An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus
Identifieur interne : 001B43 ( Istex/Checkpoint ); précédent : 001B42; suivant : 001B44An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus
Auteurs : Chuan Qin ; Jianwei Wang ; Qiang Wei ; Mingpeng She ; Wayne A. Marasco [États-Unis] ; Hong Jiang ; Xinming Tu ; Hua Zhu ; Lili Ren ; Hong Gao ; Li Guo ; Lan Huang ; Renquan Yang ; Zhe Cong ; Lan Guo ; Yanbin Wang ; Yali Liu ; Yili Sun ; Shumin Duan ; Jianguo Qu ; Liangbiao Chen ; Wei Tong ; Li Ruan ; Peimao Liu ; Hua Zhang ; Jianmin Zhang ; Huiyuan Zhang ; Depei Liu ; Qian Liu ; Tao Hong ; Wei He [République populaire de Chine]Source :
- The Journal of Pathology [ 0022-3417 ] ; 2005-07.
Abstract
A new SARS animal model was established by inoculating SARS coronavirus (SARS‐CoV) into rhesus macaques (Macaca mulatta) through the nasal cavity. Pathological pulmonary changes were successively detected on days 5–60 after virus inoculation. All eight animals showed a transient fever 2–3 days after inoculation. Immunological, molecular biological, and pathological studies support the establishment of this SARS animal model. Firstly, SARS‐CoV‐specific IgGs were detected in the sera of macaques from 11 to 60 days after inoculation. Secondly, SARS‐CoV RNA could be detected in pharyngeal swab samples using nested RT‐PCR in all infected animals from 5 days after virus inoculation. Finally, histopathological changes of interstitial pneumonia were found in the lungs during the 60 days after viral inoculation: these changes were less marked at later time points, indicating that an active healing process together with resolution of an acute inflammatory response was taking place in these animals. This animal model should provide insight into the mechanisms of SARS‐CoV‐related pulmonary disease and greatly facilitate the development of vaccines and therapeutics against SARS. Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Url:
DOI: 10.1002/path.1769
Affiliations:
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<front><div type="abstract" xml:lang="en">A new SARS animal model was established by inoculating SARS coronavirus (SARS‐CoV) into rhesus macaques (Macaca mulatta) through the nasal cavity. Pathological pulmonary changes were successively detected on days 5–60 after virus inoculation. All eight animals showed a transient fever 2–3 days after inoculation. Immunological, molecular biological, and pathological studies support the establishment of this SARS animal model. Firstly, SARS‐CoV‐specific IgGs were detected in the sera of macaques from 11 to 60 days after inoculation. Secondly, SARS‐CoV RNA could be detected in pharyngeal swab samples using nested RT‐PCR in all infected animals from 5 days after virus inoculation. Finally, histopathological changes of interstitial pneumonia were found in the lungs during the 60 days after viral inoculation: these changes were less marked at later time points, indicating that an active healing process together with resolution of an acute inflammatory response was taking place in these animals. This animal model should provide insight into the mechanisms of SARS‐CoV‐related pulmonary disease and greatly facilitate the development of vaccines and therapeutics against SARS. Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</div>
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