Factors associated with major structural birth defects among newborns delivered at Muhimbili National Hospital and Municipal Hospitals in Dar Es Salaam, Tanzania 2011 – 2012
Identifieur interne : 000241 ( Pmc/Curation ); précédent : 000240; suivant : 000242Factors associated with major structural birth defects among newborns delivered at Muhimbili National Hospital and Municipal Hospitals in Dar Es Salaam, Tanzania 2011 – 2012
Auteurs : Rogath Saika Kishimba [Tanzanie] ; Rose Mpembeni [Tanzanie] ; Janneth Mghamba [Tanzanie]Source :
- The Pan African Medical Journal [ 1937-8688 ] ; 2015.
Abstract
Ninety-four percent of all birth defects and 95% of deaths due to the birth defects occur in low and middle income countries, Tanzania among them. In Tanzania there are currently limited birth defects prevention strategies in place due to limited information on factors associated with the occurrence of birth defects.
We conducted a case control study that included newborns born from October, 2011 through February, 2012 at 4 participating hospitals. A case was defined as any newborn of a Dar es salaam resident with a neural tube defect, orofacial clefts, limb reduction defects or musculo-skeletal defects (SBD) born during the study period. A control was defined as the next three newborns (delivered after the case) without birth defects. Univariate, bivariate and multivariate analysis were done using Epi Info version 3.5.1.
A total of 400 newborns participated in the study, 100 cases and 300 controls. Factors associated with higher odds of a SBD included maternal fever (adjusted odds ratio (AOR) = 1.99; 95% confidence interval (CI): 1.14-3.52), maternal hypertension (AOR = 3.99; 95% CI: 1.67-9.54), and low birth weight (AOR = 3.48; 95% CI: 1.77-6.85). Antimalarial use during pregnancy was protective (AOR = 0.48; 95% CI: 0.28-0.84). Folic acid supplementation was protective only in bivariate analysis (OR = 0.56; 95% CI: 0.32-0.96).
Maternal fever, hypertension, and low birth weight are associated with higher odds of SBD. Antimalarial use during pregnancy was associated with lower odds of SBD. Early screening of pregnant mothers for hypertension and other causes of low birth weight may reduce SBD in Dar Es Salaam.
Url:
DOI: 10.11604/pamj.2015.20.153.4492
PubMed: 26525082
PubMed Central: 4613840
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<author><name sortKey="Kishimba, Rogath Saika" sort="Kishimba, Rogath Saika" uniqKey="Kishimba R" first="Rogath Saika" last="Kishimba">Rogath Saika Kishimba</name>
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<affiliation wicri:level="1"><nlm:aff id="AF0003">Ministry of Health and Social Welfare, Tanzania</nlm:aff>
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<author><name sortKey="Mghamba, Janneth" sort="Mghamba, Janneth" uniqKey="Mghamba J" first="Janneth" last="Mghamba">Janneth Mghamba</name>
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<author><name sortKey="Kishimba, Rogath Saika" sort="Kishimba, Rogath Saika" uniqKey="Kishimba R" first="Rogath Saika" last="Kishimba">Rogath Saika Kishimba</name>
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<affiliation wicri:level="1"><nlm:aff id="AF0003">Ministry of Health and Social Welfare, Tanzania</nlm:aff>
<country xml:lang="fr">Tanzanie</country>
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<author><name sortKey="Mpembeni, Rose" sort="Mpembeni, Rose" uniqKey="Mpembeni R" first="Rose" last="Mpembeni">Rose Mpembeni</name>
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<author><name sortKey="Mghamba, Janneth" sort="Mghamba, Janneth" uniqKey="Mghamba J" first="Janneth" last="Mghamba">Janneth Mghamba</name>
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<series><title level="j">The Pan African Medical Journal</title>
<idno type="eISSN">1937-8688</idno>
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<front><div type="abstract" xml:lang="en"><sec id="st1"><title>Introduction</title>
<p>Ninety-four percent of all birth defects and 95% of deaths due to the birth defects occur in low and middle income countries, Tanzania among them. In Tanzania there are currently limited birth defects prevention strategies in place due to limited information on factors associated with the occurrence of birth defects.</p>
</sec>
<sec id="st2"><title>Methods</title>
<p>We conducted a case control study that included newborns born from October, 2011 through February, 2012 at 4 participating hospitals. A case was defined as any newborn of a Dar es salaam resident with a neural tube defect, orofacial clefts, limb reduction defects or musculo-skeletal defects (SBD) born during the study period. A control was defined as the next three newborns (delivered after the case) without birth defects. Univariate, bivariate and multivariate analysis were done using Epi Info version 3.5.1.</p>
</sec>
<sec id="st3"><title>Results</title>
<p>A total of 400 newborns participated in the study, 100 cases and 300 controls. Factors associated with higher odds of a SBD included maternal fever (adjusted odds ratio (AOR) = 1.99; 95% confidence interval (CI): 1.14-3.52), maternal hypertension (AOR = 3.99; 95% CI: 1.67-9.54), and low birth weight (AOR = 3.48; 95% CI: 1.77-6.85). Antimalarial use during pregnancy was protective (AOR = 0.48; 95% CI: 0.28-0.84). Folic acid supplementation was protective only in bivariate analysis (OR = 0.56; 95% CI: 0.32-0.96).</p>
</sec>
<sec id="st4"><title>Conclusion</title>
<p>Maternal fever, hypertension, and low birth weight are associated with higher odds of SBD. Antimalarial use during pregnancy was associated with lower odds of SBD. Early screening of pregnant mothers for hypertension and other causes of low birth weight may reduce SBD in Dar Es Salaam.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Christianson, A" uniqKey="Christianson A">A Christianson</name>
</author>
<author><name sortKey="Howson, Cp" uniqKey="Howson C">CP Howson</name>
</author>
<author><name sortKey="Modell, B" uniqKey="Modell B">B Modell</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Kinasha, Ad" uniqKey="Kinasha A">AD Kinasha</name>
</author>
<author><name sortKey="Manji, K" uniqKey="Manji K">K Manji</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Karim Manji, P" uniqKey="Karim Manji P">P Karim Manji</name>
</author>
<author><name sortKey="Georgina, Lrm" uniqKey="Georgina L">LRM Georgina</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Christianson, Al" uniqKey="Christianson A">AL Christianson</name>
</author>
<author><name sortKey="Modell, B" uniqKey="Modell B">B Modell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Penchaszadeh, Vb" uniqKey="Penchaszadeh V">VB Penchaszadeh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Omo Aghoja, Vw" uniqKey="Omo Aghoja V">VW Omo-Aghoja</name>
</author>
<author><name sortKey="Omo Aghoja, Lo" uniqKey="Omo Aghoja L">LO Omo-Aghoja</name>
</author>
<author><name sortKey="Ugboko, Vi" uniqKey="Ugboko V">VI Ugboko</name>
</author>
<author><name sortKey="Obuekwe, On" uniqKey="Obuekwe O">ON Obuekwe</name>
</author>
<author><name sortKey="Saheeb, Bdo" uniqKey="Saheeb B">BDO Saheeb</name>
</author>
<author><name sortKey="Feyi Waboso, P" uniqKey="Feyi Waboso P">P Feyi-Waboso</name>
</author>
<author><name sortKey="Onowhakpor, A" uniqKey="Onowhakpor A">A Onowhakpor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fischer, M" uniqKey="Fischer M">M Fischer</name>
</author>
<author><name sortKey="Hedberg, K" uniqKey="Hedberg K">K Hedberg</name>
</author>
<author><name sortKey="Cardosi, P" uniqKey="Cardosi P">P Cardosi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thorsen, P" uniqKey="Thorsen P">P Thorsen</name>
</author>
<author><name sortKey="Vogel, I" uniqKey="Vogel I">I Vogel</name>
</author>
<author><name sortKey="Molsted, K" uniqKey="Molsted K">K Molsted</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Larsson, Pg" uniqKey="Larsson P">PG Larsson</name>
</author>
<author><name sortKey="Fahraeus, L" uniqKey="Fahraeus L">L Fahraeus</name>
</author>
<author><name sortKey="Carlsson, B" uniqKey="Carlsson B">B Carlsson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Botto, Ld" uniqKey="Botto L">LD Botto</name>
</author>
<author><name sortKey="Lynberg, Mc" uniqKey="Lynberg M">MC Lynberg</name>
</author>
<author><name sortKey="David Erickson, Jd" uniqKey="David Erickson J">JD David Erickson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lorenzo Botto, D" uniqKey="Lorenzo Botto D">D Lorenzo Botto</name>
</author>
<author><name sortKey="David Erickson, J" uniqKey="David Erickson J">J David Erickson</name>
</author>
<author><name sortKey="Joseph, Mulinare" uniqKey="Joseph M">Mulinare Joseph</name>
</author>
<author><name sortKey="Michele Lynberg, C" uniqKey="Michele Lynberg C">C Michele Lynberg</name>
</author>
<author><name sortKey="Yecai, Liu" uniqKey="Yecai L">Liu Yecai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Julie Werenberg, Dreier" uniqKey="Julie Werenberg D">Dreier Julie Werenberg</name>
</author>
<author><name sortKey="Anne Marie, Nybo Andersen" uniqKey="Anne Marie N">Nybo Andersen Anne-Marie</name>
</author>
<author><name sortKey="Gabriele, Berg Beckhoff" uniqKey="Gabriele B">Berg-Beckhoff Gabriele</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhiwen, Li" uniqKey="Zhiwen L">Li Zhiwen</name>
</author>
<author><name sortKey="Aiguo, Ren" uniqKey="Aiguo R">Ren Aiguo</name>
</author>
<author><name sortKey="Le, Zhang" uniqKey="Le Z">Zhang Le</name>
</author>
<author><name sortKey="Zhanying, Guo" uniqKey="Zhanying G">Guo Zhanying</name>
</author>
<author><name sortKey="Zhu, Li" uniqKey="Zhu L">Li Zhu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wei, Wang" uniqKey="Wei W">Wang Wei</name>
</author>
<author><name sortKey="Peng, Guan" uniqKey="Peng G">Guan Peng</name>
</author>
<author><name sortKey="Wei, Xu" uniqKey="Wei X">Xu Wei</name>
</author>
<author><name sortKey="Baosen, Zhou" uniqKey="Baosen Z">Zhou Baosen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kimberly Lebby, D" uniqKey="Kimberly Lebby D">D Kimberly Lebby</name>
</author>
<author><name sortKey="Fei, Tan" uniqKey="Fei T">Tan Fei</name>
</author>
<author><name sortKey="Perry Brown, C" uniqKey="Perry Brown C">C Perry Brown</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Czeizel, Ae" uniqKey="Czeizel A">AE Czeizel</name>
</author>
<author><name sortKey="Banhidy, F" uniqKey="Banhidy F">F Banhidy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Caton, Ar" uniqKey="Caton A">AR Caton</name>
</author>
<author><name sortKey="Bell, Em" uniqKey="Bell E">EM Bell</name>
</author>
<author><name sortKey="Druschel, Cm" uniqKey="Druschel C">CM Druschel</name>
</author>
<author><name sortKey="Werler, Mm" uniqKey="Werler M">MM Werler</name>
</author>
<author><name sortKey="Mitchell, Aa" uniqKey="Mitchell A">AA Mitchell</name>
</author>
<author><name sortKey="Browne, Ml" uniqKey="Browne M">ML Browne</name>
</author>
<author><name sortKey="Mcnutt, La" uniqKey="Mcnutt L">LA McNutt</name>
</author>
<author><name sortKey="Romitti, Pa" uniqKey="Romitti P">PA Romitti</name>
</author>
<author><name sortKey="Olney, Rs" uniqKey="Olney R">RS Olney</name>
</author>
<author><name sortKey="Correa, A" uniqKey="Correa A">A Correa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aschim, El" uniqKey="Aschim E">EL Aschim</name>
</author>
<author><name sortKey="Haugen, Tb" uniqKey="Haugen T">TB Haugen</name>
</author>
<author><name sortKey="Tretli, S" uniqKey="Tretli S">S Tretli</name>
</author>
<author><name sortKey="Daltveit, Ak" uniqKey="Daltveit A">AK Daltveit</name>
</author>
<author><name sortKey="Grotmol, T" uniqKey="Grotmol T">T Grotmol</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alissa Caton, R" uniqKey="Alissa Caton R">R Alissa Caton</name>
</author>
<author><name sortKey="Erin Bell, M" uniqKey="Erin Bell M">M Erin Bell</name>
</author>
<author><name sortKey="Charlotte Druschel, M" uniqKey="Charlotte Druschel M">M Charlotte Druschel</name>
</author>
<author><name sortKey="Martha Werler, M" uniqKey="Martha Werler M">M Martha Werler</name>
</author>
<author><name sortKey="Angela Lin, E" uniqKey="Angela Lin E">E Angela Lin</name>
</author>
<author><name sortKey="Marilyn Browne, L" uniqKey="Marilyn Browne L">L Marilyn Browne</name>
</author>
<author><name sortKey="Louise Anne, Mcnutt" uniqKey="Louise Anne M">McNutt Louise-Anne</name>
</author>
<author><name sortKey="Paul Romitti, A" uniqKey="Paul Romitti A">A Paul Romitti</name>
</author>
<author><name sortKey="Allen Mitchell, A" uniqKey="Allen Mitchell A">A Allen Mitchell</name>
</author>
<author><name sortKey="Richard Olney, S" uniqKey="Richard Olney S">S Richard Olney</name>
</author>
<author><name sortKey="Adolfo, Correa" uniqKey="Adolfo C">Correa Adolfo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sharma, A" uniqKey="Sharma A">A Sharma</name>
</author>
<author><name sortKey="Rawat, Ak" uniqKey="Rawat A">AK Rawat</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Phillips Howard, Pa" uniqKey="Phillips Howard P">PA Phillips-Howard</name>
</author>
<author><name sortKey="Wood, D" uniqKey="Wood D">D Wood</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Njamnshi, Ak" uniqKey="Njamnshi A">AK Njamnshi</name>
</author>
<author><name sortKey="Djenticheu Vde, P" uniqKey="Djenticheu Vde P">P Djenticheu Vde</name>
</author>
<author><name sortKey="Lekoubou, A" uniqKey="Lekoubou A">A Lekoubou</name>
</author>
<author><name sortKey="Guemse, M" uniqKey="Guemse M">M Guemse</name>
</author>
<author><name sortKey="Obama, Mt" uniqKey="Obama M">MT Obama</name>
</author>
<author><name sortKey="Mbu, R" uniqKey="Mbu R">R Mbu</name>
</author>
<author><name sortKey="Takongmo, S" uniqKey="Takongmo S">S Takongmo</name>
</author>
<author><name sortKey="Kago, I" uniqKey="Kago I">I Kago</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Lilah Besser, M" uniqKey="Lilah Besser M">M Lilah Besser</name>
</author>
<author><name sortKey="Laura Williams, J" uniqKey="Laura Williams J">J Laura Williams</name>
</author>
<author><name sortKey="Janet Cragan, D" uniqKey="Janet Cragan D">D Janet Cragan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zouhair, O" uniqKey="Zouhair O">O Zouhair</name>
</author>
<author><name sortKey="Amarina" uniqKey="Amarina">Amarina</name>
</author>
<author><name sortKey="Ahmed Obeidatb, Z" uniqKey="Ahmed Obeidatb Z">Z Ahmed Obeidatb</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ubbink, Jb" uniqKey="Ubbink J">JB Ubbink</name>
</author>
<author><name sortKey="Christianson, A" uniqKey="Christianson A">A Christianson</name>
</author>
<author><name sortKey="Bester, Mj" uniqKey="Bester M">MJ Bester</name>
</author>
<author><name sortKey="Van Allen, Mi" uniqKey="Van Allen M">MI Van Allen</name>
</author>
<author><name sortKey="Venter, Pa" uniqKey="Venter P">PA Venter</name>
</author>
<author><name sortKey="Delport, R" uniqKey="Delport R">R Delport</name>
</author>
<author><name sortKey="Blom, Hj" uniqKey="Blom H">HJ Blom</name>
</author>
<author><name sortKey="Van Der Merwe, A" uniqKey="Van Der Merwe A">A Van der Merwe</name>
</author>
<author><name sortKey="Potgieter, H" uniqKey="Potgieter H">H Potgieter</name>
</author>
<author><name sortKey="Vermaak, Wj" uniqKey="Vermaak W">WJ Vermaak</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Sayed, Ar" uniqKey="Sayed A">AR Sayed</name>
</author>
<author><name sortKey="Bourne, D" uniqKey="Bourne D">D Bourne</name>
</author>
<author><name sortKey="Pattinson, R" uniqKey="Pattinson R">R Pattinson</name>
</author>
<author><name sortKey="Nixon, J" uniqKey="Nixon J">J Nixon</name>
</author>
<author><name sortKey="Henderson, B" uniqKey="Henderson B">B Henderson</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Pierro, A" uniqKey="Pierro A">A Pierro</name>
</author>
<author><name sortKey="Cozz, F" uniqKey="Cozz F">F Cozz</name>
</author>
<author><name sortKey="Colarossi, G" uniqKey="Colarossi G">G Colarossi</name>
</author>
<author><name sortKey="Irving, Im" uniqKey="Irving I">IM Irving</name>
</author>
<author><name sortKey="Pierce, Am" uniqKey="Pierce A">AM Pierce</name>
</author>
<author><name sortKey="Lister, J" uniqKey="Lister J">J Lister</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mazor, M" uniqKey="Mazor M">M Mazor</name>
</author>
<author><name sortKey="Ghezzi, F" uniqKey="Ghezzi F">F Ghezzi</name>
</author>
<author><name sortKey="Maymon, E" uniqKey="Maymon E">E Maymon</name>
</author>
<author><name sortKey="Shoham Vardi, I" uniqKey="Shoham Vardi I">I Shoham-Vardi</name>
</author>
<author><name sortKey="Vardi, H" uniqKey="Vardi H">H Vardi</name>
</author>
<author><name sortKey="Hershkowitz, R" uniqKey="Hershkowitz R">R Hershkowitz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cheng, W" uniqKey="Cheng W">W Cheng</name>
</author>
<author><name sortKey="Mya, Gh" uniqKey="Mya G">GH Mya</name>
</author>
<author><name sortKey="Saing, H" uniqKey="Saing H">H Saing</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Khoury, Mj" uniqKey="Khoury M">MJ Khoury</name>
</author>
<author><name sortKey="Erickson, Jd" uniqKey="Erickson J">JD Erickson</name>
</author>
<author><name sortKey="Cordero, Jf" uniqKey="Cordero J">JF Cordero</name>
</author>
<author><name sortKey="Mccarthy, Bj" uniqKey="Mccarthy B">BJ McCarthy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bittles, Ah" uniqKey="Bittles A">AH Bittles</name>
</author>
<author><name sortKey="Mason, Wm" uniqKey="Mason W">WM Mason</name>
</author>
<author><name sortKey="Greene, J" uniqKey="Greene J">J Greene</name>
</author>
<author><name sortKey="Rao, Na" uniqKey="Rao N">NA Rao</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Hernandez Diaz, S" uniqKey="Hernandez Diaz S">S Hernández-Díaz</name>
</author>
<author><name sortKey="Werler, Mm" uniqKey="Werler M">MM Werler</name>
</author>
<author><name sortKey="Walker, Am" uniqKey="Walker A">AM Walker</name>
</author>
<author><name sortKey="Mitchell, Aa" uniqKey="Mitchell A">AA Mitchell</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Nyamtema, As" uniqKey="Nyamtema A">AS Nyamtema</name>
</author>
<author><name sortKey="Urassa, Dp" uniqKey="Urassa D">DP Urassa</name>
</author>
<author><name sortKey="Massawe, S" uniqKey="Massawe S">S Massawe</name>
</author>
<author><name sortKey="Massawe, A" uniqKey="Massawe A">A Massawe</name>
</author>
<author><name sortKey="Mtasiwa, D" uniqKey="Mtasiwa D">D Mtasiwa</name>
</author>
<author><name sortKey="Lindmark, G" uniqKey="Lindmark G">G Lindmark</name>
</author>
<author><name sortKey="Van Roosmalen, J" uniqKey="Van Roosmalen J">J Van Roosmalen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Man, Lx" uniqKey="Man L">LX Man</name>
</author>
<author><name sortKey="Chang, B" uniqKey="Chang B">B Chang</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Pan Afr Med J</journal-id>
<journal-id journal-id-type="iso-abbrev">Pan Afr Med J</journal-id>
<journal-id journal-id-type="publisher-id">PAMJ</journal-id>
<journal-title-group><journal-title>The Pan African Medical Journal</journal-title>
</journal-title-group>
<issn pub-type="epub">1937-8688</issn>
<publisher><publisher-name>The African Field Epidemiology Network</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26525082</article-id>
<article-id pub-id-type="pmc">4613840</article-id>
<article-id pub-id-type="publisher-id">PAMJ-20-153</article-id>
<article-id pub-id-type="doi">10.11604/pamj.2015.20.153.4492</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research</subject>
</subj-group>
</article-categories>
<title-group><article-title>Factors associated with major structural birth defects among newborns delivered at Muhimbili National Hospital and Municipal Hospitals in Dar Es Salaam, Tanzania 2011 – 2012</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Kishimba</surname>
<given-names>Rogath Saika</given-names>
</name>
<xref ref-type="aff" rid="AF0001">1</xref>
<xref ref-type="aff" rid="AF0003">3</xref>
<xref ref-type="corresp" rid="cor1">&</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mpembeni</surname>
<given-names>Rose</given-names>
</name>
<xref ref-type="aff" rid="AF0002">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mghamba</surname>
<given-names>Janneth</given-names>
</name>
<xref ref-type="aff" rid="AF0001">1</xref>
<xref ref-type="aff" rid="AF0003">3</xref>
</contrib>
</contrib-group>
<aff id="AF0001"><label>1</label>
Field Epidemiology and Laboratory Training Programme (FELTP), Tanzania</aff>
<aff id="AF0002"><label>2</label>
Muhimbili University of Health and Allied Sciences (MUHAS), Tanzania</aff>
<aff id="AF0003"><label>3</label>
Ministry of Health and Social Welfare, Tanzania</aff>
<author-notes><corresp id="cor1"><label>&</label>
Corresponding author: Rogath Saika Kishimba, Field Epidemiology and Laboratory Training Programme (FELTP), Tanzania</corresp>
</author-notes>
<pub-date pub-type="epub"><day>18</day>
<month>2</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="collection"><year>2015</year>
</pub-date>
<volume>20</volume>
<elocation-id>153</elocation-id>
<history><date date-type="received"><day>30</day>
<month>4</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>03</day>
<month>2</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>© Rogath Saika Kishimba et al.</copyright-statement>
<copyright-year>2015</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0/"><license-p>The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><sec id="st1"><title>Introduction</title>
<p>Ninety-four percent of all birth defects and 95% of deaths due to the birth defects occur in low and middle income countries, Tanzania among them. In Tanzania there are currently limited birth defects prevention strategies in place due to limited information on factors associated with the occurrence of birth defects.</p>
</sec>
<sec id="st2"><title>Methods</title>
<p>We conducted a case control study that included newborns born from October, 2011 through February, 2012 at 4 participating hospitals. A case was defined as any newborn of a Dar es salaam resident with a neural tube defect, orofacial clefts, limb reduction defects or musculo-skeletal defects (SBD) born during the study period. A control was defined as the next three newborns (delivered after the case) without birth defects. Univariate, bivariate and multivariate analysis were done using Epi Info version 3.5.1.</p>
</sec>
<sec id="st3"><title>Results</title>
<p>A total of 400 newborns participated in the study, 100 cases and 300 controls. Factors associated with higher odds of a SBD included maternal fever (adjusted odds ratio (AOR) = 1.99; 95% confidence interval (CI): 1.14-3.52), maternal hypertension (AOR = 3.99; 95% CI: 1.67-9.54), and low birth weight (AOR = 3.48; 95% CI: 1.77-6.85). Antimalarial use during pregnancy was protective (AOR = 0.48; 95% CI: 0.28-0.84). Folic acid supplementation was protective only in bivariate analysis (OR = 0.56; 95% CI: 0.32-0.96).</p>
</sec>
<sec id="st4"><title>Conclusion</title>
<p>Maternal fever, hypertension, and low birth weight are associated with higher odds of SBD. Antimalarial use during pregnancy was associated with lower odds of SBD. Early screening of pregnant mothers for hypertension and other causes of low birth weight may reduce SBD in Dar Es Salaam.</p>
</sec>
</abstract>
<kwd-group><kwd>Birth defects</kwd>
<kwd>risk factors</kwd>
<kwd>newborns</kwd>
<kwd>mothers</kwd>
<kwd>mortality</kwd>
<kwd>Tanzania</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
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