Detection and treatment of Fiebig stage I HIV-1 infection in young at-risk women in South Africa: a prospective cohort study.
Identifieur interne : 000732 ( PubMed/Curation ); précédent : 000731; suivant : 000733Detection and treatment of Fiebig stage I HIV-1 infection in young at-risk women in South Africa: a prospective cohort study.
Auteurs : Krista L. Dong [États-Unis] ; Amber Moodley [Afrique du Sud] ; Douglas S. Kwon [États-Unis] ; Musie S. Ghebremichael [États-Unis] ; Mary Dong [États-Unis] ; Nasreen Ismail [Afrique du Sud] ; Zaza M. Ndhlovu [Afrique du Sud] ; Jenniffer M. Mabuka [Afrique du Sud] ; Daniel M. Muema [Afrique du Sud] ; Karyn Pretorius [Afrique du Sud] ; Nina Lin [États-Unis] ; Bruce D. Walker [États-Unis] ; Thumbi Ndung'U [Allemagne]Source :
- The lancet. HIV [ 2352-3018 ] ; 2017.
Abstract
HIV incidence among young women in sub-Saharan Africa remains high and their inclusion in vaccine and cure efforts is crucial. We aimed to establish a cohort of young women detected during Fiebig stage I acute HIV infection in whom treatment was initiated immediately after diagnosis to advance research in this high-risk group.
DOI: 10.1016/S2352-3018(17)30146-7
PubMed: 28978417
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000732
Links to Exploration step
pubmed:28978417Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Detection and treatment of Fiebig stage I HIV-1 infection in young at-risk women in South Africa: a prospective cohort study.</title><author><name sortKey="Dong, Krista L" sort="Dong, Krista L" uniqKey="Dong K" first="Krista L" last="Dong">Krista L. Dong</name><affiliation wicri:level="1"><nlm:affiliation>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Infectious Disease Division, Massachusetts General Hospital, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Infectious Disease Division, Massachusetts General Hospital, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Moodley, Amber" sort="Moodley, Amber" uniqKey="Moodley A" first="Amber" last="Moodley">Amber Moodley</name><affiliation wicri:level="1"><nlm:affiliation>HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban</wicri:regionArea></affiliation></author><author><name sortKey="Kwon, Douglas S" sort="Kwon, Douglas S" uniqKey="Kwon D" first="Douglas S" last="Kwon">Douglas S. Kwon</name><affiliation wicri:level="1"><nlm:affiliation>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Infectious Disease Division, Massachusetts General Hospital, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Infectious Disease Division, Massachusetts General Hospital, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Ghebremichael, Musie S" sort="Ghebremichael, Musie S" uniqKey="Ghebremichael M" first="Musie S" last="Ghebremichael">Musie S. Ghebremichael</name><affiliation wicri:level="1"><nlm:affiliation>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA</wicri:regionArea></affiliation></author><author><name sortKey="Dong, Mary" sort="Dong, Mary" uniqKey="Dong M" first="Mary" last="Dong">Mary Dong</name><affiliation wicri:level="1"><nlm:affiliation>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA</wicri:regionArea></affiliation></author><author><name sortKey="Ismail, Nasreen" sort="Ismail, Nasreen" uniqKey="Ismail N" first="Nasreen" last="Ismail">Nasreen Ismail</name><affiliation wicri:level="1"><nlm:affiliation>HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban</wicri:regionArea></affiliation></author><author><name sortKey="Ndhlovu, Zaza M" sort="Ndhlovu, Zaza M" uniqKey="Ndhlovu Z" first="Zaza M" last="Ndhlovu">Zaza M. Ndhlovu</name><affiliation wicri:level="1"><nlm:affiliation>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban</wicri:regionArea></affiliation></author><author><name sortKey="Mabuka, Jenniffer M" sort="Mabuka, Jenniffer M" uniqKey="Mabuka J" first="Jenniffer M" last="Mabuka">Jenniffer M. Mabuka</name><affiliation wicri:level="1"><nlm:affiliation>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa; Africa Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa; Africa Health Research Institute, University of KwaZulu-Natal, Durban</wicri:regionArea></affiliation></author><author><name sortKey="Muema, Daniel M" sort="Muema, Daniel M" uniqKey="Muema D" first="Daniel M" last="Muema">Daniel M. Muema</name><affiliation wicri:level="1"><nlm:affiliation>HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa; Africa Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa; Africa Health Research Institute, University of KwaZulu-Natal, Durban</wicri:regionArea></affiliation></author><author><name sortKey="Pretorius, Karyn" sort="Pretorius, Karyn" uniqKey="Pretorius K" first="Karyn" last="Pretorius">Karyn Pretorius</name><affiliation wicri:level="1"><nlm:affiliation>HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban</wicri:regionArea></affiliation></author><author><name sortKey="Lin, Nina" sort="Lin, Nina" uniqKey="Lin N" first="Nina" last="Lin">Nina Lin</name><affiliation wicri:level="1"><nlm:affiliation>Infectious Disease Division, Massachusetts General Hospital, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Infectious Disease Division, Massachusetts General Hospital, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Walker, Bruce D" sort="Walker, Bruce D" uniqKey="Walker B" first="Bruce D" last="Walker">Bruce D. Walker</name><affiliation wicri:level="1"><nlm:affiliation>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Infectious Disease Division, Massachusetts General Hospital, Boston, MA, USA; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa; Institute for Medical Sciences and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Infectious Disease Division, Massachusetts General Hospital, Boston, MA, USA; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa; Institute for Medical Sciences and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD</wicri:regionArea></affiliation></author><author><name sortKey="Ndung U, Thumbi" sort="Ndung U, Thumbi" uniqKey="Ndung U T" first="Thumbi" last="Ndung'U">Thumbi Ndung'U</name><affiliation wicri:level="1"><nlm:affiliation>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa; Africa Health Research Institute, University of KwaZulu-Natal, Durban, South Africa; Max Planck Institute for Infection Biology, Berlin, Germany. Electronic address: ndungu@ukzn.ac.za.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa; Africa Health Research Institute, University of KwaZulu-Natal, Durban, South Africa; Max Planck Institute for Infection Biology, Berlin</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28978417</idno><idno type="pmid">28978417</idno><idno type="doi">10.1016/S2352-3018(17)30146-7</idno><idno type="wicri:Area/PubMed/Corpus">000732</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000732</idno><idno type="wicri:Area/PubMed/Curation">000732</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000732</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Detection and treatment of Fiebig stage I HIV-1 infection in young at-risk women in South Africa: a prospective cohort study.</title><author><name sortKey="Dong, Krista L" sort="Dong, Krista L" uniqKey="Dong K" first="Krista L" last="Dong">Krista L. Dong</name><affiliation wicri:level="1"><nlm:affiliation>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Infectious Disease Division, Massachusetts General Hospital, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Infectious Disease Division, Massachusetts General Hospital, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Moodley, Amber" sort="Moodley, Amber" uniqKey="Moodley A" first="Amber" last="Moodley">Amber Moodley</name><affiliation wicri:level="1"><nlm:affiliation>HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban</wicri:regionArea></affiliation></author><author><name sortKey="Kwon, Douglas S" sort="Kwon, Douglas S" uniqKey="Kwon D" first="Douglas S" last="Kwon">Douglas S. Kwon</name><affiliation wicri:level="1"><nlm:affiliation>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Infectious Disease Division, Massachusetts General Hospital, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Infectious Disease Division, Massachusetts General Hospital, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Ghebremichael, Musie S" sort="Ghebremichael, Musie S" uniqKey="Ghebremichael M" first="Musie S" last="Ghebremichael">Musie S. Ghebremichael</name><affiliation wicri:level="1"><nlm:affiliation>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA</wicri:regionArea></affiliation></author><author><name sortKey="Dong, Mary" sort="Dong, Mary" uniqKey="Dong M" first="Mary" last="Dong">Mary Dong</name><affiliation wicri:level="1"><nlm:affiliation>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA</wicri:regionArea></affiliation></author><author><name sortKey="Ismail, Nasreen" sort="Ismail, Nasreen" uniqKey="Ismail N" first="Nasreen" last="Ismail">Nasreen Ismail</name><affiliation wicri:level="1"><nlm:affiliation>HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban</wicri:regionArea></affiliation></author><author><name sortKey="Ndhlovu, Zaza M" sort="Ndhlovu, Zaza M" uniqKey="Ndhlovu Z" first="Zaza M" last="Ndhlovu">Zaza M. Ndhlovu</name><affiliation wicri:level="1"><nlm:affiliation>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban</wicri:regionArea></affiliation></author><author><name sortKey="Mabuka, Jenniffer M" sort="Mabuka, Jenniffer M" uniqKey="Mabuka J" first="Jenniffer M" last="Mabuka">Jenniffer M. Mabuka</name><affiliation wicri:level="1"><nlm:affiliation>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa; Africa Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa; Africa Health Research Institute, University of KwaZulu-Natal, Durban</wicri:regionArea></affiliation></author><author><name sortKey="Muema, Daniel M" sort="Muema, Daniel M" uniqKey="Muema D" first="Daniel M" last="Muema">Daniel M. Muema</name><affiliation wicri:level="1"><nlm:affiliation>HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa; Africa Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa; Africa Health Research Institute, University of KwaZulu-Natal, Durban</wicri:regionArea></affiliation></author><author><name sortKey="Pretorius, Karyn" sort="Pretorius, Karyn" uniqKey="Pretorius K" first="Karyn" last="Pretorius">Karyn Pretorius</name><affiliation wicri:level="1"><nlm:affiliation>HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban</wicri:regionArea></affiliation></author><author><name sortKey="Lin, Nina" sort="Lin, Nina" uniqKey="Lin N" first="Nina" last="Lin">Nina Lin</name><affiliation wicri:level="1"><nlm:affiliation>Infectious Disease Division, Massachusetts General Hospital, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Infectious Disease Division, Massachusetts General Hospital, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Walker, Bruce D" sort="Walker, Bruce D" uniqKey="Walker B" first="Bruce D" last="Walker">Bruce D. Walker</name><affiliation wicri:level="1"><nlm:affiliation>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Infectious Disease Division, Massachusetts General Hospital, Boston, MA, USA; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa; Institute for Medical Sciences and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Infectious Disease Division, Massachusetts General Hospital, Boston, MA, USA; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa; Institute for Medical Sciences and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD</wicri:regionArea></affiliation></author><author><name sortKey="Ndung U, Thumbi" sort="Ndung U, Thumbi" uniqKey="Ndung U T" first="Thumbi" last="Ndung'U">Thumbi Ndung'U</name><affiliation wicri:level="1"><nlm:affiliation>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa; Africa Health Research Institute, University of KwaZulu-Natal, Durban, South Africa; Max Planck Institute for Infection Biology, Berlin, Germany. Electronic address: ndungu@ukzn.ac.za.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa; Africa Health Research Institute, University of KwaZulu-Natal, Durban, South Africa; Max Planck Institute for Infection Biology, Berlin</wicri:regionArea></affiliation></author></analytic><series><title level="j">The lancet. HIV</title><idno type="eISSN">2352-3018</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">HIV incidence among young women in sub-Saharan Africa remains high and their inclusion in vaccine and cure efforts is crucial. We aimed to establish a cohort of young women detected during Fiebig stage I acute HIV infection in whom treatment was initiated immediately after diagnosis to advance research in this high-risk group.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">28978417</PMID><DateCreated><Year>2017</Year><Month>10</Month><Day>05</Day></DateCreated><DateRevised><Year>2017</Year><Month>10</Month><Day>05</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2352-3018</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2017</Year><Month>Sep</Month><Day>29</Day></PubDate></JournalIssue><Title>The lancet. HIV</Title><ISOAbbreviation>Lancet HIV</ISOAbbreviation></Journal><ArticleTitle>Detection and treatment of Fiebig stage I HIV-1 infection in young at-risk women in South Africa: a prospective cohort study.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">S2352-3018(17)30146-7</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/S2352-3018(17)30146-7</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">HIV incidence among young women in sub-Saharan Africa remains high and their inclusion in vaccine and cure efforts is crucial. We aimed to establish a cohort of young women detected during Fiebig stage I acute HIV infection in whom treatment was initiated immediately after diagnosis to advance research in this high-risk group.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">945 women aged 18-23 years in KwaZulu-Natal, South Africa, who were HIV uninfected and sexually active consented to HIV-1 RNA testing twice a week and biological sampling and risk assessment every 3 months during participation in a 48-96 week life-skills and job-readiness programme. We analysed the effect of immediate combination antiretroviral therapy (ART) on viraemia and immune responses, sexual risk behaviour, and the effect of the socioeconomic intervention.</AbstractText><AbstractText Label="FINDINGS" NlmCategory="RESULTS">42 women were diagnosed with acute HIV infection between Dec 1, 2012, and June 30, 2016, (incidence 8·2 per 100 person-years, 95% CI 5·9-11·1), of whom 36 (86%) were diagnosed in Fiebig stage I infection with a median initial viral load of 2·97 log10 copies per mL (IQR 2·42-3·85). 23 of these 36 women started ART at a median of 1 day (1-1) after detection, which limited the median peak viral load to 4·22 log10 copies per mL (3·27-4·83) and the CD4 nadir to 685 cells per μL (561-802). ART also suppressed viral load (to <20 copies per mL) within a median of 16 days (12-26) and, in 20 (87%) of 23 women, prevented seroconversion, as shown with western blotting. 385 women completed the 48 week socioeconomic intervention, of whom 231 were followed up for 1 year. 202 (87%) of these 231 women were placed in jobs, returned to school, or started a business.</AbstractText><AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">Frequent HIV screening combined with a socioeconomic intervention facilitated sampling and risk assessment before and after infection. In addition to detection of acute infection and immediate treatment, we established a cohort optimised for prevention and cure research.</AbstractText><AbstractText Label="FUNDING" NlmCategory="BACKGROUND">Bill & Melinda Gates Foundation, National Institute of Allergy and Infectious Diseases, International AIDS Vaccine Initiative, Wellcome Trust, Howard Hughes Medical Institute.</AbstractText><CopyrightInformation>Copyright © 2017 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dong</LastName><ForeName>Krista L</ForeName><Initials>KL</Initials><AffiliationInfo><Affiliation>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Infectious Disease Division, Massachusetts General Hospital, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moodley</LastName><ForeName>Amber</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kwon</LastName><ForeName>Douglas S</ForeName><Initials>DS</Initials><AffiliationInfo><Affiliation>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Infectious Disease Division, Massachusetts General Hospital, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ghebremichael</LastName><ForeName>Musie S</ForeName><Initials>MS</Initials><AffiliationInfo><Affiliation>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dong</LastName><ForeName>Mary</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ismail</LastName><ForeName>Nasreen</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ndhlovu</LastName><ForeName>Zaza M</ForeName><Initials>ZM</Initials><AffiliationInfo><Affiliation>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mabuka</LastName><ForeName>Jenniffer M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa; Africa Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Muema</LastName><ForeName>Daniel M</ForeName><Initials>DM</Initials><AffiliationInfo><Affiliation>HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa; Africa Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pretorius</LastName><ForeName>Karyn</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Nina</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Infectious Disease Division, Massachusetts General Hospital, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Walker</LastName><ForeName>Bruce D</ForeName><Initials>BD</Initials><AffiliationInfo><Affiliation>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Infectious Disease Division, Massachusetts General Hospital, Boston, MA, USA; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa; Institute for Medical Sciences and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ndung'u</LastName><ForeName>Thumbi</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa; Africa Health Research Institute, University of KwaZulu-Natal, Durban, South Africa; Max Planck Institute for Infection Biology, Berlin, Germany. Electronic address: ndungu@ukzn.ac.za.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>09</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Lancet HIV</MedlineTA><NlmUniqueID>101645355</NlmUniqueID><ISSNLinking>2352-3018</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>03</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>06</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>07</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>10</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>10</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>10</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28978417</ArticleId><ArticleId IdType="pii">S2352-3018(17)30146-7</ArticleId><ArticleId IdType="doi">10.1016/S2352-3018(17)30146-7</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaSubSaharaV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000732 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 000732 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= SidaSubSaharaV1
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:28978417
|texte= Detection and treatment of Fiebig stage I HIV-1 infection in young at-risk women in South Africa: a prospective cohort study.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:28978417" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a SidaSubSaharaV1
| This area was generated with Dilib version V0.6.32. |  |