Molecular pathology of emerging coronavirus infections
Identifieur interne : 000210 ( Istex/Corpus ); précédent : 000209; suivant : 000211Molecular pathology of emerging coronavirus infections
Auteurs : Lisa E. Gralinski ; Ralph S. BaricSource :
- The Journal of Pathology [ 0022-3417 ] ; 2015-01.
Abstract
Respiratory viruses can cause a wide spectrum of pulmonary diseases, ranging from mild, upper respiratory tract infections to severe and life‐threatening lower respiratory tract infections, including the development of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Viral clearance and subsequent recovery from infection require activation of an effective host immune response; however, many immune effector cells may also cause injury to host tissues. Severe acute respiratory syndrome (SARS) coronavirus and Middle East respiratory syndrome (MERS) coronavirus cause severe infection of the lower respiratory tract, with 10% and 35% overall mortality rates, respectively; however, >50% mortality rates are seen in the aged and immunosuppressed populations. While these viruses are susceptible to interferon treatment in vitro, they both encode numerous genes that allow for successful evasion of the host immune system until after high virus titres have been achieved. In this review, we discuss the importance of the innate immune response and the development of lung pathology following human coronavirus infection. © 2014 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
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DOI: 10.1002/path.4454
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<p xml:id="path4454-para-0001">Respiratory viruses can cause a wide spectrum of pulmonary diseases, ranging from mild, upper respiratory tract infections to severe and life‐threatening lower respiratory tract infections, including the development of acute lung injury (<fc>ALI</fc>
) and acute respiratory distress syndrome (<fc>ARDS</fc>
). Viral clearance and subsequent recovery from infection require activation of an effective host immune response; however, many immune effector cells may also cause injury to host tissues. Severe acute respiratory syndrome (<fc>SARS</fc>
) coronavirus and Middle East respiratory syndrome (<fc>MERS</fc>
) coronavirus cause severe infection of the lower respiratory tract, with 10% and 35% overall mortality rates, respectively; however, >50% mortality rates are seen in the aged and immunosuppressed populations. While these viruses are susceptible to interferon treatment <fi>in vitro</fi>
, they both encode numerous genes that allow for successful evasion of the host immune system until after high virus titres have been achieved. In this review, we discuss the importance of the innate immune response and the development of lung pathology following human coronavirus infection. © 2014 The Authors. <fi>The Journal of Pathology</fi>
published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.</p>
</abstract>
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<noteGroup xml:id="path4454-ntgp-0001"><note xml:id="path4454-note-0001" numbered="no">No conflicts of interest were declared.</note>
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<mods version="3.6"><titleInfo lang="en"><title>Molecular pathology of emerging coronavirus infections</title>
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<titleInfo type="abbreviated" lang="en"><title>Molecular pathology of emerging coronavirus infections</title>
</titleInfo>
<titleInfo type="alternative" contentType="CDATA" lang="en"><title>Molecular pathology of emerging coronavirus infections</title>
</titleInfo>
<name type="personal"><namePart type="given">Lisa E</namePart>
<namePart type="family">Gralinski</namePart>
<affiliation>Department of Epidemiology, University of North Carolina, NC, Chapel Hill, USA</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Ralph S</namePart>
<namePart type="family">Baric</namePart>
<affiliation>Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA</affiliation>
<affiliation>Department of Microbiology and Immunology, University of North Carolina, NC, Chapel Hill, USA</affiliation>
<affiliation>E-mail: rbaric@email.unc.ed</affiliation>
<role><roleTerm type="text">author</roleTerm>
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<originInfo><publisher>John Wiley & Sons, Ltd</publisher>
<place><placeTerm type="text">Chichester, UK</placeTerm>
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<dateIssued encoding="w3cdtf">2015-01</dateIssued>
<dateCreated encoding="w3cdtf">2014-10-11</dateCreated>
<dateCaptured encoding="w3cdtf">2014-09-18</dateCaptured>
<dateValid encoding="w3cdtf">2014-09-25</dateValid>
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<abstract>Respiratory viruses can cause a wide spectrum of pulmonary diseases, ranging from mild, upper respiratory tract infections to severe and life‐threatening lower respiratory tract infections, including the development of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Viral clearance and subsequent recovery from infection require activation of an effective host immune response; however, many immune effector cells may also cause injury to host tissues. Severe acute respiratory syndrome (SARS) coronavirus and Middle East respiratory syndrome (MERS) coronavirus cause severe infection of the lower respiratory tract, with 10% and 35% overall mortality rates, respectively; however, >50% mortality rates are seen in the aged and immunosuppressed populations. While these viruses are susceptible to interferon treatment in vitro, they both encode numerous genes that allow for successful evasion of the host immune system until after high virus titres have been achieved. In this review, we discuss the importance of the innate immune response and the development of lung pathology following human coronavirus infection. © 2014 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.</abstract>
<subject><genre>keywords</genre>
<topic>SARS‐CoV</topic>
<topic>MERS‐CoV</topic>
<topic>coronavirus</topic>
<topic>acute respiratory distress syndrome</topic>
<topic>ARDS</topic>
<topic>acute lung injury</topic>
<topic>type II pneumocytes</topic>
</subject>
<relatedItem type="host"><titleInfo><title>The Journal of Pathology</title>
</titleInfo>
<titleInfo type="abbreviated"><title>J. Pathol.</title>
</titleInfo>
<name type="personal"><namePart type="given">C Simon</namePart>
<namePart type="family">Herrington</namePart>
<role><roleTerm type="text">editor</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Philip J</namePart>
<namePart type="family">Coates</namePart>
<role><roleTerm type="text">editor</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">W Paul</namePart>
<namePart type="family">Duprex</namePart>
<role><roleTerm type="text">editor</roleTerm>
</role>
</name>
<genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre>
<subject><genre>article-category</genre>
<topic>Invited Review</topic>
<topic>Invited Reviews</topic>
</subject>
<identifier type="ISSN">0022-3417</identifier>
<identifier type="eISSN">1096-9896</identifier>
<identifier type="DOI">10.1002/(ISSN)1096-9896</identifier>
<identifier type="PublisherID">PATH</identifier>
<part><date>2015</date>
<detail type="title"><title>Viruses and Disease</title>
</detail>
<detail type="volume"><caption>vol.</caption>
<number>235</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>2</number>
</detail>
<extent unit="pages"><start>185</start>
<end>195</end>
<total>11</total>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0001"><titleInfo><title>Acute lung injury: epidemiology, pathogenesis, and treatment</title>
</titleInfo>
<name type="personal"><namePart type="given">ER</namePart>
<namePart type="family">Johnson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MA</namePart>
<namePart type="family">Matthay</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Johnson ER, Matthay MA. Acute lung injury: epidemiology, pathogenesis, and treatment. J Aerosol Med Pulm Drug Deliv 2010; 23: 243–252.</note>
<part><date>2010</date>
<detail type="volume"><caption>vol.</caption>
<number>23</number>
</detail>
<extent unit="pages"><start>243</start>
<end>252</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Aerosol Med Pulm Drug Deliv</title>
</titleInfo>
<part><date>2010</date>
<detail type="volume"><caption>vol.</caption>
<number>23</number>
</detail>
<extent unit="pages"><start>243</start>
<end>252</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0002"><titleInfo><title>Acute respiratory distress syndrome: estimated incidence and mortality rate in a 5 million‐person population base</title>
</titleInfo>
<name type="personal"><namePart type="given">HN</namePart>
<namePart type="family">Reynolds</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">McCunn</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">U</namePart>
<namePart type="family">Borg</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Reynolds HN, McCunn M, Borg U, et al. Acute respiratory distress syndrome: estimated incidence and mortality rate in a 5 million‐person population base. Crit Care 1998; 2: 29–34.</note>
<part><date>1998</date>
<detail type="volume"><caption>vol.</caption>
<number>2</number>
</detail>
<extent unit="pages"><start>29</start>
<end>34</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Crit Care</title>
</titleInfo>
<part><date>1998</date>
<detail type="volume"><caption>vol.</caption>
<number>2</number>
</detail>
<extent unit="pages"><start>29</start>
<end>34</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0003"><titleInfo><title>Epidemiological and clinical features of human coronavirus infections among different subsets of patients</title>
</titleInfo>
<name type="personal"><namePart type="given">TK</namePart>
<namePart type="family">Cabeca</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Granato</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">N</namePart>
<namePart type="family">Bellei</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Cabeca TK, Granato C, Bellei N. Epidemiological and clinical features of human coronavirus infections among different subsets of patients. Influenza Other Respir Viruses 2013; 7: 1040–1047.</note>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>7</number>
</detail>
<extent unit="pages"><start>1040</start>
<end>1047</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Influenza Other Respir Viruses</title>
</titleInfo>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>7</number>
</detail>
<extent unit="pages"><start>1040</start>
<end>1047</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0004"><titleInfo><title>Identification of a new human coronavirus</title>
</titleInfo>
<name type="personal"><namePart type="given">L</namePart>
<namePart type="family">van der Hoek</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Pyrc</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MF</namePart>
<namePart type="family">Jebbink</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">van der Hoek L, Pyrc K, Jebbink MF, et al. Identification of a new human coronavirus. Nat Med 2004; 10: 368–373.</note>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>10</number>
</detail>
<extent unit="pages"><start>368</start>
<end>373</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Nat Med</title>
</titleInfo>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>10</number>
</detail>
<extent unit="pages"><start>368</start>
<end>373</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0005"><titleInfo><title>Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia</title>
</titleInfo>
<name type="personal"><namePart type="given">PC</namePart>
<namePart type="family">Woo</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">SK</namePart>
<namePart type="family">Lau</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">CM</namePart>
<namePart type="family">Chu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Woo PC, Lau SK, Chu CM, et al. Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia. J Virol 2005; 79: 884–895.</note>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>79</number>
</detail>
<extent unit="pages"><start>884</start>
<end>895</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>79</number>
</detail>
<extent unit="pages"><start>884</start>
<end>895</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0006"><titleInfo><title>Clinico‐epidemiological characteristics of acute respiratory infections caused by coronavirus OC43, NL63 and 229E</title>
</titleInfo>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Reina</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Lopez‐Causape</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">E</namePart>
<namePart type="family">Rojo‐Molinero</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Reina J, Lopez‐Causape C, Rojo‐Molinero E, et al. Clinico‐epidemiological characteristics of acute respiratory infections caused by coronavirus OC43, NL63 and 229E. Rev Clin Esp 2014; doi: 10.1016/j.rce.2014.05.020. (in press).</note>
<part><date>2014</date>
</part>
<relatedItem type="host"><titleInfo><title>Rev Clin Esp</title>
</titleInfo>
<part><date>2014</date>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0007"><titleInfo><title>Coronavirus HKU1 and other coronavirus infections in Hong Kong</title>
</titleInfo>
<name type="personal"><namePart type="given">SK</namePart>
<namePart type="family">Lau</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">PC</namePart>
<namePart type="family">Woo</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">CC</namePart>
<namePart type="family">Yip</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Lau SK, Woo PC, Yip CC, et al. Coronavirus HKU1 and other coronavirus infections in Hong Kong. J Clin Microbiol 2006; 44: 2063–2071.</note>
<part><date>2006</date>
<detail type="volume"><caption>vol.</caption>
<number>44</number>
</detail>
<extent unit="pages"><start>2063</start>
<end>2071</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Clin Microbiol</title>
</titleInfo>
<part><date>2006</date>
<detail type="volume"><caption>vol.</caption>
<number>44</number>
</detail>
<extent unit="pages"><start>2063</start>
<end>2071</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0008"><titleInfo><title>Identification of a novel coronavirus in patients with severe acute respiratory syndrome</title>
</titleInfo>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Drosten</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Gunther</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">W</namePart>
<namePart type="family">Preiser</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Drosten C, Gunther S, Preiser W, et al. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med 2003; 348: 1967–1976.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>348</number>
</detail>
<extent unit="pages"><start>1967</start>
<end>1976</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>N Engl J Med</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>348</number>
</detail>
<extent unit="pages"><start>1967</start>
<end>1976</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0009"><titleInfo><title>http://www.who.int/csr/sars/country/table2004_04_21/en/</title>
</titleInfo>
<genre>other</genre>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0010"><titleInfo><title>http://www.who.int/csr/don/2014_07_23_mers/en/</title>
</titleInfo>
<genre>other</genre>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0011"><titleInfo><title>ProMed: http://www.promedmail.org/direct.php?id=20140912.2770252</title>
</titleInfo>
<genre>other</genre>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0012"><titleInfo><title>Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China</title>
</titleInfo>
<name type="personal"><namePart type="given">Y</namePart>
<namePart type="family">Guan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">BJ</namePart>
<namePart type="family">Zheng</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">YQ</namePart>
<namePart type="family">He</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Guan Y, Zheng BJ, He YQ, et al. Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China. Science 2003; 302: 276–278.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>302</number>
</detail>
<extent unit="pages"><start>276</start>
<end>278</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Science</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>302</number>
</detail>
<extent unit="pages"><start>276</start>
<end>278</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0013"><titleInfo><title>Severe acute respiratory syndrome coronavirus‐like virus in Chinese horseshoe bats</title>
</titleInfo>
<name type="personal"><namePart type="given">SK</namePart>
<namePart type="family">Lau</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">PC</namePart>
<namePart type="family">Woo</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">KS</namePart>
<namePart type="family">Li</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Lau SK, Woo PC, Li KS, et al. Severe acute respiratory syndrome coronavirus‐like virus in Chinese horseshoe bats. Proc Natl Acad Sci USA 2005; 102: 14040–14045.</note>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>102</number>
</detail>
<extent unit="pages"><start>14040</start>
<end>14045</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Proc Natl Acad Sci USA</title>
</titleInfo>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>102</number>
</detail>
<extent unit="pages"><start>14040</start>
<end>14045</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0014"><titleInfo><title>Bats are natural reservoirs of SARS‐like coronaviruses</title>
</titleInfo>
<name type="personal"><namePart type="given">W</namePart>
<namePart type="family">Li</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Z</namePart>
<namePart type="family">Shi</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Yu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Li W, Shi Z, Yu M, et al. Bats are natural reservoirs of SARS‐like coronaviruses. Science 2005; 310: 676–679.</note>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>310</number>
</detail>
<extent unit="pages"><start>676</start>
<end>679</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Science</title>
</titleInfo>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>310</number>
</detail>
<extent unit="pages"><start>676</start>
<end>679</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0015"><titleInfo><title>Difference in receptor usage between severe acute respiratory syndrome (SARS) coronavirus and SARS‐like coronavirus of bat origin</title>
</titleInfo>
<name type="personal"><namePart type="given">W</namePart>
<namePart type="family">Ren</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">X</namePart>
<namePart type="family">Qu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">W</namePart>
<namePart type="family">Li</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Ren W, Qu X, Li W, et al. Difference in receptor usage between severe acute respiratory syndrome (SARS) coronavirus and SARS‐like coronavirus of bat origin. J Virol 2008; 82: 1899–1907.</note>
<part><date>2008</date>
<detail type="volume"><caption>vol.</caption>
<number>82</number>
</detail>
<extent unit="pages"><start>1899</start>
<end>1907</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2008</date>
<detail type="volume"><caption>vol.</caption>
<number>82</number>
</detail>
<extent unit="pages"><start>1899</start>
<end>1907</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0016"><titleInfo><title>Isolation and characterization of a bat SARS‐like coronavirus that uses the ACE2 receptor</title>
</titleInfo>
<name type="personal"><namePart type="given">XY</namePart>
<namePart type="family">Ge</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JL</namePart>
<namePart type="family">Li</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">XL</namePart>
<namePart type="family">Yang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Ge XY, Li JL, Yang XL, et al. Isolation and characterization of a bat SARS‐like coronavirus that uses the ACE2 receptor. Nature 2013; 503: 535–538.</note>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>503</number>
</detail>
<extent unit="pages"><start>535</start>
<end>538</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Nature</title>
</titleInfo>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>503</number>
</detail>
<extent unit="pages"><start>535</start>
<end>538</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0017"><titleInfo><title>Lung pathology of severe acute respiratory syndrome (SARS): a study of eight autopsy cases from Singapore</title>
</titleInfo>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Franks</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">P</namePart>
<namePart type="family">Chong</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">P</namePart>
<namePart type="family">Chui</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Franks T, Chong P, Chui P, et al. Lung pathology of severe acute respiratory syndrome (SARS): a study of eight autopsy cases from Singapore. Hum Pathol 2003; 34: 743–748.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>34</number>
</detail>
<extent unit="pages"><start>743</start>
<end>748</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Hum Pathol</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>34</number>
</detail>
<extent unit="pages"><start>743</start>
<end>748</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0018"><titleInfo><title>The chest X‐ray image features of patients with severe SRAS: a preliminary study</title>
</titleInfo>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Liu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">X</namePart>
<namePart type="family">Tang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Jiang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Liu J, Tang X, Jiang S, et al. The chest X‐ray image features of patients with severe SRAS: a preliminary study. Chin Med J (Engl) 2003; 116: 968–971.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>116</number>
</detail>
<extent unit="pages"><start>968</start>
<end>971</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Chin Med J (Engl)</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>116</number>
</detail>
<extent unit="pages"><start>968</start>
<end>971</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0019"><titleInfo><title>Pathology and pathogenesis of severe acute respiratory syndrome</title>
</titleInfo>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Gu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Korteweg</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Gu J, Korteweg C. Pathology and pathogenesis of severe acute respiratory syndrome. Am J Pathol 2007; 170: 1136–1147.</note>
<part><date>2007</date>
<detail type="volume"><caption>vol.</caption>
<number>170</number>
</detail>
<extent unit="pages"><start>1136</start>
<end>1147</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Am J Pathol</title>
</titleInfo>
<part><date>2007</date>
<detail type="volume"><caption>vol.</caption>
<number>170</number>
</detail>
<extent unit="pages"><start>1136</start>
<end>1147</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0020"><titleInfo><title>Pulmonary pathology of severe acute respiratory syndrome in Toronto</title>
</titleInfo>
<name type="personal"><namePart type="given">DM</namePart>
<namePart type="family">Hwang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">DW</namePart>
<namePart type="family">Chamberlain</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">SM</namePart>
<namePart type="family">Poutanen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Hwang DM, Chamberlain DW, Poutanen SM, et al. Pulmonary pathology of severe acute respiratory syndrome in Toronto. Mod Pathol 2005; 18: 1–10.</note>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>18</number>
</detail>
<extent unit="pages"><start>1</start>
<end>10</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Mod Pathol</title>
</titleInfo>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>18</number>
</detail>
<extent unit="pages"><start>1</start>
<end>10</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0021"><titleInfo><title>SARS: clinical virology and pathogenesis</title>
</titleInfo>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Nicholls</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">XP</namePart>
<namePart type="family">Dong</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">G</namePart>
<namePart type="family">Jiang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Nicholls J, Dong XP, Jiang G, et al. SARS: clinical virology and pathogenesis. Respirology 2003; 8(suppl): S6–8.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>8</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>suppl</number>
</detail>
<extent unit="pages"><start>S6</start>
<end>8</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Respirology</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>8</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>suppl</number>
</detail>
<extent unit="pages"><start>S6</start>
<end>8</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0022"><titleInfo><title>The clinical pathology of severe acute respiratory syndrome (SARS): a report from China</title>
</titleInfo>
<name type="personal"><namePart type="given">Y</namePart>
<namePart type="family">Ding</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Wang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Shen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Ding Y, Wang H, Shen H, et al. The clinical pathology of severe acute respiratory syndrome (SARS): a report from China. J Pathol 2003; 200: 282–289.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>200</number>
</detail>
<extent unit="pages"><start>282</start>
<end>289</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Pathol</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>200</number>
</detail>
<extent unit="pages"><start>282</start>
<end>289</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0023"><titleInfo><title>Evolution of pulmonary pathology in severe acute respiratory syndrome</title>
</titleInfo>
<name type="personal"><namePart type="given">CH</namePart>
<namePart type="family">Hsiao</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MZ</namePart>
<namePart type="family">Wu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">CL</namePart>
<namePart type="family">Chen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Hsiao CH, Wu MZ, Chen CL, et al. Evolution of pulmonary pathology in severe acute respiratory syndrome. J Formos Med Assoc 2005; 104: 75–81.</note>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>104</number>
</detail>
<extent unit="pages"><start>75</start>
<end>81</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Formos Med Assoc</title>
</titleInfo>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>104</number>
</detail>
<extent unit="pages"><start>75</start>
<end>81</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0024"><titleInfo><title>Clinical progression and viral load in a community outbreak of coronavirus‐associated SARS pneumonia: a prospective study</title>
</titleInfo>
<name type="personal"><namePart type="given">JS</namePart>
<namePart type="family">Peiris</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">CM</namePart>
<namePart type="family">Chu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">VC</namePart>
<namePart type="family">Cheng</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Peiris JS, Chu CM, Cheng VC, et al. Clinical progression and viral load in a community outbreak of coronavirus‐associated SARS pneumonia: a prospective study. Lancet 2003; 361: 1767–1772.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>361</number>
</detail>
<extent unit="pages"><start>1767</start>
<end>1772</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Lancet</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>361</number>
</detail>
<extent unit="pages"><start>1767</start>
<end>1772</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0025"><titleInfo><title>Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia</title>
</titleInfo>
<name type="personal"><namePart type="given">AM</namePart>
<namePart type="family">Zaki</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">van Boheemen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">TM</namePart>
<namePart type="family">Bestebroer</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Zaki AM, van Boheemen S, Bestebroer TM, et al. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med 2012; 367: 1814–1820.</note>
<part><date>2012</date>
<detail type="volume"><caption>vol.</caption>
<number>367</number>
</detail>
<extent unit="pages"><start>1814</start>
<end>1820</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>N Engl J Med</title>
</titleInfo>
<part><date>2012</date>
<detail type="volume"><caption>vol.</caption>
<number>367</number>
</detail>
<extent unit="pages"><start>1814</start>
<end>1820</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0026"><titleInfo><title>Hospital‐associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description</title>
</titleInfo>
<name type="personal"><namePart type="given">MM</namePart>
<namePart type="family">Al‐Abdallat</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">DC</namePart>
<namePart type="family">Payne</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Alqasrawi</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Al‐Abdallat MM, Payne DC, Alqasrawi S, et al. Hospital‐associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description. Clin Infect Dis 2014; 59: 1225–1233.</note>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>59</number>
</detail>
<extent unit="pages"><start>1225</start>
<end>1233</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Clin Infect Dis</title>
</titleInfo>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>59</number>
</detail>
<extent unit="pages"><start>1225</start>
<end>1233</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0027"><titleInfo><title>Isolation of MERS coronavirus from a dromedary camel, Qatar, 2014</title>
</titleInfo>
<name type="personal"><namePart type="given">VS</namePart>
<namePart type="family">Raj</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">EA</namePart>
<namePart type="family">Farag</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">CB</namePart>
<namePart type="family">Reusken</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Raj VS, Farag EA, Reusken CB, et al. Isolation of MERS coronavirus from a dromedary camel, Qatar, 2014. Emerg Infect Dis 2014; 20: 1339–1342.</note>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>20</number>
</detail>
<extent unit="pages"><start>1339</start>
<end>1342</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Emerg Infect Dis</title>
</titleInfo>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>20</number>
</detail>
<extent unit="pages"><start>1339</start>
<end>1342</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0028"><titleInfo><title>Rooting the phylogenetic tree of MERS‐coronavirus by characterization of a conspecific virus from an African bat</title>
</titleInfo>
<name type="personal"><namePart type="given">VM</namePart>
<namePart type="family">Corman</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">NL</namePart>
<namePart type="family">Ithete</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">LR</namePart>
<namePart type="family">Richards</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Corman VM, Ithete NL, Richards LR, et al. Rooting the phylogenetic tree of MERS‐coronavirus by characterization of a conspecific virus from an African bat. J Virol 2014; 88: 11297–11303.</note>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>88</number>
</detail>
<extent unit="pages"><start>11297</start>
<end>11303</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>88</number>
</detail>
<extent unit="pages"><start>11297</start>
<end>11303</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0029"><titleInfo><title>Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study</title>
</titleInfo>
<name type="personal"><namePart type="given">CB</namePart>
<namePart type="family">Reusken</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">BL</namePart>
<namePart type="family">Haagmans</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MA</namePart>
<namePart type="family">Muller</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Reusken CB, Haagmans BL, Muller MA, et al. Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study. Lancet Infect Dis 2013; 13: 859–866.</note>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>13</number>
</detail>
<extent unit="pages"><start>859</start>
<end>866</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Lancet Infect Dis</title>
</titleInfo>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>13</number>
</detail>
<extent unit="pages"><start>859</start>
<end>866</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0030"><titleInfo><title>Antibodies against MERS coronavirus in dromedary camels, Kenya, 1992–2013</title>
</titleInfo>
<name type="personal"><namePart type="given">VM</namePart>
<namePart type="family">Corman</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Jores</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">B</namePart>
<namePart type="family">Meyer</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Corman VM, Jores J, Meyer B, et al. Antibodies against MERS coronavirus in dromedary camels, Kenya, 1992–2013. Emerg Infect Dis 2014; 20: 1319–1322.</note>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>20</number>
</detail>
<extent unit="pages"><start>1319</start>
<end>1322</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Emerg Infect Dis</title>
</titleInfo>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>20</number>
</detail>
<extent unit="pages"><start>1319</start>
<end>1322</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0031"><titleInfo><title>Aetiology: Koch's postulates fulfilled for SARS virus</title>
</titleInfo>
<name type="personal"><namePart type="given">RA</namePart>
<namePart type="family">Fouchier</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Kuiken</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Schutten</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Fouchier RA, Kuiken T, Schutten M, et al. Aetiology: Koch's postulates fulfilled for SARS virus. Nature 2003; 423: 240.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>423</number>
</detail>
<extent unit="pages"><start>240</start>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Nature</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>423</number>
</detail>
<extent unit="pages"><start>240</start>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0032"><titleInfo><title>Pegylated interferon‐α protects type 1 pneumocytes against SARS coronavirus infection in macaques</title>
</titleInfo>
<name type="personal"><namePart type="given">BL</namePart>
<namePart type="family">Haagmans</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Kuiken</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">BE</namePart>
<namePart type="family">Martina</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Haagmans BL, Kuiken T, Martina BE, et al. Pegylated interferon‐α protects type 1 pneumocytes against SARS coronavirus infection in macaques. Nat Med 2004; 10: 290–293.</note>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>10</number>
</detail>
<extent unit="pages"><start>290</start>
<end>293</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Nat Med</title>
</titleInfo>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>10</number>
</detail>
<extent unit="pages"><start>290</start>
<end>293</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0033"><titleInfo><title>Replication of SARS coronavirus administered into the respiratory tract of African green, rhesus and cynomolgus monkeys</title>
</titleInfo>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">McAuliffe</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">L</namePart>
<namePart type="family">Vogel</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Roberts</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">McAuliffe J, Vogel L, Roberts A, et al. Replication of SARS coronavirus administered into the respiratory tract of African green, rhesus and cynomolgus monkeys. Virology 2004; 330: 8–15.</note>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>330</number>
</detail>
<extent unit="pages"><start>8</start>
<end>15</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Virology</title>
</titleInfo>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>330</number>
</detail>
<extent unit="pages"><start>8</start>
<end>15</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0034"><titleInfo><title>Infection with MERS‐CoV causes lethal pneumonia in the common marmoset</title>
</titleInfo>
<name type="personal"><namePart type="given">D</namePart>
<namePart type="family">Falzarano</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">E</namePart>
<namePart type="family">de Wit</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">F</namePart>
<namePart type="family">Feldmann</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Falzarano D, de Wit E, Feldmann F, et al. Infection with MERS‐CoV causes lethal pneumonia in the common marmoset. PLoS Pathog 2014; 10: e1004250.</note>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>10</number>
</detail>
<extent unit="pages"><start>e1004250</start>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>PLoS Pathog</title>
</titleInfo>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>10</number>
</detail>
<extent unit="pages"><start>e1004250</start>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0035"><titleInfo><title>Middle East respiratory syndrome coronavirus (MERS‐CoV) causes transient lower respiratory tract infection in rhesus macaques</title>
</titleInfo>
<name type="personal"><namePart type="given">E</namePart>
<namePart type="family">de Wit</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">AL</namePart>
<namePart type="family">Rasmussen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">D</namePart>
<namePart type="family">Falzarano</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">de Wit E, Rasmussen AL, Falzarano D, et al. Middle East respiratory syndrome coronavirus (MERS‐CoV) causes transient lower respiratory tract infection in rhesus macaques. Proc Natl Acad Sci USA 2013; 110: 16598–16603.</note>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>110</number>
</detail>
<extent unit="pages"><start>16598</start>
<end>16603</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Proc Natl Acad Sci USA</title>
</titleInfo>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>110</number>
</detail>
<extent unit="pages"><start>16598</start>
<end>16603</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0036"><titleInfo><title>Prior infection and passive transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus in the respiratory tract of mice</title>
</titleInfo>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Subbarao</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">McAuliffe</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">L</namePart>
<namePart type="family">Vogel</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Subbarao K, McAuliffe J, Vogel L, et al. Prior infection and passive transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus in the respiratory tract of mice. J Virol 2004; 78: 3572–3577.</note>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>78</number>
</detail>
<extent unit="pages"><start>3572</start>
<end>3577</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>78</number>
</detail>
<extent unit="pages"><start>3572</start>
<end>3577</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0037"><titleInfo><title>Mechanisms of host defense following severe acute respiratory syndrome‐coronavirus (SARS‐CoV) pulmonary infection of mice</title>
</titleInfo>
<name type="personal"><namePart type="given">WG</namePart>
<namePart type="family">Glass</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Subbarao</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">B</namePart>
<namePart type="family">Murphy</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Glass WG, Subbarao K, Murphy B, et al. Mechanisms of host defense following severe acute respiratory syndrome‐coronavirus (SARS‐CoV) pulmonary infection of mice. J Immunol 2004; 173: 4030–4039.</note>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>173</number>
</detail>
<extent unit="pages"><start>4030</start>
<end>4039</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Immunol</title>
</titleInfo>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>173</number>
</detail>
<extent unit="pages"><start>4030</start>
<end>4039</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0038"><titleInfo><title>Mice susceptible to SARS coronavirus</title>
</titleInfo>
<name type="personal"><namePart type="given">DE</namePart>
<namePart type="family">Wentworth</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">L</namePart>
<namePart type="family">Gillim‐Ross</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">N</namePart>
<namePart type="family">Espina</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Wentworth DE, Gillim‐Ross L, Espina N, et al. Mice susceptible to SARS coronavirus. Emerg Infect Dis 2004; 10: 1293–1296.</note>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>10</number>
</detail>
<extent unit="pages"><start>1293</start>
<end>1296</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Emerg Infect Dis</title>
</titleInfo>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>10</number>
</detail>
<extent unit="pages"><start>1293</start>
<end>1296</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0039"><titleInfo><title>Aged BALB/c mice as a model for increased severity of severe acute respiratory syndrome in elderly humans</title>
</titleInfo>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Roberts</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Paddock</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">L</namePart>
<namePart type="family">Vogel</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Roberts A, Paddock C, Vogel L, et al. Aged BALB/c mice as a model for increased severity of severe acute respiratory syndrome in elderly humans. J Virol 2005; 79: 5833–5838.</note>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>79</number>
</detail>
<extent unit="pages"><start>5833</start>
<end>5838</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>79</number>
</detail>
<extent unit="pages"><start>5833</start>
<end>5838</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0040"><titleInfo><title>A mouse‐adapted SARS‐coronavirus causes disease and mortality in BALB/c mice</title>
</titleInfo>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Roberts</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">D</namePart>
<namePart type="family">Deming</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">CD</namePart>
<namePart type="family">Paddock</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Roberts A, Deming D, Paddock CD, et al. A mouse‐adapted SARS‐coronavirus causes disease and mortality in BALB/c mice. PLoS Pathog 2007; 3: e5.</note>
<part><date>2007</date>
<detail type="volume"><caption>vol.</caption>
<number>3</number>
</detail>
<extent unit="pages"><start>e5</start>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>PLoS Pathog</title>
</titleInfo>
<part><date>2007</date>
<detail type="volume"><caption>vol.</caption>
<number>3</number>
</detail>
<extent unit="pages"><start>e5</start>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0041"><titleInfo><title>Successful vaccination strategies that protect aged mice from lethal challenge from influenza virus and heterologous severe acute respiratory syndrome coronavirus</title>
</titleInfo>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Sheahan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Whitmore</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Long</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Sheahan T, Whitmore A, Long K, et al. Successful vaccination strategies that protect aged mice from lethal challenge from influenza virus and heterologous severe acute respiratory syndrome coronavirus. J Virol; 85: 217–230.</note>
<part><detail type="volume"><caption>vol.</caption>
<number>85</number>
</detail>
<extent unit="pages"><start>217</start>
<end>230</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><detail type="volume"><caption>vol.</caption>
<number>85</number>
</detail>
<extent unit="pages"><start>217</start>
<end>230</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0042"><titleInfo><title>Molecular determinants of severe acute respiratory syndrome coronavirus pathogenesis and virulence in young and aged mouse models of human disease</title>
</titleInfo>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Frieman</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">B</namePart>
<namePart type="family">Yount</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Agnihothram</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Frieman M, Yount B, Agnihothram S, et al. Molecular determinants of severe acute respiratory syndrome coronavirus pathogenesis and virulence in young and aged mouse models of human disease. J Virol 2012; 86: 884–897.</note>
<part><date>2012</date>
<detail type="volume"><caption>vol.</caption>
<number>86</number>
</detail>
<extent unit="pages"><start>884</start>
<end>897</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2012</date>
<detail type="volume"><caption>vol.</caption>
<number>86</number>
</detail>
<extent unit="pages"><start>884</start>
<end>897</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0043"><titleInfo><title>Mechanisms of severe acute respiratory syndrome coronavirus‐induced acute lung injury</title>
</titleInfo>
<name type="personal"><namePart type="given">LE</namePart>
<namePart type="family">Gralinski</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Bankhead 3rd</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Jeng</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Gralinski LE, Bankhead A, 3rd, Jeng S, et al. Mechanisms of severe acute respiratory syndrome coronavirus‐induced acute lung injury. mBio 2013; 4: e00271–13.</note>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>4</number>
</detail>
<extent unit="pages"><start>e00271</start>
<end>13</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>mBio</title>
</titleInfo>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>4</number>
</detail>
<extent unit="pages"><start>e00271</start>
<end>13</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0044"><titleInfo><title>Rapid generation of a mouse model for Middle East respiratory syndrome</title>
</titleInfo>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Zhao</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Li</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Wohlford‐Lenane</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Zhao J, Li K, Wohlford‐Lenane C, et al. Rapid generation of a mouse model for Middle East respiratory syndrome. Proc Natl Acad Sci USA; 111: 4970–4975.</note>
<part><detail type="volume"><caption>vol.</caption>
<number>111</number>
</detail>
<extent unit="pages"><start>4970</start>
<end>4975</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Proc Natl Acad Sci USA</title>
</titleInfo>
<part><detail type="volume"><caption>vol.</caption>
<number>111</number>
</detail>
<extent unit="pages"><start>4970</start>
<end>4975</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0045"><titleInfo><title>Danger, diversity and priming in innate antiviral immunity</title>
</titleInfo>
<name type="personal"><namePart type="given">SE</namePart>
<namePart type="family">Collins</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">KL</namePart>
<namePart type="family">Mossman</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Collins SE, Mossman KL. Danger, diversity and priming in innate antiviral immunity. Cytokine Growth Factor Rev 2014, In press.</note>
<part><date>2014</date>
</part>
<relatedItem type="host"><titleInfo><title>Cytokine Growth Factor Rev</title>
</titleInfo>
<part><date>2014</date>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0046"><titleInfo><title>Pathogenic and opportunistic respiratory bacteria‐induced apoptosis</title>
</titleInfo>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Lancellotti</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RF</namePart>
<namePart type="family">Pereira</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">GG</namePart>
<namePart type="family">Cury</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Lancellotti M, Pereira RF, Cury GG, et al. Pathogenic and opportunistic respiratory bacteria‐induced apoptosis. Braz J Infect Dis 2009; 13: 226–231.</note>
<part><date>2009</date>
<detail type="volume"><caption>vol.</caption>
<number>13</number>
</detail>
<extent unit="pages"><start>226</start>
<end>231</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Braz J Infect Dis</title>
</titleInfo>
<part><date>2009</date>
<detail type="volume"><caption>vol.</caption>
<number>13</number>
</detail>
<extent unit="pages"><start>226</start>
<end>231</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0047"><titleInfo><title>Inhibition of NF‐κB‐mediated inflammation in severe acute respiratory syndrome coronavirus‐infected mice increases survival</title>
</titleInfo>
<name type="personal"><namePart type="given">ML</namePart>
<namePart type="family">DeDiego</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JL</namePart>
<namePart type="family">Nieto‐Torres</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JA</namePart>
<namePart type="family">Regla‐Nava</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">DeDiego ML, Nieto‐Torres JL, Regla‐Nava JA, et al. Inhibition of NF‐κB‐mediated inflammation in severe acute respiratory syndrome coronavirus‐infected mice increases survival. J Virol 2014; 88: 913–924.</note>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>88</number>
</detail>
<extent unit="pages"><start>913</start>
<end>924</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>88</number>
</detail>
<extent unit="pages"><start>913</start>
<end>924</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0048"><titleInfo><title>SARS‐CoV papain‐like protease ubiquitin‐like domain and catalytic domain regulate antagonism of IRF3 and NF‐κB signaling</title>
</titleInfo>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Frieman</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Ratia</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RE</namePart>
<namePart type="family">Johnston</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Frieman M, Ratia K, Johnston RE, et al. SARS‐CoV papain‐like protease ubiquitin‐like domain and catalytic domain regulate antagonism of IRF3 and NF‐κB signaling. J Virol 2009; 83: 6689–6705.</note>
<part><date>2009</date>
<detail type="volume"><caption>vol.</caption>
<number>83</number>
</detail>
<extent unit="pages"><start>6689</start>
<end>6705</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2009</date>
<detail type="volume"><caption>vol.</caption>
<number>83</number>
</detail>
<extent unit="pages"><start>6689</start>
<end>6705</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0049"><titleInfo><title>Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress response and apoptosis</title>
</titleInfo>
<name type="personal"><namePart type="given">ML</namePart>
<namePart type="family">DeDiego</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JL</namePart>
<namePart type="family">Nieto‐Torres</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JM</namePart>
<namePart type="family">Jimenez‐Guardeno</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">DeDiego ML, Nieto‐Torres JL, Jimenez‐Guardeno JM, et al. Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress response and apoptosis. PLoS Pathog 2011; 7: e1002315.</note>
<part><date>2011</date>
<detail type="volume"><caption>vol.</caption>
<number>7</number>
</detail>
<extent unit="pages"><start>e1002315</start>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>PLoS Pathog</title>
</titleInfo>
<part><date>2011</date>
<detail type="volume"><caption>vol.</caption>
<number>7</number>
</detail>
<extent unit="pages"><start>e1002315</start>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0050"><titleInfo><title>Coronavirus virulence genes with main focus on SARS‐CoV envelope gene</title>
</titleInfo>
<name type="personal"><namePart type="given">ML</namePart>
<namePart type="family">DeDiego</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JL</namePart>
<namePart type="family">Nieto‐Torres</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JM</namePart>
<namePart type="family">Jimenez‐Guardeno</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">DeDiego ML, Nieto‐Torres JL, Jimenez‐Guardeno JM, et al. Coronavirus virulence genes with main focus on SARS‐CoV envelope gene. Virus Res 2014; doi: 10.1016/j.virusres.2014.07.024. (in press).</note>
<part><date>2014</date>
</part>
<relatedItem type="host"><titleInfo><title>Virus Res</title>
</titleInfo>
<part><date>2014</date>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0051"><titleInfo><title>A live attenuated severe acute respiratory syndrome coronavirus is immunogenic and efficacious in golden Syrian hamsters</title>
</titleInfo>
<name type="personal"><namePart type="given">EW</namePart>
<namePart type="family">Lamirande</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">ML</namePart>
<namePart type="family">DeDiego</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Roberts</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Lamirande EW, DeDiego ML, Roberts A, et al. A live attenuated severe acute respiratory syndrome coronavirus is immunogenic and efficacious in golden Syrian hamsters. J Virol 2008; 82: 7721–7724.</note>
<part><date>2008</date>
<detail type="volume"><caption>vol.</caption>
<number>82</number>
</detail>
<extent unit="pages"><start>7721</start>
<end>7724</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2008</date>
<detail type="volume"><caption>vol.</caption>
<number>82</number>
</detail>
<extent unit="pages"><start>7721</start>
<end>7724</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0052"><titleInfo><title>Complete protection against severe acute respiratory syndrome coronavirus‐mediated lethal respiratory disease in aged mice by immunization with a mouse‐adapted virus lacking E protein</title>
</titleInfo>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Fett</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">ML</namePart>
<namePart type="family">DeDiego</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JA</namePart>
<namePart type="family">Regla‐Nava</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Fett C, DeDiego ML, Regla‐Nava JA, et al. Complete protection against severe acute respiratory syndrome coronavirus‐mediated lethal respiratory disease in aged mice by immunization with a mouse‐adapted virus lacking E protein. J Virol 2013; 87: 6551–6559.</note>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>87</number>
</detail>
<extent unit="pages"><start>6551</start>
<end>6559</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>87</number>
</detail>
<extent unit="pages"><start>6551</start>
<end>6559</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0053"><titleInfo><title>Engineering a replication‐competent, propagation‐defective Middle East respiratory syndrome coronavirus as a vaccine candidate</title>
</titleInfo>
<name type="personal"><namePart type="given">F</namePart>
<namePart type="family">Almazan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">ML</namePart>
<namePart type="family">DeDiego</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">I</namePart>
<namePart type="family">Sola</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Almazan F, DeDiego ML, Sola I, et al. Engineering a replication‐competent, propagation‐defective Middle East respiratory syndrome coronavirus as a vaccine candidate. mBio 2013; 4: e00650–13.</note>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>4</number>
</detail>
<extent unit="pages"><start>e00650</start>
<end>13</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>mBio</title>
</titleInfo>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>4</number>
</detail>
<extent unit="pages"><start>e00650</start>
<end>13</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0054"><titleInfo><title>Treatment of SARS with human interferons</title>
</titleInfo>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Cinatl</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">B</namePart>
<namePart type="family">Morgenstern</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">G</namePart>
<namePart type="family">Bauer</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Cinatl J, Morgenstern B, Bauer G, et al. Treatment of SARS with human interferons. Lancet 2003; 362: 293–294.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>362</number>
</detail>
<extent unit="pages"><start>293</start>
<end>294</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Lancet</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>362</number>
</detail>
<extent unit="pages"><start>293</start>
<end>294</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0055"><titleInfo><title>Sensitivity of SARS/MERS CoV to interferons and other drugs based on achievable serum concentrations in humans</title>
</titleInfo>
<name type="personal"><namePart type="given">DR</namePart>
<namePart type="family">Strayer</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">R</namePart>
<namePart type="family">Dickey</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">WA</namePart>
<namePart type="family">Carter</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Strayer DR, Dickey R, Carter WA. Sensitivity of SARS/MERS CoV to interferons and other drugs based on achievable serum concentrations in humans. Infect Disord Drug Targets 2014; 14: 37–43.</note>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>14</number>
</detail>
<extent unit="pages"><start>37</start>
<end>43</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Infect Disord Drug Targets</title>
</titleInfo>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>14</number>
</detail>
<extent unit="pages"><start>37</start>
<end>43</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0056"><titleInfo><title>SARS‐CoV pathogenesis is regulated by a STAT1 dependent but a type I, II and III interferon receptor independent mechanism</title>
</titleInfo>
<name type="personal"><namePart type="given">MB</namePart>
<namePart type="family">Frieman</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Chen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">TE</namePart>
<namePart type="family">Morrison</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Frieman MB, Chen J, Morrison TE, et al. SARS‐CoV pathogenesis is regulated by a STAT1 dependent but a type I, II and III interferon receptor independent mechanism. PloS Pathog 2010; 6: e1000849.</note>
<part><date>2010</date>
<detail type="volume"><caption>vol.</caption>
<number>6</number>
</detail>
<extent unit="pages"><start>e1000849</start>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>PloS Pathog</title>
</titleInfo>
<part><date>2010</date>
<detail type="volume"><caption>vol.</caption>
<number>6</number>
</detail>
<extent unit="pages"><start>e1000849</start>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0057"><titleInfo><title>MyD88 is required for protection from lethal infection with a mouse‐adapted SARS‐CoV</title>
</titleInfo>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Sheahan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">TE</namePart>
<namePart type="family">Morrison</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">W</namePart>
<namePart type="family">Funkhouser</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Sheahan T, Morrison TE, Funkhouser W, et al. MyD88 is required for protection from lethal infection with a mouse‐adapted SARS‐CoV. PLoS Pathog 2008; 4: e1000240.</note>
<part><date>2008</date>
<detail type="volume"><caption>vol.</caption>
<number>4</number>
</detail>
<extent unit="pages"><start>e1000240</start>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>PLoS Pathog</title>
</titleInfo>
<part><date>2008</date>
<detail type="volume"><caption>vol.</caption>
<number>4</number>
</detail>
<extent unit="pages"><start>e1000240</start>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0058"><titleInfo><title>SARS coronavirus and innate immunity</title>
</titleInfo>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Frieman</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Heise</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">R</namePart>
<namePart type="family">Baric</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Frieman M, Heise M, Baric R. SARS coronavirus and innate immunity. Virus Res 2008; 133: 101–112.</note>
<part><date>2008</date>
<detail type="volume"><caption>vol.</caption>
<number>133</number>
</detail>
<extent unit="pages"><start>101</start>
<end>112</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Virus Res</title>
</titleInfo>
<part><date>2008</date>
<detail type="volume"><caption>vol.</caption>
<number>133</number>
</detail>
<extent unit="pages"><start>101</start>
<end>112</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0059"><titleInfo><title>Severe acute respiratory syndrome coronavirus open reading frame (ORF) 3b, ORF 6, and nucleocapsid proteins function as interferon antagonists</title>
</titleInfo>
<name type="personal"><namePart type="given">SA</namePart>
<namePart type="family">Kopecky‐Bromberg</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">L</namePart>
<namePart type="family">Martínez‐Sobrido</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Frieman</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Kopecky‐Bromberg SA, Martínez‐Sobrido L, Frieman M, et al. Severe acute respiratory syndrome coronavirus open reading frame (ORF) 3b, ORF 6, and nucleocapsid proteins function as interferon antagonists. J Virol 2007; 81: 548–557.</note>
<part><date>2007</date>
<detail type="volume"><caption>vol.</caption>
<number>81</number>
</detail>
<extent unit="pages"><start>548</start>
<end>557</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2007</date>
<detail type="volume"><caption>vol.</caption>
<number>81</number>
</detail>
<extent unit="pages"><start>548</start>
<end>557</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0060"><titleInfo><title>The structural and accessory proteins M, ORF 4a, ORF 4b, and ORF 5 of Middle East respiratory syndrome coronavirus (MERS‐CoV) are potent interferon antagonists</title>
</titleInfo>
<name type="personal"><namePart type="given">Y</namePart>
<namePart type="family">Yang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">L</namePart>
<namePart type="family">Zhang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Geng</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Yang Y, Zhang L, Geng H, et al. The structural and accessory proteins M, ORF 4a, ORF 4b, and ORF 5 of Middle East respiratory syndrome coronavirus (MERS‐CoV) are potent interferon antagonists. Protein Cell 2013; 4: 951–961.</note>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>4</number>
</detail>
<extent unit="pages"><start>951</start>
<end>961</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Protein Cell</title>
</titleInfo>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>4</number>
</detail>
<extent unit="pages"><start>951</start>
<end>961</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0061"><titleInfo><title>The ORF4b‐encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signalling</title>
</titleInfo>
<name type="personal"><namePart type="given">KL</namePart>
<namePart type="family">Matthews</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">CM</namePart>
<namePart type="family">Coleman</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Y</namePart>
<namePart type="family">van der Meer</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Matthews KL, Coleman CM, van der Meer Y, et al. The ORF4b‐encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signalling. J Gen Virol 2014; 95: 874–882.</note>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>95</number>
</detail>
<extent unit="pages"><start>874</start>
<end>882</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Gen Virol</title>
</titleInfo>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>95</number>
</detail>
<extent unit="pages"><start>874</start>
<end>882</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0062"><titleInfo><title>SARS coronavirus pathogenesis: host innate immune responses and viral antagonism of interferon</title>
</titleInfo>
<name type="personal"><namePart type="given">AL</namePart>
<namePart type="family">Totura</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RS</namePart>
<namePart type="family">Baric</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Totura AL, Baric RS. SARS coronavirus pathogenesis: host innate immune responses and viral antagonism of interferon. Curr Opin Virol 2012; 2: 264–275.</note>
<part><date>2012</date>
<detail type="volume"><caption>vol.</caption>
<number>2</number>
</detail>
<extent unit="pages"><start>264</start>
<end>275</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Curr Opin Virol</title>
</titleInfo>
<part><date>2012</date>
<detail type="volume"><caption>vol.</caption>
<number>2</number>
</detail>
<extent unit="pages"><start>264</start>
<end>275</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0063"><titleInfo><title>Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon‐stimulated gene responses</title>
</titleInfo>
<name type="personal"><namePart type="given">VD</namePart>
<namePart type="family">Menachery</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">AJ</namePart>
<namePart type="family">Eisfeld</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Schafer</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Menachery VD, Eisfeld AJ, Schafer A, et al. Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon‐stimulated gene responses. mBio 2014; 5: e01174–14.</note>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>5</number>
</detail>
<extent unit="pages"><start>e01174</start>
<end>14</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>mBio</title>
</titleInfo>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>5</number>
</detail>
<extent unit="pages"><start>e01174</start>
<end>14</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0064"><titleInfo><title>SARS‐coronavirus replication/transcription complexes are membrane‐protected and need a host factor for activity in vitro</title>
</titleInfo>
<name type="personal"><namePart type="given">MJ</namePart>
<namePart type="family">van Hemert</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">SH</namePart>
<namePart type="family">van den Worm</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Knoops</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">van Hemert MJ, van den Worm SH, Knoops K, et al. SARS‐coronavirus replication/transcription complexes are membrane‐protected and need a host factor for activity in vitro. PloS Pathog 2008; 4: e1000054.</note>
<part><date>2008</date>
<detail type="volume"><caption>vol.</caption>
<number>4</number>
</detail>
<extent unit="pages"><start>e1000054</start>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>PloS Pathog</title>
</titleInfo>
<part><date>2008</date>
<detail type="volume"><caption>vol.</caption>
<number>4</number>
</detail>
<extent unit="pages"><start>e1000054</start>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0065"><titleInfo><title>SARS‐coronavirus replication is supported by a reticulovesicular network of modified endoplasmic reticulum</title>
</titleInfo>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Knoops</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Kikkert</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">SH</namePart>
<namePart type="family">Worm</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Knoops K, Kikkert M, Worm SH, et al. SARS‐coronavirus replication is supported by a reticulovesicular network of modified endoplasmic reticulum. PLoS Biol 2008; 6: e226.</note>
<part><date>2008</date>
<detail type="volume"><caption>vol.</caption>
<number>6</number>
</detail>
<extent unit="pages"><start>e226</start>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>PLoS Biol</title>
</titleInfo>
<part><date>2008</date>
<detail type="volume"><caption>vol.</caption>
<number>6</number>
</detail>
<extent unit="pages"><start>e226</start>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0066"><titleInfo><title>Length‐dependent recognition of double‐stranded ribonucleic acids by retinoic acid‐inducible gene‐I and melanoma differentiation‐associated gene 5</title>
</titleInfo>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Kato</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">O</namePart>
<namePart type="family">Takeuchi</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">E</namePart>
<namePart type="family">Mikamo‐Satoh</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Kato H, Takeuchi O, Mikamo‐Satoh E, et al. Length‐dependent recognition of double‐stranded ribonucleic acids by retinoic acid‐inducible gene‐I and melanoma differentiation‐associated gene 5. J Exp Med 2008; 205: 1601–1610.</note>
<part><date>2008</date>
<detail type="volume"><caption>vol.</caption>
<number>205</number>
</detail>
<extent unit="pages"><start>1601</start>
<end>1610</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Exp Med</title>
</titleInfo>
<part><date>2008</date>
<detail type="volume"><caption>vol.</caption>
<number>205</number>
</detail>
<extent unit="pages"><start>1601</start>
<end>1610</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0067"><titleInfo><title>The broad‐spectrum antiviral functions of IFIT and IFITM proteins</title>
</titleInfo>
<name type="personal"><namePart type="given">MS</namePart>
<namePart type="family">Diamond</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Farzan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Diamond MS, Farzan M. The broad‐spectrum antiviral functions of IFIT and IFITM proteins. Nat Rev Immunol 2013; 13: 46–57.</note>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>13</number>
</detail>
<extent unit="pages"><start>46</start>
<end>57</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Nat Rev Immunol</title>
</titleInfo>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>13</number>
</detail>
<extent unit="pages"><start>46</start>
<end>57</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0068"><titleInfo><title>2'‐O methylation of the viral mRNA cap evades host restriction by IFIT family members</title>
</titleInfo>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Daffis</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">KJ</namePart>
<namePart type="family">Szretter</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Schriewer</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Daffis S, Szretter KJ, Schriewer J, et al. 2'‐O methylation of the viral mRNA cap evades host restriction by IFIT family members. Nature 2010; 468: 452–456.</note>
<part><date>2010</date>
<detail type="volume"><caption>vol.</caption>
<number>468</number>
</detail>
<extent unit="pages"><start>452</start>
<end>456</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Nature</title>
</titleInfo>
<part><date>2010</date>
<detail type="volume"><caption>vol.</caption>
<number>468</number>
</detail>
<extent unit="pages"><start>452</start>
<end>456</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0069"><titleInfo><title>Attenuation and restoration of severe acute respiratory syndrome coronavirus mutant lacking 2′‐O‐methyltransferase activity</title>
</titleInfo>
<name type="personal"><namePart type="given">VD</namePart>
<namePart type="family">Menachery</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">BL</namePart>
<namePart type="family">Yount Jr.</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">L</namePart>
<namePart type="family">Josset</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Menachery VD, Yount BL, Jr., Josset L, et al. Attenuation and restoration of severe acute respiratory syndrome coronavirus mutant lacking 2′‐O‐methyltransferase activity. J Virol 2014; 88: 4251–4264.</note>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>88</number>
</detail>
<extent unit="pages"><start>4251</start>
<end>4264</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>88</number>
</detail>
<extent unit="pages"><start>4251</start>
<end>4264</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0070"><titleInfo><title>SARS‐CoV virus–host interactions and comparative etiologies of acute respiratory distress syndrome as determined by transcriptional and cytokine profiling of formalin‐fixed paraffin‐embedded tissues</title>
</titleInfo>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Baas</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JK</namePart>
<namePart type="family">Taubenberger</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">PY</namePart>
<namePart type="family">Chong</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Baas T, Taubenberger JK, Chong PY, et al. SARS‐CoV virus–host interactions and comparative etiologies of acute respiratory distress syndrome as determined by transcriptional and cytokine profiling of formalin‐fixed paraffin‐embedded tissues. J Interferon Cytokine Res 2006; 26: 309–317.</note>
<part><date>2006</date>
<detail type="volume"><caption>vol.</caption>
<number>26</number>
</detail>
<extent unit="pages"><start>309</start>
<end>317</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Interferon Cytokine Res</title>
</titleInfo>
<part><date>2006</date>
<detail type="volume"><caption>vol.</caption>
<number>26</number>
</detail>
<extent unit="pages"><start>309</start>
<end>317</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0071"><titleInfo><title>Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane</title>
</titleInfo>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Frieman</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">B</namePart>
<namePart type="family">Yount</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Heise</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Frieman M, Yount B, Heise M, et al. Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane. J Virol 2007; 81: 9812–9824.</note>
<part><date>2007</date>
<detail type="volume"><caption>vol.</caption>
<number>81</number>
</detail>
<extent unit="pages"><start>9812</start>
<end>9824</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2007</date>
<detail type="volume"><caption>vol.</caption>
<number>81</number>
</detail>
<extent unit="pages"><start>9812</start>
<end>9824</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0072"><titleInfo><title>Severe acute respiratory syndrome coronavirus protein 6 is required for optimal replication</title>
</titleInfo>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Zhao</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Falcon</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Zhou</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Zhao J, Falcon A, Zhou H, et al. Severe acute respiratory syndrome coronavirus protein 6 is required for optimal replication. J Virol 2009; 83: 2368–2373.</note>
<part><date>2009</date>
<detail type="volume"><caption>vol.</caption>
<number>83</number>
</detail>
<extent unit="pages"><start>2368</start>
<end>2373</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2009</date>
<detail type="volume"><caption>vol.</caption>
<number>83</number>
</detail>
<extent unit="pages"><start>2368</start>
<end>2373</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0073"><titleInfo><title>MERS‐coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon‐α treatment</title>
</titleInfo>
<name type="personal"><namePart type="given">AH</namePart>
<namePart type="family">de Wilde</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">VS</namePart>
<namePart type="family">Raj</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">D</namePart>
<namePart type="family">Oudshoorn</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">de Wilde AH, Raj VS, Oudshoorn D, et al. MERS‐coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon‐α treatment. J Gen Virol 2013; 94: 1749–1760.</note>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>94</number>
</detail>
<extent unit="pages"><start>1749</start>
<end>1760</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Gen Virol</title>
</titleInfo>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>94</number>
</detail>
<extent unit="pages"><start>1749</start>
<end>1760</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0074"><titleInfo><title>Functional genomics highlights differential induction of antiviral pathways in the lungs of SARS‐CoV‐infected macaques</title>
</titleInfo>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">de Lang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Baas</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Teal</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">de Lang A, Baas T, Teal T, et al. Functional genomics highlights differential induction of antiviral pathways in the lungs of SARS‐CoV‐infected macaques. PLoS Pathog 2007; 3: e112.</note>
<part><date>2007</date>
<detail type="volume"><caption>vol.</caption>
<number>3</number>
</detail>
<extent unit="pages"><start>e112</start>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>PLoS Pathog</title>
</titleInfo>
<part><date>2007</date>
<detail type="volume"><caption>vol.</caption>
<number>3</number>
</detail>
<extent unit="pages"><start>e112</start>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0075"><titleInfo><title>Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK–STAT signaling pathway</title>
</titleInfo>
<name type="personal"><namePart type="given">MA</namePart>
<namePart type="family">Meraz</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JM</namePart>
<namePart type="family">White</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">KC</namePart>
<namePart type="family">Sheehan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Meraz MA, White JM, Sheehan KC, et al. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK–STAT signaling pathway. Cell 1996; 84: 431–442.</note>
<part><date>1996</date>
<detail type="volume"><caption>vol.</caption>
<number>84</number>
</detail>
<extent unit="pages"><start>431</start>
<end>442</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Cell</title>
</titleInfo>
<part><date>1996</date>
<detail type="volume"><caption>vol.</caption>
<number>84</number>
</detail>
<extent unit="pages"><start>431</start>
<end>442</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0076"><titleInfo><title>Resolution of primary severe acute respiratory syndrome‐associated coronavirus infection requires Stat1</title>
</titleInfo>
<name type="personal"><namePart type="given">RJ</namePart>
<namePart type="family">Hogan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">G</namePart>
<namePart type="family">Gao</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Rowe</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Hogan RJ, Gao G, Rowe T, et al. Resolution of primary severe acute respiratory syndrome‐associated coronavirus infection requires Stat1. J Virol 2004; 78: 11416–11421.</note>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>78</number>
</detail>
<extent unit="pages"><start>11416</start>
<end>11421</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>78</number>
</detail>
<extent unit="pages"><start>11416</start>
<end>11421</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0077"><titleInfo><title>Transcriptomic analysis reveals a mechanism for a prefibrotic phenotype in STAT1 knockout mice during severe acute respiratory syndrome coronavirus infection</title>
</titleInfo>
<name type="personal"><namePart type="given">GA</namePart>
<namePart type="family">Zornetzer</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MB</namePart>
<namePart type="family">Frieman</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">E</namePart>
<namePart type="family">Rosenzweig</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Zornetzer GA, Frieman MB, Rosenzweig E, et al. Transcriptomic analysis reveals a mechanism for a prefibrotic phenotype in STAT1 knockout mice during severe acute respiratory syndrome coronavirus infection. J Virol 2010; 84: 11297–11309.</note>
<part><date>2010</date>
<detail type="volume"><caption>vol.</caption>
<number>84</number>
</detail>
<extent unit="pages"><start>11297</start>
<end>11309</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2010</date>
<detail type="volume"><caption>vol.</caption>
<number>84</number>
</detail>
<extent unit="pages"><start>11297</start>
<end>11309</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0078"><titleInfo><title>Induction of alternatively activated macrophages enhances pathogenesis during severe acute respiratory syndrome coronavirus infection</title>
</titleInfo>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Page</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">L</namePart>
<namePart type="family">Goicochea</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Matthews</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Page C, Goicochea L, Matthews K, et al. Induction of alternatively activated macrophages enhances pathogenesis during severe acute respiratory syndrome coronavirus infection. J Virol 2012; 86: 13334–13349.</note>
<part><date>2012</date>
<detail type="volume"><caption>vol.</caption>
<number>86</number>
</detail>
<extent unit="pages"><start>13334</start>
<end>13349</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2012</date>
<detail type="volume"><caption>vol.</caption>
<number>86</number>
</detail>
<extent unit="pages"><start>13334</start>
<end>13349</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0079"><titleInfo><title>Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis</title>
</titleInfo>
<name type="personal"><namePart type="given">I</namePart>
<namePart type="family">Hamming</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">W</namePart>
<namePart type="family">Timens</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">ML</namePart>
<namePart type="family">Bulthuis</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Hamming I, Timens W, Bulthuis ML, et al. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol 2004; 203: 631–637.</note>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>203</number>
</detail>
<extent unit="pages"><start>631</start>
<end>637</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Pathol</title>
</titleInfo>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>203</number>
</detail>
<extent unit="pages"><start>631</start>
<end>637</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0080"><titleInfo><title>A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus‐induced lung injury</title>
</titleInfo>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Kuba</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Y</namePart>
<namePart type="family">Imai</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Rao</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Kuba K, Imai Y, Rao S, et al. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus‐induced lung injury. Nat Med 2005; 11: 875–879.</note>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>11</number>
</detail>
<extent unit="pages"><start>875</start>
<end>879</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Nat Med</title>
</titleInfo>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>11</number>
</detail>
<extent unit="pages"><start>875</start>
<end>879</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0081"><titleInfo><title>Replication‐dependent downregulation of cellular angiotensin‐converting enzyme 2 protein expression by human coronavirus NL63</title>
</titleInfo>
<name type="personal"><namePart type="given">R</namePart>
<namePart type="family">Dijkman</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MF</namePart>
<namePart type="family">Jebbink</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Deijs</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Dijkman R, Jebbink MF, Deijs M, et al. Replication‐dependent downregulation of cellular angiotensin‐converting enzyme 2 protein expression by human coronavirus NL63. J Gen Virol 2012; 93: 1924–1929.</note>
<part><date>2012</date>
<detail type="volume"><caption>vol.</caption>
<number>93</number>
</detail>
<extent unit="pages"><start>1924</start>
<end>1929</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Gen Virol</title>
</titleInfo>
<part><date>2012</date>
<detail type="volume"><caption>vol.</caption>
<number>93</number>
</detail>
<extent unit="pages"><start>1924</start>
<end>1929</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0082"><titleInfo><title>Angiotensin‐converting enzyme 2 protects from severe acute lung failure</title>
</titleInfo>
<name type="personal"><namePart type="given">Y</namePart>
<namePart type="family">Imai</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Kuba</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Rao</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Imai Y, Kuba K, Rao S, et al. Angiotensin‐converting enzyme 2 protects from severe acute lung failure. Nature 2005; 436: 112–116.</note>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>436</number>
</detail>
<extent unit="pages"><start>112</start>
<end>116</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Nature</title>
</titleInfo>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>436</number>
</detail>
<extent unit="pages"><start>112</start>
<end>116</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0083"><titleInfo><title>Membrane‐associated zinc peptidase families: comparing ACE and ACE2</title>
</titleInfo>
<name type="personal"><namePart type="given">JL</namePart>
<namePart type="family">Guy</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">DW</namePart>
<namePart type="family">Lambert</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">FJ</namePart>
<namePart type="family">Warner</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Guy JL, Lambert DW, Warner FJ, et al. Membrane‐associated zinc peptidase families: comparing ACE and ACE2. Biochim Biophys Acta 2005; 1751: 2–8.</note>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>1751</number>
</detail>
<extent unit="pages"><start>2</start>
<end>8</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Biochim Biophys Acta</title>
</titleInfo>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>1751</number>
</detail>
<extent unit="pages"><start>2</start>
<end>8</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0084"><titleInfo><title>Angiotensin‐converting enzyme 2 in lung diseases</title>
</titleInfo>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Kuba</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Y</namePart>
<namePart type="family">Imai</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JM</namePart>
<namePart type="family">Penninger</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Kuba K, Imai Y, Penninger JM. Angiotensin‐converting enzyme 2 in lung diseases. Curr Opin Pharmacol 2006; 6: 271–276.</note>
<part><date>2006</date>
<detail type="volume"><caption>vol.</caption>
<number>6</number>
</detail>
<extent unit="pages"><start>271</start>
<end>276</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Curr Opin Pharmacol</title>
</titleInfo>
<part><date>2006</date>
<detail type="volume"><caption>vol.</caption>
<number>6</number>
</detail>
<extent unit="pages"><start>271</start>
<end>276</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0085"><titleInfo><title>Systemic inhibition of the angiotensin‐converting enzyme limits lipopolysaccharide‐induced lung neutrophil recruitment through both bradykinin and angiotensin II‐regulated pathways</title>
</titleInfo>
<name type="personal"><namePart type="given">PG</namePart>
<namePart type="family">Arndt</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">SK</namePart>
<namePart type="family">Young</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">KR</namePart>
<namePart type="family">Poch</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Arndt PG, Young SK, Poch KR, et al. Systemic inhibition of the angiotensin‐converting enzyme limits lipopolysaccharide‐induced lung neutrophil recruitment through both bradykinin and angiotensin II‐regulated pathways. J Immunol 2006; 177: 7233–7241.</note>
<part><date>2006</date>
<detail type="volume"><caption>vol.</caption>
<number>177</number>
</detail>
<extent unit="pages"><start>7233</start>
<end>7241</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Immunol</title>
</titleInfo>
<part><date>2006</date>
<detail type="volume"><caption>vol.</caption>
<number>177</number>
</detail>
<extent unit="pages"><start>7233</start>
<end>7241</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0086"><titleInfo><title>Genetic epidemiology of acute respiratory distress syndrome: implications for future prevention and treatment</title>
</titleInfo>
<name type="personal"><namePart type="given">MN</namePart>
<namePart type="family">Gong</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Gong MN. Genetic epidemiology of acute respiratory distress syndrome: implications for future prevention and treatment. Clin Chest Med 2006; 27: 705–724.</note>
<part><date>2006</date>
<detail type="volume"><caption>vol.</caption>
<number>27</number>
</detail>
<extent unit="pages"><start>705</start>
<end>724</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Clin Chest Med</title>
</titleInfo>
<part><date>2006</date>
<detail type="volume"><caption>vol.</caption>
<number>27</number>
</detail>
<extent unit="pages"><start>705</start>
<end>724</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0087"><titleInfo><title>Bacteria‐specific neutrophil dysfunction associated with interferon‐stimulated gene expression in the acute respiratory distress syndrome</title>
</titleInfo>
<name type="personal"><namePart type="given">KC</namePart>
<namePart type="family">Malcolm</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JE</namePart>
<namePart type="family">Kret</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RL</namePart>
<namePart type="family">Young</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Malcolm KC, Kret JE, Young RL, et al. Bacteria‐specific neutrophil dysfunction associated with interferon‐stimulated gene expression in the acute respiratory distress syndrome. PLoS One 2011; 6: e21958.</note>
<part><date>2011</date>
<detail type="volume"><caption>vol.</caption>
<number>6</number>
</detail>
<extent unit="pages"><start>e21958</start>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>PLoS One</title>
</titleInfo>
<part><date>2011</date>
<detail type="volume"><caption>vol.</caption>
<number>6</number>
</detail>
<extent unit="pages"><start>e21958</start>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0088"><titleInfo><title>Interferon‐mediated immunopathological events are associated with atypical innate and adaptive immune responses in patients with severe acute respiratory syndrome</title>
</titleInfo>
<name type="personal"><namePart type="given">MJ</namePart>
<namePart type="family">Cameron</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">L</namePart>
<namePart type="family">Ran</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">L</namePart>
<namePart type="family">Xu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Cameron MJ, Ran L, Xu L, et al. Interferon‐mediated immunopathological events are associated with atypical innate and adaptive immune responses in patients with severe acute respiratory syndrome. J Virol 2007; 81: 8692–8706.</note>
<part><date>2007</date>
<detail type="volume"><caption>vol.</caption>
<number>81</number>
</detail>
<extent unit="pages"><start>8692</start>
<end>8706</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2007</date>
<detail type="volume"><caption>vol.</caption>
<number>81</number>
</detail>
<extent unit="pages"><start>8692</start>
<end>8706</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0089"><titleInfo><title>Verma GP. Fundamentals of Histology. New Age International Pvt Ltd Publishers: New Delhi, India; 2001.</title>
</titleInfo>
<note type="citation/reference">Verma GP. Fundamentals of Histology. New Age International Pvt Ltd Publishers: New Delhi, India; 2001.</note>
<name type="personal"><namePart type="given">GP</namePart>
<namePart type="family">Verma</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>book</genre>
<originInfo><publisher>New Age International Pvt Ltd Publishers</publisher>
<place><placeTerm type="text">New Delhi, India</placeTerm>
</place>
</originInfo>
<part><date>2001</date>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0090"><titleInfo><title>Alveolar epithelial type II cell: defender of the alveolus revisited</title>
</titleInfo>
<name type="personal"><namePart type="given">H.</namePart>
<namePart type="family">Fehrenbach</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Fehrenbach H. Alveolar epithelial type II cell: defender of the alveolus revisited. Respir Res 2001; 2: 33–46.</note>
<part><date>2001</date>
<detail type="volume"><caption>vol.</caption>
<number>2</number>
</detail>
<extent unit="pages"><start>33</start>
<end>46</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Respir Res</title>
</titleInfo>
<part><date>2001</date>
<detail type="volume"><caption>vol.</caption>
<number>2</number>
</detail>
<extent unit="pages"><start>33</start>
<end>46</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0091"><titleInfo><title>Evasion by stealth. inefficient immune activation underlies poor T cell response and severe disease in SARS‐CoV infected mice</title>
</titleInfo>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Zhao</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Zhao</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">N</namePart>
<namePart type="family">Van Rooijen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Zhao J, Zhao J, Van Rooijen N, et al. Evasion by stealth. inefficient immune activation underlies poor T cell response and severe disease in SARS‐CoV infected mice. PloS Pathog 2009; 5: e1000636.</note>
<part><date>2009</date>
<detail type="volume"><caption>vol.</caption>
<number>5</number>
</detail>
<extent unit="pages"><start>e1000636</start>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>PloS Pathog</title>
</titleInfo>
<part><date>2009</date>
<detail type="volume"><caption>vol.</caption>
<number>5</number>
</detail>
<extent unit="pages"><start>e1000636</start>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0092"><titleInfo><title>Coagulation cascade proteinases in lung injury and fibrosis</title>
</titleInfo>
<name type="personal"><namePart type="given">RC</namePart>
<namePart type="family">Chambers</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">CJ</namePart>
<namePart type="family">Scotton</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Chambers RC, Scotton CJ. Coagulation cascade proteinases in lung injury and fibrosis. Proc Am Thorac Soc 2012; 9: 96–101.</note>
<part><date>2012</date>
<detail type="volume"><caption>vol.</caption>
<number>9</number>
</detail>
<extent unit="pages"><start>96</start>
<end>101</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Proc Am Thorac Soc</title>
</titleInfo>
<part><date>2012</date>
<detail type="volume"><caption>vol.</caption>
<number>9</number>
</detail>
<extent unit="pages"><start>96</start>
<end>101</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0093"><titleInfo><title>Tissue and cellular tropism of the coronavirus associated with severe acute respiratory syndrome: an in‐situ hybridization study of fatal cases</title>
</titleInfo>
<name type="personal"><namePart type="given">KF</namePart>
<namePart type="family">To</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JH</namePart>
<namePart type="family">Tong</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">PK</namePart>
<namePart type="family">Chan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">To KF, Tong JH, Chan PK, et al. Tissue and cellular tropism of the coronavirus associated with severe acute respiratory syndrome: an in‐situ hybridization study of fatal cases. J Pathol 2004; 202: 157–163.</note>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>202</number>
</detail>
<extent unit="pages"><start>157</start>
<end>163</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Pathol</title>
</titleInfo>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>202</number>
</detail>
<extent unit="pages"><start>157</start>
<end>163</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0094"><titleInfo><title>Influenza A viruses target type II pneumocytes in the human lung</title>
</titleInfo>
<name type="personal"><namePart type="given">VK</namePart>
<namePart type="family">Weinheimer</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Becher</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Tonnies</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Weinheimer VK, Becher A, Tonnies M, et al. Influenza A viruses target type II pneumocytes in the human lung. J Infect Dis 2012; 206: 1685–1694.</note>
<part><date>2012</date>
<detail type="volume"><caption>vol.</caption>
<number>206</number>
</detail>
<extent unit="pages"><start>1685</start>
<end>1694</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Infect Dis</title>
</titleInfo>
<part><date>2012</date>
<detail type="volume"><caption>vol.</caption>
<number>206</number>
</detail>
<extent unit="pages"><start>1685</start>
<end>1694</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0095"><titleInfo><title>Surfactant alteration and replacement in acute respiratory distress syndrome</title>
</titleInfo>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Gunther</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Ruppert</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">R</namePart>
<namePart type="family">Schmidt</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Gunther A, Ruppert C, Schmidt R, et al. Surfactant alteration and replacement in acute respiratory distress syndrome. Respir Res 2001; 2: 353–364.</note>
<part><date>2001</date>
<detail type="volume"><caption>vol.</caption>
<number>2</number>
</detail>
<extent unit="pages"><start>353</start>
<end>364</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Respir Res</title>
</titleInfo>
<part><date>2001</date>
<detail type="volume"><caption>vol.</caption>
<number>2</number>
</detail>
<extent unit="pages"><start>353</start>
<end>364</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0096"><titleInfo><title>Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome</title>
</titleInfo>
<name type="personal"><namePart type="given">CK</namePart>
<namePart type="family">Wong</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">CW</namePart>
<namePart type="family">Lam</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">AK</namePart>
<namePart type="family">Wu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Wong CK, Lam CW, Wu AK, et al. Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome. Clin Exp Immunol 2004; 136: 95–103.</note>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>136</number>
</detail>
<extent unit="pages"><start>95</start>
<end>103</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Clin Exp Immunol</title>
</titleInfo>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>136</number>
</detail>
<extent unit="pages"><start>95</start>
<end>103</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0097"><titleInfo><title>Inflammatory cytokine profile in children with severe acute respiratory syndrome</title>
</titleInfo>
<name type="personal"><namePart type="given">PC</namePart>
<namePart type="family">Ng</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">CW</namePart>
<namePart type="family">Lam</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">AM</namePart>
<namePart type="family">Li</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Ng PC, Lam CW, Li AM, et al. Inflammatory cytokine profile in children with severe acute respiratory syndrome. Pediatrics 2004; 113: e7–14.</note>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>113</number>
</detail>
<extent unit="pages"><start>e7</start>
<end>14</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Pediatrics</title>
</titleInfo>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>113</number>
</detail>
<extent unit="pages"><start>e7</start>
<end>14</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0098"><titleInfo><title>The spectrum of pathological changes in severe acute respiratory syndrome (SARS)</title>
</titleInfo>
<name type="personal"><namePart type="given">OY</namePart>
<namePart type="family">Cheung</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JW</namePart>
<namePart type="family">Chan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">CK</namePart>
<namePart type="family">Ng</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Cheung OY, Chan JW, Ng CK, et al. The spectrum of pathological changes in severe acute respiratory syndrome (SARS). Histopathology 2004; 45: 119–124.</note>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>45</number>
</detail>
<extent unit="pages"><start>119</start>
<end>124</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Histopathology</title>
</titleInfo>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>45</number>
</detail>
<extent unit="pages"><start>119</start>
<end>124</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0099"><titleInfo><title>Clinical features and short‐term outcomes of 144 patients with SARS in the greater Toronto area</title>
</titleInfo>
<name type="personal"><namePart type="given">CM</namePart>
<namePart type="family">Booth</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">LM</namePart>
<namePart type="family">Matukas</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">GA</namePart>
<namePart type="family">Tomlinson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Booth CM, Matukas LM, Tomlinson GA, et al. Clinical features and short‐term outcomes of 144 patients with SARS in the greater Toronto area. J Am Med Assoc 2003; 289: 2801–2809.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>289</number>
</detail>
<extent unit="pages"><start>2801</start>
<end>2809</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Am Med Assoc</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>289</number>
</detail>
<extent unit="pages"><start>2801</start>
<end>2809</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0100"><titleInfo><title>Nonhuman primate models for SARS</title>
</titleInfo>
<name type="personal"><namePart type="given">BL</namePart>
<namePart type="family">Haagmans</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">AD</namePart>
<namePart type="family">Osterhaus</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Haagmans BL, Osterhaus AD. Nonhuman primate models for SARS. PLoS Med 2006; 3: e194.</note>
<part><date>2006</date>
<detail type="volume"><caption>vol.</caption>
<number>3</number>
</detail>
<extent unit="pages"><start>e194</start>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>PLoS Med</title>
</titleInfo>
<part><date>2006</date>
<detail type="volume"><caption>vol.</caption>
<number>3</number>
</detail>
<extent unit="pages"><start>e194</start>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0101"><titleInfo><title>Current view on alveolar coagulation and fibrinolysis in acute inflammatory and chronic interstitial lung diseases</title>
</titleInfo>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Wygrecka</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">E</namePart>
<namePart type="family">Jablonska</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Guenther</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Wygrecka M, Jablonska E, Guenther A, et al. Current view on alveolar coagulation and fibrinolysis in acute inflammatory and chronic interstitial lung diseases. Thromb Haemost 2008; 99: 494–501.</note>
<part><date>2008</date>
<detail type="volume"><caption>vol.</caption>
<number>99</number>
</detail>
<extent unit="pages"><start>494</start>
<end>501</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Thromb Haemost</title>
</titleInfo>
<part><date>2008</date>
<detail type="volume"><caption>vol.</caption>
<number>99</number>
</detail>
<extent unit="pages"><start>494</start>
<end>501</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0102"><titleInfo><title>Distinct severe acute respiratory syndrome coronavirus‐induced acute lung injury pathways in two different nonhuman primate species</title>
</titleInfo>
<name type="personal"><namePart type="given">SL</namePart>
<namePart type="family">Smits</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JM</namePart>
<namePart type="family">van den Brand</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">de Lang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Smits SL, van den Brand JM, de Lang A, et al. Distinct severe acute respiratory syndrome coronavirus‐induced acute lung injury pathways in two different nonhuman primate species. J Virol; 85: 4234–4245.</note>
<part><detail type="volume"><caption>vol.</caption>
<number>85</number>
</detail>
<extent unit="pages"><start>4234</start>
<end>4245</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><detail type="volume"><caption>vol.</caption>
<number>85</number>
</detail>
<extent unit="pages"><start>4234</start>
<end>4245</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0103"><titleInfo><title>Review article: coagulation cascade and therapeutics update: relevance to nephrology. Part 1: Overview of coagulation, thrombophilias and history of anticoagulants</title>
</titleInfo>
<name type="personal"><namePart type="given">RL</namePart>
<namePart type="family">Adams</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RJ</namePart>
<namePart type="family">Bird</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Adams RL, Bird RJ. Review article: coagulation cascade and therapeutics update: relevance to nephrology. Part 1: Overview of coagulation, thrombophilias and history of anticoagulants. Nephrology (Carlton) 2009; 14: 462–470.</note>
<part><date>2009</date>
<detail type="volume"><caption>vol.</caption>
<number>14</number>
</detail>
<extent unit="pages"><start>462</start>
<end>470</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Nephrology (Carlton)</title>
</titleInfo>
<part><date>2009</date>
<detail type="volume"><caption>vol.</caption>
<number>14</number>
</detail>
<extent unit="pages"><start>462</start>
<end>470</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0104"><titleInfo><title>Molecular mechanisms of fibrinolysis</title>
</titleInfo>
<name type="personal"><namePart type="given">G</namePart>
<namePart type="family">Cesarman‐Maus</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">KA</namePart>
<namePart type="family">Hajjar</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Cesarman‐Maus G, Hajjar KA. Molecular mechanisms of fibrinolysis. Br J Haematol 2005; 129: 307–321.</note>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>129</number>
</detail>
<extent unit="pages"><start>307</start>
<end>321</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Br J Haematol</title>
</titleInfo>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>129</number>
</detail>
<extent unit="pages"><start>307</start>
<end>321</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0105"><titleInfo><title>Severe acute respiratory syndrome‐associated coronavirus nucleocapsid protein interacts with Smad3 and modulates transforming growth factor‐β signaling</title>
</titleInfo>
<name type="personal"><namePart type="given">X</namePart>
<namePart type="family">Zhao</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JM</namePart>
<namePart type="family">Nicholls</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">YG</namePart>
<namePart type="family">Chen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Zhao X, Nicholls JM, Chen YG. Severe acute respiratory syndrome‐associated coronavirus nucleocapsid protein interacts with Smad3 and modulates transforming growth factor‐β signaling. J Biol Chem 2008; 283: 3272–3280.</note>
<part><date>2008</date>
<detail type="volume"><caption>vol.</caption>
<number>283</number>
</detail>
<extent unit="pages"><start>3272</start>
<end>3280</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Biol Chem</title>
</titleInfo>
<part><date>2008</date>
<detail type="volume"><caption>vol.</caption>
<number>283</number>
</detail>
<extent unit="pages"><start>3272</start>
<end>3280</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0106"><titleInfo><title>Compartment‐ and cell‐specific expression of coagulation and fibrinolysis factors in the murine lung undergoing inhalational versus intravenous endotoxin application</title>
</titleInfo>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Wygrecka</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">P</namePart>
<namePart type="family">Markart</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Ruppert</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Wygrecka M, Markart P, Ruppert C, et al. Compartment‐ and cell‐specific expression of coagulation and fibrinolysis factors in the murine lung undergoing inhalational versus intravenous endotoxin application. Thromb Haemost 2004; 92: 529–540.</note>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>92</number>
</detail>
<extent unit="pages"><start>529</start>
<end>540</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Thromb Haemost</title>
</titleInfo>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>92</number>
</detail>
<extent unit="pages"><start>529</start>
<end>540</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0107"><titleInfo><title>Suppression of plasminogen activator inhibitor‐1 by RNA interference attenuates pulmonary fibrosis</title>
</titleInfo>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Senoo</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">N</namePart>
<namePart type="family">Hattori</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Tanimoto</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Senoo T, Hattori N, Tanimoto T, et al. Suppression of plasminogen activator inhibitor‐1 by RNA interference attenuates pulmonary fibrosis. Thorax 2010; 65: 334–340.</note>
<part><date>2010</date>
<detail type="volume"><caption>vol.</caption>
<number>65</number>
</detail>
<extent unit="pages"><start>334</start>
<end>340</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Thorax</title>
</titleInfo>
<part><date>2010</date>
<detail type="volume"><caption>vol.</caption>
<number>65</number>
</detail>
<extent unit="pages"><start>334</start>
<end>340</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0108"><titleInfo><title>Severe acute respiratory syndrome: report of treatment and outcome after a major outbreak</title>
</titleInfo>
<name type="personal"><namePart type="given">JJ</namePart>
<namePart type="family">Sung</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Wu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">GM</namePart>
<namePart type="family">Joynt</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Sung JJ, Wu A, Joynt GM, et al. Severe acute respiratory syndrome: report of treatment and outcome after a major outbreak. Thorax 2004; 59: 414–420.</note>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>59</number>
</detail>
<extent unit="pages"><start>414</start>
<end>420</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Thorax</title>
</titleInfo>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>59</number>
</detail>
<extent unit="pages"><start>414</start>
<end>420</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0109"><titleInfo><title>Clinical features and viral diagnosis of two cases of infection with Middle East respiratory syndrome coronavirus: a report of nosocomial transmission</title>
</titleInfo>
<name type="personal"><namePart type="given">B</namePart>
<namePart type="family">Guery</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Poissy</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">L</namePart>
<namePart type="family">el Mansouf</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Guery B, Poissy J, el Mansouf L, et al. Clinical features and viral diagnosis of two cases of infection with Middle East respiratory syndrome coronavirus: a report of nosocomial transmission. Lancet 2013; 381: 2265–2272.</note>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>381</number>
</detail>
<extent unit="pages"><start>2265</start>
<end>2272</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Lancet</title>
</titleInfo>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>381</number>
</detail>
<extent unit="pages"><start>2265</start>
<end>2272</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0110"><titleInfo><title>Does unrestrained single‐chamber plethysmography provide a valid assessment of airway responsiveness in allergic BALB/c mice?</title>
</titleInfo>
<name type="personal"><namePart type="given">Q</namePart>
<namePart type="family">Zhang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Lai</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Xie</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Zhang Q, Lai K, Xie J, et al. Does unrestrained single‐chamber plethysmography provide a valid assessment of airway responsiveness in allergic BALB/c mice? Respir Res 2009; 10: 61.</note>
<part><date>2009</date>
<detail type="volume"><caption>vol.</caption>
<number>10</number>
</detail>
<extent unit="pages"><start>61</start>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Respir Res</title>
</titleInfo>
<part><date>2009</date>
<detail type="volume"><caption>vol.</caption>
<number>10</number>
</detail>
<extent unit="pages"><start>61</start>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0111"><titleInfo><title>Body plethysmography – its principles and clinical use</title>
</titleInfo>
<name type="personal"><namePart type="given">CP</namePart>
<namePart type="family">Criee</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Sorichter</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">HJ</namePart>
<namePart type="family">Smith</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Criee CP, Sorichter S, Smith HJ, et al. Body plethysmography – its principles and clinical use. Respir Med 2011; 105: 959–971.</note>
<part><date>2011</date>
<detail type="volume"><caption>vol.</caption>
<number>105</number>
</detail>
<extent unit="pages"><start>959</start>
<end>971</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Respir Med</title>
</titleInfo>
<part><date>2011</date>
<detail type="volume"><caption>vol.</caption>
<number>105</number>
</detail>
<extent unit="pages"><start>959</start>
<end>971</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0112"><titleInfo><title>ARDS Network (NHLBI) studies: successes and challenges in ARDS clinical research</title>
</titleInfo>
<name type="personal"><namePart type="given">BT</namePart>
<namePart type="family">Thompson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">GR</namePart>
<namePart type="family">Bernard</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Thompson BT, Bernard GR. ARDS Network (NHLBI) studies: successes and challenges in ARDS clinical research. Crit Care Clin 2011; 27: 459–468.</note>
<part><date>2011</date>
<detail type="volume"><caption>vol.</caption>
<number>27</number>
</detail>
<extent unit="pages"><start>459</start>
<end>468</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Crit Care Clin</title>
</titleInfo>
<part><date>2011</date>
<detail type="volume"><caption>vol.</caption>
<number>27</number>
</detail>
<extent unit="pages"><start>459</start>
<end>468</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0113"><titleInfo><title>Human and bovine coronaviruses recognize sialic acid‐containing receptors similar to those of influenza C viruses</title>
</titleInfo>
<name type="personal"><namePart type="given">R</namePart>
<namePart type="family">Vlasak</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">W</namePart>
<namePart type="family">Luytjes</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">W</namePart>
<namePart type="family">Spaan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Vlasak R, Luytjes W, Spaan W, et al. Human and bovine coronaviruses recognize sialic acid‐containing receptors similar to those of influenza C viruses. Proc Natl Acad Sci USA 1988; 85: 4526–4529.</note>
<part><date>1988</date>
<detail type="volume"><caption>vol.</caption>
<number>85</number>
</detail>
<extent unit="pages"><start>4526</start>
<end>4529</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Proc Natl Acad Sci USA</title>
</titleInfo>
<part><date>1988</date>
<detail type="volume"><caption>vol.</caption>
<number>85</number>
</detail>
<extent unit="pages"><start>4526</start>
<end>4529</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0114"><titleInfo><title>HLA class I antigen serves as a receptor for human coronavirus OC43</title>
</titleInfo>
<name type="personal"><namePart type="given">AR</namePart>
<namePart type="family">Collins</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Collins AR. HLA class I antigen serves as a receptor for human coronavirus OC43. Immunol Invest 1993; 22: 95–103.</note>
<part><date>1993</date>
<detail type="volume"><caption>vol.</caption>
<number>22</number>
</detail>
<extent unit="pages"><start>95</start>
<end>103</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Immunol Invest</title>
</titleInfo>
<part><date>1993</date>
<detail type="volume"><caption>vol.</caption>
<number>22</number>
</detail>
<extent unit="pages"><start>95</start>
<end>103</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0115"><titleInfo><title>Complete genomic sequence of human coronavirus OC43: molecular clock analysis suggests a relatively recent zoonotic coronavirus transmission event</title>
</titleInfo>
<name type="personal"><namePart type="given">L</namePart>
<namePart type="family">Vijgen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">E</namePart>
<namePart type="family">Keyaerts</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">E</namePart>
<namePart type="family">Moes</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Vijgen L, Keyaerts E, Moes E, et al. Complete genomic sequence of human coronavirus OC43: molecular clock analysis suggests a relatively recent zoonotic coronavirus transmission event. J Virol 2005; 79: 1595–1604.</note>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>79</number>
</detail>
<extent unit="pages"><start>1595</start>
<end>1604</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>79</number>
</detail>
<extent unit="pages"><start>1595</start>
<end>1604</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0116"><titleInfo><title>Isolation and characterization of current human coronavirus strains in primary human epithelial cell cultures reveal differences in target cell tropism</title>
</titleInfo>
<name type="personal"><namePart type="given">R</namePart>
<namePart type="family">Dijkman</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MF</namePart>
<namePart type="family">Jebbink</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">SM</namePart>
<namePart type="family">Koekkoek</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Dijkman R, Jebbink MF, Koekkoek SM, et al. Isolation and characterization of current human coronavirus strains in primary human epithelial cell cultures reveal differences in target cell tropism. J Virol 2013; 87: 6081–6090.</note>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>87</number>
</detail>
<extent unit="pages"><start>6081</start>
<end>6090</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>87</number>
</detail>
<extent unit="pages"><start>6081</start>
<end>6090</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0117"><titleInfo><title>Human macrophages are susceptible to coronavirus OC43</title>
</titleInfo>
<name type="personal"><namePart type="given">AR</namePart>
<namePart type="family">Collins</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Collins AR. Human macrophages are susceptible to coronavirus OC43. Adv Exp Med Biol 1998; 440: 635–639.</note>
<part><date>1998</date>
<detail type="volume"><caption>vol.</caption>
<number>440</number>
</detail>
<extent unit="pages"><start>635</start>
<end>639</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Adv Exp Med Biol</title>
</titleInfo>
<part><date>1998</date>
<detail type="volume"><caption>vol.</caption>
<number>440</number>
</detail>
<extent unit="pages"><start>635</start>
<end>639</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0118"><titleInfo><title>Infection of primary cultures of human neural cells by human coronaviruses 229E and OC43</title>
</titleInfo>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Bonavia</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">N</namePart>
<namePart type="family">Arbour</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">VW</namePart>
<namePart type="family">Yong</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Bonavia A, Arbour N, Yong VW, et al. Infection of primary cultures of human neural cells by human coronaviruses 229E and OC43. J Virol 1997; 71: 800–806.</note>
<part><date>1997</date>
<detail type="volume"><caption>vol.</caption>
<number>71</number>
</detail>
<extent unit="pages"><start>800</start>
<end>806</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>1997</date>
<detail type="volume"><caption>vol.</caption>
<number>71</number>
</detail>
<extent unit="pages"><start>800</start>
<end>806</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0119"><titleInfo><title>An outbreak of coronavirus OC43 respiratory infection in Normandy, France</title>
</titleInfo>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Vabret</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Mourez</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Gouarin</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Vabret A, Mourez T, Gouarin S, et al. An outbreak of coronavirus OC43 respiratory infection in Normandy, France. Clin Infect Dis 2003; 36: 985–989.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>36</number>
</detail>
<extent unit="pages"><start>985</start>
<end>989</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Clin Infect Dis</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>36</number>
</detail>
<extent unit="pages"><start>985</start>
<end>989</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0120"><titleInfo><title>Human aminopeptidase N is a receptor for human coronavirus 229E</title>
</titleInfo>
<name type="personal"><namePart type="given">CL</namePart>
<namePart type="family">Yeager</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RA</namePart>
<namePart type="family">Ashmun</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RK</namePart>
<namePart type="family">Williams</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Yeager CL, Ashmun RA, Williams RK, et al. Human aminopeptidase N is a receptor for human coronavirus 229E. Nature 1992; 357: 420–422.</note>
<part><date>1992</date>
<detail type="volume"><caption>vol.</caption>
<number>357</number>
</detail>
<extent unit="pages"><start>420</start>
<end>422</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Nature</title>
</titleInfo>
<part><date>1992</date>
<detail type="volume"><caption>vol.</caption>
<number>357</number>
</detail>
<extent unit="pages"><start>420</start>
<end>422</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0121"><titleInfo><title>Distant relatives of severe acute respiratory syndrome coronavirus and close relatives of human coronavirus 229E in bats, Ghana</title>
</titleInfo>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Pfefferle</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Oppong</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JF</namePart>
<namePart type="family">Drexler</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Pfefferle S, Oppong S, Drexler JF, et al. Distant relatives of severe acute respiratory syndrome coronavirus and close relatives of human coronavirus 229E in bats, Ghana. Emerg Infect Dis 2009; 15: 1377–1384.</note>
<part><date>2009</date>
<detail type="volume"><caption>vol.</caption>
<number>15</number>
</detail>
<extent unit="pages"><start>1377</start>
<end>1384</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Emerg Infect Dis</title>
</titleInfo>
<part><date>2009</date>
<detail type="volume"><caption>vol.</caption>
<number>15</number>
</detail>
<extent unit="pages"><start>1377</start>
<end>1384</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0122"><titleInfo><title>Mosaic structure of human coronavirus NL63; one thousand years of evolution</title>
</titleInfo>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Pyrc</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">R</namePart>
<namePart type="family">Dijkman</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">L</namePart>
<namePart type="family">Deng</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Pyrc K, Dijkman R, Deng L, et al. Mosaic structure of human coronavirus NL63; one thousand years of evolution. J Mol Biol 2006; 364: 964–973.</note>
<part><date>2006</date>
<detail type="volume"><caption>vol.</caption>
<number>364</number>
</detail>
<extent unit="pages"><start>964</start>
<end>973</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Mol Biol</title>
</titleInfo>
<part><date>2006</date>
<detail type="volume"><caption>vol.</caption>
<number>364</number>
</detail>
<extent unit="pages"><start>964</start>
<end>973</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0123"><titleInfo><title>Replication of human respiratory coronavirus strain 229E in human macrophages</title>
</titleInfo>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Patterson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MR</namePart>
<namePart type="family">Macnaughton</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Patterson S, Macnaughton MR. Replication of human respiratory coronavirus strain 229E in human macrophages. J Gen Virol 1982; 60: 307–314.</note>
<part><date>1982</date>
<detail type="volume"><caption>vol.</caption>
<number>60</number>
</detail>
<extent unit="pages"><start>307</start>
<end>314</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Gen Virol</title>
</titleInfo>
<part><date>1982</date>
<detail type="volume"><caption>vol.</caption>
<number>60</number>
</detail>
<extent unit="pages"><start>307</start>
<end>314</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0124"><titleInfo><title>The behaviour of recent isolates of human respiratory coronavirus in vitro and in volunteers: evidence of heterogeneity among 229E‐related strains</title>
</titleInfo>
<name type="personal"><namePart type="given">SE</namePart>
<namePart type="family">Reed</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Reed SE. The behaviour of recent isolates of human respiratory coronavirus in vitro and in volunteers: evidence of heterogeneity among 229E‐related strains. J Med Virol 1984; 13: 179–192.</note>
<part><date>1984</date>
<detail type="volume"><caption>vol.</caption>
<number>13</number>
</detail>
<extent unit="pages"><start>179</start>
<end>192</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Med Virol</title>
</titleInfo>
<part><date>1984</date>
<detail type="volume"><caption>vol.</caption>
<number>13</number>
</detail>
<extent unit="pages"><start>179</start>
<end>192</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0125"><titleInfo><title>Coronavirus 229E‐related pneumonia in immunocompromised patients</title>
</titleInfo>
<name type="personal"><namePart type="given">F</namePart>
<namePart type="family">Pene</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Merlat</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Vabret</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Pene F, Merlat A, Vabret A, et al. Coronavirus 229E‐related pneumonia in immunocompromised patients. Clin Infect Dis 2003; 37: 929–932.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>37</number>
</detail>
<extent unit="pages"><start>929</start>
<end>932</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Clin Infect Dis</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>37</number>
</detail>
<extent unit="pages"><start>929</start>
<end>932</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0126"><titleInfo><title>Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry</title>
</titleInfo>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Hofmann</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Pyrc</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">L</namePart>
<namePart type="family">van der Hoek</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Hofmann H, Pyrc K, van der Hoek L, et al. Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry. Proc Natl Acad Sci USA 2005; 102: 7988–7993.</note>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>102</number>
</detail>
<extent unit="pages"><start>7988</start>
<end>7993</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Proc Natl Acad Sci USA</title>
</titleInfo>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>102</number>
</detail>
<extent unit="pages"><start>7988</start>
<end>7993</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0127"><titleInfo><title>Evidence supporting a zoonotic origin of human coronavirus strain NL63</title>
</titleInfo>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Huynh</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Li</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">B</namePart>
<namePart type="family">Yount</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Huynh J, Li S, Yount B, et al. Evidence supporting a zoonotic origin of human coronavirus strain NL63. J Virol 2012; 86: 12816–12825.</note>
<part><date>2012</date>
<detail type="volume"><caption>vol.</caption>
<number>86</number>
</detail>
<extent unit="pages"><start>12816</start>
<end>12825</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2012</date>
<detail type="volume"><caption>vol.</caption>
<number>86</number>
</detail>
<extent unit="pages"><start>12816</start>
<end>12825</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0128"><titleInfo><title>New human coronavirus, HCoV‐NL63, associated with severe lower respiratory tract disease in Australia</title>
</titleInfo>
<name type="personal"><namePart type="given">KE</namePart>
<namePart type="family">Arden</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MD</namePart>
<namePart type="family">Nissen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">TP</namePart>
<namePart type="family">Sloots</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Arden KE, Nissen MD, Sloots TP, et al. New human coronavirus, HCoV‐NL63, associated with severe lower respiratory tract disease in Australia. J Med Virol 2005; 75: 455–462.</note>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>75</number>
</detail>
<extent unit="pages"><start>455</start>
<end>462</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Med Virol</title>
</titleInfo>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>75</number>
</detail>
<extent unit="pages"><start>455</start>
<end>462</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0129"><titleInfo><title>Croup is associated with the novel coronavirus NL63</title>
</titleInfo>
<name type="personal"><namePart type="given">L</namePart>
<namePart type="family">van der Hoek</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Sure</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">G</namePart>
<namePart type="family">Ihorst</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">van der Hoek L, Sure K, Ihorst G, et al. Croup is associated with the novel coronavirus NL63. PLoS Med 2005; 2: e240.</note>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>2</number>
</detail>
<extent unit="pages"><start>e240</start>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>PLoS Med</title>
</titleInfo>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>2</number>
</detail>
<extent unit="pages"><start>e240</start>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0130"><titleInfo><title>Detection of the new human coronavirus HKU1: a report of six cases</title>
</titleInfo>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Vabret</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Dina</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Gouarin</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Vabret A, Dina J, Gouarin S, et al. Detection of the new human coronavirus HKU1: a report of six cases. Clin Infect Dis 2006; 42: 634–639.</note>
<part><date>2006</date>
<detail type="volume"><caption>vol.</caption>
<number>42</number>
</detail>
<extent unit="pages"><start>634</start>
<end>639</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Clin Infect Dis</title>
</titleInfo>
<part><date>2006</date>
<detail type="volume"><caption>vol.</caption>
<number>42</number>
</detail>
<extent unit="pages"><start>634</start>
<end>639</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0131"><titleInfo><title>Detection of human coronaviruses in children with acute gastroenteritis</title>
</titleInfo>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Risku</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Lappalainen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Rasanen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Risku M, Lappalainen S, Rasanen S, et al. Detection of human coronaviruses in children with acute gastroenteritis. J Clin Virol 2010; 48: 27–30.</note>
<part><date>2010</date>
<detail type="volume"><caption>vol.</caption>
<number>48</number>
</detail>
<extent unit="pages"><start>27</start>
<end>30</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Clin Virol</title>
</titleInfo>
<part><date>2010</date>
<detail type="volume"><caption>vol.</caption>
<number>48</number>
</detail>
<extent unit="pages"><start>27</start>
<end>30</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0132"><titleInfo><title>pH‐dependent entry of severe acute respiratory syndrome coronavirus is mediated by the spike glycoprotein and enhanced by dendritic cell transfer through DC‐SIGN</title>
</titleInfo>
<name type="personal"><namePart type="given">ZY</namePart>
<namePart type="family">Yang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Y</namePart>
<namePart type="family">Huang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">L</namePart>
<namePart type="family">Ganesh</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Yang ZY, Huang Y, Ganesh L, et al. pH‐dependent entry of severe acute respiratory syndrome coronavirus is mediated by the spike glycoprotein and enhanced by dendritic cell transfer through DC‐SIGN. J Virol 2004; 78: 5642–5650.</note>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>78</number>
</detail>
<extent unit="pages"><start>5642</start>
<end>5650</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>78</number>
</detail>
<extent unit="pages"><start>5642</start>
<end>5650</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0133"><titleInfo><title>A novel coronavirus associated with severe acute respiratory syndrome</title>
</titleInfo>
<name type="personal"><namePart type="given">TG</namePart>
<namePart type="family">Ksiazek</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">D</namePart>
<namePart type="family">Erdman</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">CS</namePart>
<namePart type="family">Goldsmith</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Ksiazek TG, Erdman D, Goldsmith CS, et al. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med 2003; 348: 1953–1966.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>348</number>
</detail>
<extent unit="pages"><start>1953</start>
<end>1966</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>N Engl J Med</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>348</number>
</detail>
<extent unit="pages"><start>1953</start>
<end>1966</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0134"><titleInfo><title>Evolutionary insights into the ecology of coronaviruses</title>
</titleInfo>
<name type="personal"><namePart type="given">D</namePart>
<namePart type="family">Vijaykrishna</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">GJ</namePart>
<namePart type="family">Smith</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JX</namePart>
<namePart type="family">Zhang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Vijaykrishna D, Smith GJ, Zhang JX, et al. Evolutionary insights into the ecology of coronaviruses. J Virol 2007; 81: 4012–4020.</note>
<part><date>2007</date>
<detail type="volume"><caption>vol.</caption>
<number>81</number>
</detail>
<extent unit="pages"><start>4012</start>
<end>4020</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2007</date>
<detail type="volume"><caption>vol.</caption>
<number>81</number>
</detail>
<extent unit="pages"><start>4012</start>
<end>4020</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0135"><titleInfo><title>Evidence of the recombinant origin of a bat severe acute respiratory syndrome (SARS)‐like coronavirus and its implications on the direct ancestor of SARS coronavirus</title>
</titleInfo>
<name type="personal"><namePart type="given">CC</namePart>
<namePart type="family">Hon</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">TY</namePart>
<namePart type="family">Lam</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">ZL</namePart>
<namePart type="family">Shi</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Hon CC, Lam TY, Shi ZL, et al. Evidence of the recombinant origin of a bat severe acute respiratory syndrome (SARS)‐like coronavirus and its implications on the direct ancestor of SARS coronavirus. J Virol 2008; 82: 1819–1826.</note>
<part><date>2008</date>
<detail type="volume"><caption>vol.</caption>
<number>82</number>
</detail>
<extent unit="pages"><start>1819</start>
<end>1826</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2008</date>
<detail type="volume"><caption>vol.</caption>
<number>82</number>
</detail>
<extent unit="pages"><start>1819</start>
<end>1826</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0136"><titleInfo><title>Severe acute respiratory syndrome coronavirus infection of human ciliated airway epithelia: role of ciliated cells in viral spread in the conducting airways of the lungs</title>
</titleInfo>
<name type="personal"><namePart type="given">AC</namePart>
<namePart type="family">Sims</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RS</namePart>
<namePart type="family">Baric</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">B</namePart>
<namePart type="family">Yount</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Sims AC, Baric RS, Yount B, et al. Severe acute respiratory syndrome coronavirus infection of human ciliated airway epithelia: role of ciliated cells in viral spread in the conducting airways of the lungs. J Virol 2005; 79: 15511–15524.</note>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>79</number>
</detail>
<extent unit="pages"><start>15511</start>
<end>15524</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>79</number>
</detail>
<extent unit="pages"><start>15511</start>
<end>15524</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0137"><titleInfo><title>Time course and cellular localization of SARS‐CoV nucleoprotein and RNA in lungs from fatal cases of SARS</title>
</titleInfo>
<name type="personal"><namePart type="given">JM</namePart>
<namePart type="family">Nicholls</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Butany</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">LL</namePart>
<namePart type="family">Poon</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Nicholls JM, Butany J, Poon LL, et al. Time course and cellular localization of SARS‐CoV nucleoprotein and RNA in lungs from fatal cases of SARS. PLoS Med 2006; 3: e27.</note>
<part><date>2006</date>
<detail type="volume"><caption>vol.</caption>
<number>3</number>
</detail>
<extent unit="pages"><start>e27</start>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>PLoS Med</title>
</titleInfo>
<part><date>2006</date>
<detail type="volume"><caption>vol.</caption>
<number>3</number>
</detail>
<extent unit="pages"><start>e27</start>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0138"><titleInfo><title>Lung pathology of fatal severe acute respiratory syndrome</title>
</titleInfo>
<name type="personal"><namePart type="given">JM</namePart>
<namePart type="family">Nicholls</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">LL</namePart>
<namePart type="family">Poon</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">KC</namePart>
<namePart type="family">Lee</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Nicholls JM, Poon LL, Lee KC, et al. Lung pathology of fatal severe acute respiratory syndrome. Lancet 2003; 361: 1773–1778.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>361</number>
</detail>
<extent unit="pages"><start>1773</start>
<end>1778</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Lancet</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>361</number>
</detail>
<extent unit="pages"><start>1773</start>
<end>1778</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0139"><titleInfo><title>Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus‐EMC</title>
</titleInfo>
<name type="personal"><namePart type="given">VS</namePart>
<namePart type="family">Raj</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Mou</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">SL</namePart>
<namePart type="family">Smits</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Raj VS, Mou H, Smits SL, et al. Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus‐EMC. Nature; 495: 251–254.</note>
<part><detail type="volume"><caption>vol.</caption>
<number>495</number>
</detail>
<extent unit="pages"><start>251</start>
<end>254</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Nature</title>
</titleInfo>
<part><detail type="volume"><caption>vol.</caption>
<number>495</number>
</detail>
<extent unit="pages"><start>251</start>
<end>254</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0140"><titleInfo><title>Spread, circulation, and evolution of the Middle East respiratory syndrome coronavirus</title>
</titleInfo>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Cotten</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">SJ</namePart>
<namePart type="family">Watson</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">AI</namePart>
<namePart type="family">Zumla</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Cotten M, Watson SJ, Zumla AI, et al. Spread, circulation, and evolution of the Middle East respiratory syndrome coronavirus. mBio 2014; 5: e01062–13.</note>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>5</number>
</detail>
<extent unit="pages"><start>e01062</start>
<end>13</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>mBio</title>
</titleInfo>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>5</number>
</detail>
<extent unit="pages"><start>e01062</start>
<end>13</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0141"><titleInfo><title>Human cell tropism and innate immune system interactions of human respiratory coronavirus EMC compared to those of severe acute respiratory syndrome coronavirus</title>
</titleInfo>
<name type="personal"><namePart type="given">F</namePart>
<namePart type="family">Zielecki</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Weber</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Eickmann</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Zielecki F, Weber M, Eickmann M, et al. Human cell tropism and innate immune system interactions of human respiratory coronavirus EMC compared to those of severe acute respiratory syndrome coronavirus. J Virol 2013; 87: 5300–5304.</note>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>87</number>
</detail>
<extent unit="pages"><start>5300</start>
<end>5304</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>87</number>
</detail>
<extent unit="pages"><start>5300</start>
<end>5304</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0142"><titleInfo><title>In‐vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East respiratory syndrome (MERS) coronavirus infection</title>
</titleInfo>
<name type="personal"><namePart type="given">I</namePart>
<namePart type="family">Eckerle</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MA</namePart>
<namePart type="family">Muller</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Kallies</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Eckerle I, Muller MA, Kallies S, et al. In‐vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East respiratory syndrome (MERS) coronavirus infection. Virol J 2013; 10: 359.</note>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>10</number>
</detail>
<extent unit="pages"><start>359</start>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Virol J</title>
</titleInfo>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>10</number>
</detail>
<extent unit="pages"><start>359</start>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0143"><titleInfo><title>Productive replication of Middle East respiratory syndrome coronavirus in monocyte‐derived dendritic cells modulates innate immune response</title>
</titleInfo>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Chu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Zhou</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">BH</namePart>
<namePart type="family">Wong</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Chu H, Zhou J, Wong BH, et al. Productive replication of Middle East respiratory syndrome coronavirus in monocyte‐derived dendritic cells modulates innate immune response. Virology 2014; 454–455: 197–205.</note>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>454–455</number>
</detail>
<extent unit="pages"><start>197</start>
<end>205</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Virology</title>
</titleInfo>
<part><date>2014</date>
<detail type="volume"><caption>vol.</caption>
<number>454–455</number>
</detail>
<extent unit="pages"><start>197</start>
<end>205</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0144"><titleInfo><title>Family cluster of Middle East respiratory syndrome coronavirus infections</title>
</titleInfo>
<name type="personal"><namePart type="given">ZA</namePart>
<namePart type="family">Memish</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">AI</namePart>
<namePart type="family">Zumla</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RF</namePart>
<namePart type="family">Al‐Hakeem</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Memish ZA, Zumla AI, Al‐Hakeem RF, et al. Family cluster of Middle East respiratory syndrome coronavirus infections. N Engl J Med 2013; 368: 2487–2494.</note>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>368</number>
</detail>
<extent unit="pages"><start>2487</start>
<end>2494</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>N Engl J Med</title>
</titleInfo>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>368</number>
</detail>
<extent unit="pages"><start>2487</start>
<end>2494</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0145"><titleInfo><title>Severe acute respiratory syndrome coronavirus infection of golden Syrian hamsters</title>
</titleInfo>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Roberts</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">L</namePart>
<namePart type="family">Vogel</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Guarner</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Roberts A, Vogel L, Guarner J, et al. Severe acute respiratory syndrome coronavirus infection of golden Syrian hamsters. J Virol 2005; 79: 503–511.</note>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>79</number>
</detail>
<extent unit="pages"><start>503</start>
<end>511</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>79</number>
</detail>
<extent unit="pages"><start>503</start>
<end>511</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0146"><titleInfo><title>Virology: SARS virus infection of cats and ferrets</title>
</titleInfo>
<name type="personal"><namePart type="given">BE</namePart>
<namePart type="family">Martina</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">BL</namePart>
<namePart type="family">Haagmans</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Kuiken</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Martina BE, Haagmans BL, Kuiken T, et al. Virology: SARS virus infection of cats and ferrets. Nature 2003; 425: 915.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>425</number>
</detail>
<extent unit="pages"><start>915</start>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Nature</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>425</number>
</detail>
<extent unit="pages"><start>915</start>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0147"><titleInfo><title>Macaque model for severe acute respiratory syndrome</title>
</titleInfo>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Rowe</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">G</namePart>
<namePart type="family">Gao</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RJ</namePart>
<namePart type="family">Hogan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Rowe T, Gao G, Hogan RJ, et al. Macaque model for severe acute respiratory syndrome. J Virol 2004; 78: 11401–11404.</note>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>78</number>
</detail>
<extent unit="pages"><start>11401</start>
<end>11404</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>78</number>
</detail>
<extent unit="pages"><start>11401</start>
<end>11404</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0148"><titleInfo><title>Cynomolgus macaque as an animal model for severe acute respiratory syndrome</title>
</titleInfo>
<name type="personal"><namePart type="given">JV</namePart>
<namePart type="family">Lawler</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">TP</namePart>
<namePart type="family">Endy</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">LE</namePart>
<namePart type="family">Hensley</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Lawler JV, Endy TP, Hensley LE, et al. Cynomolgus macaque as an animal model for severe acute respiratory syndrome. PLoS Med 2006; 3: e149.</note>
<part><date>2006</date>
<detail type="volume"><caption>vol.</caption>
<number>3</number>
</detail>
<extent unit="pages"><start>e149</start>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>PLoS Med</title>
</titleInfo>
<part><date>2006</date>
<detail type="volume"><caption>vol.</caption>
<number>3</number>
</detail>
<extent unit="pages"><start>e149</start>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0149"><titleInfo><title>Exacerbated innate host response to SARS‐CoV in aged non‐human primates</title>
</titleInfo>
<name type="personal"><namePart type="given">SL</namePart>
<namePart type="family">Smits</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">de Lang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JM</namePart>
<namePart type="family">van den Brand</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Smits SL, de Lang A, van den Brand JM, et al. Exacerbated innate host response to SARS‐CoV in aged non‐human primates. PLoS Pathog 2010; 6: e1000756.</note>
<part><date>2010</date>
<detail type="volume"><caption>vol.</caption>
<number>6</number>
</detail>
<extent unit="pages"><start>e1000756</start>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>PLoS Pathog</title>
</titleInfo>
<part><date>2010</date>
<detail type="volume"><caption>vol.</caption>
<number>6</number>
</detail>
<extent unit="pages"><start>e1000756</start>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0150"><titleInfo><title>Lethal infection of K18‐hACE2 mice infected with severe acute respiratory syndrome coronavirus</title>
</titleInfo>
<name type="personal"><namePart type="given">PB</namePart>
<namePart type="family">McCray Jr.</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">L</namePart>
<namePart type="family">Pewe</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Wohlford‐Lenane</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">McCray PB, Jr., Pewe L, Wohlford‐Lenane C, et al. Lethal infection of K18‐hACE2 mice infected with severe acute respiratory syndrome coronavirus. J Virol 2007; 81: 813–821.</note>
<part><date>2007</date>
<detail type="volume"><caption>vol.</caption>
<number>81</number>
</detail>
<extent unit="pages"><start>813</start>
<end>821</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Virol</title>
</titleInfo>
<part><date>2007</date>
<detail type="volume"><caption>vol.</caption>
<number>81</number>
</detail>
<extent unit="pages"><start>813</start>
<end>821</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0151"><titleInfo><title>Macrophage plasticity and polarization in tissue repair and remodelling</title>
</titleInfo>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Mantovani</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">SK</namePart>
<namePart type="family">Biswas</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MR</namePart>
<namePart type="family">Galdiero</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">A</namePart>
<namePart type="family">Sica</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Locati</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Mantovani A, Biswas SK, Galdiero MR, Sica A, Locati M. Macrophage plasticity and polarization in tissue repair and remodelling. J Pathol 2013; 229: 176–185.</note>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>229</number>
</detail>
<extent unit="pages"><start>176</start>
<end>185</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Pathol</title>
</titleInfo>
<part><date>2013</date>
<detail type="volume"><caption>vol.</caption>
<number>229</number>
</detail>
<extent unit="pages"><start>176</start>
<end>185</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="path4454-cit-0152"><titleInfo><title>Pathogenesis of Middle East respiratory syndrome coronavirus</title>
</titleInfo>
<genre>journal-article</genre>
<note type="citation/reference">van den Brand JMA, Smits SL. Haagmans BL. Pathogenesis of Middle East respiratory syndrome coronavirus. J Pathol 2015; 235: 175–184.</note>
<part><date>2015</date>
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