Therapy with a severe acute respiratory syndrome- associated coronavirus-neutralizing human monoclonal antibody reduces disease severity and viral burden in golden syrian hamsters
Identifieur interne : 004405 ( Main/Curation ); précédent : 004404; suivant : 004406Therapy with a severe acute respiratory syndrome- associated coronavirus-neutralizing human monoclonal antibody reduces disease severity and viral burden in golden syrian hamsters
Auteurs : Anjeanette Roberts [États-Unis] ; William D. Thomas [États-Unis] ; Jeannette Guarner [États-Unis] ; Elaine W. Lamirande [États-Unis] ; Gregory J. Babcock [États-Unis] ; Thomas C. Greenough [États-Unis] ; Leatrice Vogel [États-Unis] ; Norman Hayes [États-Unis] ; John L. Sullivan [États-Unis] ; Sherif Zaki [États-Unis] ; Kanta Subbarao [États-Unis] ; Donna M. Ambrosino [États-Unis]Source :
- The Journal of infectious diseases [ 0022-1899 ] ; 2006.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (administration et posologie), Anticorps antiviraux (sang), Anticorps antiviraux (usage thérapeutique), Anticorps monoclonaux (administration et posologie), Anticorps monoclonaux (usage thérapeutique), Charge virale, Cricetinae, Femelle, Immunoglobuline G (sang), Immunothérapie, Mesocricetus, Modèles animaux de maladie humaine, Pneumopathies interstitielles (anatomopathologie), Poumon (anatomopathologie), Poumon (virologie), Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (physiopathologie), Syndrome respiratoire aigu sévère (virologie), Tests de neutralisation, Virus du SRAS (immunologie), Virus du SRAS (physiologie).
- MESH :
- administration et posologie : Anticorps antiviraux, Anticorps monoclonaux.
- anatomopathologie : Pneumopathies interstitielles, Poumon.
- immunologie : Virus du SRAS.
- physiologie : Virus du SRAS.
- physiopathologie : Syndrome respiratoire aigu sévère.
- sang : Anticorps antiviraux, Immunoglobuline G.
- usage thérapeutique : Anticorps antiviraux, Anticorps monoclonaux.
- virologie : Poumon, Syndrome respiratoire aigu sévère.
- Pascal (Inist)
- Animaux, Charge virale, Coronavirus, Cricetinae, Femelle, Homme, Hamster, Immunothérapie, Mesocricetus, Modèles animaux de maladie humaine, Syndrome respiratoire aigu sévère, Tests de neutralisation, Traitement, Anticorps neutralisant, Anticorps monoclonal, Microbiologie, Infection, Syndrome respiratoire aigu sévère.
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal (administration & dosage), Antibodies, Monoclonal (therapeutic use), Antibodies, Viral (administration & dosage), Antibodies, Viral (blood), Antibodies, Viral (therapeutic use), Coronavirus, Cricetinae, Disease Models, Animal, Female, Hamster, Human, Immunoglobulin G (blood), Immunotherapy, Infection, Lung (pathology), Lung (virology), Lung Diseases, Interstitial (pathology), Mesocricetus, Microbiology, Monoclonal antibody, Neutralization Tests, Neutralizing antibody, SARS Virus (immunology), SARS Virus (physiology), Severe Acute Respiratory Syndrome (physiopathology), Severe Acute Respiratory Syndrome (therapy), Severe Acute Respiratory Syndrome (virology), Severe acute respiratory syndrome, Treatment, Viral Load.
- MESH :
- chemical , administration & dosage : Antibodies, Monoclonal, Antibodies, Viral.
- chemical , blood : Antibodies, Viral, Immunoglobulin G.
- chemical , therapeutic use : Antibodies, Monoclonal, Antibodies, Viral.
- immunology : SARS Virus.
- pathology : Lung, Lung Diseases, Interstitial.
- physiology : SARS Virus.
- physiopathology : Severe Acute Respiratory Syndrome.
- therapy : Severe Acute Respiratory Syndrome.
- virology : Lung, Severe Acute Respiratory Syndrome.
- Animals, Cricetinae, Disease Models, Animal, Female, Immunotherapy, Mesocricetus, Neutralization Tests, Viral Load.
Abstract
Background. Immunotherapy with monoclonal antibodies (MAbs) offers safe interventions for the prevention of infection in patients after organ transplantation and for the treatment of cancers and autoimmune diseases. MAb 201 is a severe acute respiratory syndrome-associated coronavirus (SARS-CoV)-specific MAb that prevents establishment of viral replication in vitro and prevents viral replication in vivo when administered prophylactically. The efficacy of MAb 201 in the treatment of SARS was evaluated in golden Syrian hamsters, an animal model that supports SARS-CoV replication to high levels and displays severe pathological changes associated with infection, including pneumonitis and pulmonary consolidation. Methods. Golden Syrian hamsters that were intranasally inoculated with SARS-CoV were treated with various doses of MAb 201 or an irrelevant MAb 24 h after inoculation. Two to 7 days after infection, the hamsters were killed, and their lungs were collected for evaluation of viral titers and pathological findings. Results. Postexposure treatment with MAb 201 can alleviate the viral burden and associated pathological findings in a golden Syrian hamster model of SARS-CoV infection. After a hamster is treated with MAb 201, its viral burden is reduced by 102.4-103.9 50% tissue-culture infectious doses per gram of tissue, and the severity of associated pathological findings, including interstitial pneumonitis and consolidation, is also remarkably reduced. Conclusions. The demonstration of successful postexposure MAb 201 therapy in an animal model that demonstrates viral replication and associated pulmonary pathological findings suggests that MAb 201 may be useful in the arsenal of tools to combat SARS.
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Pascal:06-0186247Le document en format XML
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<author><name sortKey="Sullivan, John L" sort="Sullivan, John L" uniqKey="Sullivan J" first="John L." last="Sullivan">John L. Sullivan</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Departments of Pediatrics and Molecular Medicine, University of Massachusetts Medical School</s1>
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<author><name sortKey="Zaki, Sherif" sort="Zaki, Sherif" uniqKey="Zaki S" first="Sherif" last="Zaki">Sherif Zaki</name>
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<author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name>
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<term>Antibodies, Monoclonal (therapeutic use)</term>
<term>Antibodies, Viral (administration & dosage)</term>
<term>Antibodies, Viral (blood)</term>
<term>Antibodies, Viral (therapeutic use)</term>
<term>Coronavirus</term>
<term>Cricetinae</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Hamster</term>
<term>Human</term>
<term>Immunoglobulin G (blood)</term>
<term>Immunotherapy</term>
<term>Infection</term>
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<term>Lung (virology)</term>
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<term>Mesocricetus</term>
<term>Microbiology</term>
<term>Monoclonal antibody</term>
<term>Neutralization Tests</term>
<term>Neutralizing antibody</term>
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<term>SARS Virus (physiology)</term>
<term>Severe Acute Respiratory Syndrome (physiopathology)</term>
<term>Severe Acute Respiratory Syndrome (therapy)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Severe acute respiratory syndrome</term>
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<term>Anticorps antiviraux (sang)</term>
<term>Anticorps antiviraux (usage thérapeutique)</term>
<term>Anticorps monoclonaux (administration et posologie)</term>
<term>Anticorps monoclonaux (usage thérapeutique)</term>
<term>Charge virale</term>
<term>Cricetinae</term>
<term>Femelle</term>
<term>Immunoglobuline G (sang)</term>
<term>Immunothérapie</term>
<term>Mesocricetus</term>
<term>Modèles animaux de maladie humaine</term>
<term>Pneumopathies interstitielles (anatomopathologie)</term>
<term>Poumon (anatomopathologie)</term>
<term>Poumon (virologie)</term>
<term>Syndrome respiratoire aigu sévère ()</term>
<term>Syndrome respiratoire aigu sévère (physiopathologie)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Tests de neutralisation</term>
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<term>Virus du SRAS (physiologie)</term>
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<term>Antibodies, Viral</term>
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<term>Immunoglobulin G</term>
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<term>Antibodies, Viral</term>
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<term>Anticorps monoclonaux</term>
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<term>Poumon</term>
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<term>Lung Diseases, Interstitial</term>
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<term>Immunoglobuline G</term>
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<term>Anticorps monoclonaux</term>
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<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Lung</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cricetinae</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Immunotherapy</term>
<term>Mesocricetus</term>
<term>Neutralization Tests</term>
<term>Viral Load</term>
</keywords>
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<term>Charge virale</term>
<term>Coronavirus</term>
<term>Cricetinae</term>
<term>Femelle</term>
<term>Homme</term>
<term>Hamster</term>
<term>Immunothérapie</term>
<term>Mesocricetus</term>
<term>Modèles animaux de maladie humaine</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Tests de neutralisation</term>
<term>Traitement</term>
<term>Anticorps neutralisant</term>
<term>Anticorps monoclonal</term>
<term>Microbiologie</term>
<term>Infection</term>
<term>Syndrome respiratoire aigu sévère</term>
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<front><div type="abstract" xml:lang="en">Background. Immunotherapy with monoclonal antibodies (MAbs) offers safe interventions for the prevention of infection in patients after organ transplantation and for the treatment of cancers and autoimmune diseases. MAb 201 is a severe acute respiratory syndrome-associated coronavirus (SARS-CoV)-specific MAb that prevents establishment of viral replication in vitro and prevents viral replication in vivo when administered prophylactically. The efficacy of MAb 201 in the treatment of SARS was evaluated in golden Syrian hamsters, an animal model that supports SARS-CoV replication to high levels and displays severe pathological changes associated with infection, including pneumonitis and pulmonary consolidation. Methods. Golden Syrian hamsters that were intranasally inoculated with SARS-CoV were treated with various doses of MAb 201 or an irrelevant MAb 24 h after inoculation. Two to 7 days after infection, the hamsters were killed, and their lungs were collected for evaluation of viral titers and pathological findings. Results. Postexposure treatment with MAb 201 can alleviate the viral burden and associated pathological findings in a golden Syrian hamster model of SARS-CoV infection. After a hamster is treated with MAb 201, its viral burden is reduced by 10<sup>2.4</sup>
-10<sup>3.9</sup>
50% tissue-culture infectious doses per gram of tissue, and the severity of associated pathological findings, including interstitial pneumonitis and consolidation, is also remarkably reduced. Conclusions. The demonstration of successful postexposure MAb 201 therapy in an animal model that demonstrates viral replication and associated pulmonary pathological findings suggests that MAb 201 may be useful in the arsenal of tools to combat SARS.</div>
</front>
</TEI>
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<placeName><region type="state">Maryland</region>
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<sZ>8 aut.</sZ>
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</inist:fA14>
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<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sullivan, John L" sort="Sullivan, John L" uniqKey="Sullivan J" first="John L." last="Sullivan">John L. Sullivan</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Departments of Pediatrics and Molecular Medicine, University of Massachusetts Medical School</s1>
<s2>Worcester</s2>
<s3>USA</s3>
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</inist:fA14>
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<wicri:noRegion>Worcester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zaki, Sherif" sort="Zaki, Sherif" uniqKey="Zaki S" first="Sherif" last="Zaki">Sherif Zaki</name>
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<s2>Atlanta, Georgia</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health</s1>
<s2>Bethesda, Maryland</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
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</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ambrosino, Donna M" sort="Ambrosino, Donna M" uniqKey="Ambrosino D" first="Donna M." last="Ambrosino">Donna M. Ambrosino</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Massachusetts Biologic Laboratories, University of Massachusetts Medical School, Jamaica Plain</s1>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
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</affiliation>
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</analytic>
<series><title level="j" type="main">The Journal of infectious diseases</title>
<title level="j" type="abbreviated">J. infect. dis.</title>
<idno type="ISSN">0022-1899</idno>
<imprint><date when="2006">2006</date>
</imprint>
</series>
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<seriesStmt><title level="j" type="main">The Journal of infectious diseases</title>
<title level="j" type="abbreviated">J. infect. dis.</title>
<idno type="ISSN">0022-1899</idno>
</seriesStmt>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coronavirus</term>
<term>Hamster</term>
<term>Human</term>
<term>Infection</term>
<term>Microbiology</term>
<term>Monoclonal antibody</term>
<term>Neutralizing antibody</term>
<term>Severe acute respiratory syndrome</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Coronavirus</term>
<term>Homme</term>
<term>Hamster</term>
<term>Traitement</term>
<term>Anticorps neutralisant</term>
<term>Anticorps monoclonal</term>
<term>Microbiologie</term>
<term>Infection</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
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<front><div type="abstract" xml:lang="en">Background. Immunotherapy with monoclonal antibodies (MAbs) offers safe interventions for the prevention of infection in patients after organ transplantation and for the treatment of cancers and autoimmune diseases. MAb 201 is a severe acute respiratory syndrome-associated coronavirus (SARS-CoV)-specific MAb that prevents establishment of viral replication in vitro and prevents viral replication in vivo when administered prophylactically. The efficacy of MAb 201 in the treatment of SARS was evaluated in golden Syrian hamsters, an animal model that supports SARS-CoV replication to high levels and displays severe pathological changes associated with infection, including pneumonitis and pulmonary consolidation. Methods. Golden Syrian hamsters that were intranasally inoculated with SARS-CoV were treated with various doses of MAb 201 or an irrelevant MAb 24 h after inoculation. Two to 7 days after infection, the hamsters were killed, and their lungs were collected for evaluation of viral titers and pathological findings. Results. Postexposure treatment with MAb 201 can alleviate the viral burden and associated pathological findings in a golden Syrian hamster model of SARS-CoV infection. After a hamster is treated with MAb 201, its viral burden is reduced by 10<sup>2.4</sup>
-10<sup>3.9</sup>
50% tissue-culture infectious doses per gram of tissue, and the severity of associated pathological findings, including interstitial pneumonitis and consolidation, is also remarkably reduced. Conclusions. The demonstration of successful postexposure MAb 201 therapy in an animal model that demonstrates viral replication and associated pulmonary pathological findings suggests that MAb 201 may be useful in the arsenal of tools to combat SARS.</div>
</front>
</TEI>
</INIST>
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<author><name sortKey="Roberts, Anjeanette" sort="Roberts, Anjeanette" uniqKey="Roberts A" first="Anjeanette" last="Roberts">Anjeanette Roberts</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thomas, William D" sort="Thomas, William D" uniqKey="Thomas W" first="William D" last="Thomas">William D. Thomas</name>
</author>
<author><name sortKey="Guarner, Jeannette" sort="Guarner, Jeannette" uniqKey="Guarner J" first="Jeannette" last="Guarner">Jeannette Guarner</name>
</author>
<author><name sortKey="Lamirande, Elaine W" sort="Lamirande, Elaine W" uniqKey="Lamirande E" first="Elaine W" last="Lamirande">Elaine W. Lamirande</name>
</author>
<author><name sortKey="Babcock, Gregory J" sort="Babcock, Gregory J" uniqKey="Babcock G" first="Gregory J" last="Babcock">Gregory J. Babcock</name>
</author>
<author><name sortKey="Greenough, Thomas C" sort="Greenough, Thomas C" uniqKey="Greenough T" first="Thomas C" last="Greenough">Thomas C. Greenough</name>
</author>
<author><name sortKey="Vogel, Leatrice" sort="Vogel, Leatrice" uniqKey="Vogel L" first="Leatrice" last="Vogel">Leatrice Vogel</name>
</author>
<author><name sortKey="Hayes, Norman" sort="Hayes, Norman" uniqKey="Hayes N" first="Norman" last="Hayes">Norman Hayes</name>
</author>
<author><name sortKey="Sullivan, John L" sort="Sullivan, John L" uniqKey="Sullivan J" first="John L" last="Sullivan">John L. Sullivan</name>
</author>
<author><name sortKey="Zaki, Sherif" sort="Zaki, Sherif" uniqKey="Zaki S" first="Sherif" last="Zaki">Sherif Zaki</name>
</author>
<author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name>
</author>
<author><name sortKey="Ambrosino, Donna M" sort="Ambrosino, Donna M" uniqKey="Ambrosino D" first="Donna M" last="Ambrosino">Donna M. Ambrosino</name>
</author>
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<date when="2006">2006</date>
<idno type="RBID">pubmed:16453264</idno>
<idno type="pmid">16453264</idno>
<idno type="doi">10.1086/500143</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Therapy with a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody reduces disease severity and viral burden in golden Syrian hamsters.</title>
<author><name sortKey="Roberts, Anjeanette" sort="Roberts, Anjeanette" uniqKey="Roberts A" first="Anjeanette" last="Roberts">Anjeanette Roberts</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thomas, William D" sort="Thomas, William D" uniqKey="Thomas W" first="William D" last="Thomas">William D. Thomas</name>
</author>
<author><name sortKey="Guarner, Jeannette" sort="Guarner, Jeannette" uniqKey="Guarner J" first="Jeannette" last="Guarner">Jeannette Guarner</name>
</author>
<author><name sortKey="Lamirande, Elaine W" sort="Lamirande, Elaine W" uniqKey="Lamirande E" first="Elaine W" last="Lamirande">Elaine W. Lamirande</name>
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<author><name sortKey="Babcock, Gregory J" sort="Babcock, Gregory J" uniqKey="Babcock G" first="Gregory J" last="Babcock">Gregory J. Babcock</name>
</author>
<author><name sortKey="Greenough, Thomas C" sort="Greenough, Thomas C" uniqKey="Greenough T" first="Thomas C" last="Greenough">Thomas C. Greenough</name>
</author>
<author><name sortKey="Vogel, Leatrice" sort="Vogel, Leatrice" uniqKey="Vogel L" first="Leatrice" last="Vogel">Leatrice Vogel</name>
</author>
<author><name sortKey="Hayes, Norman" sort="Hayes, Norman" uniqKey="Hayes N" first="Norman" last="Hayes">Norman Hayes</name>
</author>
<author><name sortKey="Sullivan, John L" sort="Sullivan, John L" uniqKey="Sullivan J" first="John L" last="Sullivan">John L. Sullivan</name>
</author>
<author><name sortKey="Zaki, Sherif" sort="Zaki, Sherif" uniqKey="Zaki S" first="Sherif" last="Zaki">Sherif Zaki</name>
</author>
<author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name>
</author>
<author><name sortKey="Ambrosino, Donna M" sort="Ambrosino, Donna M" uniqKey="Ambrosino D" first="Donna M" last="Ambrosino">Donna M. Ambrosino</name>
</author>
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<series><title level="j">The Journal of infectious diseases</title>
<idno type="ISSN">0022-1899</idno>
<imprint><date when="2006" type="published">2006</date>
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<term>Antibodies, Monoclonal (therapeutic use)</term>
<term>Antibodies, Viral (administration & dosage)</term>
<term>Antibodies, Viral (blood)</term>
<term>Antibodies, Viral (therapeutic use)</term>
<term>Cricetinae</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Immunoglobulin G (blood)</term>
<term>Immunotherapy</term>
<term>Lung (pathology)</term>
<term>Lung (virology)</term>
<term>Lung Diseases, Interstitial (pathology)</term>
<term>Mesocricetus</term>
<term>Neutralization Tests</term>
<term>SARS Virus (immunology)</term>
<term>SARS Virus (physiology)</term>
<term>Severe Acute Respiratory Syndrome (physiopathology)</term>
<term>Severe Acute Respiratory Syndrome (therapy)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Viral Load</term>
</keywords>
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<term>Anticorps antiviraux (administration et posologie)</term>
<term>Anticorps antiviraux (sang)</term>
<term>Anticorps antiviraux (usage thérapeutique)</term>
<term>Anticorps monoclonaux (administration et posologie)</term>
<term>Anticorps monoclonaux (usage thérapeutique)</term>
<term>Charge virale</term>
<term>Cricetinae</term>
<term>Femelle</term>
<term>Immunoglobuline G (sang)</term>
<term>Immunothérapie</term>
<term>Mesocricetus</term>
<term>Modèles animaux de maladie humaine</term>
<term>Pneumopathies interstitielles (anatomopathologie)</term>
<term>Poumon (anatomopathologie)</term>
<term>Poumon (virologie)</term>
<term>Syndrome respiratoire aigu sévère ()</term>
<term>Syndrome respiratoire aigu sévère (physiopathologie)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Tests de neutralisation</term>
<term>Virus du SRAS (immunologie)</term>
<term>Virus du SRAS (physiologie)</term>
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<term>Anticorps monoclonaux</term>
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<term>Syndrome respiratoire aigu sévère</term>
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<term>Severe Acute Respiratory Syndrome</term>
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<term>Cricetinae</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Immunotherapy</term>
<term>Mesocricetus</term>
<term>Neutralization Tests</term>
<term>Viral Load</term>
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<term>Charge virale</term>
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<term>Femelle</term>
<term>Immunothérapie</term>
<term>Mesocricetus</term>
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<front><div type="abstract" xml:lang="en">Immunotherapy with monoclonal antibodies (MAbs) offers safe interventions for the prevention of infection in patients after organ transplantation and for the treatment of cancers and autoimmune diseases. MAb 201 is a severe acute respiratory syndrome-associated coronavirus (SARS-CoV)-specific MAb that prevents establishment of viral replication in vitro and prevents viral replication in vivo when administered prophylactically. The efficacy of MAb 201 in the treatment of SARS was evaluated in golden Syrian hamsters, an animal model that supports SARS-CoV replication to high levels and displays severe pathological changes associated with infection, including pneumonitis and pulmonary consolidation.</div>
</front>
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