotechnology, University of Helsinki, P.O. Box 56, Viikinkaari 9</s1>
<s2>00014 Helsinki</s2>
<s3>FIN</s3>
<sZ>4 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>00014 Helsinki</wicri:noRegion>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dutartre, Helene" sort="Dutartre, Helene" uniqKey="Dutartre H" first="Hélène" last="Dutartre">Hélène Dutartre</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Frangeui, Antoine" sort="Frangeui, Antoine" uniqKey="Frangeui A" first="Antoine" last="Frangeui">Antoine Frangeui</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gruez, Arnaud" sort="Gruez, Arnaud" uniqKey="Gruez A" first="Arnaud" last="Gruez">Arnaud Gruez</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Campanacci, Valerie" sort="Campanacci, Valerie" uniqKey="Campanacci V" first="Valérie" last="Campanacci">Valérie Campanacci</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cambillau, Christian" sort="Cambillau, Christian" uniqKey="Cambillau C" first="Christian" last="Cambillau">Christian Cambillau</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ziebuhr, John" sort="Ziebuhr, John" uniqKey="Ziebuhr J" first="John" last="Ziebuhr">John Ziebuhr</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Virology and Immunology, University of Wilrzburg, Versbacher Strasse 7</s1>
<s2>97078 Würzburg</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Basse-Franconie</region>
<settlement type="city">Wurtzbourg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Centre for Cancer Research and Cell Biology, School of Biomedical Sciences, The Queen's University of Belfast, 97 Lisbum Rd</s1>
<s2>Belfast BT9 7BL</s2>
<s3>GBR</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Belfast BT9 7BL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ahola, Tero" sort="Ahola, Tero" uniqKey="Ahola T" first="Tero" last="Ahola">Tero Ahola</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Program in Cellular Biotechnology, Institute of Biotechnology, University of Helsinki, P.O. Box 56, Viikinkaari 9</s1>
<s2>00014 Helsinki</s2>
<s3>FIN</s3>
<sZ>4 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>00014 Helsinki</wicri:noRegion>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Canard, Bruno" sort="Canard, Bruno" uniqKey="Canard B" first="Bruno" last="Canard">Bruno Canard</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">06-0412132</idno>
<date when="2006">2006</date>
<idno type="stanalyst">PASCAL 06-0412132 INIST</idno>
<idno type="RBID">Pascal:06-0412132</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000467</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000523</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000431</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000431</idno>
<idno type="wicri:doubleKey">0022-538X:2006:Egloff M:structural:and:functional</idno>
<idno type="wicri:Area/Main/Merge">004632</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:16912299</idno>
<idno type="wicri:Area/PubMed/Corpus">002125</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002125</idno>
<idno type="wicri:Area/PubMed/Curation">002125</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002125</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001F86</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001F86</idno>
<idno type="wicri:Area/Ncbi/Merge">001621</idno>
<idno type="wicri:Area/Ncbi/Curation">001621</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001621</idno>
<idno type="wicri:doubleKey">0022-538X:2006:Egloff M:structural:and:functional</idno>
<idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-02459228</idno>
<idno type="url">https://hal.archives-ouvertes.fr/hal-02459228</idno>
<idno type="wicri:Area/Hal/Corpus">000146</idno>
<idno type="wicri:Area/Hal/Curation">000146</idno>
<idno type="wicri:Area/Hal/Checkpoint">000171</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000171</idno>
<idno type="wicri:doubleKey">0022-538X:2006:Egloff M:structural:and:functional</idno>
<idno type="wicri:Area/Main/Merge">003E62</idno>
<idno type="wicri:Area/Main/Curation">004413</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains</title>
<author><name sortKey="Egloff, Marie Pierre" sort="Egloff, Marie Pierre" uniqKey="Egloff M" first="Marie-Pierre" last="Egloff">Marie-Pierre Egloff</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Malet, Helene" sort="Malet, Helene" uniqKey="Malet H" first="Hélène" last="Malet">Hélène Malet</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Putics, Akos" sort="Putics, Akos" uniqKey="Putics A" first="Akos" last="Putics">Akos Putics</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Virology and Immunology, University of Wilrzburg, Versbacher Strasse 7</s1>
<s2>97078 Würzburg</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Basse-Franconie</region>
<settlement type="city">Wurtzbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Heinonen, Maarit" sort="Heinonen, Maarit" uniqKey="Heinonen M" first="Maarit" last="Heinonen">Maarit Heinonen</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Program in Cellular Biotechnology, Institute of Biotechnology, University of Helsinki, P.O. Box 56, Viikinkaari 9</s1>
<s2>00014 Helsinki</s2>
<s3>FIN</s3>
<sZ>4 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>00014 Helsinki</wicri:noRegion>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dutartre, Helene" sort="Dutartre, Helene" uniqKey="Dutartre H" first="Hélène" last="Dutartre">Hélène Dutartre</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Frangeui, Antoine" sort="Frangeui, Antoine" uniqKey="Frangeui A" first="Antoine" last="Frangeui">Antoine Frangeui</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gruez, Arnaud" sort="Gruez, Arnaud" uniqKey="Gruez A" first="Arnaud" last="Gruez">Arnaud Gruez</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Campanacci, Valerie" sort="Campanacci, Valerie" uniqKey="Campanacci V" first="Valérie" last="Campanacci">Valérie Campanacci</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cambillau, Christian" sort="Cambillau, Christian" uniqKey="Cambillau C" first="Christian" last="Cambillau">Christian Cambillau</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ziebuhr, John" sort="Ziebuhr, John" uniqKey="Ziebuhr J" first="John" last="Ziebuhr">John Ziebuhr</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Virology and Immunology, University of Wilrzburg, Versbacher Strasse 7</s1>
<s2>97078 Würzburg</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Basse-Franconie</region>
<settlement type="city">Wurtzbourg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Centre for Cancer Research and Cell Biology, School of Biomedical Sciences, The Queen's University of Belfast, 97 Lisbum Rd</s1>
<s2>Belfast BT9 7BL</s2>
<s3>GBR</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Belfast BT9 7BL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ahola, Tero" sort="Ahola, Tero" uniqKey="Ahola T" first="Tero" last="Ahola">Tero Ahola</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Program in Cellular Biotechnology, Institute of Biotechnology, University of Helsinki, P.O. Box 56, Viikinkaari 9</s1>
<s2>00014 Helsinki</s2>
<s3>FIN</s3>
<sZ>4 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>00014 Helsinki</wicri:noRegion>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Canard, Bruno" sort="Canard, Bruno" uniqKey="Canard B" first="Bruno" last="Canard">Bruno Canard</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
<imprint><date when="2006">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ADP</term>
<term>Adenosine Diphosphate Ribose (analogs & derivatives)</term>
<term>Adenosine Diphosphate Ribose (chemistry)</term>
<term>Adenosine Diphosphate Ribose (metabolism)</term>
<term>Amino Acid Sequence</term>
<term>Crystallography</term>
<term>Hepatitis E virus (chemistry)</term>
<term>Hepatitis E virus (metabolism)</term>
<term>Histones (chemistry)</term>
<term>Histones (metabolism)</term>
<term>Microbiology</term>
<term>Models, Molecular</term>
<term>Molecular Sequence Data</term>
<term>Poly Adenosine Diphosphate Ribose (metabolism)</term>
<term>Poly(ADP-ribose) Polymerases (metabolism)</term>
<term>SARS Virus (chemistry)</term>
<term>SARS Virus (metabolism)</term>
<term>Semliki forest virus (chemistry)</term>
<term>Semliki forest virus (metabolism)</term>
<term>Structure-Activity Relationship</term>
<term>Virology</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adénosine diphosphate ribose ()</term>
<term>Adénosine diphosphate ribose (analogues et dérivés)</term>
<term>Adénosine diphosphate ribose (métabolisme)</term>
<term>Cristallographie</term>
<term>Données de séquences moléculaires</term>
<term>Histone ()</term>
<term>Histone (métabolisme)</term>
<term>Modèles moléculaires</term>
<term>Poly adénosine diphosphate ribose (métabolisme)</term>
<term>Poly(ADP-ribose) polymerases (métabolisme)</term>
<term>Relation structure-activité</term>
<term>Séquence d'acides aminés</term>
<term>Virus de l'hépatite E ()</term>
<term>Virus de l'hépatite E (métabolisme)</term>
<term>Virus de la forêt de Semliki ()</term>
<term>Virus de la forêt de Semliki (métabolisme)</term>
<term>Virus du SRAS ()</term>
<term>Virus du SRAS (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Adenosine Diphosphate Ribose</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Adenosine Diphosphate Ribose</term>
<term>Histones</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Adenosine Diphosphate Ribose</term>
<term>Histones</term>
<term>Poly Adenosine Diphosphate Ribose</term>
<term>Poly(ADP-ribose) Polymerases</term>
</keywords>
<keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Adénosine diphosphate ribose</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Hepatitis E virus</term>
<term>SARS Virus</term>
<term>Semliki forest virus</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Hepatitis E virus</term>
<term>SARS Virus</term>
<term>Semliki forest virus</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Adénosine diphosphate ribose</term>
<term>Histone</term>
<term>Poly adénosine diphosphate ribose</term>
<term>Poly(ADP-ribose) polymerases</term>
<term>Virus de l'hépatite E</term>
<term>Virus de la forêt de Semliki</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Crystallography</term>
<term>Models, Molecular</term>
<term>Molecular Sequence Data</term>
<term>Structure-Activity Relationship</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>ADP</term>
<term>Adénosine diphosphate ribose</term>
<term>Cristallographie</term>
<term>Données de séquences moléculaires</term>
<term>Histone</term>
<term>Microbiologie</term>
<term>Modèles moléculaires</term>
<term>Relation structure-activité</term>
<term>Séquence d'acides aminés</term>
<term>Virologie</term>
<term>Virus de l'hépatite E</term>
<term>Virus de la forêt de Semliki</term>
<term>Virus du SRAS</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Macro domains constitute a protein module family found associated with specific histones and proteins involved in chromatin metabolism. In addition, a small number of animal RNA viruses, such as corona- and toroviruses, alphaviruses, and hepatitis E virus, encode macro domains for which, however, structural and functional information is extremely limited. Here, we characterized the macro domains from hepatitis E virus, Semliki Forest virus, and severe acute respiratory syndrome coronavirus (SARS-CoV). The crystal structure of the SARS-CoV macro domain was determined at 1.8-Å resolution in complex with ADP-ribose. Information derived from structural, mutational, and sequence analyses suggests a close phylogenetic and, most probably, functional relationship between viral and cellular macro domain homologs. The data revealed that viral macro domains have relatively poor ADP-ribose 1"-phosphohydrolase activities (which were previously proposed to be their biologically relevant function) but bind efficiently free and poly(ADP-ribose) polymerase 1-bound poly-(ADP-ribose) in vitro. Collectively, these results suggest to further evaluate the role of viral macro domains in host response to viral infection.</div>
</front>
</TEI>
<double idat="0022-538X:2006:Egloff M:structural:and:functional"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains</title>
<author><name sortKey="Egloff, Marie Pierre" sort="Egloff, Marie Pierre" uniqKey="Egloff M" first="Marie-Pierre" last="Egloff">Marie-Pierre Egloff</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Malet, Helene" sort="Malet, Helene" uniqKey="Malet H" first="Hélène" last="Malet">Hélène Malet</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Putics, Akos" sort="Putics, Akos" uniqKey="Putics A" first="Akos" last="Putics">Akos Putics</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Virology and Immunology, University of Wilrzburg, Versbacher Strasse 7</s1>
<s2>97078 Würzburg</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Basse-Franconie</region>
<settlement type="city">Wurtzbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Heinonen, Maarit" sort="Heinonen, Maarit" uniqKey="Heinonen M" first="Maarit" last="Heinonen">Maarit Heinonen</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Program in Cellular Biotechnology, Institute of Biotechnology, University of Helsinki, P.O. Box 56, Viikinkaari 9</s1>
<s2>00014 Helsinki</s2>
<s3>FIN</s3>
<sZ>4 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>00014 Helsinki</wicri:noRegion>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dutartre, Helene" sort="Dutartre, Helene" uniqKey="Dutartre H" first="Hélène" last="Dutartre">Hélène Dutartre</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Frangeui, Antoine" sort="Frangeui, Antoine" uniqKey="Frangeui A" first="Antoine" last="Frangeui">Antoine Frangeui</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gruez, Arnaud" sort="Gruez, Arnaud" uniqKey="Gruez A" first="Arnaud" last="Gruez">Arnaud Gruez</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Campanacci, Valerie" sort="Campanacci, Valerie" uniqKey="Campanacci V" first="Valérie" last="Campanacci">Valérie Campanacci</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cambillau, Christian" sort="Cambillau, Christian" uniqKey="Cambillau C" first="Christian" last="Cambillau">Christian Cambillau</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ziebuhr, John" sort="Ziebuhr, John" uniqKey="Ziebuhr J" first="John" last="Ziebuhr">John Ziebuhr</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Virology and Immunology, University of Wilrzburg, Versbacher Strasse 7</s1>
<s2>97078 Würzburg</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Basse-Franconie</region>
<settlement type="city">Wurtzbourg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Centre for Cancer Research and Cell Biology, School of Biomedical Sciences, The Queen's University of Belfast, 97 Lisbum Rd</s1>
<s2>Belfast BT9 7BL</s2>
<s3>GBR</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Belfast BT9 7BL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ahola, Tero" sort="Ahola, Tero" uniqKey="Ahola T" first="Tero" last="Ahola">Tero Ahola</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Program in Cellular Biotechnology, Institute of Biotechnology, University of Helsinki, P.O. Box 56, Viikinkaari 9</s1>
<s2>00014 Helsinki</s2>
<s3>FIN</s3>
<sZ>4 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>00014 Helsinki</wicri:noRegion>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Canard, Bruno" sort="Canard, Bruno" uniqKey="Canard B" first="Bruno" last="Canard">Bruno Canard</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">06-0412132</idno>
<date when="2006">2006</date>
<idno type="stanalyst">PASCAL 06-0412132 INIST</idno>
<idno type="RBID">Pascal:06-0412132</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000467</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000523</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000431</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000431</idno>
<idno type="wicri:doubleKey">0022-538X:2006:Egloff M:structural:and:functional</idno>
<idno type="wicri:Area/Main/Merge">004632</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains</title>
<author><name sortKey="Egloff, Marie Pierre" sort="Egloff, Marie Pierre" uniqKey="Egloff M" first="Marie-Pierre" last="Egloff">Marie-Pierre Egloff</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Malet, Helene" sort="Malet, Helene" uniqKey="Malet H" first="Hélène" last="Malet">Hélène Malet</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Putics, Akos" sort="Putics, Akos" uniqKey="Putics A" first="Akos" last="Putics">Akos Putics</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Virology and Immunology, University of Wilrzburg, Versbacher Strasse 7</s1>
<s2>97078 Würzburg</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Basse-Franconie</region>
<settlement type="city">Wurtzbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Heinonen, Maarit" sort="Heinonen, Maarit" uniqKey="Heinonen M" first="Maarit" last="Heinonen">Maarit Heinonen</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Program in Cellular Biotechnology, Institute of Biotechnology, University of Helsinki, P.O. Box 56, Viikinkaari 9</s1>
<s2>00014 Helsinki</s2>
<s3>FIN</s3>
<sZ>4 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>00014 Helsinki</wicri:noRegion>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dutartre, Helene" sort="Dutartre, Helene" uniqKey="Dutartre H" first="Hélène" last="Dutartre">Hélène Dutartre</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Frangeui, Antoine" sort="Frangeui, Antoine" uniqKey="Frangeui A" first="Antoine" last="Frangeui">Antoine Frangeui</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gruez, Arnaud" sort="Gruez, Arnaud" uniqKey="Gruez A" first="Arnaud" last="Gruez">Arnaud Gruez</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Campanacci, Valerie" sort="Campanacci, Valerie" uniqKey="Campanacci V" first="Valérie" last="Campanacci">Valérie Campanacci</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cambillau, Christian" sort="Cambillau, Christian" uniqKey="Cambillau C" first="Christian" last="Cambillau">Christian Cambillau</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ziebuhr, John" sort="Ziebuhr, John" uniqKey="Ziebuhr J" first="John" last="Ziebuhr">John Ziebuhr</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Virology and Immunology, University of Wilrzburg, Versbacher Strasse 7</s1>
<s2>97078 Würzburg</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Basse-Franconie</region>
<settlement type="city">Wurtzbourg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Centre for Cancer Research and Cell Biology, School of Biomedical Sciences, The Queen's University of Belfast, 97 Lisbum Rd</s1>
<s2>Belfast BT9 7BL</s2>
<s3>GBR</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Belfast BT9 7BL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ahola, Tero" sort="Ahola, Tero" uniqKey="Ahola T" first="Tero" last="Ahola">Tero Ahola</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Program in Cellular Biotechnology, Institute of Biotechnology, University of Helsinki, P.O. Box 56, Viikinkaari 9</s1>
<s2>00014 Helsinki</s2>
<s3>FIN</s3>
<sZ>4 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>00014 Helsinki</wicri:noRegion>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Canard, Bruno" sort="Canard, Bruno" uniqKey="Canard B" first="Bruno" last="Canard">Bruno Canard</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'lngénieurs de Luminy-Case 925, 163 Ave. de Luminy</s1>
<s2>13288 Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
<imprint><date when="2006">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ADP</term>
<term>Microbiology</term>
<term>Virology</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>ADP</term>
<term>Microbiologie</term>
<term>Virologie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Macro domains constitute a protein module family found associated with specific histones and proteins involved in chromatin metabolism. In addition, a small number of animal RNA viruses, such as corona- and toroviruses, alphaviruses, and hepatitis E virus, encode macro domains for which, however, structural and functional information is extremely limited. Here, we characterized the macro domains from hepatitis E virus, Semliki Forest virus, and severe acute respiratory syndrome coronavirus (SARS-CoV). The crystal structure of the SARS-CoV macro domain was determined at 1.8-Å resolution in complex with ADP-ribose. Information derived from structural, mutational, and sequence analyses suggests a close phylogenetic and, most probably, functional relationship between viral and cellular macro domain homologs. The data revealed that viral macro domains have relatively poor ADP-ribose 1"-phosphohydrolase activities (which were previously proposed to be their biologically relevant function) but bind efficiently free and poly(ADP-ribose) polymerase 1-bound poly-(ADP-ribose) in vitro. Collectively, these results suggest to further evaluate the role of viral macro domains in host response to viral infection.</div>
</front>
</TEI>
</INIST>
<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains.</title>
<author><name sortKey="Egloff, Marie Pierre" sort="Egloff, Marie Pierre" uniqKey="Egloff M" first="Marie-Pierre" last="Egloff">Marie-Pierre Egloff</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'Ingénieurs de Luminy-Case 925, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'Ingénieurs de Luminy-Case 925</wicri:regionArea>
<wicri:noRegion>Ecole Supérieure d'Ingénieurs de Luminy-Case 925</wicri:noRegion>
<wicri:noRegion>Ecole Supérieure d'Ingénieurs de Luminy-Case 925</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Malet, Helene" sort="Malet, Helene" uniqKey="Malet H" first="Hélène" last="Malet">Hélène Malet</name>
</author>
<author><name sortKey="Putics, Akos" sort="Putics, Akos" uniqKey="Putics A" first="Akos" last="Putics">Akos Putics</name>
</author>
<author><name sortKey="Heinonen, Maarit" sort="Heinonen, Maarit" uniqKey="Heinonen M" first="Maarit" last="Heinonen">Maarit Heinonen</name>
</author>
<author><name sortKey="Dutartre, Helene" sort="Dutartre, Helene" uniqKey="Dutartre H" first="Hélène" last="Dutartre">Hélène Dutartre</name>
</author>
<author><name sortKey="Frangeul, Antoine" sort="Frangeul, Antoine" uniqKey="Frangeul A" first="Antoine" last="Frangeul">Antoine Frangeul</name>
</author>
<author><name sortKey="Gruez, Arnaud" sort="Gruez, Arnaud" uniqKey="Gruez A" first="Arnaud" last="Gruez">Arnaud Gruez</name>
</author>
<author><name sortKey="Campanacci, Valerie" sort="Campanacci, Valerie" uniqKey="Campanacci V" first="Valérie" last="Campanacci">Valérie Campanacci</name>
</author>
<author><name sortKey="Cambillau, Christian" sort="Cambillau, Christian" uniqKey="Cambillau C" first="Christian" last="Cambillau">Christian Cambillau</name>
</author>
<author><name sortKey="Ziebuhr, John" sort="Ziebuhr, John" uniqKey="Ziebuhr J" first="John" last="Ziebuhr">John Ziebuhr</name>
</author>
<author><name sortKey="Ahola, Tero" sort="Ahola, Tero" uniqKey="Ahola T" first="Tero" last="Ahola">Tero Ahola</name>
</author>
<author><name sortKey="Canard, Bruno" sort="Canard, Bruno" uniqKey="Canard B" first="Bruno" last="Canard">Bruno Canard</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2006">2006</date>
<idno type="RBID">pubmed:16912299</idno>
<idno type="pmid">16912299</idno>
<idno type="doi">10.1128/JVI.00713-06</idno>
<idno type="wicri:Area/PubMed/Corpus">002125</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002125</idno>
<idno type="wicri:Area/PubMed/Curation">002125</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002125</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001F86</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001F86</idno>
<idno type="wicri:Area/Ncbi/Merge">001621</idno>
<idno type="wicri:Area/Ncbi/Curation">001621</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001621</idno>
<idno type="wicri:doubleKey">0022-538X:2006:Egloff M:structural:and:functional</idno>
<idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-02459228</idno>
<idno type="url">https://hal.archives-ouvertes.fr/hal-02459228</idno>
<idno type="wicri:Area/Hal/Corpus">000146</idno>
<idno type="wicri:Area/Hal/Curation">000146</idno>
<idno type="wicri:Area/Hal/Checkpoint">000171</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000171</idno>
<idno type="wicri:doubleKey">0022-538X:2006:Egloff M:structural:and:functional</idno>
<idno type="wicri:Area/Main/Merge">003E62</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains.</title>
<author><name sortKey="Egloff, Marie Pierre" sort="Egloff, Marie Pierre" uniqKey="Egloff M" first="Marie-Pierre" last="Egloff">Marie-Pierre Egloff</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'Ingénieurs de Luminy-Case 925, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'Ingénieurs de Luminy-Case 925</wicri:regionArea>
<wicri:noRegion>Ecole Supérieure d'Ingénieurs de Luminy-Case 925</wicri:noRegion>
<wicri:noRegion>Ecole Supérieure d'Ingénieurs de Luminy-Case 925</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Malet, Helene" sort="Malet, Helene" uniqKey="Malet H" first="Hélène" last="Malet">Hélène Malet</name>
</author>
<author><name sortKey="Putics, Akos" sort="Putics, Akos" uniqKey="Putics A" first="Akos" last="Putics">Akos Putics</name>
</author>
<author><name sortKey="Heinonen, Maarit" sort="Heinonen, Maarit" uniqKey="Heinonen M" first="Maarit" last="Heinonen">Maarit Heinonen</name>
</author>
<author><name sortKey="Dutartre, Helene" sort="Dutartre, Helene" uniqKey="Dutartre H" first="Hélène" last="Dutartre">Hélène Dutartre</name>
</author>
<author><name sortKey="Frangeul, Antoine" sort="Frangeul, Antoine" uniqKey="Frangeul A" first="Antoine" last="Frangeul">Antoine Frangeul</name>
</author>
<author><name sortKey="Gruez, Arnaud" sort="Gruez, Arnaud" uniqKey="Gruez A" first="Arnaud" last="Gruez">Arnaud Gruez</name>
</author>
<author><name sortKey="Campanacci, Valerie" sort="Campanacci, Valerie" uniqKey="Campanacci V" first="Valérie" last="Campanacci">Valérie Campanacci</name>
</author>
<author><name sortKey="Cambillau, Christian" sort="Cambillau, Christian" uniqKey="Cambillau C" first="Christian" last="Cambillau">Christian Cambillau</name>
</author>
<author><name sortKey="Ziebuhr, John" sort="Ziebuhr, John" uniqKey="Ziebuhr J" first="John" last="Ziebuhr">John Ziebuhr</name>
</author>
<author><name sortKey="Ahola, Tero" sort="Ahola, Tero" uniqKey="Ahola T" first="Tero" last="Ahola">Tero Ahola</name>
</author>
<author><name sortKey="Canard, Bruno" sort="Canard, Bruno" uniqKey="Canard B" first="Bruno" last="Canard">Bruno Canard</name>
</author>
</analytic>
<series><title level="j">Journal of virology</title>
<idno type="ISSN">0022-538X</idno>
<imprint><date when="2006" type="published">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenosine Diphosphate Ribose (analogs & derivatives)</term>
<term>Adenosine Diphosphate Ribose (chemistry)</term>
<term>Adenosine Diphosphate Ribose (metabolism)</term>
<term>Amino Acid Sequence</term>
<term>Crystallography</term>
<term>Hepatitis E virus (chemistry)</term>
<term>Hepatitis E virus (metabolism)</term>
<term>Histones (chemistry)</term>
<term>Histones (metabolism)</term>
<term>Models, Molecular</term>
<term>Molecular Sequence Data</term>
<term>Poly Adenosine Diphosphate Ribose (metabolism)</term>
<term>Poly(ADP-ribose) Polymerases (metabolism)</term>
<term>SARS Virus (chemistry)</term>
<term>SARS Virus (metabolism)</term>
<term>Semliki forest virus (chemistry)</term>
<term>Semliki forest virus (metabolism)</term>
<term>Structure-Activity Relationship</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adénosine diphosphate ribose ()</term>
<term>Adénosine diphosphate ribose (analogues et dérivés)</term>
<term>Adénosine diphosphate ribose (métabolisme)</term>
<term>Cristallographie</term>
<term>Données de séquences moléculaires</term>
<term>Histone ()</term>
<term>Histone (métabolisme)</term>
<term>Modèles moléculaires</term>
<term>Poly adénosine diphosphate ribose (métabolisme)</term>
<term>Poly(ADP-ribose) polymerases (métabolisme)</term>
<term>Relation structure-activité</term>
<term>Séquence d'acides aminés</term>
<term>Virus de l'hépatite E ()</term>
<term>Virus de l'hépatite E (métabolisme)</term>
<term>Virus de la forêt de Semliki ()</term>
<term>Virus de la forêt de Semliki (métabolisme)</term>
<term>Virus du SRAS ()</term>
<term>Virus du SRAS (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Adenosine Diphosphate Ribose</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Adenosine Diphosphate Ribose</term>
<term>Histones</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Adenosine Diphosphate Ribose</term>
<term>Histones</term>
<term>Poly Adenosine Diphosphate Ribose</term>
<term>Poly(ADP-ribose) Polymerases</term>
</keywords>
<keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Adénosine diphosphate ribose</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Hepatitis E virus</term>
<term>SARS Virus</term>
<term>Semliki forest virus</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Hepatitis E virus</term>
<term>SARS Virus</term>
<term>Semliki forest virus</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Adénosine diphosphate ribose</term>
<term>Histone</term>
<term>Poly adénosine diphosphate ribose</term>
<term>Poly(ADP-ribose) polymerases</term>
<term>Virus de l'hépatite E</term>
<term>Virus de la forêt de Semliki</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Crystallography</term>
<term>Models, Molecular</term>
<term>Molecular Sequence Data</term>
<term>Structure-Activity Relationship</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adénosine diphosphate ribose</term>
<term>Cristallographie</term>
<term>Données de séquences moléculaires</term>
<term>Histone</term>
<term>Modèles moléculaires</term>
<term>Relation structure-activité</term>
<term>Séquence d'acides aminés</term>
<term>Virus de l'hépatite E</term>
<term>Virus de la forêt de Semliki</term>
<term>Virus du SRAS</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Macro domains constitute a protein module family found associated with specific histones and proteins involved in chromatin metabolism. In addition, a small number of animal RNA viruses, such as corona- and toroviruses, alphaviruses, and hepatitis E virus, encode macro domains for which, however, structural and functional information is extremely limited. Here, we characterized the macro domains from hepatitis E virus, Semliki Forest virus, and severe acute respiratory syndrome coronavirus (SARS-CoV). The crystal structure of the SARS-CoV macro domain was determined at 1.8-Angstroms resolution in complex with ADP-ribose. Information derived from structural, mutational, and sequence analyses suggests a close phylogenetic and, most probably, functional relationship between viral and cellular macro domain homologs. The data revealed that viral macro domains have relatively poor ADP-ribose 1"-phosphohydrolase activities (which were previously proposed to be their biologically relevant function) but bind efficiently free and poly(ADP-ribose) polymerase 1-bound poly(ADP-ribose) in vitro. Collectively, these results suggest to further evaluate the role of viral macro domains in host response to viral infection.</div>
</front>
</TEI>
</PubMed>
</double>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004413 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 004413 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= Main |étape= Curation |type= RBID |clé= Pascal:06-0412132 |texte= Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains }}
This area was generated with Dilib version V0.6.33. |