Molecular pathology of emerging coronavirus infections
Identifieur interne : 000210 ( Istex/Curation ); précédent : 000209; suivant : 000211Molecular pathology of emerging coronavirus infections
Auteurs : Lisa E. Gralinski [États-Unis] ; Ralph S. Baric [États-Unis]Source :
- The Journal of Pathology [ 0022-3417 ] ; 2015-01.
Abstract
Respiratory viruses can cause a wide spectrum of pulmonary diseases, ranging from mild, upper respiratory tract infections to severe and life‐threatening lower respiratory tract infections, including the development of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Viral clearance and subsequent recovery from infection require activation of an effective host immune response; however, many immune effector cells may also cause injury to host tissues. Severe acute respiratory syndrome (SARS) coronavirus and Middle East respiratory syndrome (MERS) coronavirus cause severe infection of the lower respiratory tract, with 10% and 35% overall mortality rates, respectively; however, >50% mortality rates are seen in the aged and immunosuppressed populations. While these viruses are susceptible to interferon treatment in vitro, they both encode numerous genes that allow for successful evasion of the host immune system until after high virus titres have been achieved. In this review, we discuss the importance of the innate immune response and the development of lung pathology following human coronavirus infection. © 2014 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
Url:
DOI: 10.1002/path.4454
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000210
Links to Exploration step
ISTEX:EC2D3140AE38AD33FDB2F751563138FD7F2BE310Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Molecular pathology of emerging coronavirus infections</title>
<author><name sortKey="Gralinski, Lisa E" sort="Gralinski, Lisa E" uniqKey="Gralinski L" first="Lisa E" last="Gralinski">Lisa E. Gralinski</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Epidemiology, University of North Carolina, NC, Chapel Hill, USA</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of North Carolina, NC, Chapel Hill</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S" last="Baric">Ralph S. Baric</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of North Carolina, Chapel Hill, NC</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Department of Microbiology and Immunology, University of North Carolina, NC, Chapel Hill, USA</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of North Carolina, NC, Chapel Hill</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>E-mail: rbaric@email.unc.ed</mods:affiliation>
<wicri:noCountry code="no comma">E-mail: rbaric@email.unc.ed</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:EC2D3140AE38AD33FDB2F751563138FD7F2BE310</idno>
<date when="2015" year="2015">2015</date>
<idno type="doi">10.1002/path.4454</idno>
<idno type="url">https://api.istex.fr/ark:/67375/WNG-ZXMDQVLL-L/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000210</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000210</idno>
<idno type="wicri:Area/Istex/Curation">000210</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main">Molecular pathology of emerging coronavirus infections</title>
<author><name sortKey="Gralinski, Lisa E" sort="Gralinski, Lisa E" uniqKey="Gralinski L" first="Lisa E" last="Gralinski">Lisa E. Gralinski</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Epidemiology, University of North Carolina, NC, Chapel Hill, USA</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of North Carolina, NC, Chapel Hill</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S" last="Baric">Ralph S. Baric</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of North Carolina, Chapel Hill, NC</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Department of Microbiology and Immunology, University of North Carolina, NC, Chapel Hill, USA</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of North Carolina, NC, Chapel Hill</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>E-mail: rbaric@email.unc.ed</mods:affiliation>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">The Journal of Pathology</title>
<title level="j" type="sub">Viruses and Disease</title>
<title level="j" type="alt">THE JOURNAL OF PATHOLOGY</title>
<idno type="ISSN">0022-3417</idno>
<idno type="eISSN">1096-9896</idno>
<imprint><biblScope unit="vol">235</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="185">185</biblScope>
<biblScope unit="page" to="195">195</biblScope>
<biblScope unit="page-count">11</biblScope>
<publisher>John Wiley & Sons, Ltd</publisher>
<pubPlace>Chichester, UK</pubPlace>
<date type="published" when="2015-01">2015-01</date>
</imprint>
<idno type="ISSN">0022-3417</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0022-3417</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">Respiratory viruses can cause a wide spectrum of pulmonary diseases, ranging from mild, upper respiratory tract infections to severe and life‐threatening lower respiratory tract infections, including the development of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Viral clearance and subsequent recovery from infection require activation of an effective host immune response; however, many immune effector cells may also cause injury to host tissues. Severe acute respiratory syndrome (SARS) coronavirus and Middle East respiratory syndrome (MERS) coronavirus cause severe infection of the lower respiratory tract, with 10% and 35% overall mortality rates, respectively; however, >50% mortality rates are seen in the aged and immunosuppressed populations. While these viruses are susceptible to interferon treatment in vitro, they both encode numerous genes that allow for successful evasion of the host immune system until after high virus titres have been achieved. In this review, we discuss the importance of the innate immune response and the development of lung pathology following human coronavirus infection. © 2014 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000210 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 000210 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= Istex |étape= Curation |type= RBID |clé= ISTEX:EC2D3140AE38AD33FDB2F751563138FD7F2BE310 |texte= Molecular pathology of emerging coronavirus infections }}
![]() | This area was generated with Dilib version V0.6.33. | ![]() |