Screening for pulmonary tuberculosis in HIV-infected individuals: AIDS Clinical Trials Group Protocol A5253.
Identifieur interne : 001221 ( PubMed/Curation ); précédent : 001220; suivant : 001222Screening for pulmonary tuberculosis in HIV-infected individuals: AIDS Clinical Trials Group Protocol A5253.
Auteurs : S. Swindells [États-Unis] ; L. Komarow ; S. Tripathy ; K P Cain ; R R Macgregor ; J M Achkar ; A. Gupta ; V G Veloso ; A. Asmelash ; A E Omoz-Oarhe ; S. Gengiah ; U. Lalloo ; R. Allen ; C. Shiboski ; J. Andersen ; S S Qasba ; D K KatzensteinSource :
- The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease [ 1815-7920 ] ; 2013.
Descripteurs français
- KwdFr :
- Adulte, Afrique subsaharienne (épidémiologie), Algorithmes, Brésil (épidémiologie), Co-infection, Dépistage systématique (), Expectoration (microbiologie), Femelle, Fièvre (microbiologie), Humains, Inde (épidémiologie), Infections à VIH (diagnostic), Infections à VIH (épidémiologie), Microscopie de fluorescence, Mycobacterium tuberculosis (isolement et purification), Mâle, Norme de soins, Numération des lymphocytes CD4, Perte de poids, Protocoles cliniques, Prévalence, Pérou (épidémiologie), Radiographie thoracique, Sudation, Techniques bactériologiques, Toux (microbiologie), Tuberculose pulmonaire (diagnostic), Tuberculose pulmonaire (microbiologie), Tuberculose pulmonaire (épidémiologie), Valeur prédictive des tests, Études prospectives, Études transversales.
- MESH :
- diagnostic : Infections à VIH, Tuberculose pulmonaire.
- isolement et purification : Mycobacterium tuberculosis.
- microbiologie : Expectoration, Fièvre, Toux, Tuberculose pulmonaire.
- épidémiologie : Afrique subsaharienne, Brésil, Inde, Infections à VIH, Pérou, Tuberculose pulmonaire.
- Adulte, Algorithmes, Co-infection, Dépistage systématique, Femelle, Humains, Microscopie de fluorescence, Mâle, Norme de soins, Numération des lymphocytes CD4, Perte de poids, Protocoles cliniques, Prévalence, Radiographie thoracique, Sudation, Techniques bactériologiques, Valeur prédictive des tests, Études prospectives, Études transversales.
- Wicri :
English descriptors
- KwdEn :
- Adult, Africa South of the Sahara (epidemiology), Algorithms, Bacteriological Techniques, Brazil (epidemiology), CD4 Lymphocyte Count, Clinical Protocols, Coinfection, Cough (microbiology), Cross-Sectional Studies, Female, Fever (microbiology), HIV Infections (diagnosis), HIV Infections (epidemiology), Humans, India (epidemiology), Male, Mass Screening (methods), Microscopy, Fluorescence, Mycobacterium tuberculosis (isolation & purification), Peru (epidemiology), Predictive Value of Tests, Prevalence, Prospective Studies, Radiography, Thoracic, Sputum (microbiology), Standard of Care, Sweating, Tuberculosis, Pulmonary (diagnosis), Tuberculosis, Pulmonary (epidemiology), Tuberculosis, Pulmonary (microbiology), Weight Loss.
- MESH :
- geographic , epidemiology : Africa South of the Sahara, Brazil, India, Peru.
- diagnosis : HIV Infections, Tuberculosis, Pulmonary.
- epidemiology : HIV Infections, Tuberculosis, Pulmonary.
- isolation & purification : Mycobacterium tuberculosis.
- methods : Mass Screening.
- microbiology : Cough, Fever, Sputum, Tuberculosis, Pulmonary.
- Adult, Algorithms, Bacteriological Techniques, CD4 Lymphocyte Count, Clinical Protocols, Coinfection, Cross-Sectional Studies, Female, Humans, Male, Microscopy, Fluorescence, Predictive Value of Tests, Prevalence, Prospective Studies, Radiography, Thoracic, Standard of Care, Sweating, Weight Loss.
Abstract
Improved tuberculosis (TB) screening is urgently needed for human immunodeficiency virus (HIV) infected patients.
DOI: 10.5588/ijtld.12.0737
PubMed: 23485388
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transversales</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Africa South of the Sahara</term><term>Brazil</term><term>India</term><term>Peru</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>HIV Infections</term><term>Tuberculosis, Pulmonary</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à VIH</term><term>Tuberculose pulmonaire</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>HIV Infections</term><term>Tuberculosis, Pulmonary</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Mycobacterium tuberculosis</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Mycobacterium tuberculosis</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Mass Screening</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Expectoration</term><term>Fièvre</term><term>Toux</term><term>Tuberculose pulmonaire</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Cough</term><term>Fever</term><term>Sputum</term><term>Tuberculosis, Pulmonary</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Afrique subsaharienne</term><term>Brésil</term><term>Inde</term><term>Infections à VIH</term><term>Pérou</term><term>Tuberculose pulmonaire</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Algorithms</term><term>Bacteriological Techniques</term><term>CD4 Lymphocyte Count</term><term>Clinical Protocols</term><term>Coinfection</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Microscopy, Fluorescence</term><term>Predictive Value of Tests</term><term>Prevalence</term><term>Prospective Studies</term><term>Radiography, Thoracic</term><term>Standard of Care</term><term>Sweating</term><term>Weight Loss</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Algorithmes</term><term>Co-infection</term><term>Dépistage systématique</term><term>Femelle</term><term>Humains</term><term>Microscopie de fluorescence</term><term>Mâle</term><term>Norme de soins</term><term>Numération des lymphocytes CD4</term><term>Perte de poids</term><term>Protocoles cliniques</term><term>Prévalence</term><term>Radiographie thoracique</term><term>Sudation</term><term>Techniques bactériologiques</term><term>Valeur prédictive des tests</term><term>Études prospectives</term><term>Études transversales</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Brésil</term><term>Inde</term><term>Pérou</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Improved tuberculosis (TB) screening is urgently needed for human immunodeficiency virus (HIV) infected patients.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23485388</PMID><DateCreated><Year>2013</Year><Month>03</Month><Day>14</Day></DateCreated><DateCompleted><Year>2013</Year><Month>08</Month><Day>30</Day></DateCompleted><DateRevised><Year>2016</Year><Month>12</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1815-7920</ISSN><JournalIssue CitedMedium="Internet"><Volume>17</Volume><Issue>4</Issue><PubDate><Year>2013</Year><Month>Apr</Month></PubDate></JournalIssue><Title>The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease</Title><ISOAbbreviation>Int. J. Tuberc. Lung Dis.</ISOAbbreviation></Journal><ArticleTitle>Screening for pulmonary tuberculosis in HIV-infected individuals: AIDS Clinical Trials Group Protocol A5253.</ArticleTitle><Pagination><MedlinePgn>532-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.5588/ijtld.12.0737</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Improved tuberculosis (TB) screening is urgently needed for human immunodeficiency virus (HIV) infected patients.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">An observational, multi-country, cross-sectional study of HIV-infected patients to compare a standardized diagnostic evaluation (SDE) for TB with standard of care (SOC). SOC evaluations included TB symptom review (current cough, fever, night sweats and/or weight loss), sputum Ziehl-Neelsen staining and chest radiography. SDE screening added extended clinical signs and symptoms and fluorescent microscopy (FM). All participants underwent all evaluations. Mycobacterium tuberculosis on sputum culture was the primary outcome.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">A total of 801 participants were enrolled from Botswana, Malawi, South Africa, Zimbabwe, India, Peru and Brazil. The median age was 33 years; 37% were male, and median CD4 count was 275 cells/mm(3). Thirty-one participants (4%) had a positive culture on Löwenstein-Jensen media and 54 (8%) on MGIT. All but one positive culture came from sub-Saharan Africa, where the prevalence of TB was 54/445 (12%). SOC screening had 54% sensitivity (95%CI 40-67) and 76% specificity (95%CI 72-80). Positive and negative predictive values were respectively 24% and 92%. No elements of the SDE improved the predictive values of SOC.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Symptom-based screening with smear microscopy was insufficiently sensitive. More sensitive diagnostic testing is required for HIV-infected patients.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Swindells</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198-8106, USA. sswindells@unmc.edu</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Komarow</LastName><ForeName>L</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Tripathy</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Cain</LastName><ForeName>K P</ForeName><Initials>KP</Initials></Author><Author ValidYN="Y"><LastName>MacGregor</LastName><ForeName>R R</ForeName><Initials>RR</Initials></Author><Author ValidYN="Y"><LastName>Achkar</LastName><ForeName>J M</ForeName><Initials>JM</Initials></Author><Author ValidYN="Y"><LastName>Gupta</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Veloso</LastName><ForeName>V G</ForeName><Initials>VG</Initials></Author><Author ValidYN="Y"><LastName>Asmelash</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Omoz-Oarhe</LastName><ForeName>A E</ForeName><Initials>AE</Initials></Author><Author ValidYN="Y"><LastName>Gengiah</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Lalloo</LastName><ForeName>U</ForeName><Initials>U</Initials></Author><Author ValidYN="Y"><LastName>Allen</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Shiboski</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Andersen</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Qasba</LastName><ForeName>S S</ForeName><Initials>SS</Initials></Author><Author ValidYN="Y"><LastName>Katzenstein</LastName><ForeName>D K</ForeName><Initials>DK</Initials></Author><Author ValidYN="Y"><CollectiveName>AIDS Clinical Trials Group 5253 Study Team</CollectiveName></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>U01 AI069497</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 AI069438</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 AI069453</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 AI069476</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 AI069417</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 AI051519</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 AI068636</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 AI069469</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 AI069518</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UM1 AI069463</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 AI069456</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 AI068634</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Int J Tuberc Lung Dis</MedlineTA><NlmUniqueID>9706389</NlmUniqueID><ISSNLinking>1027-3719</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Trop Med Int Health. 2004 Jun;9(6):A11-5</RefSource><PMID Version="1">15189469</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Infect Dis. 2006 Apr 1;42(7):1040-7</RefSource><PMID Version="1">16511773</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Tuberc Lung Dis. 2007 May;11(5):485-95</RefSource><PMID Version="1">17439669</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2007 Jun 16;369(9578):2042-9</RefSource><PMID Version="1">17574096</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J 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Version="1">21814495</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet Infect Dis. 2012 May;12(5):373-80</RefSource><PMID Version="1">22277215</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2010 Feb 25;362(8):707-16</RefSource><PMID Version="1">20181972</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017954" MajorTopicYN="N" Type="Geographic">Africa South of the Sahara</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000465" MajorTopicYN="N">Algorithms</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001431" MajorTopicYN="N">Bacteriological Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001938" MajorTopicYN="N" 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