Structural and functional characterization of MERS coronavirus papain-like protease.
Identifieur interne : 001568 ( Main/Curation ); précédent : 001567; suivant : 001569Structural and functional characterization of MERS coronavirus papain-like protease.
Auteurs : Min-Han Lin ; Shang-Ju Chuang ; Chiao-Che Chen ; Shu-Chun Cheng ; Kai-Wen Cheng ; Chao-Hsiung Lin ; Chiao-Yin Sun [Taïwan] ; Chi-Yuan ChouSource :
- Journal of biomedical science [ 1423-0127 ] ; 2014.
Descripteurs français
- KwdFr :
- Antiviraux (), Cysteine endopeptidases (), Cysteine endopeptidases (biosynthèse), Cysteine endopeptidases (génétique), Europe, Humains, Ions (), Maturation post-traductionnelle des protéines, Métaux (), Protéines virales (), Protéines virales (biosynthèse), Protéines virales (génétique), Protéolyse, Régulation de l'expression des gènes viraux, Virus du SRAS (), Virus du SRAS (enzymologie), Virus du SRAS (génétique).
- MESH :
- biosynthèse : Cysteine endopeptidases, Protéines virales.
- enzymologie : Virus du SRAS.
- génétique : Cysteine endopeptidases, Protéines virales, Virus du SRAS.
- Antiviraux, Cysteine endopeptidases, Europe, Humains, Ions, Maturation post-traductionnelle des protéines, Métaux, Protéines virales, Protéolyse, Régulation de l'expression des gènes viraux, Virus du SRAS.
English descriptors
- KwdEn :
- Antiviral Agents (chemistry), Cysteine Endopeptidases (biosynthesis), Cysteine Endopeptidases (chemistry), Cysteine Endopeptidases (genetics), Europe, Gene Expression Regulation, Viral, Humans, Ions (chemistry), Metals (chemistry), Protein Processing, Post-Translational, Proteolysis, SARS Virus (chemistry), SARS Virus (enzymology), SARS Virus (genetics), Viral Proteins (biosynthesis), Viral Proteins (chemistry), Viral Proteins (genetics).
- MESH :
- chemical , biosynthesis : Cysteine Endopeptidases, Viral Proteins.
- chemical , chemistry : Antiviral Agents, Cysteine Endopeptidases, Ions, Metals, Viral Proteins.
- chemical , genetics : Cysteine Endopeptidases, Viral Proteins.
- geographic : Europe.
- chemistry : SARS Virus.
- enzymology : SARS Virus.
- genetics : SARS Virus.
- Gene Expression Regulation, Viral, Humans, Protein Processing, Post-Translational, Proteolysis.
Abstract
A new highly pathogenic human coronavirus (CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), has emerged in Jeddah and Saudi Arabia and quickly spread to some European countries since September 2012. Until 15 May 2014, it has infected at least 572 people with a fatality rate of about 30% globally. Studies to understand the virus and to develop antiviral drugs or therapy are necessary and urgent. In the present study, MERS-CoV papain-like protease (PLpro) is expressed, and its structural and functional consequences are elucidated.
DOI: 10.1186/1423-0127-21-54
PubMed: 24898546
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pubmed:24898546Le document en format XML
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<author><name sortKey="Chuang, Shang Ju" sort="Chuang, Shang Ju" uniqKey="Chuang S" first="Shang-Ju" last="Chuang">Shang-Ju Chuang</name>
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<author><name sortKey="Chen, Chiao Che" sort="Chen, Chiao Che" uniqKey="Chen C" first="Chiao-Che" last="Chen">Chiao-Che Chen</name>
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<author><name sortKey="Cheng, Kai Wen" sort="Cheng, Kai Wen" uniqKey="Cheng K" first="Kai-Wen" last="Cheng">Kai-Wen Cheng</name>
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<term>Cysteine Endopeptidases (genetics)</term>
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<term>Humans</term>
<term>Ions (chemistry)</term>
<term>Metals (chemistry)</term>
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<term>SARS Virus (enzymology)</term>
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<term>Viral Proteins (chemistry)</term>
<term>Viral Proteins (genetics)</term>
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<term>Humains</term>
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<term>Régulation de l'expression des gènes viraux</term>
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<term>Virus du SRAS (enzymologie)</term>
<term>Virus du SRAS (génétique)</term>
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<term>Viral Proteins</term>
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<term>Cysteine Endopeptidases</term>
<term>Ions</term>
<term>Metals</term>
<term>Viral Proteins</term>
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<term>Viral Proteins</term>
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<term>Protéines virales</term>
<term>Virus du SRAS</term>
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<term>Protein Processing, Post-Translational</term>
<term>Proteolysis</term>
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<term>Cysteine endopeptidases</term>
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<term>Maturation post-traductionnelle des protéines</term>
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<front><div type="abstract" xml:lang="en">A new highly pathogenic human coronavirus (CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), has emerged in Jeddah and Saudi Arabia and quickly spread to some European countries since September 2012. Until 15 May 2014, it has infected at least 572 people with a fatality rate of about 30% globally. Studies to understand the virus and to develop antiviral drugs or therapy are necessary and urgent. In the present study, MERS-CoV papain-like protease (PLpro) is expressed, and its structural and functional consequences are elucidated.</div>
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