Human (non‐severe acute respiratory syndrome) coronavirus infections in hospitalised children in France
Identifieur interne : 000751 ( Istex/Corpus ); précédent : 000750; suivant : 000752Human (non‐severe acute respiratory syndrome) coronavirus infections in hospitalised children in France
Auteurs : Astrid Vabret ; Julia Dina ; Stéphanie Gouarin ; Joëlle Petitjean ; Valérie Tripey ; Jacques Brouard ; François FreymuthSource :
- Journal of Paediatrics and Child Health [ 1034-4810 ] ; 2008-04.
Abstract
Aim: This study has two objectives: to study the clinical symptoms associated with the detection of the four human coronaviruses (HCoVs), 229E, OC43, NL63 and HKU1 types, in the respiratory specimens sampled from hospitalised children in France between September 2004 and May 2005; and to develop a multiplex reverse transcription polymerase chain reaction (RT‐PCR) assay allowing for the simultaneous detection of the four HCoVs. Methods: 1002 respiratory specimens were tested for HCoVs. The clinical and epidemiological data were compared on the basis of the type HCoV infection. Results: A hundred coronaviruses, 33 NL63, 2229E, 27 OC43 and 38 HKU1, were detected in 97 (9.8%) of 1002 samples negative in routine tests. The clinical and epidemiological characteristics of the study children were compared in three groups, 24 OC43‐, 27 NL63‐ and 34 HKU1‐infected children. HCoVs were identified mainly in children with upper and lower respiratory tract infections (50.5% vs. 29.4%). The significant difference in clinical presentation between the three coronavirus groups was the very low association between lower respiratory tract illness and HKU1 detection. Conclusions: HCoV detection in hospitalised children without any other respiratory virus detection was associated with upper and a significant rate of lower respiratory tract illness. The four types of HCoVs were detected, and new types NL63 and HKU1 represented a substantial portion of detection. The multiplex RT‐PCR enabled a sensitive one‐time detection and the characterisation of all of the known HCoV types with the exception severe acute respiratory syndrome‐coronavirus.
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DOI: 10.1111/j.1440-1754.2007.01246.x
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and</mods:affiliation></affiliation></author><author><name sortKey="Petitjean, Joelle" sort="Petitjean, Joelle" uniqKey="Petitjean J" first="Joëlle" last="Petitjean">Joëlle Petitjean</name><affiliation><mods:affiliation>Laboratory of Virology and</mods:affiliation></affiliation></author><author><name sortKey="Tripey, Valerie" sort="Tripey, Valerie" uniqKey="Tripey V" first="Valérie" last="Tripey">Valérie Tripey</name><affiliation><mods:affiliation>Pediatric Department, University Hospital of Caen, Caen, France</mods:affiliation></affiliation></author><author><name sortKey="Brouard, Jacques" sort="Brouard, Jacques" uniqKey="Brouard J" first="Jacques" last="Brouard">Jacques Brouard</name><affiliation><mods:affiliation>Pediatric Department, University Hospital of Caen, Caen, France</mods:affiliation></affiliation></author><author><name sortKey="Freymuth, Francois" sort="Freymuth, Francois" uniqKey="Freymuth F" first="François" last="Freymuth">François 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and</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: vabret‐a@chu‐caen.fr</mods:affiliation></affiliation></author><author><name sortKey="Dina, Julia" sort="Dina, Julia" uniqKey="Dina J" first="Julia" last="Dina">Julia Dina</name><affiliation><mods:affiliation>Laboratory of Virology and</mods:affiliation></affiliation></author><author><name sortKey="Gouarin, Stephanie" sort="Gouarin, Stephanie" uniqKey="Gouarin S" first="Stéphanie" last="Gouarin">Stéphanie Gouarin</name><affiliation><mods:affiliation>Laboratory of Virology and</mods:affiliation></affiliation></author><author><name sortKey="Petitjean, Joelle" sort="Petitjean, Joelle" uniqKey="Petitjean J" first="Joëlle" last="Petitjean">Joëlle Petitjean</name><affiliation><mods:affiliation>Laboratory of Virology and</mods:affiliation></affiliation></author><author><name sortKey="Tripey, Valerie" sort="Tripey, Valerie" uniqKey="Tripey V" first="Valérie" last="Tripey">Valérie Tripey</name><affiliation><mods:affiliation>Pediatric Department, University Hospital of Caen, Caen, France</mods:affiliation></affiliation></author><author><name sortKey="Brouard, Jacques" sort="Brouard, Jacques" uniqKey="Brouard J" first="Jacques" last="Brouard">Jacques Brouard</name><affiliation><mods:affiliation>Pediatric Department, University Hospital of Caen, Caen, France</mods:affiliation></affiliation></author><author><name sortKey="Freymuth, Francois" sort="Freymuth, Francois" uniqKey="Freymuth F" first="François" last="Freymuth">François Freymuth</name><affiliation><mods:affiliation>Laboratory of Virology and</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Paediatrics and Child Health</title><title level="j" type="alt">JOURNAL OF PAEDIATRICS CHILD HEALTH</title><idno type="ISSN">1034-4810</idno><idno type="eISSN">1440-1754</idno><imprint><biblScope unit="vol">44</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="176">176</biblScope><biblScope unit="page" to="181">181</biblScope><biblScope unit="page-count">6</biblScope><publisher>Blackwell Publishing Asia</publisher><pubPlace>Melbourne, Australia</pubPlace><date type="published" when="2008-04">2008-04</date></imprint><idno type="ISSN">1034-4810</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1034-4810</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Aim: This study has two objectives: to study the clinical symptoms associated with the detection of the four human coronaviruses (HCoVs), 229E, OC43, NL63 and HKU1 types, in the respiratory specimens sampled from hospitalised children in France between September 2004 and May 2005; and to develop a multiplex reverse transcription polymerase chain reaction (RT‐PCR) assay allowing for the simultaneous detection of the four HCoVs. Methods: 1002 respiratory specimens were tested for HCoVs. The clinical and epidemiological data were compared on the basis of the type HCoV infection. Results: A hundred coronaviruses, 33 NL63, 2229E, 27 OC43 and 38 HKU1, were detected in 97 (9.8%) of 1002 samples negative in routine tests. The clinical and epidemiological characteristics of the study children were compared in three groups, 24 OC43‐, 27 NL63‐ and 34 HKU1‐infected children. HCoVs were identified mainly in children with upper and lower respiratory tract infections (50.5% vs. 29.4%). The significant difference in clinical presentation between the three coronavirus groups was the very low association between lower respiratory tract illness and HKU1 detection. Conclusions: HCoV detection in hospitalised children without any other respiratory virus detection was associated with upper and a significant rate of lower respiratory tract illness. The four types of HCoVs were detected, and new types NL63 and HKU1 represented a substantial portion of detection. 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Methods: 1002 respiratory specimens were tested for HCoVs. The clinical and epidemiological data were compared on the basis of the type HCoV infection. Results: A hundred coronaviruses, 33 NL63, 2229E, 27 OC43 and 38 HKU1, were detected in 97 (9.8%) of 1002 samples negative in routine tests. The clinical and epidemiological characteristics of the study children were compared in three groups, 24 OC43‐, 27 NL63‐ and 34 HKU1‐infected children. HCoVs were identified mainly in children with upper and lower respiratory tract infections (50.5% vs. 29.4%). The significant difference in clinical presentation between the three coronavirus groups was the very low association between lower respiratory tract illness and HKU1 detection. Conclusions: HCoV detection in hospitalised children without any other respiratory virus detection was associated with upper and a significant rate of lower respiratory tract illness. The four types of HCoVs were detected, and new types NL63 and HKU1 represented a substantial portion of detection. The multiplex RT‐PCR enabled a sensitive one‐time detection and the characterisation of all of the known HCoV types with the exception severe acute respiratory syndrome‐coronavirus.</abstract><qualityIndicators><score>8.81</score><pdfWordCount>3906</pdfWordCount><pdfCharCount>25076</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>7</pdfPageCount><pdfPageSize>595 x 842 pts (A4)</pdfPageSize><pdfWordsPerPage>558</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>242</abstractWordCount><abstractCharCount>1648</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Human (non‐severe acute respiratory syndrome) coronavirus infections in hospitalised children in France</title><pmid><json:string>17999671</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Journal of Paediatrics and Child 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al.</json:string><json:string>Woo et al.</json:string><json:string>Kuypers et al.</json:string><json:string>Gerna et al.</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-4MSMZQ9N-G</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - pediatrics</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - pediatrics</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Pediatrics, Perinatology, and Child Health</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences 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type="first">Astrid</forename><surname>Vabret</surname></persName><affiliation><orgName type="laboratory">Laboratory of Virology and</orgName></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Julia</forename><surname>Dina</surname></persName><affiliation><orgName type="laboratory">Laboratory of Virology and</orgName></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Stéphanie</forename><surname>Gouarin</surname></persName><affiliation><orgName type="laboratory">Laboratory of Virology and</orgName></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Joëlle</forename><surname>Petitjean</surname></persName><affiliation><orgName type="laboratory">Laboratory of Virology and</orgName></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Valérie</forename><surname>Tripey</surname></persName><affiliation><orgName type="division">Pediatric 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<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract xml:lang="en" style="main"><p><hi rend="bold">Aim: </hi> This study has two objectives: to study the clinical symptoms associated with the detection of the four human coronaviruses (HCoVs), 229E, OC43, NL63 and HKU1 types, in the respiratory specimens sampled from hospitalised children in France between September 2004 and May 2005; and to develop a multiplex reverse transcription polymerase chain reaction (RT‐PCR) assay allowing for the simultaneous detection of the four HCoVs.</p><p><hi rend="bold">Methods: </hi> 1002 respiratory specimens were tested for HCoVs. The clinical and epidemiological data were compared on the basis of the type HCoV infection.</p><p><hi rend="bold">Results: </hi> A hundred coronaviruses, 33 NL63, 2229E, 27 OC43 and 38 HKU1, were detected in 97 (9.8%) of 1002 samples negative in routine tests. The clinical and epidemiological characteristics of the study children were compared in three groups, 24 OC43‐, 27 NL63‐ and 34 HKU1‐infected children. HCoVs were identified mainly in children with upper and lower respiratory tract infections (50.5% vs. 29.4%). The significant difference in clinical presentation between the three coronavirus groups was the very low association between lower respiratory tract illness and HKU1 detection.</p><p><hi rend="bold">Conclusions: </hi> HCoV detection in hospitalised children without any other respiratory virus detection was associated with upper and a significant rate of lower respiratory tract illness. The four types of HCoVs were detected, and new types NL63 and HKU1 represented a substantial portion of detection. The multiplex RT‐PCR enabled a sensitive one‐time detection and the characterisation of all of the known HCoV types with the exception severe acute respiratory syndrome‐coronavirus.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">coronavirus</term><term xml:id="k2">epidemiology</term><term xml:id="k3">hospitalised children</term><term xml:id="k4">multiplex RT‐PCR</term><term xml:id="k5">respiratory tract infection</term></keywords><keywords rend="tocHeading1"><term>Original Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-4MSMZQ9N-G/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Asia</publisherName><publisherLoc>Melbourne, Australia</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1440-1754</doi><issn type="print">1034-4810</issn><issn type="electronic">1440-1754</issn><idGroup><id type="product" value="JPC"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF PAEDIATRICS CHILD HEALTH">Journal of Paediatrics and Child Health</title></titleGroup></publicationMeta><publicationMeta level="part" position="04004"><doi origin="wiley">10.1111/jpc.2008.44.issue-4</doi><numberingGroup><numbering type="journalVolume" number="44">44</numbering><numbering type="journalIssue" number="4">4</numbering></numberingGroup><coverDate startDate="2008-04">April 2008</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="5" status="forIssue"><doi origin="wiley">10.1111/j.1440-1754.2007.01246.x</doi><idGroup><id type="unit" value="JPC1246"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="tocHeading1">Original Articles</title></titleGroup><copyright>© 2007 The Authors</copyright><eventGroup><event type="firstOnline" date="2007-11-12"></event><event type="publishedOnlineFinalForm" date="2007-11-12"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-16"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-31"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-30"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="176">176</numbering><numbering type="pageLast" number="181">181</numbering></numberingGroup><correspondenceTo>Dr Astrid Vabret, Laboratory of Virology, University Hospital of Caen, Avenue Georges Clemenceau, 14033 Caen cedex, France. Fax: +33 2 31 27 25 57; email: <email normalForm="vabret-a@chu-caen.fr">vabret‐a@chu‐caen.fr</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JPC.JPC1246.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Accepted for publication 30 August 2007.</unparsedEditorialHistory><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="1"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="26"></count><count type="wordTotal" number="4291"></count><count type="linksPubMed" number="0"></count><count type="linksCrossRef" number="0"></count></countGroup><titleGroup><title type="main">Human (non‐severe acute respiratory syndrome) coronavirus infections in hospitalised children in France</title><title type="shortAuthors">A Vabret <i>et al.</i></title><title type="short">Human coronavirus infections</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" corresponding="yes"><personName><givenNames>Astrid</givenNames><familyName>Vabret</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>Julia</givenNames><familyName>Dina</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>Stéphanie</givenNames><familyName>Gouarin</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>Joëlle</givenNames><familyName>Petitjean</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a2"><personName><givenNames>Valérie</givenNames><familyName>Tripey</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a2"><personName><givenNames>Jacques</givenNames><familyName>Brouard</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a1"><personName><givenNames>François</givenNames><familyName>Freymuth</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Laboratory of Virology and</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="FR"><unparsedAffiliation>Pediatric Department, University Hospital of Caen, Caen, France</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">coronavirus</keyword><keyword xml:id="k2">epidemiology</keyword><keyword xml:id="k3">hospitalised children</keyword><keyword xml:id="k4">multiplex RT‐PCR</keyword><keyword xml:id="k5">respiratory tract infection</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>Aim: </b> This study has two objectives: to study the clinical symptoms associated with the detection of the four human coronaviruses (HCoVs), 229E, OC43, NL63 and HKU1 types, in the respiratory specimens sampled from hospitalised children in France between September 2004 and May 2005; and to develop a multiplex reverse transcription polymerase chain reaction (RT‐PCR) assay allowing for the simultaneous detection of the four HCoVs.</p><p><b>Methods: </b> 1002 respiratory specimens were tested for HCoVs. The clinical and epidemiological data were compared on the basis of the type HCoV infection.</p><p><b>Results: </b> A hundred coronaviruses, 33 NL63, 2229E, 27 OC43 and 38 HKU1, were detected in 97 (9.8%) of 1002 samples negative in routine tests. The clinical and epidemiological characteristics of the study children were compared in three groups, 24 OC43‐, 27 NL63‐ and 34 HKU1‐infected children. HCoVs were identified mainly in children with upper and lower respiratory tract infections (50.5% vs. 29.4%). The significant difference in clinical presentation between the three coronavirus groups was the very low association between lower respiratory tract illness and HKU1 detection.</p><p><b>Conclusions: </b> HCoV detection in hospitalised children without any other respiratory virus detection was associated with upper and a significant rate of lower respiratory tract illness. The four types of HCoVs were detected, and new types NL63 and HKU1 represented a substantial portion of detection. The multiplex RT‐PCR enabled a sensitive one‐time detection and the characterisation of all of the known HCoV types with the exception severe acute respiratory syndrome‐coronavirus.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Human (non‐severe acute respiratory syndrome) coronavirus infections in hospitalised children in France</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Human coronavirus infections</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Human (non‐severe acute respiratory syndrome) coronavirus infections in hospitalised children in France</title></titleInfo><name type="personal"><namePart type="given">Astrid</namePart><namePart type="family">Vabret</namePart><affiliation>Laboratory of Virology and</affiliation><affiliation>E-mail: vabret‐a@chu‐caen.fr</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Julia</namePart><namePart type="family">Dina</namePart><affiliation>Laboratory of Virology and</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Stéphanie</namePart><namePart type="family">Gouarin</namePart><affiliation>Laboratory of Virology and</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Joëlle</namePart><namePart type="family">Petitjean</namePart><affiliation>Laboratory of Virology and</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Valérie</namePart><namePart type="family">Tripey</namePart><affiliation>Pediatric Department, University Hospital of Caen, Caen, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jacques</namePart><namePart type="family">Brouard</namePart><affiliation>Pediatric Department, University Hospital of Caen, Caen, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">François</namePart><namePart type="family">Freymuth</namePart><affiliation>Laboratory of Virology and</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Asia</publisher><place><placeTerm type="text">Melbourne, Australia</placeTerm></place><dateIssued encoding="w3cdtf">2008-04</dateIssued><edition>Accepted for publication 30 August 2007.</edition><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">2</extent><extent unit="tables">1</extent><extent unit="formulas">0</extent><extent unit="references">26</extent><extent unit="linksCrossRef">0</extent><extent unit="words">4291</extent></physicalDescription><abstract lang="en">Aim: This study has two objectives: to study the clinical symptoms associated with the detection of the four human coronaviruses (HCoVs), 229E, OC43, NL63 and HKU1 types, in the respiratory specimens sampled from hospitalised children in France between September 2004 and May 2005; and to develop a multiplex reverse transcription polymerase chain reaction (RT‐PCR) assay allowing for the simultaneous detection of the four HCoVs. Methods: 1002 respiratory specimens were tested for HCoVs. The clinical and epidemiological data were compared on the basis of the type HCoV infection. Results: A hundred coronaviruses, 33 NL63, 2229E, 27 OC43 and 38 HKU1, were detected in 97 (9.8%) of 1002 samples negative in routine tests. The clinical and epidemiological characteristics of the study children were compared in three groups, 24 OC43‐, 27 NL63‐ and 34 HKU1‐infected children. HCoVs were identified mainly in children with upper and lower respiratory tract infections (50.5% vs. 29.4%). The significant difference in clinical presentation between the three coronavirus groups was the very low association between lower respiratory tract illness and HKU1 detection. Conclusions: HCoV detection in hospitalised children without any other respiratory virus detection was associated with upper and a significant rate of lower respiratory tract illness. The four types of HCoVs were detected, and new types NL63 and HKU1 represented a substantial portion of detection. 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