Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS‐CoV) in SARS patients: implications for pathogenesis and virus transmission pathways
Identifieur interne : 000179 ( Istex/Corpus ); précédent : 000178; suivant : 000180Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS‐CoV) in SARS patients: implications for pathogenesis and virus transmission pathways
Auteurs : Yanqing Ding ; Li He ; Qingling Zhang ; Zhongxi Huang ; Xiaoyan Che ; Jinlin Hou ; Huijun Wang ; Hong Shen ; Liwen Qiu ; Zhuguo Li ; Jian Geng ; Junjie Cai ; Huixia Han ; Xin Li ; Wei Kang ; Desheng Weng ; Ping Liang ; Shibo JiangSource :
- The Journal of Pathology [ 0022-3417 ] ; 2004-06.
English descriptors
- Teeft :
- Ace2, Acidophilic cells, Adrenal gland, Assay, Autopsy tissues, Bone marrow, Central vein, Cerebral neurones, Control patients, Coronavirus, Cytopathic effect, Ding, Eighth hospital, Epithelial, Epithelial cells, Epithelium, Family members, Fang hospital, Functional receptor, Gastric parietal cells, Gastrointestinal system, Gastrointestinal tract, Gene fragments, Great britain, Guangdong province, Guangzhou, Guangzhou city, Guangzhou institute, Health administration, Inclusion bodies, Infectious diseases, John wiley sons, Kimball research institute, Light microscope, Little information, Lung tissue, Lung tissues, Lymph node, Medical university, Natural sciences, Neutral formaldehyde, Novel coronavirus, Organ distribution, Other diseases, Other organs, Other people, Pancreatic acinar cells, Pathol, Pathological changes, Pathological society, Polymerase, Polymerase gene expression, Polymerase gene fragment, Polymerase gene fragments, Positive cells, Positive signal, Present study, Primary target, Protein expression, Protein gene, Receptor, Renal tubule, Respiratory diseases, Respiratory syndrome, Respiratory system, Sars, Sars cases, Sars coronavirus, Sars epidemics, Sars patients, Second hospital, Small intestine, Standard saline citrate, Sweat gland, Sweat gland cells, Syndrome, Testis, Thoracic aortic aneurysm, Tissue sections, Total number, Transmission electron microscopy, Tubule, Uninfected vero, Viral, Viral immunology, Viral inclusion body, Virus particles, Yanqing ding, York blood center, Zhongshan university.
Abstract
We previously identified the major pathological changes in the respiratory and immune systems of patients who died of severe acute respiratory syndrome (SARS) but gained little information on the organ distribution of SARS‐associated coronavirus (SARS‐CoV). In the present study, we used a murine monoclonal antibody specific for SARS‐CoV nucleoprotein, and probes specific for a SARS‐CoV RNA polymerase gene fragment, for immunohistochemistry and in situ hybridization, respectively, to detect SARS‐CoV systematically in tissues from patients who died of SARS. SARS‐CoV was found in lung, trachea/bronchus, stomach, small intestine, distal convoluted renal tubule, sweat gland, parathyroid, pituitary, pancreas, adrenal gland, liver and cerebrum, but was not detected in oesophagus, spleen, lymph node, bone marrow, heart, aorta, cerebellum, thyroid, testis, ovary, uterus or muscle. These results suggest that, in addition to the respiratory system, the gastrointestinal tract and other organs with detectable SARS‐CoV may also be targets of SARS‐CoV infection. The pathological changes in these organs may be caused directly by the cytopathic effect mediated by local replication of the SARS‐CoV; or indirectly as a result of systemic responses to respiratory failure or the harmful immune response induced by viral infection. In addition to viral spread through a respiratory route, SARS‐CoV in the intestinal tract, kidney and sweat glands may be excreted via faeces, urine and sweat, thereby leading to virus transmission. This study provides important information for understanding the pathogenesis of SARS‐CoV infection and sheds light on possible virus transmission pathways. This data will be useful for designing new strategies for prevention and treatment of SARS. Copyright © 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Url:
DOI: 10.1002/path.1560
Links to Exploration step
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<author><name sortKey="Huang, Zhongxi" sort="Huang, Zhongxi" uniqKey="Huang Z" first="Zhongxi" last="Huang">Zhongxi Huang</name>
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<affiliation><mods:affiliation>Yanqing Ding, Department of Pathology, First Military Medical University, Guangzhou 5101515, China.Shibo Jiang, Laboratory of Viral Immunology, Lindsley F. Kimball Research Institute, New York Blood Center, 310 East 67th Street, New York, NY 10021, USA.</mods:affiliation>
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<term>Bone marrow</term>
<term>Central vein</term>
<term>Cerebral neurones</term>
<term>Control patients</term>
<term>Coronavirus</term>
<term>Cytopathic effect</term>
<term>Ding</term>
<term>Eighth hospital</term>
<term>Epithelial</term>
<term>Epithelial cells</term>
<term>Epithelium</term>
<term>Family members</term>
<term>Fang hospital</term>
<term>Functional receptor</term>
<term>Gastric parietal cells</term>
<term>Gastrointestinal system</term>
<term>Gastrointestinal tract</term>
<term>Gene fragments</term>
<term>Great britain</term>
<term>Guangdong province</term>
<term>Guangzhou</term>
<term>Guangzhou city</term>
<term>Guangzhou institute</term>
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<term>Inclusion bodies</term>
<term>Infectious diseases</term>
<term>John wiley sons</term>
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<term>Light microscope</term>
<term>Little information</term>
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<front><div type="abstract" xml:lang="en">We previously identified the major pathological changes in the respiratory and immune systems of patients who died of severe acute respiratory syndrome (SARS) but gained little information on the organ distribution of SARS‐associated coronavirus (SARS‐CoV). In the present study, we used a murine monoclonal antibody specific for SARS‐CoV nucleoprotein, and probes specific for a SARS‐CoV RNA polymerase gene fragment, for immunohistochemistry and in situ hybridization, respectively, to detect SARS‐CoV systematically in tissues from patients who died of SARS. SARS‐CoV was found in lung, trachea/bronchus, stomach, small intestine, distal convoluted renal tubule, sweat gland, parathyroid, pituitary, pancreas, adrenal gland, liver and cerebrum, but was not detected in oesophagus, spleen, lymph node, bone marrow, heart, aorta, cerebellum, thyroid, testis, ovary, uterus or muscle. These results suggest that, in addition to the respiratory system, the gastrointestinal tract and other organs with detectable SARS‐CoV may also be targets of SARS‐CoV infection. The pathological changes in these organs may be caused directly by the cytopathic effect mediated by local replication of the SARS‐CoV; or indirectly as a result of systemic responses to respiratory failure or the harmful immune response induced by viral infection. In addition to viral spread through a respiratory route, SARS‐CoV in the intestinal tract, kidney and sweat glands may be excreted via faeces, urine and sweat, thereby leading to virus transmission. This study provides important information for understanding the pathogenesis of SARS‐CoV infection and sheds light on possible virus transmission pathways. This data will be useful for designing new strategies for prevention and treatment of SARS. Copyright © 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</div>
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<json:item><name>Li He</name>
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<json:item><name>Liwen Qiu</name>
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<json:item><name>Zhuguo Li</name>
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<json:item><name>Jian Geng</name>
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<json:item><name>Junjie Cai</name>
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<json:item><name>Huixia Han</name>
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<json:item><name>Xin Li</name>
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<json:item><name>Wei Kang</name>
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<json:item><name>Desheng Weng</name>
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<json:item><name>Ping Liang</name>
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<abstract>We previously identified the major pathological changes in the respiratory and immune systems of patients who died of severe acute respiratory syndrome (SARS) but gained little information on the organ distribution of SARS‐associated coronavirus (SARS‐CoV). In the present study, we used a murine monoclonal antibody specific for SARS‐CoV nucleoprotein, and probes specific for a SARS‐CoV RNA polymerase gene fragment, for immunohistochemistry and in situ hybridization, respectively, to detect SARS‐CoV systematically in tissues from patients who died of SARS. SARS‐CoV was found in lung, trachea/bronchus, stomach, small intestine, distal convoluted renal tubule, sweat gland, parathyroid, pituitary, pancreas, adrenal gland, liver and cerebrum, but was not detected in oesophagus, spleen, lymph node, bone marrow, heart, aorta, cerebellum, thyroid, testis, ovary, uterus or muscle. These results suggest that, in addition to the respiratory system, the gastrointestinal tract and other organs with detectable SARS‐CoV may also be targets of SARS‐CoV infection. The pathological changes in these organs may be caused directly by the cytopathic effect mediated by local replication of the SARS‐CoV; or indirectly as a result of systemic responses to respiratory failure or the harmful immune response induced by viral infection. In addition to viral spread through a respiratory route, SARS‐CoV in the intestinal tract, kidney and sweat glands may be excreted via faeces, urine and sweat, thereby leading to virus transmission. This study provides important information for understanding the pathogenesis of SARS‐CoV infection and sheds light on possible virus transmission pathways. This data will be useful for designing new strategies for prevention and treatment of SARS. Copyright © 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</abstract>
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<title>Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS‐CoV) in SARS patients: implications for pathogenesis and virus transmission pathways</title>
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<p>We previously identified the major pathological changes in the respiratory and immune systems of patients who died of severe acute respiratory syndrome (SARS) but gained little information on the organ distribution of SARS‐associated coronavirus (SARS‐CoV). In the present study, we used a murine monoclonal antibody specific for SARS‐CoV nucleoprotein, and probes specific for a SARS‐CoV RNA polymerase gene fragment, for immunohistochemistry and <hi rend="italic">in situ</hi>
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<p>We previously identified the major pathological changes in the respiratory and immune systems of patients who died of severe acute respiratory syndrome (SARS) but gained little information on the organ distribution of SARS‐associated coronavirus (SARS‐CoV). In the present study, we used a murine monoclonal antibody specific for SARS‐CoV nucleoprotein, and probes specific for a SARS‐CoV RNA polymerase gene fragment, for immunohistochemistry and <i>in situ</i>
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<abstract lang="en">We previously identified the major pathological changes in the respiratory and immune systems of patients who died of severe acute respiratory syndrome (SARS) but gained little information on the organ distribution of SARS‐associated coronavirus (SARS‐CoV). In the present study, we used a murine monoclonal antibody specific for SARS‐CoV nucleoprotein, and probes specific for a SARS‐CoV RNA polymerase gene fragment, for immunohistochemistry and in situ hybridization, respectively, to detect SARS‐CoV systematically in tissues from patients who died of SARS. SARS‐CoV was found in lung, trachea/bronchus, stomach, small intestine, distal convoluted renal tubule, sweat gland, parathyroid, pituitary, pancreas, adrenal gland, liver and cerebrum, but was not detected in oesophagus, spleen, lymph node, bone marrow, heart, aorta, cerebellum, thyroid, testis, ovary, uterus or muscle. These results suggest that, in addition to the respiratory system, the gastrointestinal tract and other organs with detectable SARS‐CoV may also be targets of SARS‐CoV infection. The pathological changes in these organs may be caused directly by the cytopathic effect mediated by local replication of the SARS‐CoV; or indirectly as a result of systemic responses to respiratory failure or the harmful immune response induced by viral infection. In addition to viral spread through a respiratory route, SARS‐CoV in the intestinal tract, kidney and sweat glands may be excreted via faeces, urine and sweat, thereby leading to virus transmission. This study provides important information for understanding the pathogenesis of SARS‐CoV infection and sheds light on possible virus transmission pathways. This data will be useful for designing new strategies for prevention and treatment of SARS. Copyright © 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</abstract>
<note type="funding">Chinese National Foundation of Natural Sciences - No. 30340015; </note>
<note type="funding">Military Foundation of Medical Science - No. 03F016‐2; </note>
<note type="funding">Foundation of Natural Sciences of Guangdong Province - No. GD2003‐80; </note>
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<name type="personal"><namePart type="given">TG</namePart>
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<role><roleTerm type="text">author</roleTerm>
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<name type="personal"><namePart type="given">CS</namePart>
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<note type="citation/reference">Ksiazek TG, Erdman D, Goldsmith CS, et al. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med 2003; 348: 1953–1966.</note>
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<detail type="volume"><caption>vol.</caption>
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<extent unit="pages"><start>1953</start>
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</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>348</number>
</detail>
<extent unit="pages"><start>1953</start>
<end>1966</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit3"><titleInfo><title>Identification of a novel coronavirus in patients with severe acute respiratory syndrome</title>
</titleInfo>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Drosten</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Gunther</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">W</namePart>
<namePart type="family">Preiser</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Drosten C, Gunther S, Preiser W, et al. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med 2003; 348: 1967–1976.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>348</number>
</detail>
<extent unit="pages"><start>1967</start>
<end>1976</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>N Engl J Med</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>348</number>
</detail>
<extent unit="pages"><start>1967</start>
<end>1976</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit4"><titleInfo><title>Coronavirus as a possible cause of severe acute respiratory syndrome</title>
</titleInfo>
<name type="personal"><namePart type="given">JS</namePart>
<namePart type="family">Peiris</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">ST</namePart>
<namePart type="family">Lai</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">LL</namePart>
<namePart type="family">Poon</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Peiris JS, Lai ST, Poon LL, et al. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet 2003; 361: 1319–1325.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>361</number>
</detail>
<extent unit="pages"><start>1319</start>
<end>1325</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Lancet</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>361</number>
</detail>
<extent unit="pages"><start>1319</start>
<end>1325</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit5"><titleInfo><title>The genome sequence of the SARS‐associated coronavirus</title>
</titleInfo>
<name type="personal"><namePart type="given">MA</namePart>
<namePart type="family">Marra</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">SJM</namePart>
<namePart type="family">Jones</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">CR</namePart>
<namePart type="family">Astell</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Marra MA, Jones SJM, Astell CR, et al. The genome sequence of the SARS‐associated coronavirus. Science 2003; 300: 1399–1404.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>300</number>
</detail>
<extent unit="pages"><start>1399</start>
<end>1404</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Science</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>300</number>
</detail>
<extent unit="pages"><start>1399</start>
<end>1404</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit6"><titleInfo><title>Characterization of a novel coronavirus associated with severe acute respiratory syndrome</title>
</titleInfo>
<name type="personal"><namePart type="given">PA</namePart>
<namePart type="family">Rota</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MS</namePart>
<namePart type="family">Oberste</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">SS</namePart>
<namePart type="family">Monroe</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Rota PA, Oberste MS, Monroe SS, et al. Characterization of a novel coronavirus associated with severe acute respiratory syndrome. Science 2003; 300: 1394–1399.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>300</number>
</detail>
<extent unit="pages"><start>1394</start>
<end>1399</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Science</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>300</number>
</detail>
<extent unit="pages"><start>1394</start>
<end>1399</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit7"><titleInfo><title>Isolation and characterization of viruses related to the SARS coronavirus from animals in Southern China</title>
</titleInfo>
<name type="personal"><namePart type="given">Y</namePart>
<namePart type="family">Guan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">BJ</namePart>
<namePart type="family">Zheng</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">YQ</namePart>
<namePart type="family">He</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Guan Y, Zheng BJ, He YQ, et al. Isolation and characterization of viruses related to the SARS coronavirus from animals in Southern China. Science 2003; 302: 276–278.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>302</number>
</detail>
<extent unit="pages"><start>276</start>
<end>278</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Science</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>302</number>
</detail>
<extent unit="pages"><start>276</start>
<end>278</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit8"><titleInfo><title>Angiotensin‐converting enzyme 2 is a functional receptor for the SARS coronavirus</title>
</titleInfo>
<name type="personal"><namePart type="given">WH</namePart>
<namePart type="family">Li</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MJ</namePart>
<namePart type="family">Moore</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">NY</namePart>
<namePart type="family">Vasilieva</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Li WH, Moore MJ, Vasilieva NY, et al. Angiotensin‐converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature 2003; 426: 450–454.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>426</number>
</detail>
<extent unit="pages"><start>450</start>
<end>454</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Nature</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>426</number>
</detail>
<extent unit="pages"><start>450</start>
<end>454</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit9"><titleInfo><title>A 193‐amino‐acid fragment of the SARS coronavirus S protein efficiently binds angiotensin‐converting enzyme 2</title>
</titleInfo>
<name type="personal"><namePart type="given">SK</namePart>
<namePart type="family">Wong</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">W</namePart>
<namePart type="family">Li</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MJ</namePart>
<namePart type="family">Moore</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Wong SK, Li W, Moore MJ, et al. A 193‐amino‐acid fragment of the SARS coronavirus S protein efficiently binds angiotensin‐converting enzyme 2. J Biol Chem 2003; 279: 3197–3201.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>279</number>
</detail>
<extent unit="pages"><start>3197</start>
<end>3201</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Biol Chem</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>279</number>
</detail>
<extent unit="pages"><start>3197</start>
<end>3201</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit10"><titleInfo><title>The SARS‐CoV S glycoprotein: expression and functional characterization</title>
</titleInfo>
<name type="personal"><namePart type="given">X</namePart>
<namePart type="family">Xiao</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Chakraborti</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">AS</namePart>
<namePart type="family">Dimitrov</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Xiao X, Chakraborti S, Dimitrov AS, et al. The SARS‐CoV S glycoprotein: expression and functional characterization. Biochem Biophys Res Commun 2003; 312: 1159–1164.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>312</number>
</detail>
<extent unit="pages"><start>1159</start>
<end>1164</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Biochem Biophys Res Commun</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>312</number>
</detail>
<extent unit="pages"><start>1159</start>
<end>1164</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit11"><titleInfo><title>The secret life of ACE2 as a receptor for the SARS virus</title>
</titleInfo>
<name type="personal"><namePart type="given">DS</namePart>
<namePart type="family">Dimitrov</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Dimitrov DS. The secret life of ACE2 as a receptor for the SARS virus. Cell 2003; 115: 652–653.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>115</number>
</detail>
<extent unit="pages"><start>652</start>
<end>653</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Cell</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>115</number>
</detail>
<extent unit="pages"><start>652</start>
<end>653</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit12"><titleInfo><title>Interaction between the heptad repeat 1 and 2 regions in spike protein of SARS‐associated coronavirus: implication for virus fusogenic mechanism and identification of fusion inhibitors</title>
</titleInfo>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Liu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">G</namePart>
<namePart type="family">Xiao</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Y</namePart>
<namePart type="family">Chen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Liu S, Xiao G, Chen Y, et al. Interaction between the heptad repeat 1 and 2 regions in spike protein of SARS‐associated coronavirus: implication for virus fusogenic mechanism and identification of fusion inhibitors. Lancet 2004; 363: 938–947.</note>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>363</number>
</detail>
<extent unit="pages"><start>938</start>
<end>947</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Lancet</title>
</titleInfo>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>363</number>
</detail>
<extent unit="pages"><start>938</start>
<end>947</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit13"><titleInfo><title>Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome</title>
</titleInfo>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Kuiken</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RAM</namePart>
<namePart type="family">Fouchier</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Schutten</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Kuiken T, Fouchier RAM, Schutten M, et al. Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome. Lancet 2003; 362: 263–270.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>362</number>
</detail>
<extent unit="pages"><start>263</start>
<end>270</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Lancet</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>362</number>
</detail>
<extent unit="pages"><start>263</start>
<end>270</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit14"><titleInfo><title>Identification of an epitope of SARS‐coronavirus nucleocapsid protein</title>
</titleInfo>
<name type="personal"><namePart type="given">Y</namePart>
<namePart type="family">Lin</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">X</namePart>
<namePart type="family">Shen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RF</namePart>
<namePart type="family">Yang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Lin Y, Shen X, Yang RF, et al. Identification of an epitope of SARS‐coronavirus nucleocapsid protein. Cell Res 2003; 13: 141–145.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>13</number>
</detail>
<extent unit="pages"><start>141</start>
<end>145</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Cell Res</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>13</number>
</detail>
<extent unit="pages"><start>141</start>
<end>145</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit15"><titleInfo><title>WHO. Consensus document on the epidemiology of severe acute respiratory syndrome (SARS). www.who.int 2003.</title>
</titleInfo>
<name type="corporate"><namePart>WHO</namePart>
</name>
<genre>other</genre>
<part><date>2003</date>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit16"><titleInfo><title>Macfie, N. China confirms SARS case in Southern Guangzhou. Reuters Health Information. www.medscape.com/viewarticle/466 710 2004.</title>
</titleInfo>
<genre>other</genre>
<part><date>2004</date>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit17"><titleInfo><title>The clinical pathology of severe acute respiratory syndrome (SARS): a report from China</title>
</titleInfo>
<name type="personal"><namePart type="given">Y</namePart>
<namePart type="family">Ding</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Wang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Shen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Ding Y, Wang H, Shen H, et al. The clinical pathology of severe acute respiratory syndrome (SARS): a report from China. J Pathol 2003; 200: 282–289.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>200</number>
</detail>
<extent unit="pages"><start>282</start>
<end>289</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J Pathol</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>200</number>
</detail>
<extent unit="pages"><start>282</start>
<end>289</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit18"><titleInfo><title>Fatal aspergillosis in a patient with SARS who was treated with corticosteroids</title>
</titleInfo>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Wang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Y</namePart>
<namePart type="family">Ding</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">X</namePart>
<namePart type="family">Li</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Wang H, Ding Y, Li X, et al. Fatal aspergillosis in a patient with SARS who was treated with corticosteroids. N Engl J Med 2003; 349: 507–508.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>349</number>
</detail>
<extent unit="pages"><start>507</start>
<end>508</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>N Engl J Med</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>349</number>
</detail>
<extent unit="pages"><start>507</start>
<end>508</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit19"><titleInfo><title>Rapid and efficient preparation of monoclonal antibodies against SARS‐associated coronavirus nucleocapsid protein by immunizing mice</title>
</titleInfo>
<name type="personal"><namePart type="given">XY</namePart>
<namePart type="family">Che</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">LW</namePart>
<namePart type="family">Qiu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">YX</namePart>
<namePart type="family">Pan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Che XY, Qiu LW, Pan YX, et al. Rapid and efficient preparation of monoclonal antibodies against SARS‐associated coronavirus nucleocapsid protein by immunizing mice. Di Yi Jun Yi Da Xue Xue Bao 2003; 23: 640–642.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>23</number>
</detail>
<extent unit="pages"><start>640</start>
<end>642</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Di Yi Jun Yi Da Xue Xue Bao</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>23</number>
</detail>
<extent unit="pages"><start>640</start>
<end>642</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit20"><titleInfo><title>Increased localization and substrate activation of protein kinase C delta in lung epithelial cells following exposure to asbestos</title>
</titleInfo>
<name type="personal"><namePart type="given">KM</namePart>
<namePart type="family">Lounsbury</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Stern</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">D</namePart>
<namePart type="family">Taatjes</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Lounsbury KM, Stern M, Taatjes D, et al. Increased localization and substrate activation of protein kinase C delta in lung epithelial cells following exposure to asbestos. Am J Pathol 2002; 160: 1991–2000.</note>
<part><date>2002</date>
<detail type="volume"><caption>vol.</caption>
<number>160</number>
</detail>
<extent unit="pages"><start>1991</start>
<end>2000</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Am J Pathol</title>
</titleInfo>
<part><date>2002</date>
<detail type="volume"><caption>vol.</caption>
<number>160</number>
</detail>
<extent unit="pages"><start>1991</start>
<end>2000</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit21"><titleInfo><title>Clinical detection of polymerase gene of SARS‐associated coronavirus</title>
</titleInfo>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Yang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">ZH</namePart>
<namePart type="family">Wang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">JJ</namePart>
<namePart type="family">Chen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Yang J, Wang ZH, Chen JJ, et al. Clinical detection of polymerase gene of SARS‐associated coronavirus. Di Yi Jun Yi Da Xue Xue Bao 2003; 23: 424–427.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>23</number>
</detail>
<extent unit="pages"><start>424</start>
<end>427</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Di Yi Jun Yi Da Xue Xue Bao</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>23</number>
</detail>
<extent unit="pages"><start>424</start>
<end>427</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit22"><titleInfo><title>Antibody response of patients with severe acute respiratory syndrome (SARS) to nucleocapsid antigen of SARS‐associated coronavirus</title>
</titleInfo>
<name type="personal"><namePart type="given">XY</namePart>
<namePart type="family">Che</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">W</namePart>
<namePart type="family">Hao</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">LW</namePart>
<namePart type="family">Qiu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Che XY, Hao W, Qiu LW, et al. Antibody response of patients with severe acute respiratory syndrome (SARS) to nucleocapsid antigen of SARS‐associated coronavirus. Di Yi Jun Yi Da Xue Xue Bao 2003; 23: 637–639.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>23</number>
</detail>
<extent unit="pages"><start>637</start>
<end>639</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Di Yi Jun Yi Da Xue Xue Bao</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>23</number>
</detail>
<extent unit="pages"><start>637</start>
<end>639</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit23"><titleInfo><title>SARS in China. The big question now: will it be back?</title>
</titleInfo>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Enserink</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Enserink M. SARS in China. The big question now: will it be back? Science 2003; 301: 299.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>301</number>
</detail>
<extent unit="pages"><start>299</start>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Science</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>301</number>
</detail>
<extent unit="pages"><start>299</start>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit24"><titleInfo><title>Infectious diseases: Singapore lab faulted in SARS case</title>
</titleInfo>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Enserink</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Enserink M. Infectious diseases: Singapore lab faulted in SARS case. Science 2003; 301: 1824.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>301</number>
</detail>
<extent unit="pages"><start>1824</start>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Science</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>301</number>
</detail>
<extent unit="pages"><start>1824</start>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit25"><titleInfo><title>Study on etiology and pathology of severe acute respiratory syndrome</title>
</titleInfo>
<name type="personal"><namePart type="given">Y</namePart>
<namePart type="family">Ding</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">HJ</namePart>
<namePart type="family">Wang</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Shen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Ding Y, Wang HJ, Shen H, et al. Study on etiology and pathology of severe acute respiratory syndrome. Zhonghua Bing Li Xue Za Zhi 2003; 32: 195–200.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>32</number>
</detail>
<extent unit="pages"><start>195</start>
<end>200</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Zhonghua Bing Li Xue Za Zhi</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>32</number>
</detail>
<extent unit="pages"><start>195</start>
<end>200</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit26"><titleInfo><title>Human aminopeptidase N is a receptor for human coronavirus 229E</title>
</titleInfo>
<name type="personal"><namePart type="given">CL</namePart>
<namePart type="family">Yeager</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RA</namePart>
<namePart type="family">Ashmun</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">RK</namePart>
<namePart type="family">Williams</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Yeager CL, Ashmun RA, Williams RK, et al. Human aminopeptidase N is a receptor for human coronavirus 229E. Nature 1992; 357: 420–422.</note>
<part><date>1992</date>
<detail type="volume"><caption>vol.</caption>
<number>357</number>
</detail>
<extent unit="pages"><start>420</start>
<end>422</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Nature</title>
</titleInfo>
<part><date>1992</date>
<detail type="volume"><caption>vol.</caption>
<number>357</number>
</detail>
<extent unit="pages"><start>420</start>
<end>422</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit27"><titleInfo><title>Aminopeptidase N is a major receptor for the entero‐pathogenic coronavirus TGEV</title>
</titleInfo>
<name type="personal"><namePart type="given">B</namePart>
<namePart type="family">Delmas</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Gelfi</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">R</namePart>
<namePart type="family">L'Haridon</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Delmas B, Gelfi J, L'Haridon R, et al. Aminopeptidase N is a major receptor for the entero‐pathogenic coronavirus TGEV. Nature 1992; 357: 417–420.</note>
<part><date>1992</date>
<detail type="volume"><caption>vol.</caption>
<number>357</number>
</detail>
<extent unit="pages"><start>417</start>
<end>420</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Nature</title>
</titleInfo>
<part><date>1992</date>
<detail type="volume"><caption>vol.</caption>
<number>357</number>
</detail>
<extent unit="pages"><start>417</start>
<end>420</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit28"><titleInfo><title>Aminopeptidase N inhibitors and SARS</title>
</titleInfo>
<name type="personal"><namePart type="given">DP</namePart>
<namePart type="family">Kontoyiannis</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">R</namePart>
<namePart type="family">Pasqualini</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">W</namePart>
<namePart type="family">Arap</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Kontoyiannis DP, Pasqualini R, Arap W. Aminopeptidase N inhibitors and SARS. Lancet 2003; 361: 1558.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>361</number>
</detail>
<extent unit="pages"><start>1558</start>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Lancet</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>361</number>
</detail>
<extent unit="pages"><start>1558</start>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit29"><titleInfo><title>Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme</title>
</titleInfo>
<name type="personal"><namePart type="given">D</namePart>
<namePart type="family">Harmer</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Gilbert</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">R</namePart>
<namePart type="family">Borman</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Harmer D, Gilbert M, Borman R, et al. Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme. FEBS Lett 2002; 532: 107–110.</note>
<part><date>2002</date>
<detail type="volume"><caption>vol.</caption>
<number>532</number>
</detail>
<extent unit="pages"><start>107</start>
<end>110</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>FEBS Lett</title>
</titleInfo>
<part><date>2002</date>
<detail type="volume"><caption>vol.</caption>
<number>532</number>
</detail>
<extent unit="pages"><start>107</start>
<end>110</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit30"><titleInfo><title>Enteric involvement of severe acute respiratory syndrome‐associated coronavirus infection</title>
</titleInfo>
<name type="personal"><namePart type="given">WK</namePart>
<namePart type="family">Leung</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">KF</namePart>
<namePart type="family">To</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">PK</namePart>
<namePart type="family">Chan</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Leung WK, To KF, Chan PK, et al. Enteric involvement of severe acute respiratory syndrome‐associated coronavirus infection. Gastroenterology 2003; 125: 1011–1017.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>125</number>
</detail>
<extent unit="pages"><start>1011</start>
<end>1017</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Gastroenterology</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>125</number>
</detail>
<extent unit="pages"><start>1011</start>
<end>1017</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit31"><titleInfo><title>SARS: protecting against a deadly disease</title>
</titleInfo>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Rados</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Rados C. SARS: protecting against a deadly disease. FDA Consum 2003; 37: 14–17.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>37</number>
</detail>
<extent unit="pages"><start>14</start>
<end>17</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>FDA Consum</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>37</number>
</detail>
<extent unit="pages"><start>14</start>
<end>17</end>
</extent>
</part>
</relatedItem>
</relatedItem>
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