Therapy with a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody reduces disease severity and viral burden in golden Syrian hamsters.
Identifieur interne : 003E12 ( Main/Merge ); précédent : 003E11; suivant : 003E13Therapy with a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody reduces disease severity and viral burden in golden Syrian hamsters.
Auteurs : Anjeanette Roberts [États-Unis] ; William D. Thomas ; Jeannette Guarner ; Elaine W. Lamirande ; Gregory J. Babcock ; Thomas C. Greenough ; Leatrice Vogel ; Norman Hayes ; John L. Sullivan ; Sherif Zaki ; Kanta Subbarao ; Donna M. AmbrosinoSource :
- The Journal of infectious diseases [ 0022-1899 ] ; 2006.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (administration et posologie), Anticorps antiviraux (sang), Anticorps antiviraux (usage thérapeutique), Anticorps monoclonaux (administration et posologie), Anticorps monoclonaux (usage thérapeutique), Charge virale, Cricetinae, Femelle, Immunoglobuline G (sang), Immunothérapie, Mesocricetus, Modèles animaux de maladie humaine, Pneumopathies interstitielles (anatomopathologie), Poumon (anatomopathologie), Poumon (virologie), Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (physiopathologie), Syndrome respiratoire aigu sévère (virologie), Tests de neutralisation, Virus du SRAS (immunologie), Virus du SRAS (physiologie).
- MESH :
- administration et posologie : Anticorps antiviraux, Anticorps monoclonaux.
- anatomopathologie : Pneumopathies interstitielles, Poumon.
- immunologie : Virus du SRAS.
- physiologie : Virus du SRAS.
- physiopathologie : Syndrome respiratoire aigu sévère.
- sang : Anticorps antiviraux, Immunoglobuline G.
- usage thérapeutique : Anticorps antiviraux, Anticorps monoclonaux.
- virologie : Poumon, Syndrome respiratoire aigu sévère.
- Animaux, Charge virale, Cricetinae, Femelle, Immunothérapie, Mesocricetus, Modèles animaux de maladie humaine, Syndrome respiratoire aigu sévère, Tests de neutralisation.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal (administration & dosage), Antibodies, Monoclonal (therapeutic use), Antibodies, Viral (administration & dosage), Antibodies, Viral (blood), Antibodies, Viral (therapeutic use), Cricetinae, Disease Models, Animal, Female, Immunoglobulin G (blood), Immunotherapy, Lung (pathology), Lung (virology), Lung Diseases, Interstitial (pathology), Mesocricetus, Neutralization Tests, SARS Virus (immunology), SARS Virus (physiology), Severe Acute Respiratory Syndrome (physiopathology), Severe Acute Respiratory Syndrome (therapy), Severe Acute Respiratory Syndrome (virology), Viral Load.
- MESH :
- chemical , administration & dosage : Antibodies, Monoclonal, Antibodies, Viral.
- chemical , blood : Antibodies, Viral, Immunoglobulin G.
- chemical , therapeutic use : Antibodies, Monoclonal, Antibodies, Viral.
- immunology : SARS Virus.
- pathology : Lung, Lung Diseases, Interstitial.
- physiology : SARS Virus.
- physiopathology : Severe Acute Respiratory Syndrome.
- therapy : Severe Acute Respiratory Syndrome.
- virology : Lung, Severe Acute Respiratory Syndrome.
- Animals, Cricetinae, Disease Models, Animal, Female, Immunotherapy, Mesocricetus, Neutralization Tests, Viral Load.
Abstract
Immunotherapy with monoclonal antibodies (MAbs) offers safe interventions for the prevention of infection in patients after organ transplantation and for the treatment of cancers and autoimmune diseases. MAb 201 is a severe acute respiratory syndrome-associated coronavirus (SARS-CoV)-specific MAb that prevents establishment of viral replication in vitro and prevents viral replication in vivo when administered prophylactically. The efficacy of MAb 201 in the treatment of SARS was evaluated in golden Syrian hamsters, an animal model that supports SARS-CoV replication to high levels and displays severe pathological changes associated with infection, including pneumonitis and pulmonary consolidation.
DOI: 10.1086/500143
PubMed: 16453264
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pubmed:16453264Le document en format XML
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xml:lang="en">Immunotherapy with monoclonal antibodies (MAbs) offers safe interventions for the prevention of infection in patients after organ transplantation and for the treatment of cancers and autoimmune diseases. MAb 201 is a severe acute respiratory syndrome-associated coronavirus (SARS-CoV)-specific MAb that prevents establishment of viral replication in vitro and prevents viral replication in vivo when administered prophylactically. The efficacy of MAb 201 in the treatment of SARS was evaluated in golden Syrian hamsters, an animal model that supports SARS-CoV replication to high levels and displays severe pathological changes associated with infection, including pneumonitis and pulmonary consolidation.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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