Materno-fetal transmission of human coronaviruses: a prospective pilot study
Identifieur interne : 000933 ( Istex/Corpus ); précédent : 000932; suivant : 000934Materno-fetal transmission of human coronaviruses: a prospective pilot study
Auteurs : A. Gagneur ; E. Dirson ; S. Audebert ; S. Vallet ; M. C. Legrand-Quillien ; Y. Laurent ; M. Collet ; J. Sizun ; E. Oger ; C. PayanSource :
- European Journal of Clinical Microbiology & Infectious Diseases [ 0934-9723 ] ; 2008-09-01.
Abstract
Abstract: This prospective pilot study investigates the possibility of materno-fetal transmission of human coronaviruses (HCoV) responsible for cases of neonatal infection. This vertical transmission was studied with 159 samples from mother-child couples: maternal vaginal (MV) and respiratory (MR) samples during labor; and newborn gastric sample (NG) with detection of HCoV (229E, OC-43, NL-63, HKU1) via real time RT PCR. HCoV was detected in 12 samples (229E: 11; HKU1: 1) from seven mother-child couples. For three couples, only MR tested positive (cases 1–3). For two other couples all three samples (MV, MR and NG) tested positive (cases 4 and 5). For case 6, only MV and NG tested positive. In case 7, only MV was positive. Possible vertical transmission of HCoV was hypothesized in this pilot study and requires further investigation on a larger scale.
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DOI: 10.1007/s10096-008-0505-7
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Gagneur</name><affiliation><mods:affiliation>Department of Pediatrics, CHU Morvan, 2 avenue Foch, 29609, Brest cedex, France</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: arnaud.gagneur@chu-brest.fr</mods:affiliation></affiliation></author><author><name sortKey="Dirson, E" sort="Dirson, E" uniqKey="Dirson E" first="E." last="Dirson">E. Dirson</name><affiliation><mods:affiliation>Department of Pediatrics, CHU Morvan, 2 avenue Foch, 29609, Brest cedex, France</mods:affiliation></affiliation></author><author><name sortKey="Audebert, S" sort="Audebert, S" uniqKey="Audebert S" first="S." last="Audebert">S. Audebert</name><affiliation><mods:affiliation>Department of Pediatrics, CHU Morvan, 2 avenue Foch, 29609, Brest cedex, France</mods:affiliation></affiliation></author><author><name sortKey="Vallet, S" sort="Vallet, S" uniqKey="Vallet S" first="S." last="Vallet">S. 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This vertical transmission was studied with 159 samples from mother-child couples: maternal vaginal (MV) and respiratory (MR) samples during labor; and newborn gastric sample (NG) with detection of HCoV (229E, OC-43, NL-63, HKU1) via real time RT PCR. HCoV was detected in 12 samples (229E: 11; HKU1: 1) from seven mother-child couples. For three couples, only MR tested positive (cases 1–3). For two other couples all three samples (MV, MR and NG) tested positive (cases 4 and 5). For case 6, only MV and NG tested positive. In case 7, only MV was positive. Possible vertical transmission of HCoV was hypothesized in this pilot study and requires further investigation on a larger scale.</div></front></TEI><istex><corpusName>springer-journals</corpusName><author><json:item><name>A. 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Legrand-Quillien</name><affiliations><json:string>Department of Microbiology, EA 3882 Laboratory of Biodiversity and Microbial Ecology, Brest cedex, France</json:string></affiliations></json:item><json:item><name>Y. Laurent</name><affiliations><json:string>Department of Gynecology-Obstetrics, Brest cedex, France</json:string></affiliations></json:item><json:item><name>M. Collet</name><affiliations><json:string>Department of Gynecology-Obstetrics, Brest cedex, France</json:string></affiliations></json:item><json:item><name>J. Sizun</name><affiliations><json:string>Department of Pediatrics, CHU Morvan, 2 avenue Foch, 29609, Brest cedex, France</json:string></affiliations></json:item><json:item><name>E. Oger</name><affiliations><json:string>Center for Clinical Investigation, INSERM CIC 0502, CHU Brest, 2 avenue Foch, 29609, Brest cedex, France</json:string></affiliations></json:item><json:item><name>C. Payan</name><affiliations><json:string>Department of Microbiology, EA 3882 Laboratory of Biodiversity and Microbial Ecology, Brest cedex, France</json:string></affiliations></json:item></author><articleId><json:string>505</json:string><json:string>s10096-008-0505-7</json:string></articleId><arkIstex>ark:/67375/VQC-RMV6F9LW-D</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>OriginalPaper</json:string></originalGenre><abstract>Abstract: This prospective pilot study investigates the possibility of materno-fetal transmission of human coronaviruses (HCoV) responsible for cases of neonatal infection. This vertical transmission was studied with 159 samples from mother-child couples: maternal vaginal (MV) and respiratory (MR) samples during labor; and newborn gastric sample (NG) with detection of HCoV (229E, OC-43, NL-63, HKU1) via real time RT PCR. HCoV was detected in 12 samples (229E: 11; HKU1: 1) from seven mother-child couples. For three couples, only MR tested positive (cases 1–3). For two other couples all three samples (MV, MR and NG) tested positive (cases 4 and 5). For case 6, only MV and NG tested positive. In case 7, only MV was positive. 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This vertical transmission was studied with 159 samples from mother-child couples: maternal vaginal (MV) and respiratory (MR) samples during labor; and newborn gastric sample (NG) with detection of HCoV (229E, OC-43, NL-63, HKU1) via real time RT PCR. HCoV was detected in 12 samples (229E: 11; HKU1: 1) from seven mother-child couples. For three couples, only MR tested positive (cases 1–3). For two other couples all three samples (MV, MR and NG) tested positive (cases 4 and 5). For case 6, only MV and NG tested positive. In case 7, only MV was positive. Possible vertical transmission of HCoV was hypothesized in this pilot study and requires further investigation on a larger scale.</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>Biomedicine</head><item><term>Internal Medicine</term></item><item><term>Medical Microbiology</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-10-23">Created</change><change when="2008-09-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-RMV6F9LW-D/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus springer-journals not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" 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Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1" CorrespondingAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>A.</GivenName><FamilyName>Gagneur</FamilyName></AuthorName><Contact><Phone>+33-2-98223668</Phone><Fax>+33-2-98223986</Fax><Email>arnaud.gagneur@chu-brest.fr</Email></Contact></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>E.</GivenName><FamilyName>Dirson</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>S.</GivenName><FamilyName>Audebert</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff2"><AuthorName DisplayOrder="Western"><GivenName>S.</GivenName><FamilyName>Vallet</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff2"><AuthorName DisplayOrder="Western"><GivenName>M.</GivenName><GivenName>C.</GivenName><FamilyName>Legrand-Quillien</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff3"><AuthorName DisplayOrder="Western"><GivenName>Y.</GivenName><FamilyName>Laurent</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff3"><AuthorName DisplayOrder="Western"><GivenName>M.</GivenName><FamilyName>Collet</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>J.</GivenName><FamilyName>Sizun</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff4"><AuthorName DisplayOrder="Western"><GivenName>E.</GivenName><FamilyName>Oger</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff2"><AuthorName DisplayOrder="Western"><GivenName>C.</GivenName><FamilyName>Payan</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Department of Pediatrics</OrgDivision><OrgName>CHU Morvan</OrgName><OrgAddress><Street>2 avenue Foch</Street><Postcode>29609</Postcode><City>Brest cedex</City><Country Code="FR">France</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgDivision>Department of Microbiology</OrgDivision><OrgName>EA 3882 Laboratory of Biodiversity and Microbial Ecology</OrgName><OrgAddress><City>Brest cedex</City><Country Code="FR">France</Country></OrgAddress></Affiliation><Affiliation ID="Aff3"><OrgName>Department of Gynecology-Obstetrics</OrgName><OrgAddress><City>Brest cedex</City><Country Code="FR">France</Country></OrgAddress></Affiliation><Affiliation ID="Aff4"><OrgDivision>Center for Clinical Investigation</OrgDivision><OrgName>INSERM CIC 0502, CHU Brest</OrgName><OrgAddress><Street>2 avenue Foch</Street><Postcode>29609</Postcode><City>Brest cedex</City><Country Code="FR">France</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading><Para>This prospective pilot study investigates the possibility of materno-fetal transmission of human coronaviruses (HCoV) responsible for cases of neonatal infection. This vertical transmission was studied with 159 samples from mother-child couples: maternal vaginal (MV) and respiratory (MR) samples during labor; and newborn gastric sample (NG) with detection of HCoV (229E, OC-43, NL-63, HKU1) via real time RT PCR. HCoV was detected in 12 samples (229E: 11; HKU1: 1) from seven mother-child couples. For three couples, only MR tested positive (cases 1–3). For two other couples all three samples (MV, MR and NG) tested positive (cases 4 and 5). For case 6, only MV and NG tested positive. In case 7, only MV was positive. Possible vertical transmission of HCoV was hypothesized in this pilot study and requires further investigation on a larger scale.</Para></Abstract><ArticleNote Type="Misc"><SimplePara>The experiments in this study comply with the current laws of France regarding clinical research.</SimplePara></ArticleNote></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Materno-fetal transmission of human coronaviruses: a prospective pilot study</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Materno-fetal transmission of human coronaviruses: a prospective pilot study</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">A.</namePart><namePart type="family">Gagneur</namePart><affiliation>Department of Pediatrics, CHU Morvan, 2 avenue Foch, 29609, Brest cedex, France</affiliation><affiliation>E-mail: arnaud.gagneur@chu-brest.fr</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Dirson</namePart><affiliation>Department of Pediatrics, CHU Morvan, 2 avenue Foch, 29609, Brest cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Audebert</namePart><affiliation>Department of Pediatrics, CHU Morvan, 2 avenue Foch, 29609, Brest cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Vallet</namePart><affiliation>Department of Microbiology, EA 3882 Laboratory of Biodiversity and Microbial Ecology, Brest cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="given">C.</namePart><namePart type="family">Legrand-Quillien</namePart><affiliation>Department of Microbiology, EA 3882 Laboratory of Biodiversity and Microbial Ecology, Brest cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Laurent</namePart><affiliation>Department of Gynecology-Obstetrics, Brest cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Collet</namePart><affiliation>Department of Gynecology-Obstetrics, Brest cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Sizun</namePart><affiliation>Department of Pediatrics, CHU Morvan, 2 avenue Foch, 29609, Brest cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Oger</namePart><affiliation>Center for Clinical Investigation, INSERM CIC 0502, CHU Brest, 2 avenue Foch, 29609, Brest cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Payan</namePart><affiliation>Department of Microbiology, EA 3882 Laboratory of Biodiversity and Microbial Ecology, Brest cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">2007-10-23</dateCreated><dateIssued encoding="w3cdtf">2008-09-01</dateIssued><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: This prospective pilot study investigates the possibility of materno-fetal transmission of human coronaviruses (HCoV) responsible for cases of neonatal infection. This vertical transmission was studied with 159 samples from mother-child couples: maternal vaginal (MV) and respiratory (MR) samples during labor; and newborn gastric sample (NG) with detection of HCoV (229E, OC-43, NL-63, HKU1) via real time RT PCR. HCoV was detected in 12 samples (229E: 11; HKU1: 1) from seven mother-child couples. For three couples, only MR tested positive (cases 1–3). For two other couples all three samples (MV, MR and NG) tested positive (cases 4 and 5). For case 6, only MV and NG tested positive. In case 7, only MV was positive. Possible vertical transmission of HCoV was hypothesized in this pilot study and requires further investigation on a larger scale.</abstract><note>Concise Article</note><relatedItem type="host"><titleInfo><title>European Journal of Clinical Microbiology & Infectious Diseases</title></titleInfo><titleInfo type="abbreviated"><title>Eur J Clin Microbiol Infect Dis</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">2008-08-11</dateIssued><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><subject><genre>Biomedicine</genre><topic>Internal Medicine</topic><topic>Medical Microbiology</topic></subject><identifier type="ISSN">0934-9723</identifier><identifier type="eISSN">1435-4373</identifier><identifier type="JournalID">10096</identifier><identifier type="IssueArticleCount">18</identifier><identifier type="VolumeIssueCount">12</identifier><part><date>2008</date><detail type="volume"><number>27</number><caption>vol.</caption></detail><detail type="issue"><number>9</number><caption>no.</caption></detail><extent unit="pages"><start>863</start><end>866</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 2008</recordOrigin></recordInfo></relatedItem><identifier type="istex">86791192E695549E2A62F11F0E0E42AA9B714BBE</identifier><identifier type="ark">ark:/67375/VQC-RMV6F9LW-D</identifier><identifier type="DOI">10.1007/s10096-008-0505-7</identifier><identifier type="ArticleID">505</identifier><identifier type="ArticleID">s10096-008-0505-7</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag, 2008</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Springer-Verlag, 2008</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-RMV6F9LW-D/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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