Incidence of HIV-Associated Tuberculosis among Individuals Taking Combination Antiretroviral Therapy: A Systematic Review and Meta-Analysis
Identifieur interne : 002B30 ( Pmc/Curation ); précédent : 002B29; suivant : 002B31Incidence of HIV-Associated Tuberculosis among Individuals Taking Combination Antiretroviral Therapy: A Systematic Review and Meta-Analysis
Auteurs : Tendesayi Kufa [Afrique du Sud] ; Tonderai Mabuto [Afrique du Sud] ; Evans Muchiri [Afrique du Sud] ; Salome Charalambous [Afrique du Sud] ; Dominique Rosillon [Belgique] ; Gavin Churchyard [Afrique du Sud] ; Rebecca C. Harris [Belgique]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Abstract
Knowledge of tuberculosis incidence and associated factors is required for the development and evaluation of strategies to reduce the burden of HIV-associated tuberculosis.
Systematic literature review and meta-analysis of tuberculosis incidence rates among HIV-infected individuals taking combination antiretroviral therapy.
From PubMed, EMBASE and Global Index Medicus databases, 42 papers describing 43 cohorts (32 from high/intermediate and 11 from low tuberculosis burden settings) were included in the qualitative review and 33 in the quantitative review. Cohorts from high/intermediate burden settings were smaller in size, had lower median CD4 cell counts at study entry and fewer person-years of follow up. Tuberculosis incidence rates were higher in studies from Sub-Saharan Africa and from World Bank low/middle income countries. Tuberculosis incidence rates decreased with increasing CD4 count at study entry and duration on combination antiretroviral therapy. Summary estimates of tuberculosis incidence among individuals on combination antiretroviral therapy were higher for cohorts from high/intermediate burden settings compared to those from the low tuberculosis burden settings (4.17 per 100 person-years [95% Confidence Interval (CI) 3.39–5.14 per 100 person-years] vs. 0.4 per 100 person-years [95% CI 0.23–0.69 per 100 person-years]) with significant heterogeneity observed between the studies.
Tuberculosis incidence rates were high among individuals on combination antiretroviral therapy in high/intermediate burden settings. Interventions to prevent tuberculosis in this population should address geographical, socioeconomic and individual factors such as low CD4 counts and prior history of tuberculosis.
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DOI: 10.1371/journal.pone.0111209
PubMed: 25393281
PubMed Central: 4230893
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Harris</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>CROMSOURCE on behalf of GlaxoSmithKline Vaccines, Wavre, Belgium</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>CROMSOURCE on behalf of GlaxoSmithKline Vaccines, Wavre</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25393281</idno><idno type="pmc">4230893</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230893</idno><idno type="RBID">PMC:4230893</idno><idno type="doi">10.1371/journal.pone.0111209</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002B31</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002B31</idno><idno type="wicri:Area/Pmc/Curation">002B30</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002B30</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Incidence of HIV-Associated Tuberculosis among Individuals Taking Combination Antiretroviral Therapy: A Systematic Review and Meta-Analysis</title><author><name sortKey="Kufa, Tendesayi" sort="Kufa, Tendesayi" uniqKey="Kufa T" first="Tendesayi" last="Kufa">Tendesayi Kufa</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>The Aurum Institute, Johannesburg, South Africa</addr-line></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>The Aurum Institute, Johannesburg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>The School of Public Health, University of the Witwatersrand, Johannesburg, South Africa</addr-line></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>The School of Public Health, University of the Witwatersrand, Johannesburg</wicri:regionArea></affiliation></author><author><name sortKey="Mabuto, Tonderai" sort="Mabuto, Tonderai" uniqKey="Mabuto T" first="Tonderai" last="Mabuto">Tonderai Mabuto</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>The Aurum Institute, Johannesburg, South Africa</addr-line></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>The Aurum Institute, Johannesburg</wicri:regionArea></affiliation></author><author><name sortKey="Muchiri, Evans" sort="Muchiri, Evans" uniqKey="Muchiri E" first="Evans" last="Muchiri">Evans Muchiri</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>The Aurum Institute, Johannesburg, South Africa</addr-line></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>The Aurum Institute, Johannesburg</wicri:regionArea></affiliation></author><author><name sortKey="Charalambous, Salome" sort="Charalambous, Salome" uniqKey="Charalambous S" first="Salome" last="Charalambous">Salome Charalambous</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>The Aurum Institute, Johannesburg, South Africa</addr-line></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>The Aurum Institute, Johannesburg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>The School of Public Health, University of the Witwatersrand, Johannesburg, South Africa</addr-line></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>The School of Public Health, University of the Witwatersrand, Johannesburg</wicri:regionArea></affiliation></author><author><name sortKey="Rosillon, Dominique" sort="Rosillon, Dominique" uniqKey="Rosillon D" first="Dominique" last="Rosillon">Dominique Rosillon</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>GlaxoSmithKline Vaccines, Wavre, Belgium</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>GlaxoSmithKline Vaccines, Wavre</wicri:regionArea></affiliation></author><author><name sortKey="Churchyard, Gavin" sort="Churchyard, Gavin" uniqKey="Churchyard G" first="Gavin" last="Churchyard">Gavin Churchyard</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>The Aurum Institute, Johannesburg, South Africa</addr-line></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>The Aurum Institute, Johannesburg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>The School of Public Health, University of the Witwatersrand, Johannesburg, South Africa</addr-line></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>The School of Public Health, University of the Witwatersrand, Johannesburg</wicri:regionArea></affiliation></author><author><name sortKey="Harris, Rebecca C" sort="Harris, Rebecca C" uniqKey="Harris R" first="Rebecca C." last="Harris">Rebecca C. Harris</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>CROMSOURCE on behalf of GlaxoSmithKline Vaccines, Wavre, Belgium</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>CROMSOURCE on behalf of GlaxoSmithKline Vaccines, Wavre</wicri:regionArea></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Knowledge of tuberculosis incidence and associated factors is required for the development and evaluation of strategies to reduce the burden of HIV-associated tuberculosis.</p></sec><sec><title>Methods</title><p>Systematic literature review and meta-analysis of tuberculosis incidence rates among HIV-infected individuals taking combination antiretroviral therapy.</p></sec><sec><title>Results</title><p>From PubMed, EMBASE and Global Index Medicus databases, 42 papers describing 43 cohorts (32 from high/intermediate and 11 from low tuberculosis burden settings) were included in the qualitative review and 33 in the quantitative review. Cohorts from high/intermediate burden settings were smaller in size, had lower median CD4 cell counts at study entry and fewer person-years of follow up. Tuberculosis incidence rates were higher in studies from Sub-Saharan Africa and from World Bank low/middle income countries. Tuberculosis incidence rates decreased with increasing CD4 count at study entry and duration on combination antiretroviral therapy. Summary estimates of tuberculosis incidence among individuals on combination antiretroviral therapy were higher for cohorts from high/intermediate burden settings compared to those from the low tuberculosis burden settings (4.17 per 100 person-years [95% Confidence Interval (CI) 3.39–5.14 per 100 person-years] vs. 0.4 per 100 person-years [95% CI 0.23–0.69 per 100 person-years]) with significant heterogeneity observed between the studies.</p></sec><sec><title>Conclusions</title><p>Tuberculosis incidence rates were high among individuals on combination antiretroviral therapy in high/intermediate burden settings. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25393281</article-id><article-id pub-id-type="pmc">4230893</article-id><article-id pub-id-type="publisher-id">PONE-D-14-12481</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0111209</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Biology and Life Sciences</subject><subj-group><subject>Plant Science</subject><subj-group><subject>Plant Pathology</subject><subj-group><subject>Infectious Disease Epidemiology</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine and health sciences</subject><subj-group><subject>Epidemiology</subject><subj-group><subject>Clinical epidemiology</subject><subject>HIV epidemiology</subject></subj-group></subj-group><subj-group><subject>Infectious Diseases</subject><subj-group><subject>Bacterial Diseases</subject><subj-group><subject>Tuberculosis</subject></subj-group></subj-group></subj-group><subj-group><subject>Tropical Diseases</subject></subj-group></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Research and Analysis Methods</subject><subj-group><subject>Database and Informatics Methods</subject></subj-group></subj-group></article-categories><title-group><article-title>Incidence of HIV-Associated Tuberculosis among Individuals Taking Combination Antiretroviral Therapy: A Systematic Review and Meta-Analysis</article-title><alt-title alt-title-type="running-head">Incidence of Tuberculosis on Combination Antiretroviral Therapy</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kufa</surname><given-names>Tendesayi</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mabuto</surname><given-names>Tonderai</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>Muchiri</surname><given-names>Evans</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Charalambous</surname><given-names>Salome</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rosillon</surname><given-names>Dominique</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Churchyard</surname><given-names>Gavin</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Harris</surname><given-names>Rebecca C.</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>The Aurum Institute, Johannesburg, South Africa</addr-line></aff><aff id="aff2"><label>2</label><addr-line>The School of Public Health, University of the Witwatersrand, Johannesburg, South Africa</addr-line></aff><aff id="aff3"><label>3</label><addr-line>GlaxoSmithKline Vaccines, Wavre, Belgium</addr-line></aff><aff id="aff4"><label>4</label><addr-line>CROMSOURCE on behalf of GlaxoSmithKline Vaccines, Wavre, Belgium</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Wilkinson</surname><given-names>Robert J.</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>Institute of Infectious Diseases and Molecular Medicine, South Africa</addr-line></aff><author-notes><corresp id="cor1">* E-mail: <email>tkufa@auruminstitute.org</email> (TK); <email>tmabuto@auruminstitute.org</email> (TM)</corresp><fn fn-type="conflict"><p><bold>Competing Interests: </bold>The authors have read the journal's policy and have the following conflicts: DR is employed by GlaxoSmithKline Vaccines and has stock ownership in the GlaxoSmithKline Group of Companies. RH was an employee of CROM source working on behalf of GlaxoSmithKline Vaccines. All other authors declare no conflicts of interest. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.</p></fn><fn fn-type="con"><p>Conceived and designed the experiments: TK SC GC RCH. Performed the experiments: TK TM. Analyzed the data: TK TM EM SC DR GC RCH. Contributed reagents/materials/analysis tools: TK TM EM SC DR GC RCH. Wrote the paper: TK. Reviewed iterative versions of the manuscript: TM EM SC DR GC RCH. Conducted the literature search and came up with a list of studies of studies for inclusion in the review: TK TM.</p></fn></author-notes><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>13</day><month>11</month><year>2014</year></pub-date><volume>9</volume><issue>11</issue><elocation-id>e111209</elocation-id><history><date date-type="received"><day>19</day><month>3</month><year>2014</year></date><date date-type="accepted"><day>26</day><month>9</month><year>2014</year></date></history><permissions><copyright-year>2014</copyright-year><copyright-holder>Kufa et al</copyright-holder><license><license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><abstract><sec><title>Background</title><p>Knowledge of tuberculosis incidence and associated factors is required for the development and evaluation of strategies to reduce the burden of HIV-associated tuberculosis.</p></sec><sec><title>Methods</title><p>Systematic literature review and meta-analysis of tuberculosis incidence rates among HIV-infected individuals taking combination antiretroviral therapy.</p></sec><sec><title>Results</title><p>From PubMed, EMBASE and Global Index Medicus databases, 42 papers describing 43 cohorts (32 from high/intermediate and 11 from low tuberculosis burden settings) were included in the qualitative review and 33 in the quantitative review. Cohorts from high/intermediate burden settings were smaller in size, had lower median CD4 cell counts at study entry and fewer person-years of follow up. Tuberculosis incidence rates were higher in studies from Sub-Saharan Africa and from World Bank low/middle income countries. Tuberculosis incidence rates decreased with increasing CD4 count at study entry and duration on combination antiretroviral therapy. Summary estimates of tuberculosis incidence among individuals on combination antiretroviral therapy were higher for cohorts from high/intermediate burden settings compared to those from the low tuberculosis burden settings (4.17 per 100 person-years [95% Confidence Interval (CI) 3.39–5.14 per 100 person-years] vs. 0.4 per 100 person-years [95% CI 0.23–0.69 per 100 person-years]) with significant heterogeneity observed between the studies.</p></sec><sec><title>Conclusions</title><p>Tuberculosis incidence rates were high among individuals on combination antiretroviral therapy in high/intermediate burden settings. Interventions to prevent tuberculosis in this population should address geographical, socioeconomic and individual factors such as low CD4 counts and prior history of tuberculosis.</p></sec></abstract><funding-group><funding-statement>GlaxoSmithKline Biologicals S.A. funded the work disclosed in this manuscript (for data collection for the reported study). Co-author Dominique Rosillon is employed by GlaxoSmithKline Vaccines and co-author Rebecca C. Harris was employed by CROMsource during the course of the study. GlaxoSmithKline provided support in the form of salary for author DR, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of this author is articulated in the ‘author contributions’ section. CROMsource provided support in the form of salary for author RCH, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement></funding-group><counts><page-count count="11"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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