Factors associated with major structural birth defects among newborns delivered at Muhimbili National Hospital and Municipal Hospitals in Dar Es Salaam, Tanzania 2011 – 2012
Identifieur interne : 000241 ( Pmc/Curation ); précédent : 000240; suivant : 000242Factors associated with major structural birth defects among newborns delivered at Muhimbili National Hospital and Municipal Hospitals in Dar Es Salaam, Tanzania 2011 – 2012
Auteurs : Rogath Saika Kishimba [Tanzanie] ; Rose Mpembeni [Tanzanie] ; Janneth Mghamba [Tanzanie]Source :
- The Pan African Medical Journal [ 1937-8688 ] ; 2015.
Abstract
Ninety-four percent of all birth defects and 95% of deaths due to the birth defects occur in low and middle income countries, Tanzania among them. In Tanzania there are currently limited birth defects prevention strategies in place due to limited information on factors associated with the occurrence of birth defects.
We conducted a case control study that included newborns born from October, 2011 through February, 2012 at 4 participating hospitals. A case was defined as any newborn of a Dar es salaam resident with a neural tube defect, orofacial clefts, limb reduction defects or musculo-skeletal defects (SBD) born during the study period. A control was defined as the next three newborns (delivered after the case) without birth defects. Univariate, bivariate and multivariate analysis were done using Epi Info version 3.5.1.
A total of 400 newborns participated in the study, 100 cases and 300 controls. Factors associated with higher odds of a SBD included maternal fever (adjusted odds ratio (AOR) = 1.99; 95% confidence interval (CI): 1.14-3.52), maternal hypertension (AOR = 3.99; 95% CI: 1.67-9.54), and low birth weight (AOR = 3.48; 95% CI: 1.77-6.85). Antimalarial use during pregnancy was protective (AOR = 0.48; 95% CI: 0.28-0.84). Folic acid supplementation was protective only in bivariate analysis (OR = 0.56; 95% CI: 0.32-0.96).
Maternal fever, hypertension, and low birth weight are associated with higher odds of SBD. Antimalarial use during pregnancy was associated with lower odds of SBD. Early screening of pregnant mothers for hypertension and other causes of low birth weight may reduce SBD in Dar Es Salaam.
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DOI: 10.11604/pamj.2015.20.153.4492
PubMed: 26525082
PubMed Central: 4613840
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Factors associated with major structural birth defects among newborns delivered at Muhimbili National Hospital and Municipal Hospitals in Dar Es Salaam, Tanzania 2011 – 2012</title><author><name sortKey="Kishimba, Rogath Saika" sort="Kishimba, Rogath Saika" uniqKey="Kishimba R" first="Rogath Saika" last="Kishimba">Rogath Saika Kishimba</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Field Epidemiology and Laboratory Training Programme (FELTP), Tanzania</nlm:aff><country xml:lang="fr">Tanzanie</country><wicri:regionArea>Field Epidemiology and Laboratory Training Programme (FELTP)</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0003">Ministry of Health and Social Welfare, Tanzania</nlm:aff><country xml:lang="fr">Tanzanie</country><wicri:regionArea>Ministry of Health and Social Welfare</wicri:regionArea></affiliation></author><author><name sortKey="Mpembeni, Rose" sort="Mpembeni, Rose" uniqKey="Mpembeni R" first="Rose" last="Mpembeni">Rose Mpembeni</name><affiliation wicri:level="1"><nlm:aff id="AF0002">Muhimbili University of Health and Allied Sciences (MUHAS), Tanzania</nlm:aff><country xml:lang="fr">Tanzanie</country><wicri:regionArea>Muhimbili University of Health and Allied Sciences (MUHAS)</wicri:regionArea></affiliation></author><author><name sortKey="Mghamba, Janneth" sort="Mghamba, Janneth" uniqKey="Mghamba J" first="Janneth" last="Mghamba">Janneth Mghamba</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Field Epidemiology and Laboratory Training Programme (FELTP), Tanzania</nlm:aff><country xml:lang="fr">Tanzanie</country><wicri:regionArea>Field Epidemiology and Laboratory Training Programme (FELTP)</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0003">Ministry of Health and Social Welfare, Tanzania</nlm:aff><country xml:lang="fr">Tanzanie</country><wicri:regionArea>Ministry of Health and Social Welfare</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26525082</idno><idno type="pmc">4613840</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613840</idno><idno type="RBID">PMC:4613840</idno><idno type="doi">10.11604/pamj.2015.20.153.4492</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000241</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000241</idno><idno type="wicri:Area/Pmc/Curation">000241</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000241</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Factors associated with major structural birth defects among newborns delivered at Muhimbili National Hospital and Municipal Hospitals in Dar Es Salaam, Tanzania 2011 – 2012</title><author><name sortKey="Kishimba, Rogath Saika" sort="Kishimba, Rogath Saika" uniqKey="Kishimba R" first="Rogath Saika" last="Kishimba">Rogath Saika Kishimba</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Field Epidemiology and Laboratory Training Programme (FELTP), Tanzania</nlm:aff><country xml:lang="fr">Tanzanie</country><wicri:regionArea>Field Epidemiology and Laboratory Training Programme (FELTP)</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0003">Ministry of Health and Social Welfare, Tanzania</nlm:aff><country xml:lang="fr">Tanzanie</country><wicri:regionArea>Ministry of Health and Social Welfare</wicri:regionArea></affiliation></author><author><name sortKey="Mpembeni, Rose" sort="Mpembeni, Rose" uniqKey="Mpembeni R" first="Rose" last="Mpembeni">Rose Mpembeni</name><affiliation wicri:level="1"><nlm:aff id="AF0002">Muhimbili University of Health and Allied Sciences (MUHAS), Tanzania</nlm:aff><country xml:lang="fr">Tanzanie</country><wicri:regionArea>Muhimbili University of Health and Allied Sciences (MUHAS)</wicri:regionArea></affiliation></author><author><name sortKey="Mghamba, Janneth" sort="Mghamba, Janneth" uniqKey="Mghamba J" first="Janneth" last="Mghamba">Janneth Mghamba</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Field Epidemiology and Laboratory Training Programme (FELTP), Tanzania</nlm:aff><country xml:lang="fr">Tanzanie</country><wicri:regionArea>Field Epidemiology and Laboratory Training Programme (FELTP)</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0003">Ministry of Health and Social Welfare, Tanzania</nlm:aff><country xml:lang="fr">Tanzanie</country><wicri:regionArea>Ministry of Health and Social Welfare</wicri:regionArea></affiliation></author></analytic><series><title level="j">The Pan African Medical Journal</title><idno type="eISSN">1937-8688</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Introduction</title><p>Ninety-four percent of all birth defects and 95% of deaths due to the birth defects occur in low and middle income countries, Tanzania among them. In Tanzania there are currently limited birth defects prevention strategies in place due to limited information on factors associated with the occurrence of birth defects.</p></sec><sec id="st2"><title>Methods</title><p>We conducted a case control study that included newborns born from October, 2011 through February, 2012 at 4 participating hospitals. A case was defined as any newborn of a Dar es salaam resident with a neural tube defect, orofacial clefts, limb reduction defects or musculo-skeletal defects (SBD) born during the study period. A control was defined as the next three newborns (delivered after the case) without birth defects. Univariate, bivariate and multivariate analysis were done using Epi Info version 3.5.1.</p></sec><sec id="st3"><title>Results</title><p>A total of 400 newborns participated in the study, 100 cases and 300 controls. Factors associated with higher odds of a SBD included maternal fever (adjusted odds ratio (AOR) = 1.99; 95% confidence interval (CI): 1.14-3.52), maternal hypertension (AOR = 3.99; 95% CI: 1.67-9.54), and low birth weight (AOR = 3.48; 95% CI: 1.77-6.85). Antimalarial use during pregnancy was protective (AOR = 0.48; 95% CI: 0.28-0.84). Folic acid supplementation was protective only in bivariate analysis (OR = 0.56; 95% CI: 0.32-0.96).</p></sec><sec id="st4"><title>Conclusion</title><p>Maternal fever, hypertension, and low birth weight are associated with higher odds of SBD. Antimalarial use during pregnancy was associated with lower odds of SBD. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Pan Afr Med J</journal-id><journal-id journal-id-type="iso-abbrev">Pan Afr Med J</journal-id><journal-id journal-id-type="publisher-id">PAMJ</journal-id><journal-title-group><journal-title>The Pan African Medical Journal</journal-title></journal-title-group><issn pub-type="epub">1937-8688</issn><publisher><publisher-name>The African Field Epidemiology Network</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26525082</article-id><article-id pub-id-type="pmc">4613840</article-id><article-id pub-id-type="publisher-id">PAMJ-20-153</article-id><article-id pub-id-type="doi">10.11604/pamj.2015.20.153.4492</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research</subject></subj-group></article-categories><title-group><article-title>Factors associated with major structural birth defects among newborns delivered at Muhimbili National Hospital and Municipal Hospitals in Dar Es Salaam, Tanzania 2011 – 2012</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kishimba</surname><given-names>Rogath Saika</given-names></name><xref ref-type="aff" rid="AF0001">1</xref><xref ref-type="aff" rid="AF0003">3</xref><xref ref-type="corresp" rid="cor1">&</xref></contrib><contrib contrib-type="author"><name><surname>Mpembeni</surname><given-names>Rose</given-names></name><xref ref-type="aff" rid="AF0002">2</xref></contrib><contrib contrib-type="author"><name><surname>Mghamba</surname><given-names>Janneth</given-names></name><xref ref-type="aff" rid="AF0001">1</xref><xref ref-type="aff" rid="AF0003">3</xref></contrib></contrib-group><aff id="AF0001"><label>1</label>Field Epidemiology and Laboratory Training Programme (FELTP), Tanzania</aff><aff id="AF0002"><label>2</label>Muhimbili University of Health and Allied Sciences (MUHAS), Tanzania</aff><aff id="AF0003"><label>3</label>Ministry of Health and Social Welfare, Tanzania</aff><author-notes><corresp id="cor1"><label>&</label>Corresponding author: Rogath Saika Kishimba, Field Epidemiology and Laboratory Training Programme (FELTP), Tanzania</corresp></author-notes><pub-date pub-type="epub"><day>18</day><month>2</month><year>2015</year></pub-date><pub-date pub-type="collection"><year>2015</year></pub-date><volume>20</volume><elocation-id>153</elocation-id><history><date date-type="received"><day>30</day><month>4</month><year>2014</year></date><date date-type="accepted"><day>03</day><month>2</month><year>2015</year></date></history><permissions><copyright-statement>© Rogath Saika Kishimba et al.</copyright-statement><copyright-year>2015</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0/"><license-p>The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec id="st1"><title>Introduction</title><p>Ninety-four percent of all birth defects and 95% of deaths due to the birth defects occur in low and middle income countries, Tanzania among them. In Tanzania there are currently limited birth defects prevention strategies in place due to limited information on factors associated with the occurrence of birth defects.</p></sec><sec id="st2"><title>Methods</title><p>We conducted a case control study that included newborns born from October, 2011 through February, 2012 at 4 participating hospitals. A case was defined as any newborn of a Dar es salaam resident with a neural tube defect, orofacial clefts, limb reduction defects or musculo-skeletal defects (SBD) born during the study period. A control was defined as the next three newborns (delivered after the case) without birth defects. Univariate, bivariate and multivariate analysis were done using Epi Info version 3.5.1.</p></sec><sec id="st3"><title>Results</title><p>A total of 400 newborns participated in the study, 100 cases and 300 controls. Factors associated with higher odds of a SBD included maternal fever (adjusted odds ratio (AOR) = 1.99; 95% confidence interval (CI): 1.14-3.52), maternal hypertension (AOR = 3.99; 95% CI: 1.67-9.54), and low birth weight (AOR = 3.48; 95% CI: 1.77-6.85). Antimalarial use during pregnancy was protective (AOR = 0.48; 95% CI: 0.28-0.84). Folic acid supplementation was protective only in bivariate analysis (OR = 0.56; 95% CI: 0.32-0.96).</p></sec><sec id="st4"><title>Conclusion</title><p>Maternal fever, hypertension, and low birth weight are associated with higher odds of SBD. Antimalarial use during pregnancy was associated with lower odds of SBD. Early screening of pregnant mothers for hypertension and other causes of low birth weight may reduce SBD in Dar Es Salaam.</p></sec></abstract><kwd-group><kwd>Birth defects</kwd><kwd>risk factors</kwd><kwd>newborns</kwd><kwd>mothers</kwd><kwd>mortality</kwd><kwd>Tanzania</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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