Maternal colonisation with Streptococcus agalactiae, and associated stillbirth and neonatal disease in coastal Kenya
Identifieur interne : 001B26 ( Pmc/Corpus ); précédent : 001B25; suivant : 001B27Maternal colonisation with Streptococcus agalactiae, and associated stillbirth and neonatal disease in coastal Kenya
Auteurs : Anna C. Seale ; Angela C. Koech ; Anna E. Sheppard ; Hellen C. Barsosio ; Joyce Langat ; Emily Anyango ; Stella Mwakio ; Salim Mwarumba ; Susan C. Morpeth ; Kirimi Anampiu ; Alison Vaughan ; Adam Giess ; Polycarp Mogeni ; Leahbell Walusuna ; Hope Mwangudzah ; Doris Mwanzui ; Mariam Salim ; Bryn Kemp ; Caroline Jones ; Neema Mturi ; Benjamin Tsofa ; Edward Mumbo ; David Mulewa ; Victor Bandika ; Musimbi Soita ; Maureen Owiti ; Norris Onzere ; A Sarah Walker ; Stephanie J. Schrag ; Stephen H. Kennedy ; Greg Fegan ; Derrick W. Crook ; James A. BerkleySource :
- Nature microbiology [ 2058-5276 ] ; 2016.
Abstract
Url:
DOI: 10.1038/nmicrobiol.2016.67
PubMed: 27572968
PubMed Central: 4936517
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PMC:4936517Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Maternal colonisation with <italic>Streptococcus agalactiae</italic>,
and associated stillbirth and neonatal disease in coastal Kenya</title><author><name sortKey="Seale, Anna C" sort="Seale, Anna C" uniqKey="Seale A" first="Anna C" last="Seale">Anna C. Seale</name><affiliation><nlm:aff id="A1">Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Koech, Angela C" sort="Koech, Angela C" uniqKey="Koech A" first="Angela C" last="Koech">Angela C. Koech</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Sheppard, Anna E" sort="Sheppard, Anna E" uniqKey="Sheppard A" first="Anna E" last="Sheppard">Anna E. Sheppard</name><affiliation><nlm:aff id="A3">Modernizing Medical Microbiology Consortium, Nuffield Department of Medicine, University of Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Barsosio, Hellen C" sort="Barsosio, Hellen C" uniqKey="Barsosio H" first="Hellen C" last="Barsosio">Hellen C. Barsosio</name><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Langat, Joyce" sort="Langat, Joyce" uniqKey="Langat J" first="Joyce" last="Langat">Joyce Langat</name><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Anyango, Emily" sort="Anyango, Emily" uniqKey="Anyango E" first="Emily" last="Anyango">Emily Anyango</name><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Mwakio, Stella" sort="Mwakio, Stella" uniqKey="Mwakio S" first="Stella" last="Mwakio">Stella Mwakio</name><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Mwarumba, Salim" sort="Mwarumba, Salim" uniqKey="Mwarumba S" first="Salim" last="Mwarumba">Salim Mwarumba</name><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Morpeth, Susan C" sort="Morpeth, Susan C" uniqKey="Morpeth S" first="Susan C" last="Morpeth">Susan C. Morpeth</name><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation><affiliation><nlm:aff id="A4">London School of Hygiene and Tropical Medicine, London, UK</nlm:aff></affiliation></author><author><name sortKey="Anampiu, Kirimi" sort="Anampiu, Kirimi" uniqKey="Anampiu K" first="Kirimi" last="Anampiu">Kirimi Anampiu</name><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Vaughan, Alison" sort="Vaughan, Alison" uniqKey="Vaughan A" first="Alison" last="Vaughan">Alison Vaughan</name><affiliation><nlm:aff id="A3">Modernizing Medical Microbiology Consortium, Nuffield Department of Medicine, University of Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Giess, Adam" sort="Giess, Adam" uniqKey="Giess A" first="Adam" last="Giess">Adam Giess</name><affiliation><nlm:aff id="A3">Modernizing Medical Microbiology Consortium, Nuffield Department of Medicine, University of Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Mogeni, Polycarp" sort="Mogeni, Polycarp" uniqKey="Mogeni P" first="Polycarp" last="Mogeni">Polycarp Mogeni</name><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Walusuna, Leahbell" sort="Walusuna, Leahbell" uniqKey="Walusuna L" first="Leahbell" last="Walusuna">Leahbell Walusuna</name><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Mwangudzah, Hope" sort="Mwangudzah, Hope" uniqKey="Mwangudzah H" first="Hope" last="Mwangudzah">Hope Mwangudzah</name><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Mwanzui, Doris" sort="Mwanzui, Doris" uniqKey="Mwanzui D" first="Doris" last="Mwanzui">Doris Mwanzui</name><affiliation><nlm:aff id="A5">Maternity Department, Kilifi County Hospital, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Salim, Mariam" sort="Salim, Mariam" uniqKey="Salim M" first="Mariam" last="Salim">Mariam Salim</name><affiliation><nlm:aff id="A5">Maternity Department, Kilifi County Hospital, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Kemp, Bryn" sort="Kemp, Bryn" uniqKey="Kemp B" first="Bryn" last="Kemp">Bryn Kemp</name><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Nuffield Department of Obstetrics and Gynaecology, University of Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Jones, Caroline" sort="Jones, Caroline" uniqKey="Jones C" first="Caroline" last="Jones">Caroline Jones</name><affiliation><nlm:aff id="A1">Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation><affiliation><nlm:aff id="A4">London School of Hygiene and Tropical Medicine, London, UK</nlm:aff></affiliation></author><author><name sortKey="Mturi, Neema" sort="Mturi, Neema" uniqKey="Mturi N" first="Neema" last="Mturi">Neema Mturi</name><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Tsofa, Benjamin" sort="Tsofa, Benjamin" uniqKey="Tsofa B" first="Benjamin" last="Tsofa">Benjamin Tsofa</name><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Mumbo, Edward" sort="Mumbo, Edward" uniqKey="Mumbo E" first="Edward" last="Mumbo">Edward Mumbo</name><affiliation><nlm:aff id="A7">County Ministry of Health, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Mulewa, David" sort="Mulewa, David" uniqKey="Mulewa D" first="David" last="Mulewa">David Mulewa</name><affiliation><nlm:aff id="A7">County Ministry of Health, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Bandika, Victor" sort="Bandika, Victor" uniqKey="Bandika V" first="Victor" last="Bandika">Victor Bandika</name><affiliation><nlm:aff id="A8">Department of Paediatrics, Coast Provincial General Hospital, Mombasa, Kenya</nlm:aff></affiliation></author><author><name sortKey="Soita, Musimbi" sort="Soita, Musimbi" uniqKey="Soita M" first="Musimbi" last="Soita">Musimbi Soita</name><affiliation><nlm:aff id="A9">Department of Obstetrics and Gynaecology, Coast Provincial General Hospital, Mombasa, Kenya</nlm:aff></affiliation></author><author><name sortKey="Owiti, Maureen" sort="Owiti, Maureen" uniqKey="Owiti M" first="Maureen" last="Owiti">Maureen Owiti</name><affiliation><nlm:aff id="A5">Maternity Department, Kilifi County Hospital, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Onzere, Norris" sort="Onzere, Norris" uniqKey="Onzere N" first="Norris" last="Onzere">Norris Onzere</name><affiliation><nlm:aff id="A5">Maternity Department, Kilifi County Hospital, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Walker, A Sarah" sort="Walker, A Sarah" uniqKey="Walker A" first="A Sarah" last="Walker">A Sarah Walker</name><affiliation><nlm:aff id="A3">Modernizing Medical Microbiology Consortium, Nuffield Department of Medicine, University of Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Schrag, Stephanie J" sort="Schrag, Stephanie J" uniqKey="Schrag S" first="Stephanie J" last="Schrag">Stephanie J. Schrag</name><affiliation><nlm:aff id="A10">Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, USA</nlm:aff></affiliation></author><author><name sortKey="Kennedy, Stephen H" sort="Kennedy, Stephen H" uniqKey="Kennedy S" first="Stephen H" last="Kennedy">Stephen H. Kennedy</name><affiliation><nlm:aff id="A6">Nuffield Department of Obstetrics and Gynaecology, University of Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Fegan, Greg" sort="Fegan, Greg" uniqKey="Fegan G" first="Greg" last="Fegan">Greg Fegan</name><affiliation><nlm:aff id="A1">Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Crook, Derrick W" sort="Crook, Derrick W" uniqKey="Crook D" first="Derrick W" last="Crook">Derrick W. Crook</name><affiliation><nlm:aff id="A3">Modernizing Medical Microbiology Consortium, Nuffield Department of Medicine, University of Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Berkley, James A" sort="Berkley, James A" uniqKey="Berkley J" first="James A" last="Berkley">James A. Berkley</name><affiliation><nlm:aff id="A1">Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27572968</idno><idno type="pmc">4936517</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936517</idno><idno type="RBID">PMC:4936517</idno><idno type="doi">10.1038/nmicrobiol.2016.67</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001B26</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001B26</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Maternal colonisation with <italic>Streptococcus agalactiae</italic>,
and associated stillbirth and neonatal disease in coastal Kenya</title><author><name sortKey="Seale, Anna C" sort="Seale, Anna C" uniqKey="Seale A" first="Anna C" last="Seale">Anna C. Seale</name><affiliation><nlm:aff id="A1">Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Koech, Angela C" sort="Koech, Angela C" uniqKey="Koech A" first="Angela C" last="Koech">Angela C. Koech</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Sheppard, Anna E" sort="Sheppard, Anna E" uniqKey="Sheppard A" first="Anna E" last="Sheppard">Anna E. Sheppard</name><affiliation><nlm:aff id="A3">Modernizing Medical Microbiology Consortium, Nuffield Department of Medicine, University of Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Barsosio, Hellen C" sort="Barsosio, Hellen C" uniqKey="Barsosio H" first="Hellen C" last="Barsosio">Hellen C. Barsosio</name><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Langat, Joyce" sort="Langat, Joyce" uniqKey="Langat J" first="Joyce" last="Langat">Joyce Langat</name><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Anyango, Emily" sort="Anyango, Emily" uniqKey="Anyango E" first="Emily" last="Anyango">Emily Anyango</name><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Mwakio, Stella" sort="Mwakio, Stella" uniqKey="Mwakio S" first="Stella" last="Mwakio">Stella Mwakio</name><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Mwarumba, Salim" sort="Mwarumba, Salim" uniqKey="Mwarumba S" first="Salim" last="Mwarumba">Salim Mwarumba</name><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Morpeth, Susan C" sort="Morpeth, Susan C" uniqKey="Morpeth S" first="Susan C" last="Morpeth">Susan C. Morpeth</name><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation><affiliation><nlm:aff id="A4">London School of Hygiene and Tropical Medicine, London, UK</nlm:aff></affiliation></author><author><name sortKey="Anampiu, Kirimi" sort="Anampiu, Kirimi" uniqKey="Anampiu K" first="Kirimi" last="Anampiu">Kirimi Anampiu</name><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Vaughan, Alison" sort="Vaughan, Alison" uniqKey="Vaughan A" first="Alison" last="Vaughan">Alison Vaughan</name><affiliation><nlm:aff id="A3">Modernizing Medical Microbiology Consortium, Nuffield Department of Medicine, University of Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Giess, Adam" sort="Giess, Adam" uniqKey="Giess A" first="Adam" last="Giess">Adam Giess</name><affiliation><nlm:aff id="A3">Modernizing Medical Microbiology Consortium, Nuffield Department of Medicine, University of Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Mogeni, Polycarp" sort="Mogeni, Polycarp" uniqKey="Mogeni P" first="Polycarp" last="Mogeni">Polycarp Mogeni</name><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Walusuna, Leahbell" sort="Walusuna, Leahbell" uniqKey="Walusuna L" first="Leahbell" last="Walusuna">Leahbell Walusuna</name><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Mwangudzah, Hope" sort="Mwangudzah, Hope" uniqKey="Mwangudzah H" first="Hope" last="Mwangudzah">Hope Mwangudzah</name><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Mwanzui, Doris" sort="Mwanzui, Doris" uniqKey="Mwanzui D" first="Doris" last="Mwanzui">Doris Mwanzui</name><affiliation><nlm:aff id="A5">Maternity Department, Kilifi County Hospital, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Salim, Mariam" sort="Salim, Mariam" uniqKey="Salim M" first="Mariam" last="Salim">Mariam Salim</name><affiliation><nlm:aff id="A5">Maternity Department, Kilifi County Hospital, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Kemp, Bryn" sort="Kemp, Bryn" uniqKey="Kemp B" first="Bryn" last="Kemp">Bryn Kemp</name><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Nuffield Department of Obstetrics and Gynaecology, University of Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Jones, Caroline" sort="Jones, Caroline" uniqKey="Jones C" first="Caroline" last="Jones">Caroline Jones</name><affiliation><nlm:aff id="A1">Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation><affiliation><nlm:aff id="A4">London School of Hygiene and Tropical Medicine, London, UK</nlm:aff></affiliation></author><author><name sortKey="Mturi, Neema" sort="Mturi, Neema" uniqKey="Mturi N" first="Neema" last="Mturi">Neema Mturi</name><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Tsofa, Benjamin" sort="Tsofa, Benjamin" uniqKey="Tsofa B" first="Benjamin" last="Tsofa">Benjamin Tsofa</name><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Mumbo, Edward" sort="Mumbo, Edward" uniqKey="Mumbo E" first="Edward" last="Mumbo">Edward Mumbo</name><affiliation><nlm:aff id="A7">County Ministry of Health, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Mulewa, David" sort="Mulewa, David" uniqKey="Mulewa D" first="David" last="Mulewa">David Mulewa</name><affiliation><nlm:aff id="A7">County Ministry of Health, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Bandika, Victor" sort="Bandika, Victor" uniqKey="Bandika V" first="Victor" last="Bandika">Victor Bandika</name><affiliation><nlm:aff id="A8">Department of Paediatrics, Coast Provincial General Hospital, Mombasa, Kenya</nlm:aff></affiliation></author><author><name sortKey="Soita, Musimbi" sort="Soita, Musimbi" uniqKey="Soita M" first="Musimbi" last="Soita">Musimbi Soita</name><affiliation><nlm:aff id="A9">Department of Obstetrics and Gynaecology, Coast Provincial General Hospital, Mombasa, Kenya</nlm:aff></affiliation></author><author><name sortKey="Owiti, Maureen" sort="Owiti, Maureen" uniqKey="Owiti M" first="Maureen" last="Owiti">Maureen Owiti</name><affiliation><nlm:aff id="A5">Maternity Department, Kilifi County Hospital, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Onzere, Norris" sort="Onzere, Norris" uniqKey="Onzere N" first="Norris" last="Onzere">Norris Onzere</name><affiliation><nlm:aff id="A5">Maternity Department, Kilifi County Hospital, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Walker, A Sarah" sort="Walker, A Sarah" uniqKey="Walker A" first="A Sarah" last="Walker">A Sarah Walker</name><affiliation><nlm:aff id="A3">Modernizing Medical Microbiology Consortium, Nuffield Department of Medicine, University of Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Schrag, Stephanie J" sort="Schrag, Stephanie J" uniqKey="Schrag S" first="Stephanie J" last="Schrag">Stephanie J. Schrag</name><affiliation><nlm:aff id="A10">Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, USA</nlm:aff></affiliation></author><author><name sortKey="Kennedy, Stephen H" sort="Kennedy, Stephen H" uniqKey="Kennedy S" first="Stephen H" last="Kennedy">Stephen H. Kennedy</name><affiliation><nlm:aff id="A6">Nuffield Department of Obstetrics and Gynaecology, University of Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Fegan, Greg" sort="Fegan, Greg" uniqKey="Fegan G" first="Greg" last="Fegan">Greg Fegan</name><affiliation><nlm:aff id="A1">Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Crook, Derrick W" sort="Crook, Derrick W" uniqKey="Crook D" first="Derrick W" last="Crook">Derrick W. Crook</name><affiliation><nlm:aff id="A3">Modernizing Medical Microbiology Consortium, Nuffield Department of Medicine, University of Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Berkley, James A" sort="Berkley, James A" uniqKey="Berkley J" first="James A" last="Berkley">James A. Berkley</name><affiliation><nlm:aff id="A1">Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A2">KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</nlm:aff></affiliation></author></analytic><series><title level="j">Nature microbiology</title><idno type="eISSN">2058-5276</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1"><italic>Streptococcus agalactiae</italic> (Group B Streptococcus, GBS)
causes neonatal disease and stillbirth, but its burden in sub-Saharan Africa is
uncertain. We assessed maternal recto-vaginal GBS colonisation (7967 women),
stillbirth and neonatal disease. Whole genome sequencing was used to determine
serotypes, sequence types (ST), and phylogeny. We found low maternal GBS
colonisation prevalence (934/7967, 12%), but comparatively high incidence of
GBS-associated stillbirth and early onset neonatal disease (EOD) in hospital
(0.91(0.25-2.3)/1000 births; 0.76(0.25-1.77)/1000 live-births respectively).
However, using a population denominator, EOD incidence was considerably reduced
(0.13(0.07-0.21)/1000 live-births). Treated cases of EOD had very high case
fatality (17/36, 47%), especially within 24 hours of birth, making
under-ascertainment of community-born cases highly likely, both here and in
similar facility-based studies. Maternal GBS colonisation was less common in
women with low socio-economic status, HIV infection and undernutrition, but when
GBS-colonised, they were more likely colonised by the most virulent clone, CC17.
CC17 accounted for 267/915(29%) of maternal colonising (265/267(99%) serotype
III, 2/267(0.7%) serotype IV), and 51/73(70%) of neonatal disease cases (all
serotype III). Trivalent (Ia/II/III) and pentavalent (Ia/Ib/II/III/V) vaccines
would cover 71/73(97%) and 72/73(99%) of disease-causing serotypes respectively.
Serotype IV should be considered for inclusion, with evidence of capsular
switching in CC17 strains.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101674869</journal-id><journal-id journal-id-type="pubmed-jr-id">44774</journal-id><journal-id journal-id-type="nlm-ta">Nat Microbiol</journal-id><journal-id journal-id-type="iso-abbrev">Nat Microbiol</journal-id><journal-title-group><journal-title>Nature microbiology</journal-title></journal-title-group><issn pub-type="epub">2058-5276</issn></journal-meta><article-meta><article-id pub-id-type="pmid">27572968</article-id><article-id pub-id-type="pmc">4936517</article-id><article-id pub-id-type="doi">10.1038/nmicrobiol.2016.67</article-id><article-id pub-id-type="manuscript">EMS68774</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Maternal colonisation with <italic>Streptococcus agalactiae</italic>,
and associated stillbirth and neonatal disease in coastal Kenya</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Seale</surname><given-names>Anna C</given-names></name><degrees>DPhil</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="corresp" rid="CR1">*</xref></contrib><contrib contrib-type="author"><name><surname>Koech</surname><given-names>Angela C</given-names></name><degrees>MBChB</degrees><xref ref-type="aff" rid="A1">2</xref></contrib><contrib contrib-type="author"><name><surname>Sheppard</surname><given-names>Anna E</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Barsosio</surname><given-names>Hellen C</given-names></name><degrees>MBChB</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Langat</surname><given-names>Joyce</given-names></name><degrees>HND</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Anyango</surname><given-names>Emily</given-names></name><degrees>HND</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Mwakio</surname><given-names>Stella</given-names></name><degrees>HND</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Mwarumba</surname><given-names>Salim</given-names></name><degrees>MSc</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Morpeth</surname><given-names>Susan C</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Anampiu</surname><given-names>Kirimi</given-names></name><degrees>HND</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Vaughan</surname><given-names>Alison</given-names></name><degrees>BSc</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Giess</surname><given-names>Adam</given-names></name><degrees>MSc</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Mogeni</surname><given-names>Polycarp</given-names></name><degrees>MSc</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Walusuna</surname><given-names>Leahbell</given-names></name><degrees>MSc</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Mwangudzah</surname><given-names>Hope</given-names></name><degrees>HND</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Mwanzui</surname><given-names>Doris</given-names></name><degrees>RN</degrees><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Salim</surname><given-names>Mariam</given-names></name><degrees>RN</degrees><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Kemp</surname><given-names>Bryn</given-names></name><degrees>DPhil</degrees><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Jones</surname><given-names>Caroline</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Mturi</surname><given-names>Neema</given-names></name><degrees>MRCPCH</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Tsofa</surname><given-names>Benjamin</given-names></name><degrees>DPH</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Mumbo</surname><given-names>Edward</given-names></name><degrees>BScN</degrees><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Mulewa</surname><given-names>David</given-names></name><degrees>MBChB</degrees><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Bandika</surname><given-names>Victor</given-names></name><degrees>MMed</degrees><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Soita</surname><given-names>Musimbi</given-names></name><degrees>MMed</degrees><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Owiti</surname><given-names>Maureen</given-names></name><degrees>MMed</degrees><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Onzere</surname><given-names>Norris</given-names></name><degrees>MMed</degrees><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Walker</surname><given-names>A Sarah</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Schrag</surname><given-names>Stephanie J</given-names></name><degrees>DPhil</degrees><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Kennedy</surname><given-names>Stephen H</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Fegan</surname><given-names>Greg</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Crook</surname><given-names>Derrick W</given-names></name><degrees>FRCPath</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Berkley</surname><given-names>James A</given-names></name><degrees>FRCPCH</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib></contrib-group><aff id="A1"><label>1</label>Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, UK</aff><aff id="A2"><label>2</label>KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya</aff><aff id="A3"><label>3</label>Modernizing Medical Microbiology Consortium, Nuffield Department of Medicine, University of Oxford, UK</aff><aff id="A4"><label>4</label>London School of Hygiene and Tropical Medicine, London, UK</aff><aff id="A5"><label>5</label>Maternity Department, Kilifi County Hospital, Kilifi, Kenya</aff><aff id="A6"><label>6</label>Nuffield Department of Obstetrics and Gynaecology, University of Oxford, UK</aff><aff id="A7"><label>7</label>County Ministry of Health, Kilifi, Kenya</aff><aff id="A8"><label>8</label>Department of Paediatrics, Coast Provincial General Hospital, Mombasa, Kenya</aff><aff id="A9"><label>9</label>Department of Obstetrics and Gynaecology, Coast Provincial General Hospital, Mombasa, Kenya</aff><aff id="A10"><label>10</label>Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, USA</aff><author-notes><corresp id="CR1"><bold>Corresponding author</bold> Correspondence to Anna Seale
KEMRI-Wellcome Trust, PO Box 230, Kilifi 80108, Kenya. +254 41 7522155
<email>anna.seale@gmail.com</email>.</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>9</day><month>6</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>23</day><month>5</month><year>2016</year></pub-date><pub-date pub-type="collection"><day>23</day><month>5</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>1</month><year>2017</year></pub-date><volume>1</volume><issue>7</issue><fpage>16067</fpage><lpage>16067</lpage><pmc-comment>elocation-id from pubmed: 10.1038/nmicrobiol.2016.67</pmc-comment>
<abstract><p id="P1"><italic>Streptococcus agalactiae</italic> (Group B Streptococcus, GBS)
causes neonatal disease and stillbirth, but its burden in sub-Saharan Africa is
uncertain. We assessed maternal recto-vaginal GBS colonisation (7967 women),
stillbirth and neonatal disease. Whole genome sequencing was used to determine
serotypes, sequence types (ST), and phylogeny. We found low maternal GBS
colonisation prevalence (934/7967, 12%), but comparatively high incidence of
GBS-associated stillbirth and early onset neonatal disease (EOD) in hospital
(0.91(0.25-2.3)/1000 births; 0.76(0.25-1.77)/1000 live-births respectively).
However, using a population denominator, EOD incidence was considerably reduced
(0.13(0.07-0.21)/1000 live-births). Treated cases of EOD had very high case
fatality (17/36, 47%), especially within 24 hours of birth, making
under-ascertainment of community-born cases highly likely, both here and in
similar facility-based studies. Maternal GBS colonisation was less common in
women with low socio-economic status, HIV infection and undernutrition, but when
GBS-colonised, they were more likely colonised by the most virulent clone, CC17.
CC17 accounted for 267/915(29%) of maternal colonising (265/267(99%) serotype
III, 2/267(0.7%) serotype IV), and 51/73(70%) of neonatal disease cases (all
serotype III). Trivalent (Ia/II/III) and pentavalent (Ia/Ib/II/III/V) vaccines
would cover 71/73(97%) and 72/73(99%) of disease-causing serotypes respectively.
Serotype IV should be considered for inclusion, with evidence of capsular
switching in CC17 strains.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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