An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus
Identifieur interne : 000151 ( Istex/Corpus ); précédent : 000150; suivant : 000152An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus
Auteurs : Chuan Qin ; Jianwei Wang ; Qiang Wei ; Mingpeng She ; Wayne A. Marasco ; Hong Jiang ; Xinming Tu ; Hua Zhu ; Lili Ren ; Hong Gao ; Li Guo ; Lan Huang ; Renquan Yang ; Zhe Cong ; Lan Guo ; Yanbin Wang ; Yali Liu ; Yili Sun ; Shumin Duan ; Jianguo Qu ; Liangbiao Chen ; Wei Tong ; Li Ruan ; Peimao Liu ; Hua Zhang ; Jianmin Zhang ; Huiyuan Zhang ; Depei Liu ; Qian Liu ; Tao Hong ; Wei HeSource :
- The Journal of Pathology [ 0022-3417 ] ; 2005-07.
Abstract
A new SARS animal model was established by inoculating SARS coronavirus (SARS‐CoV) into rhesus macaques (Macaca mulatta) through the nasal cavity. Pathological pulmonary changes were successively detected on days 5–60 after virus inoculation. All eight animals showed a transient fever 2–3 days after inoculation. Immunological, molecular biological, and pathological studies support the establishment of this SARS animal model. Firstly, SARS‐CoV‐specific IgGs were detected in the sera of macaques from 11 to 60 days after inoculation. Secondly, SARS‐CoV RNA could be detected in pharyngeal swab samples using nested RT‐PCR in all infected animals from 5 days after virus inoculation. Finally, histopathological changes of interstitial pneumonia were found in the lungs during the 60 days after viral inoculation: these changes were less marked at later time points, indicating that an active healing process together with resolution of an acute inflammatory response was taking place in these animals. This animal model should provide insight into the mechanisms of SARS‐CoV‐related pulmonary disease and greatly facilitate the development of vaccines and therapeutics against SARS. Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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DOI: 10.1002/path.1769
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Marasco</name><affiliation><mods:affiliation>Department of Cancer Immunology and AIDS, Dana‐Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA</mods:affiliation></affiliation></author><author><name sortKey="Jiang, Hong" sort="Jiang, Hong" uniqKey="Jiang H" first="Hong" last="Jiang">Hong Jiang</name><affiliation><mods:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</mods:affiliation></affiliation></author><author><name sortKey="Tu, Xinming" sort="Tu, Xinming" uniqKey="Tu X" first="Xinming" last="Tu">Xinming Tu</name><affiliation><mods:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</mods:affiliation></affiliation></author><author><name sortKey="Zhu, Hua" sort="Zhu, Hua" uniqKey="Zhu H" first="Hua" last="Zhu">Hua Zhu</name><affiliation><mods:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</mods:affiliation></affiliation></author><author><name sortKey="Ren, Lili" sort="Ren, Lili" uniqKey="Ren L" first="Lili" last="Ren">Lili Ren</name><affiliation><mods:affiliation>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</mods:affiliation></affiliation></author><author><name sortKey="Gao, Hong" sort="Gao, Hong" uniqKey="Gao H" first="Hong" last="Gao">Hong Gao</name><affiliation><mods:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</mods:affiliation></affiliation></author><author><name sortKey="Guo, Li" sort="Guo, Li" uniqKey="Guo L" first="Li" last="Guo">Li Guo</name><affiliation><mods:affiliation>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</mods:affiliation></affiliation></author><author><name sortKey="Huang, Lan" sort="Huang, Lan" uniqKey="Huang L" first="Lan" last="Huang">Lan Huang</name><affiliation><mods:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</mods:affiliation></affiliation></author><author><name sortKey="Yang, Renquan" sort="Yang, Renquan" uniqKey="Yang R" first="Renquan" last="Yang">Renquan Yang</name><affiliation><mods:affiliation>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</mods:affiliation></affiliation></author><author><name sortKey="Cong, Zhe" sort="Cong, Zhe" uniqKey="Cong Z" first="Zhe" last="Cong">Zhe Cong</name><affiliation><mods:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</mods:affiliation></affiliation></author><author><name sortKey="Guo, Lan" sort="Guo, Lan" uniqKey="Guo L" first="Lan" last="Guo">Lan Guo</name><affiliation><mods:affiliation>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</mods:affiliation></affiliation></author><author><name sortKey="Wang, Yanbin" sort="Wang, Yanbin" uniqKey="Wang Y" first="Yanbin" last="Wang">Yanbin Wang</name><affiliation><mods:affiliation>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</mods:affiliation></affiliation></author><author><name sortKey="Liu, Yali" sort="Liu, Yali" uniqKey="Liu Y" first="Yali" last="Liu">Yali Liu</name><affiliation><mods:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</mods:affiliation></affiliation></author><author><name sortKey="Sun, Yili" sort="Sun, Yili" uniqKey="Sun Y" first="Yili" last="Sun">Yili Sun</name><affiliation><mods:affiliation>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</mods:affiliation></affiliation></author><author><name sortKey="Duan, Shumin" sort="Duan, Shumin" uniqKey="Duan S" first="Shumin" last="Duan">Shumin Duan</name><affiliation><mods:affiliation>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</mods:affiliation></affiliation></author><author><name sortKey="Qu, Jianguo" sort="Qu, Jianguo" uniqKey="Qu J" first="Jianguo" last="Qu">Jianguo Qu</name><affiliation><mods:affiliation>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</mods:affiliation></affiliation></author><author><name sortKey="Chen, Liangbiao" sort="Chen, Liangbiao" uniqKey="Chen L" first="Liangbiao" last="Chen">Liangbiao Chen</name><affiliation><mods:affiliation>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</mods:affiliation></affiliation></author><author><name sortKey="Tong, Wei" sort="Tong, Wei" uniqKey="Tong W" first="Wei" last="Tong">Wei Tong</name><affiliation><mods:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</mods:affiliation></affiliation></author><author><name sortKey="Ruan, Li" sort="Ruan, Li" uniqKey="Ruan L" first="Li" last="Ruan">Li Ruan</name><affiliation><mods:affiliation>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</mods:affiliation></affiliation></author><author><name sortKey="Liu, Peimao" sort="Liu, Peimao" uniqKey="Liu P" first="Peimao" last="Liu">Peimao Liu</name><affiliation><mods:affiliation>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100005</mods:affiliation></affiliation></author><author><name sortKey="Zhang, Hua" sort="Zhang, Hua" uniqKey="Zhang H" first="Hua" last="Zhang">Hua Zhang</name><affiliation><mods:affiliation>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100005</mods:affiliation></affiliation></author><author><name sortKey="Zhang, Jianmin" sort="Zhang, Jianmin" uniqKey="Zhang J" first="Jianmin" last="Zhang">Jianmin Zhang</name><affiliation><mods:affiliation>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100005</mods:affiliation></affiliation></author><author><name sortKey="Zhang, Huiyuan" sort="Zhang, Huiyuan" uniqKey="Zhang H" first="Huiyuan" last="Zhang">Huiyuan Zhang</name><affiliation><mods:affiliation>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100005</mods:affiliation></affiliation></author><author><name sortKey="Liu, Depei" sort="Liu, Depei" uniqKey="Liu D" first="Depei" last="Liu">Depei Liu</name><affiliation><mods:affiliation>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100005</mods:affiliation></affiliation></author><author><name sortKey="Liu, Qian" sort="Liu, Qian" uniqKey="Liu Q" first="Qian" last="Liu">Qian Liu</name><affiliation><mods:affiliation>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100005</mods:affiliation></affiliation></author><author><name sortKey="Hong, Tao" sort="Hong, Tao" uniqKey="Hong T" first="Tao" last="Hong">Tao Hong</name><affiliation><mods:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100005</mods:affiliation></affiliation></author><author><name sortKey="He, Wei" sort="He, Wei" uniqKey="He W" first="Wei" last="He">Wei He</name><affiliation><mods:affiliation>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100005</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: heweiimu@public.bta.net.cn</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), 5 Dong Dan San Tiao, Beijing, China, 100005.</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:5658B284977EEB3DA9DC65A54511B6BAE95753AF</idno><date when="2005" year="2005">2005</date><idno type="doi">10.1002/path.1769</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-R330XNKT-T/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000151</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000151</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus</title><author><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name><affiliation><mods:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</mods:affiliation></affiliation></author><author><name sortKey="Wang, Jianwei" sort="Wang, Jianwei" uniqKey="Wang J" first="Jianwei" last="Wang">Jianwei Wang</name><affiliation><mods:affiliation>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</mods:affiliation></affiliation></author><author><name sortKey="Wei, Qiang" sort="Wei, Qiang" uniqKey="Wei Q" first="Qiang" last="Wei">Qiang Wei</name><affiliation><mods:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</mods:affiliation></affiliation></author><author><name sortKey="She, Mingpeng" sort="She, Mingpeng" uniqKey="She M" first="Mingpeng" last="She">Mingpeng She</name><affiliation><mods:affiliation>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100005</mods:affiliation></affiliation></author><author><name sortKey="Marasco, Wayne A" sort="Marasco, Wayne A" uniqKey="Marasco W" first="Wayne A" last="Marasco">Wayne A. Marasco</name><affiliation><mods:affiliation>Department of Cancer Immunology and AIDS, Dana‐Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA</mods:affiliation></affiliation></author><author><name sortKey="Jiang, Hong" sort="Jiang, Hong" uniqKey="Jiang H" first="Hong" last="Jiang">Hong Jiang</name><affiliation><mods:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</mods:affiliation></affiliation></author><author><name sortKey="Tu, Xinming" sort="Tu, Xinming" uniqKey="Tu X" first="Xinming" last="Tu">Xinming Tu</name><affiliation><mods:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</mods:affiliation></affiliation></author><author><name sortKey="Zhu, Hua" sort="Zhu, Hua" uniqKey="Zhu H" first="Hua" last="Zhu">Hua Zhu</name><affiliation><mods:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</mods:affiliation></affiliation></author><author><name sortKey="Ren, Lili" sort="Ren, Lili" uniqKey="Ren L" first="Lili" last="Ren">Lili Ren</name><affiliation><mods:affiliation>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</mods:affiliation></affiliation></author><author><name sortKey="Gao, Hong" sort="Gao, Hong" uniqKey="Gao H" first="Hong" last="Gao">Hong Gao</name><affiliation><mods:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</mods:affiliation></affiliation></author><author><name sortKey="Guo, Li" sort="Guo, Li" uniqKey="Guo L" first="Li" last="Guo">Li Guo</name><affiliation><mods:affiliation>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</mods:affiliation></affiliation></author><author><name sortKey="Huang, Lan" sort="Huang, Lan" uniqKey="Huang L" first="Lan" last="Huang">Lan Huang</name><affiliation><mods:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</mods:affiliation></affiliation></author><author><name sortKey="Yang, Renquan" sort="Yang, Renquan" uniqKey="Yang R" first="Renquan" last="Yang">Renquan Yang</name><affiliation><mods:affiliation>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</mods:affiliation></affiliation></author><author><name sortKey="Cong, Zhe" sort="Cong, Zhe" uniqKey="Cong Z" first="Zhe" last="Cong">Zhe Cong</name><affiliation><mods:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</mods:affiliation></affiliation></author><author><name sortKey="Guo, Lan" sort="Guo, Lan" uniqKey="Guo L" first="Lan" last="Guo">Lan Guo</name><affiliation><mods:affiliation>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</mods:affiliation></affiliation></author><author><name sortKey="Wang, Yanbin" sort="Wang, Yanbin" uniqKey="Wang Y" first="Yanbin" last="Wang">Yanbin Wang</name><affiliation><mods:affiliation>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</mods:affiliation></affiliation></author><author><name sortKey="Liu, Yali" sort="Liu, Yali" uniqKey="Liu Y" first="Yali" last="Liu">Yali Liu</name><affiliation><mods:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</mods:affiliation></affiliation></author><author><name sortKey="Sun, Yili" sort="Sun, Yili" uniqKey="Sun Y" first="Yili" last="Sun">Yili Sun</name><affiliation><mods:affiliation>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</mods:affiliation></affiliation></author><author><name sortKey="Duan, Shumin" sort="Duan, Shumin" uniqKey="Duan S" first="Shumin" last="Duan">Shumin Duan</name><affiliation><mods:affiliation>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</mods:affiliation></affiliation></author><author><name sortKey="Qu, Jianguo" sort="Qu, Jianguo" uniqKey="Qu J" first="Jianguo" last="Qu">Jianguo Qu</name><affiliation><mods:affiliation>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</mods:affiliation></affiliation></author><author><name sortKey="Chen, Liangbiao" sort="Chen, Liangbiao" uniqKey="Chen L" first="Liangbiao" last="Chen">Liangbiao Chen</name><affiliation><mods:affiliation>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</mods:affiliation></affiliation></author><author><name sortKey="Tong, Wei" sort="Tong, Wei" uniqKey="Tong W" first="Wei" last="Tong">Wei Tong</name><affiliation><mods:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</mods:affiliation></affiliation></author><author><name sortKey="Ruan, Li" sort="Ruan, Li" uniqKey="Ruan L" first="Li" last="Ruan">Li Ruan</name><affiliation><mods:affiliation>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</mods:affiliation></affiliation></author><author><name sortKey="Liu, Peimao" sort="Liu, Peimao" uniqKey="Liu P" first="Peimao" last="Liu">Peimao Liu</name><affiliation><mods:affiliation>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100005</mods:affiliation></affiliation></author><author><name sortKey="Zhang, Hua" sort="Zhang, Hua" uniqKey="Zhang H" first="Hua" last="Zhang">Hua Zhang</name><affiliation><mods:affiliation>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100005</mods:affiliation></affiliation></author><author><name sortKey="Zhang, Jianmin" sort="Zhang, Jianmin" uniqKey="Zhang J" first="Jianmin" last="Zhang">Jianmin Zhang</name><affiliation><mods:affiliation>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100005</mods:affiliation></affiliation></author><author><name sortKey="Zhang, Huiyuan" sort="Zhang, Huiyuan" uniqKey="Zhang H" first="Huiyuan" last="Zhang">Huiyuan Zhang</name><affiliation><mods:affiliation>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100005</mods:affiliation></affiliation></author><author><name sortKey="Liu, Depei" sort="Liu, Depei" uniqKey="Liu D" first="Depei" last="Liu">Depei Liu</name><affiliation><mods:affiliation>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100005</mods:affiliation></affiliation></author><author><name sortKey="Liu, Qian" sort="Liu, Qian" uniqKey="Liu Q" first="Qian" last="Liu">Qian Liu</name><affiliation><mods:affiliation>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100005</mods:affiliation></affiliation></author><author><name sortKey="Hong, Tao" sort="Hong, Tao" uniqKey="Hong T" first="Tao" last="Hong">Tao Hong</name><affiliation><mods:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100005</mods:affiliation></affiliation></author><author><name sortKey="He, Wei" sort="He, Wei" uniqKey="He W" first="Wei" last="He">Wei He</name><affiliation><mods:affiliation>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100005</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: heweiimu@public.bta.net.cn</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), 5 Dong Dan San Tiao, Beijing, China, 100005.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">The Journal of Pathology</title><title level="j" type="alt">JOURNAL OF PATHOLOGY, THE</title><idno type="ISSN">0022-3417</idno><idno type="eISSN">1096-9896</idno><imprint><biblScope unit="vol">206</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="251">251</biblScope><biblScope unit="page" to="259">259</biblScope><biblScope unit="page-count">9</biblScope><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2005-07">2005-07</date></imprint><idno type="ISSN">0022-3417</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3417</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A new SARS animal model was established by inoculating SARS coronavirus (SARS‐CoV) into rhesus macaques (Macaca mulatta) through the nasal cavity. Pathological pulmonary changes were successively detected on days 5–60 after virus inoculation. All eight animals showed a transient fever 2–3 days after inoculation. Immunological, molecular biological, and pathological studies support the establishment of this SARS animal model. Firstly, SARS‐CoV‐specific IgGs were detected in the sera of macaques from 11 to 60 days after inoculation. Secondly, SARS‐CoV RNA could be detected in pharyngeal swab samples using nested RT‐PCR in all infected animals from 5 days after virus inoculation. Finally, histopathological changes of interstitial pneumonia were found in the lungs during the 60 days after viral inoculation: these changes were less marked at later time points, indicating that an active healing process together with resolution of an acute inflammatory response was taking place in these animals. This animal model should provide insight into the mechanisms of SARS‐CoV‐related pulmonary disease and greatly facilitate the development of vaccines and therapeutics against SARS. Copyright © 2005 Pathological Society of Great Britain and Ireland. 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Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</json:string></affiliations></json:item><json:item><name>Jianwei Wang</name><affiliations><json:string>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</json:string></affiliations></json:item><json:item><name>Qiang Wei</name><affiliations><json:string>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</json:string></affiliations></json:item><json:item><name>Mingpeng She</name><affiliations><json:string>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100005</json:string></affiliations></json:item><json:item><name>Wayne A Marasco</name><affiliations><json:string>Department of Cancer Immunology and AIDS, Dana‐Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA</json:string></affiliations></json:item><json:item><name>Hong Jiang</name><affiliations><json:string>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</json:string></affiliations></json:item><json:item><name>Xinming Tu</name><affiliations><json:string>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</json:string></affiliations></json:item><json:item><name>Hua Zhu</name><affiliations><json:string>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</json:string></affiliations></json:item><json:item><name>Lili Ren</name><affiliations><json:string>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</json:string></affiliations></json:item><json:item><name>Hong Gao</name><affiliations><json:string>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</json:string></affiliations></json:item><json:item><name>Li Guo</name><affiliations><json:string>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</json:string></affiliations></json:item><json:item><name>Lan Huang</name><affiliations><json:string>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</json:string></affiliations></json:item><json:item><name>Renquan Yang</name><affiliations><json:string>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</json:string></affiliations></json:item><json:item><name>Zhe Cong</name><affiliations><json:string>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</json:string></affiliations></json:item><json:item><name>Lan Guo</name><affiliations><json:string>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</json:string></affiliations></json:item><json:item><name>Yanbin Wang</name><affiliations><json:string>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</json:string></affiliations></json:item><json:item><name>Yali Liu</name><affiliations><json:string>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</json:string></affiliations></json:item><json:item><name>Yili Sun</name><affiliations><json:string>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</json:string></affiliations></json:item><json:item><name>Shumin Duan</name><affiliations><json:string>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</json:string></affiliations></json:item><json:item><name>Jianguo Qu</name><affiliations><json:string>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</json:string></affiliations></json:item><json:item><name>Liangbiao Chen</name><affiliations><json:string>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</json:string></affiliations></json:item><json:item><name>Wei Tong</name><affiliations><json:string>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</json:string></affiliations></json:item><json:item><name>Li Ruan</name><affiliations><json:string>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</json:string></affiliations></json:item><json:item><name>Peimao Liu</name><affiliations><json:string>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100005</json:string></affiliations></json:item><json:item><name>Hua Zhang</name><affiliations><json:string>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100005</json:string></affiliations></json:item><json:item><name>Jianmin Zhang</name><affiliations><json:string>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100005</json:string></affiliations></json:item><json:item><name>Huiyuan Zhang</name><affiliations><json:string>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100005</json:string></affiliations></json:item><json:item><name>Depei Liu</name><affiliations><json:string>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100005</json:string></affiliations></json:item><json:item><name>Qian Liu</name><affiliations><json:string>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100005</json:string></affiliations></json:item><json:item><name>Tao Hong</name><affiliations><json:string>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</json:string><json:string>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</json:string><json:string>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100005</json:string></affiliations></json:item><json:item><name>Wei He</name><affiliations><json:string>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100005</json:string><json:string>E-mail: heweiimu@public.bta.net.cn</json:string><json:string>Correspondence address: Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), 5 Dong Dan San Tiao, Beijing, China, 100005.</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>SARS</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>coronavirus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>animal model</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>pathology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>rhesus monkey</value></json:item></subject><articleId><json:string>PATH1769</json:string></articleId><arkIstex>ark:/67375/WNG-R330XNKT-T</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>A new SARS animal model was established by inoculating SARS coronavirus (SARS‐CoV) into rhesus macaques (Macaca mulatta) through the nasal cavity. Pathological pulmonary changes were successively detected on days 5–60 after virus inoculation. All eight animals showed a transient fever 2–3 days after inoculation. Immunological, molecular biological, and pathological studies support the establishment of this SARS animal model. Firstly, SARS‐CoV‐specific IgGs were detected in the sera of macaques from 11 to 60 days after inoculation. Secondly, SARS‐CoV RNA could be detected in pharyngeal swab samples using nested RT‐PCR in all infected animals from 5 days after virus inoculation. Finally, histopathological changes of interstitial pneumonia were found in the lungs during the 60 days after viral inoculation: these changes were less marked at later time points, indicating that an active healing process together with resolution of an acute inflammatory response was taking place in these animals. This animal model should provide insight into the mechanisms of SARS‐CoV‐related pulmonary disease and greatly facilitate the development of vaccines and therapeutics against SARS. Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</abstract><qualityIndicators><score>9.044</score><pdfWordCount>4812</pdfWordCount><pdfCharCount>30041</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>9</pdfPageCount><pdfPageSize>595 x 842 pts (A4)</pdfPageSize><pdfWordsPerPage>535</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>186</abstractWordCount><abstractCharCount>1289</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus</title><pmid><json:string>15892035</json:string></pmid><genre><json:string>article</json:string></genre><host><title>The Journal of Pathology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1002/(ISSN)1096-9896</json:string></doi><issn><json:string>0022-3417</json:string></issn><eissn><json:string>1096-9896</json:string></eissn><publisherId><json:string>PATH</json:string></publisherId><volume>206</volume><issue>3</issue><pages><first>251</first><last>259</last><total>9</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Original Paper</value></json:item><json:item><value>Original Papers</value></json:item></subject></host><namedEntities><unitex><date><json:string>2005</json:string><json:string>2002</json:string><json:string>2/5/7</json:string></date><geogName></geogName><orgName><json:string>CAMS</json:string><json:string>National Nature Science Foundation</json:string><json:string>Starvax, Inc, Beijing, China</json:string><json:string>Institute of Medical Biology</json:string><json:string>Sons, Ltd.</json:string><json:string>Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA</json:string><json:string>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences</json:string><json:string>Biotech, China</json:string><json:string>Spain and Mitsui</json:string><json:string>Department of Cancer Immunology and AIDS</json:string><json:string>National Basic Research Programme of China</json:string><json:string>National Institutes of Health</json:string><json:string>Sons, Ltd</json:string><json:string>Institute of Virology, Chinese Centre for Disease Control and Prevention</json:string><json:string>Institute of Laboratory Animal Science of CAMS</json:string><json:string>Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences</json:string><json:string>CDC</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Qinmin Zhan</json:string><json:string>Huiyuan Luo</json:string><json:string>Hua Zhang</json:string><json:string>John Wiley</json:string><json:string>Linlin Bao</json:string><json:string>Yiyou Chen</json:string><json:string>Li Guo</json:string><json:string>Hua Zhu</json:string><json:string>Li Ruan</json:string><json:string>Qi Kong</json:string><json:string>Hong Gao</json:string><json:string>Mr Wei</json:string><json:string>Lili Ren</json:string><json:string>Yangqi Zhang</json:string><json:string>Tao Hong</json:string></persName><placeName><json:string>Germany</json:string><json:string>Finland</json:string><json:string>Beijing</json:string><json:string>Mannheim</json:string><json:string>Helsinki</json:string><json:string>China</json:string><json:string>USA</json:string><json:string>Santa Cruz</json:string><json:string>CA</json:string><json:string>San Tiao</json:string><json:string>Ireland</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>[21,22]</json:string><json:string>[7,8]</json:string><json:string>[23]</json:string><json:string>[11]</json:string><json:string>Qin et al</json:string><json:string>[8]</json:string><json:string>Kuiken et al</json:string><json:string>Fouchier et al</json:string><json:string>[13,14]</json:string><json:string>Rowe et al</json:string><json:string>[7]</json:string><json:string>[24]</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-R330XNKT-T</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - pathology</json:string><json:string>2 - oncology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - pathology</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Pathology and Forensic Medicine</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences biologiques fondamentales et appliquees. psychologie</json:string><json:string>4 - invertebres</json:string></inist></categories><publicationDate>2005</publicationDate><copyrightDate>2005</copyrightDate><doi><json:string>10.1002/path.1769</json:string></doi><id>5658B284977EEB3DA9DC65A54511B6BAE95753AF</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-R330XNKT-T/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-R330XNKT-T/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/WNG-R330XNKT-T/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus</title><title level="a" type="short" xml:lang="en">SARS animal model</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><availability><licence>Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</licence></availability><date type="published" when="2005-07"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus</title><title level="a" type="short" xml:lang="en">SARS animal model</title><author xml:id="author-0000"><persName><forename type="first">Chuan</forename><surname>Qin</surname></persName><affiliation><orgName type="institution">Institute of Laboratory Animal Science</orgName><orgName type="institution">Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</orgName><address><addrLine>Beijing</addrLine><addrLine>China, 100021</addrLine><country key="CN" xml:lang="en">CHINA</country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Jianwei</forename><surname>Wang</surname></persName><affiliation><orgName type="institution">Institute of Virology</orgName><orgName type="division">Chinese Centre for Disease Control and Prevention (CDC)</orgName><address><addrLine>Beijing</addrLine><addrLine>China, 100052</addrLine><country key="CN" xml:lang="en">CHINA</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Qiang</forename><surname>Wei</surname></persName><affiliation><orgName type="institution">Institute of Laboratory Animal Science</orgName><orgName type="institution">Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</orgName><address><addrLine>Beijing</addrLine><addrLine>China, 100021</addrLine><country key="CN" xml:lang="en">CHINA</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Mingpeng</forename><surname>She</surname></persName><affiliation><orgName type="institution">Institute of Basic Medical Sciences</orgName><orgName type="institution">Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</orgName><address><addrLine>Beijing</addrLine><addrLine>China, 100005</addrLine><country key="CN" xml:lang="en">CHINA</country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Wayne A</forename><surname>Marasco</surname></persName><affiliation><orgName type="division">Department of Cancer Immunology and AIDS</orgName><orgName type="institution">Dana‐Farber Cancer Institute</orgName><orgName type="department">Harvard Medical School</orgName><address><addrLine>Boston</addrLine><addrLine>MA 02115, USA</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Hong</forename><surname>Jiang</surname></persName><affiliation><orgName type="institution">Institute of Laboratory Animal Science</orgName><orgName type="institution">Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</orgName><address><addrLine>Beijing</addrLine><addrLine>China, 100021</addrLine><country key="CN" xml:lang="en">CHINA</country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">Xinming</forename><surname>Tu</surname></persName><affiliation><orgName type="institution">Institute of Laboratory Animal Science</orgName><orgName type="institution">Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</orgName><address><addrLine>Beijing</addrLine><addrLine>China, 100021</addrLine><country key="CN" xml:lang="en">CHINA</country></address></affiliation></author><author xml:id="author-0007"><persName><forename type="first">Hua</forename><surname>Zhu</surname></persName><affiliation><orgName type="institution">Institute of Laboratory Animal Science</orgName><orgName type="institution">Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</orgName><address><addrLine>Beijing</addrLine><addrLine>China, 100021</addrLine><country key="CN" xml:lang="en">CHINA</country></address></affiliation></author><author xml:id="author-0008"><persName><forename type="first">Lili</forename><surname>Ren</surname></persName><affiliation><orgName type="institution">Institute of Virology</orgName><orgName type="division">Chinese Centre for Disease Control and Prevention (CDC)</orgName><address><addrLine>Beijing</addrLine><addrLine>China, 100052</addrLine><country key="CN" xml:lang="en">CHINA</country></address></affiliation></author><author xml:id="author-0009"><persName><forename type="first">Hong</forename><surname>Gao</surname></persName><affiliation><orgName type="institution">Institute of Laboratory Animal Science</orgName><orgName type="institution">Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)</orgName><address><addrLine>Beijing</addrLine><addrLine>China, 100021</addrLine><country key="CN" xml:lang="en">CHINA</country></address></affiliation></author><author xml:id="author-0010"><persName><forename type="first">Li</forename><surname>Guo</surname></persName><affiliation><orgName type="institution">Institute of Virology</orgName><orgName type="division">Chinese Centre for Disease Control and Prevention (CDC)</orgName><address><addrLine>Beijing</addrLine><addrLine>China, 100052</addrLine><country key="CN" xml:lang="en">CHINA</country></address></affiliation></author><author xml:id="author-0011"><persName><forename type="first">Lan</forename><surname>Huang</surname></persName><affiliation><orgName 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Published by John Wiley & Sons, Ltd.</copyright><eventGroup><event type="manuscriptReceived" date="2004-08-04"></event><event type="manuscriptRevised" date="2004-12-21"></event><event type="manuscriptAccepted" date="2005-02-08"></event><event type="publishedOnlineEarlyUnpaginated" date="2005-05-13"></event><event type="firstOnline" date="2005-05-13"></event><event type="publishedOnlineFinalForm" date="2005-06-01"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-02-27"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-06"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-11-04"></event></eventGroup><numberingGroup><numbering type="pageFirst">251</numbering><numbering type="pageLast">259</numbering></numberingGroup><correspondenceTo>Department of Immunology, Institute of 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Pathological pulmonary changes were successively detected on days 5–60 after virus inoculation. All eight animals showed a transient fever 2–3 days after inoculation. Immunological, molecular biological, and pathological studies support the establishment of this SARS animal model. Firstly, SARS‐CoV‐specific IgGs were detected in the sera of macaques from 11 to 60 days after inoculation. Secondly, SARS‐CoV RNA could be detected in pharyngeal swab samples using nested RT‐PCR in all infected animals from 5 days after virus inoculation. Finally, histopathological changes of interstitial pneumonia were found in the lungs during the 60 days after viral inoculation: these changes were less marked at later time points, indicating that an active healing process together with resolution of an acute inflammatory response was taking place in these animals. This animal model should provide insight into the mechanisms of SARS‐CoV‐related pulmonary disease and greatly facilitate the development of vaccines and therapeutics against SARS. Copyright © 2005 Pathological Society of Great Britain and Ireland. 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type="family">Marasco</namePart><affiliation>Department of Cancer Immunology and AIDS, Dana‐Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hong</namePart><namePart type="family">Jiang</namePart><affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Xinming</namePart><namePart type="family">Tu</namePart><affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hua</namePart><namePart type="family">Zhu</namePart><affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lili</namePart><namePart type="family">Ren</namePart><affiliation>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hong</namePart><namePart type="family">Gao</namePart><affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Li</namePart><namePart type="family">Guo</namePart><affiliation>Institute of 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type="family">Chen</namePart><affiliation>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Wei</namePart><namePart type="family">Tong</namePart><affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Li</namePart><namePart type="family">Ruan</namePart><affiliation>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Peimao</namePart><namePart type="family">Liu</namePart><affiliation>Institute of Basic Medical Sciences, Chinese Academy of 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Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100005</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Depei</namePart><namePart type="family">Liu</namePart><affiliation>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100005</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Qian</namePart><namePart type="family">Liu</namePart><affiliation>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100005</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tao</namePart><namePart type="family">Hong</namePart><affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100021</affiliation><affiliation>Institute of Virology, Chinese Centre for Disease Control and Prevention (CDC), Beijing, China, 100052</affiliation><affiliation>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100005</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Wei</namePart><namePart type="family">He</namePart><affiliation>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 100005</affiliation><affiliation>E-mail: heweiimu@public.bta.net.cn</affiliation><affiliation>Correspondence address: Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), 5 Dong Dan San Tiao, Beijing, China, 100005.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>John Wiley & Sons, Ltd.</publisher><place><placeTerm type="text">Chichester, UK</placeTerm></place><dateIssued encoding="w3cdtf">2005-07</dateIssued><dateCaptured encoding="w3cdtf">2004-08-04</dateCaptured><dateValid encoding="w3cdtf">2005-02-08</dateValid><copyrightDate encoding="w3cdtf">2005</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">9</extent><extent unit="tables">4</extent><extent unit="references">24</extent></physicalDescription><abstract lang="en">A new SARS animal model was established by inoculating SARS coronavirus (SARS‐CoV) into rhesus macaques (Macaca mulatta) through the nasal cavity. Pathological pulmonary changes were successively detected on days 5–60 after virus inoculation. All eight animals showed a transient fever 2–3 days after inoculation. Immunological, molecular biological, and pathological studies support the establishment of this SARS animal model. Firstly, SARS‐CoV‐specific IgGs were detected in the sera of macaques from 11 to 60 days after inoculation. Secondly, SARS‐CoV RNA could be detected in pharyngeal swab samples using nested RT‐PCR in all infected animals from 5 days after virus inoculation. Finally, histopathological changes of interstitial pneumonia were found in the lungs during the 60 days after viral inoculation: these changes were less marked at later time points, indicating that an active healing process together with resolution of an acute inflammatory response was taking place in these animals. This animal model should provide insight into the mechanisms of SARS‐CoV‐related pulmonary disease and greatly facilitate the development of vaccines and therapeutics against SARS. Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</abstract><note type="funding">National High Technology Research and Development Programme of China - No. 2003AA208201; No. 2003AA208205; No. 2003AA208213; </note><note type="funding">National Nature Science Foundation - No. 30340026; </note><note type="funding">National Institutes of Health - No. AI‐061318; </note><note type="funding">National Basic Research Programme of China - No. 2003CB514109; </note><note type="funding">Government of Spain</note><note type="funding">Mitsui & Co</note><subject lang="en"><genre>keywords</genre><topic>SARS</topic><topic>coronavirus</topic><topic>animal model</topic><topic>pathology</topic><topic>rhesus monkey</topic></subject><relatedItem type="host"><titleInfo><title>The Journal of Pathology</title><subTitle>A Journal of the Pathological Society of Great Britain and Ireland</subTitle></titleInfo><titleInfo type="abbreviated"><title>J. 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