Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains.
Identifieur interne : 001621 ( Ncbi/Curation ); précédent : 001620; suivant : 001622Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains.
Auteurs : Marie-Pierre Egloff [France] ; Hélène Malet ; Akos Putics ; Maarit Heinonen ; Hélène Dutartre ; Antoine Frangeul ; Arnaud Gruez ; Valérie Campanacci ; Christian Cambillau ; John Ziebuhr ; Tero Ahola ; Bruno CanardSource :
- Journal of virology [ 0022-538X ] ; 2006.
Descripteurs français
- KwdFr :
- Adénosine diphosphate ribose (), Adénosine diphosphate ribose (analogues et dérivés), Adénosine diphosphate ribose (métabolisme), Cristallographie, Données de séquences moléculaires, Histone (), Histone (métabolisme), Modèles moléculaires, Poly adénosine diphosphate ribose (métabolisme), Poly(ADP-ribose) polymerases (métabolisme), Relation structure-activité, Séquence d'acides aminés, Virus de l'hépatite E (), Virus de l'hépatite E (métabolisme), Virus de la forêt de Semliki (), Virus de la forêt de Semliki (métabolisme), Virus du SRAS (), Virus du SRAS (métabolisme).
- MESH :
- analogues et dérivés : Adénosine diphosphate ribose.
- métabolisme : Adénosine diphosphate ribose, Histone, Poly adénosine diphosphate ribose, Poly(ADP-ribose) polymerases, Virus de l'hépatite E, Virus de la forêt de Semliki, Virus du SRAS.
- Adénosine diphosphate ribose, Cristallographie, Données de séquences moléculaires, Histone, Modèles moléculaires, Relation structure-activité, Séquence d'acides aminés, Virus de l'hépatite E, Virus de la forêt de Semliki, Virus du SRAS.
English descriptors
- KwdEn :
- Adenosine Diphosphate Ribose (analogs & derivatives), Adenosine Diphosphate Ribose (chemistry), Adenosine Diphosphate Ribose (metabolism), Amino Acid Sequence, Crystallography, Hepatitis E virus (chemistry), Hepatitis E virus (metabolism), Histones (chemistry), Histones (metabolism), Models, Molecular, Molecular Sequence Data, Poly Adenosine Diphosphate Ribose (metabolism), Poly(ADP-ribose) Polymerases (metabolism), SARS Virus (chemistry), SARS Virus (metabolism), Semliki forest virus (chemistry), Semliki forest virus (metabolism), Structure-Activity Relationship.
- MESH :
- chemical , analogs & derivatives : Adenosine Diphosphate Ribose.
- chemical , chemistry : Adenosine Diphosphate Ribose, Histones.
- chemical , metabolism : Adenosine Diphosphate Ribose, Histones, Poly Adenosine Diphosphate Ribose, Poly(ADP-ribose) Polymerases.
- chemistry : Hepatitis E virus, SARS Virus, Semliki forest virus.
- metabolism : Hepatitis E virus, SARS Virus, Semliki forest virus.
- Amino Acid Sequence, Crystallography, Models, Molecular, Molecular Sequence Data, Structure-Activity Relationship.
Abstract
Macro domains constitute a protein module family found associated with specific histones and proteins involved in chromatin metabolism. In addition, a small number of animal RNA viruses, such as corona- and toroviruses, alphaviruses, and hepatitis E virus, encode macro domains for which, however, structural and functional information is extremely limited. Here, we characterized the macro domains from hepatitis E virus, Semliki Forest virus, and severe acute respiratory syndrome coronavirus (SARS-CoV). The crystal structure of the SARS-CoV macro domain was determined at 1.8-Angstroms resolution in complex with ADP-ribose. Information derived from structural, mutational, and sequence analyses suggests a close phylogenetic and, most probably, functional relationship between viral and cellular macro domain homologs. The data revealed that viral macro domains have relatively poor ADP-ribose 1"-phosphohydrolase activities (which were previously proposed to be their biologically relevant function) but bind efficiently free and poly(ADP-ribose) polymerase 1-bound poly(ADP-ribose) in vitro. Collectively, these results suggest to further evaluate the role of viral macro domains in host response to viral infection.
DOI: 10.1128/JVI.00713-06
PubMed: 16912299
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France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre National de la Recherche Scientifique and Universités d'Aix-Marseille I et II, UMR 6098, Architecture et Fonction des Macromolécules Biologiques, Ecole Supérieure d'Ingénieurs de Luminy-Case 925</wicri:regionArea><wicri:noRegion>Ecole Supérieure d'Ingénieurs de Luminy-Case 925</wicri:noRegion><wicri:noRegion>Ecole Supérieure d'Ingénieurs de Luminy-Case 925</wicri:noRegion></affiliation></author><author><name sortKey="Malet, Helene" sort="Malet, Helene" uniqKey="Malet H" first="Hélène" last="Malet">Hélène Malet</name></author><author><name sortKey="Putics, Akos" sort="Putics, Akos" uniqKey="Putics A" first="Akos" last="Putics">Akos Putics</name></author><author><name sortKey="Heinonen, Maarit" sort="Heinonen, Maarit" uniqKey="Heinonen M" first="Maarit" last="Heinonen">Maarit Heinonen</name></author><author><name sortKey="Dutartre, Helene" sort="Dutartre, Helene" uniqKey="Dutartre H" first="Hélène" 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first="Bruno" last="Canard">Bruno Canard</name></author></analytic><series><title level="j">Journal of virology</title><idno type="ISSN">0022-538X</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenosine Diphosphate Ribose (analogs & derivatives)</term><term>Adenosine Diphosphate Ribose (chemistry)</term><term>Adenosine Diphosphate Ribose (metabolism)</term><term>Amino Acid Sequence</term><term>Crystallography</term><term>Hepatitis E virus (chemistry)</term><term>Hepatitis E virus (metabolism)</term><term>Histones (chemistry)</term><term>Histones (metabolism)</term><term>Models, Molecular</term><term>Molecular Sequence Data</term><term>Poly Adenosine Diphosphate Ribose (metabolism)</term><term>Poly(ADP-ribose) Polymerases (metabolism)</term><term>SARS Virus (chemistry)</term><term>SARS Virus (metabolism)</term><term>Semliki forest virus (chemistry)</term><term>Semliki forest virus (metabolism)</term><term>Structure-Activity Relationship</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adénosine diphosphate ribose ()</term><term>Adénosine diphosphate ribose (analogues et dérivés)</term><term>Adénosine diphosphate ribose (métabolisme)</term><term>Cristallographie</term><term>Données de séquences moléculaires</term><term>Histone ()</term><term>Histone (métabolisme)</term><term>Modèles moléculaires</term><term>Poly adénosine diphosphate ribose (métabolisme)</term><term>Poly(ADP-ribose) polymerases (métabolisme)</term><term>Relation structure-activité</term><term>Séquence d'acides aminés</term><term>Virus de l'hépatite E ()</term><term>Virus de l'hépatite E (métabolisme)</term><term>Virus de la forêt de Semliki ()</term><term>Virus de la forêt de Semliki (métabolisme)</term><term>Virus du SRAS ()</term><term>Virus du SRAS (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Adenosine Diphosphate Ribose</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Adenosine Diphosphate Ribose</term><term>Histones</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Adenosine Diphosphate Ribose</term><term>Histones</term><term>Poly Adenosine Diphosphate Ribose</term><term>Poly(ADP-ribose) Polymerases</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Adénosine diphosphate ribose</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Hepatitis E virus</term><term>SARS Virus</term><term>Semliki forest virus</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Hepatitis E virus</term><term>SARS Virus</term><term>Semliki forest virus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Adénosine diphosphate ribose</term><term>Histone</term><term>Poly adénosine diphosphate ribose</term><term>Poly(ADP-ribose) polymerases</term><term>Virus de l'hépatite E</term><term>Virus de la forêt de Semliki</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Crystallography</term><term>Models, Molecular</term><term>Molecular Sequence Data</term><term>Structure-Activity Relationship</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adénosine diphosphate ribose</term><term>Cristallographie</term><term>Données de séquences moléculaires</term><term>Histone</term><term>Modèles moléculaires</term><term>Relation structure-activité</term><term>Séquence d'acides aminés</term><term>Virus de l'hépatite E</term><term>Virus de la forêt de Semliki</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Macro domains constitute a protein module family found associated with specific histones and proteins involved in chromatin metabolism. In addition, a small number of animal RNA viruses, such as corona- and toroviruses, alphaviruses, and hepatitis E virus, encode macro domains for which, however, structural and functional information is extremely limited. Here, we characterized the macro domains from hepatitis E virus, Semliki Forest virus, and severe acute respiratory syndrome coronavirus (SARS-CoV). The crystal structure of the SARS-CoV macro domain was determined at 1.8-Angstroms resolution in complex with ADP-ribose. Information derived from structural, mutational, and sequence analyses suggests a close phylogenetic and, most probably, functional relationship between viral and cellular macro domain homologs. The data revealed that viral macro domains have relatively poor ADP-ribose 1"-phosphohydrolase activities (which were previously proposed to be their biologically relevant function) but bind efficiently free and poly(ADP-ribose) polymerase 1-bound poly(ADP-ribose) in vitro. Collectively, these results suggest to further evaluate the role of viral macro domains in host response to viral infection.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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