Embryonic expression of endogenous retroviral RNAs in somatic tissues adjacent to the Oikopleura germline.
Identifieur interne : 001322 ( Main/Curation ); précédent : 001321; suivant : 001323Embryonic expression of endogenous retroviral RNAs in somatic tissues adjacent to the Oikopleura germline.
Auteurs : Simon Henriet [Norvège] ; Sara Sumic [Norvège] ; Carlette Doufoundou-Guilengui [Norvège] ; Marit Flo Jensen [Norvège] ; Camille Grandmougin [Norvège] ; Kateryna Fal [Norvège] ; Eric Thompson [Norvège] ; Jean-Nicolas Volff [France] ; Daniel Chourrout [Norvège]Source :
- Nucleic acids research [ 1362-4962 ] ; 2015.
Descripteurs français
- KwdFr :
- ARN (génétique), Animaux, Cellules HEK293, Cellules germinales, Données de séquences moléculaires, Humains, Polymorphisme génétique, Protéines de l'enveloppe virale (), Régions promotrices (génétique), Régulation de l'expression des gènes au cours du développement, Rétrovirus endogènes (génétique), Similitude de séquences d'acides aminés, Séquence d'acides aminés, Urochordata (génétique).
- MESH :
- génétique : ARN, Rétrovirus endogènes, Urochordata.
- Animaux, Cellules HEK293, Cellules germinales, Données de séquences moléculaires, Humains, Polymorphisme génétique, Protéines de l'enveloppe virale, Régions promotrices (génétique), Régulation de l'expression des gènes au cours du développement, Similitude de séquences d'acides aminés, Séquence d'acides aminés.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Endogenous Retroviruses (genetics), Gene Expression Regulation, Developmental, Germ Cells, HEK293 Cells, Humans, Molecular Sequence Data, Polymorphism, Genetic, Promoter Regions, Genetic, RNA (genetics), Sequence Homology, Amino Acid, Urochordata (genetics), Viral Envelope Proteins (chemistry).
- MESH :
- chemical , chemistry : Viral Envelope Proteins.
- chemical , genetics : RNA.
- genetics : Endogenous Retroviruses, Urochordata.
- Amino Acid Sequence, Animals, Gene Expression Regulation, Developmental, Germ Cells, HEK293 Cells, Humans, Molecular Sequence Data, Polymorphism, Genetic, Promoter Regions, Genetic, Sequence Homology, Amino Acid.
Abstract
Selective pressure to maintain small genome size implies control of transposable elements, and most old classes of retrotransposons are indeed absent from the very compact genome of the tunicate Oikopleura dioica. Nonetheless, two families of retrotransposons are present, including the Tor elements. The gene organization within Tor elements is similar to that of LTR retrotransposons and retroviruses. In addition to gag and pol, many Tor elements carry a third gene encoding viral envelope-like proteins (Env) that may mediate infection. We show that the Tor family contains distinct classes of elements. In some classes, env mRNA is transcribed from the 5'LTR as in retroviruses. In others, env is transcribed from an additional promoter located downstream of the 5'LTR. Tor Env proteins are membrane-associated glycoproteins which exhibit some features of viral membrane fusion proteins. Whereas some elements are expressed in the adult testis, many others are specifically expressed in embryonic somatic cells adjacent to primordial germ cells. Such embryonic expression depends on determinants present in the Tor elements and not on their surrounding genomic environment. Our study shows that unusual modes of transcription and expression close to the germline may contribute to the proliferation of Tor elements.
DOI: 10.1093/nar/gkv169
PubMed: 25779047
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pubmed:25779047Le document en format XML
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<term>Gene Expression Regulation, Developmental</term>
<term>Germ Cells</term>
<term>HEK293 Cells</term>
<term>Humans</term>
<term>Molecular Sequence Data</term>
<term>Polymorphism, Genetic</term>
<term>Promoter Regions, Genetic</term>
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<term>Protéines de l'enveloppe virale ()</term>
<term>Régions promotrices (génétique)</term>
<term>Régulation de l'expression des gènes au cours du développement</term>
<term>Rétrovirus endogènes (génétique)</term>
<term>Similitude de séquences d'acides aminés</term>
<term>Séquence d'acides aminés</term>
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<term>Animals</term>
<term>Gene Expression Regulation, Developmental</term>
<term>Germ Cells</term>
<term>HEK293 Cells</term>
<term>Humans</term>
<term>Molecular Sequence Data</term>
<term>Polymorphism, Genetic</term>
<term>Promoter Regions, Genetic</term>
<term>Sequence Homology, Amino Acid</term>
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<term>Cellules HEK293</term>
<term>Cellules germinales</term>
<term>Données de séquences moléculaires</term>
<term>Humains</term>
<term>Polymorphisme génétique</term>
<term>Protéines de l'enveloppe virale</term>
<term>Régions promotrices (génétique)</term>
<term>Régulation de l'expression des gènes au cours du développement</term>
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<front><div type="abstract" xml:lang="en">Selective pressure to maintain small genome size implies control of transposable elements, and most old classes of retrotransposons are indeed absent from the very compact genome of the tunicate Oikopleura dioica. Nonetheless, two families of retrotransposons are present, including the Tor elements. The gene organization within Tor elements is similar to that of LTR retrotransposons and retroviruses. In addition to gag and pol, many Tor elements carry a third gene encoding viral envelope-like proteins (Env) that may mediate infection. We show that the Tor family contains distinct classes of elements. In some classes, env mRNA is transcribed from the 5'LTR as in retroviruses. In others, env is transcribed from an additional promoter located downstream of the 5'LTR. Tor Env proteins are membrane-associated glycoproteins which exhibit some features of viral membrane fusion proteins. Whereas some elements are expressed in the adult testis, many others are specifically expressed in embryonic somatic cells adjacent to primordial germ cells. Such embryonic expression depends on determinants present in the Tor elements and not on their surrounding genomic environment. Our study shows that unusual modes of transcription and expression close to the germline may contribute to the proliferation of Tor elements. </div>
</front>
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