Human coronavirus NL63 replication is cyclophilin A-dependent and inhibited by non-immunosuppressive cyclosporine A-derivatives including Alisporivir
Identifieur interne : 001639 ( Main/Curation ); précédent : 001638; suivant : 001640Human coronavirus NL63 replication is cyclophilin A-dependent and inhibited by non-immunosuppressive cyclosporine A-derivatives including Alisporivir
Auteurs : Javier Carbajo-Lozoya [Allemagne] ; Yue Ma-Lauer [Allemagne] ; Miroslav Maleševi [Allemagne] ; Martin Theuerkorn [Allemagne] ; Viktoria Kahlert [Allemagne] ; Erik Prell [Allemagne] ; Brigitte Von Brunn [Allemagne] ; Doreen Muth [Allemagne] ; Thomas F. Baumert [France] ; Christian Drosten [Allemagne] ; Gunter Fischer [Allemagne] ; Albrecht Von Brunn [Allemagne]Source :
- Virus Research [ 0168-1702 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Cyclophiline A.
- pharmacologie : Antiviraux, Ciclosporine, Tacrolimus.
- physiologie : Coronavirus humain NL63.
- Cellules Caco-2, Coronavirus humain NL63, Humains, Réaction de polymérisation en chaine en temps réel, Réplication virale.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Cyclophilin A.
- chemical , pharmacology : Antiviral Agents, Cyclosporine, Tacrolimus.
- drug effects : Coronavirus NL63, Human, Virus Replication.
- physiology : Coronavirus NL63, Human.
- Caco-2 Cells, Humans, Real-Time Polymerase Chain Reaction.
Abstract
Cyclophilin A (CypA) is a host factor for human coronavirus NL63 replication. CypA is a target for anti-coronaviral therapy. Non-immunosuppressive CsA derivatives (Alisporivir, NIM811) inhibit CoV replication. New classes of non-immunosuppressive CsA/FK506 derivatives inhibit CoV replication.
Url:
DOI: 10.1016/j.virusres.2014.02.010
PubMed: 24566223
PubMed Central: 7114444
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PMC:7114444Le document en format XML
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<term>Coronavirus NL63, Human (physiology)</term>
<term>Cyclophilin A (metabolism)</term>
<term>Cyclosporine (pharmacology)</term>
<term>Humans</term>
<term>Real-Time Polymerase Chain Reaction</term>
<term>Tacrolimus (pharmacology)</term>
<term>Virus Replication (drug effects)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Antiviraux (pharmacologie)</term>
<term>Cellules Caco-2</term>
<term>Ciclosporine (pharmacologie)</term>
<term>Coronavirus humain NL63 ()</term>
<term>Coronavirus humain NL63 (physiologie)</term>
<term>Cyclophiline A (métabolisme)</term>
<term>Humains</term>
<term>Réaction de polymérisation en chaine en temps réel</term>
<term>Réplication virale ()</term>
<term>Tacrolimus (pharmacologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cyclophilin A</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term>
<term>Cyclosporine</term>
<term>Tacrolimus</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Coronavirus NL63, Human</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cyclophiline A</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term>
<term>Ciclosporine</term>
<term>Tacrolimus</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus humain NL63</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Coronavirus NL63, Human</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Caco-2 Cells</term>
<term>Humans</term>
<term>Real-Time Polymerase Chain Reaction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Cellules Caco-2</term>
<term>Coronavirus humain NL63</term>
<term>Humains</term>
<term>Réaction de polymérisation en chaine en temps réel</term>
<term>Réplication virale</term>
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</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Highlights</title>
<p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label>
<p id="par0005">Cyclophilin A (CypA) is a host factor for human coronavirus NL63 replication.</p>
</list-item>
<list-item id="lsti0010"><label>•</label>
<p id="par0010">CypA is a target for anti-coronaviral therapy.</p>
</list-item>
<list-item id="lsti0015"><label>•</label>
<p id="par0015">Non-immunosuppressive CsA derivatives (Alisporivir, NIM811) inhibit CoV replication.</p>
</list-item>
<list-item id="lsti0020"><label>•</label>
<p id="par0020">New classes of non-immunosuppressive CsA/FK506 derivatives inhibit CoV replication.</p>
</list-item>
</list>
</p>
</div>
</front>
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