SrasV1, Main, Curation, bibRecord, 001568

Structural and functional characterization of MERS coronavirus papain-like protease.

Identifieur interne : 001568 ( Main/Curation ); précédent : 001567; suivant : 001569

Structural and functional characterization of MERS coronavirus papain-like protease.

Auteurs : Min-Han Lin ; Shang-Ju Chuang ; Chiao-Che Chen ; Shu-Chun Cheng ; Kai-Wen Cheng ; Chao-Hsiung Lin ; Chiao-Yin Sun [Taïwan] ; Chi-Yuan Chou

Source :

Journal of biomedical science [ 1423-0127 ] ; 2014.

RBID : pubmed:24898546

Descripteurs français

KwdFr :
- Antiviraux (), Cysteine endopeptidases (), Cysteine endopeptidases (biosynthèse), Cysteine endopeptidases (génétique), Europe, Humains, Ions (), Maturation post-traductionnelle des protéines, Métaux (), Protéines virales (), Protéines virales (biosynthèse), Protéines virales (génétique), Protéolyse, Régulation de l'expression des gènes viraux, Virus du SRAS (), Virus du SRAS (enzymologie), Virus du SRAS (génétique).
MESH :
- biosynthèse : Cysteine endopeptidases, Protéines virales.
- enzymologie : Virus du SRAS.
- génétique : Cysteine endopeptidases, Protéines virales, Virus du SRAS.
- Antiviraux, Cysteine endopeptidases, Europe, Humains, Ions, Maturation post-traductionnelle des protéines, Métaux, Protéines virales, Protéolyse, Régulation de l'expression des gènes viraux, Virus du SRAS.

English descriptors

KwdEn :
- Antiviral Agents (chemistry), Cysteine Endopeptidases (biosynthesis), Cysteine Endopeptidases (chemistry), Cysteine Endopeptidases (genetics), Europe, Gene Expression Regulation, Viral, Humans, Ions (chemistry), Metals (chemistry), Protein Processing, Post-Translational, Proteolysis, SARS Virus (chemistry), SARS Virus (enzymology), SARS Virus (genetics), Viral Proteins (biosynthesis), Viral Proteins (chemistry), Viral Proteins (genetics).
MESH :
- chemical , biosynthesis : Cysteine Endopeptidases, Viral Proteins.
- chemical , chemistry : Antiviral Agents, Cysteine Endopeptidases, Ions, Metals, Viral Proteins.
- chemical , genetics : Cysteine Endopeptidases, Viral Proteins.
- geographic : Europe.
- chemistry : SARS Virus.
- enzymology : SARS Virus.
- genetics : SARS Virus.
- Gene Expression Regulation, Viral, Humans, Protein Processing, Post-Translational, Proteolysis.

Abstract

A new highly pathogenic human coronavirus (CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), has emerged in Jeddah and Saudi Arabia and quickly spread to some European countries since September 2012. Until 15 May 2014, it has infected at least 572 people with a fatality rate of about 30% globally. Studies to understand the virus and to develop antiviral drugs or therapy are necessary and urgent. In the present study, MERS-CoV papain-like protease (PLpro) is expressed, and its structural and functional consequences are elucidated.

DOI: 10.1186/1423-0127-21-54
PubMed: 24898546

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pubmed:24898546

Le document en format XML

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<author><name sortKey="Chuang, Shang Ju" sort="Chuang, Shang Ju" uniqKey="Chuang S" first="Shang-Ju" last="Chuang">Shang-Ju Chuang</name>
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<author><name sortKey="Chen, Chiao Che" sort="Chen, Chiao Che" uniqKey="Chen C" first="Chiao-Che" last="Chen">Chiao-Che Chen</name>
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<affiliation wicri:level="1"><nlm:affiliation>Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112, Taiwan. fish3970@gmail.com.</nlm:affiliation>
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<author><name sortKey="Chuang, Shang Ju" sort="Chuang, Shang Ju" uniqKey="Chuang S" first="Shang-Ju" last="Chuang">Shang-Ju Chuang</name>
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<author><name sortKey="Chou, Chi Yuan" sort="Chou, Chi Yuan" uniqKey="Chou C" first="Chi-Yuan" last="Chou">Chi-Yuan Chou</name>
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<series><title level="j">Journal of biomedical science</title>
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<term>Cysteine Endopeptidases (genetics)</term>
<term>Europe</term>
<term>Gene Expression Regulation, Viral</term>
<term>Humans</term>
<term>Ions (chemistry)</term>
<term>Metals (chemistry)</term>
<term>Protein Processing, Post-Translational</term>
<term>Proteolysis</term>
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<term>SARS Virus (enzymology)</term>
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<term>Viral Proteins (chemistry)</term>
<term>Viral Proteins (genetics)</term>
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<term>Cysteine endopeptidases (génétique)</term>
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<term>Humains</term>
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<term>Virus du SRAS (enzymologie)</term>
<term>Virus du SRAS (génétique)</term>
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<term>Cysteine Endopeptidases</term>
<term>Ions</term>
<term>Metals</term>
<term>Viral Proteins</term>
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<term>Viral Proteins</term>
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<term>Protéines virales</term>
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<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Cysteine endopeptidases</term>
<term>Protéines virales</term>
<term>Virus du SRAS</term>
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<keywords scheme="MESH" xml:lang="en"><term>Gene Expression Regulation, Viral</term>
<term>Humans</term>
<term>Protein Processing, Post-Translational</term>
<term>Proteolysis</term>
</keywords>
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<term>Cysteine endopeptidases</term>
<term>Europe</term>
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<term>Ions</term>
<term>Maturation post-traductionnelle des protéines</term>
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<front><div type="abstract" xml:lang="en">A new highly pathogenic human coronavirus (CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), has emerged in Jeddah and Saudi Arabia and quickly spread to some European countries since September 2012. Until 15 May 2014, it has infected at least 572 people with a fatality rate of about 30% globally. Studies to understand the virus and to develop antiviral drugs or therapy are necessary and urgent. In the present study, MERS-CoV papain-like protease (PLpro) is expressed, and its structural and functional consequences are elucidated.</div>
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Structural and functional characterization of MERS coronavirus papain-like protease.

Structural and functional characterization of MERS coronavirus papain-like protease.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki