Vitamin D Status and Incidence of Pulmonary Tuberculosis, Opportunistic Infections, and Wasting Among HIV-Infected Tanzanian Adults Initiating Antiretroviral Therapy
Identifieur interne : 001696 ( Pmc/Corpus ); précédent : 001695; suivant : 001697Vitamin D Status and Incidence of Pulmonary Tuberculosis, Opportunistic Infections, and Wasting Among HIV-Infected Tanzanian Adults Initiating Antiretroviral Therapy
Auteurs : Christopher R. Sudfeld ; Edward L. Giovannucci ; Sheila Isanaka ; Said Aboud ; Ferdinand M. Mugusi ; Molin Wang ; Guerino Chalamilla ; Wafaie W. FawziSource :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2012.
Abstract
Url:
DOI: 10.1093/infdis/jis693
PubMed: 23162137
PubMed Central: 3537448
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PMC:3537448Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Vitamin D Status and Incidence of Pulmonary Tuberculosis, Opportunistic Infections, and Wasting Among HIV-Infected Tanzanian Adults Initiating Antiretroviral Therapy</title>
<author><name sortKey="Sudfeld, Christopher R" sort="Sudfeld, Christopher R" uniqKey="Sudfeld C" first="Christopher R." last="Sudfeld">Christopher R. Sudfeld</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Epidemiology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L." last="Giovannucci">Edward L. Giovannucci</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Epidemiology</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af3"><addr-line>Department of Nutrition</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af5"><addr-line>Channing Laboratory, Department of Medicine</addr-line>
,<institution>Brigham and Women's Hospital</institution>
,<addr-line>Boston, Massachusetts</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Isanaka, Sheila" sort="Isanaka, Sheila" uniqKey="Isanaka S" first="Sheila" last="Isanaka">Sheila Isanaka</name>
<affiliation><nlm:aff id="af3"><addr-line>Department of Nutrition</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Aboud, Said" sort="Aboud, Said" uniqKey="Aboud S" first="Said" last="Aboud">Said Aboud</name>
<affiliation><nlm:aff id="af6"><addr-line>Department of Microbiology and Immunology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mugusi, Ferdinand M" sort="Mugusi, Ferdinand M" uniqKey="Mugusi F" first="Ferdinand M." last="Mugusi">Ferdinand M. Mugusi</name>
<affiliation><nlm:aff id="af7"><addr-line>Department of Internal Medicine</addr-line>
,<institution>Muhimbili University of Health and Allied Sciences</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, Molin" sort="Wang, Molin" uniqKey="Wang M" first="Molin" last="Wang">Molin Wang</name>
<affiliation><nlm:aff id="af2"><addr-line>Department of Biostatistics</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chalamilla, Guerino" sort="Chalamilla, Guerino" uniqKey="Chalamilla G" first="Guerino" last="Chalamilla">Guerino Chalamilla</name>
<affiliation><nlm:aff id="af8"><addr-line>Management and Development for Health, Dar es Salaam</addr-line>
,<country>Tanzania</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fawzi, Wafaie W" sort="Fawzi, Wafaie W" uniqKey="Fawzi W" first="Wafaie W." last="Fawzi">Wafaie W. Fawzi</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Epidemiology</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af3"><addr-line>Department of Nutrition</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af4"><addr-line>Department of Global Health and Population</addr-line>
,<institution>Harvard School of Public Health</institution>
</nlm:aff>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Vitamin D Status and Incidence of Pulmonary Tuberculosis, Opportunistic Infections, and Wasting Among HIV-Infected Tanzanian Adults Initiating Antiretroviral Therapy</title>
<author><name sortKey="Sudfeld, Christopher R" sort="Sudfeld, Christopher R" uniqKey="Sudfeld C" first="Christopher R." last="Sudfeld">Christopher R. Sudfeld</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Epidemiology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L." last="Giovannucci">Edward L. Giovannucci</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Epidemiology</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af3"><addr-line>Department of Nutrition</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af5"><addr-line>Channing Laboratory, Department of Medicine</addr-line>
,<institution>Brigham and Women's Hospital</institution>
,<addr-line>Boston, Massachusetts</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Isanaka, Sheila" sort="Isanaka, Sheila" uniqKey="Isanaka S" first="Sheila" last="Isanaka">Sheila Isanaka</name>
<affiliation><nlm:aff id="af3"><addr-line>Department of Nutrition</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Aboud, Said" sort="Aboud, Said" uniqKey="Aboud S" first="Said" last="Aboud">Said Aboud</name>
<affiliation><nlm:aff id="af6"><addr-line>Department of Microbiology and Immunology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mugusi, Ferdinand M" sort="Mugusi, Ferdinand M" uniqKey="Mugusi F" first="Ferdinand M." last="Mugusi">Ferdinand M. Mugusi</name>
<affiliation><nlm:aff id="af7"><addr-line>Department of Internal Medicine</addr-line>
,<institution>Muhimbili University of Health and Allied Sciences</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, Molin" sort="Wang, Molin" uniqKey="Wang M" first="Molin" last="Wang">Molin Wang</name>
<affiliation><nlm:aff id="af2"><addr-line>Department of Biostatistics</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chalamilla, Guerino" sort="Chalamilla, Guerino" uniqKey="Chalamilla G" first="Guerino" last="Chalamilla">Guerino Chalamilla</name>
<affiliation><nlm:aff id="af8"><addr-line>Management and Development for Health, Dar es Salaam</addr-line>
,<country>Tanzania</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fawzi, Wafaie W" sort="Fawzi, Wafaie W" uniqKey="Fawzi W" first="Wafaie W." last="Fawzi">Wafaie W. Fawzi</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Epidemiology</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af3"><addr-line>Department of Nutrition</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af4"><addr-line>Department of Global Health and Population</addr-line>
,<institution>Harvard School of Public Health</institution>
</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of Infectious Diseases</title>
<idno type="ISSN">0022-1899</idno>
<idno type="eISSN">1537-6613</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><bold><italic>Background.</italic>
</bold>
Maintaining vitamin D sufficiency may decrease the incidence of pulmonary tuberculosis and other infectious diseases. We present the first prospective study of vitamin D among human immunodeficiency virus (HIV)–infected adults receiving antiretrovirals in sub-Saharan Africa.</p>
<p><bold><italic>Methods.</italic>
</bold>
Serum 25-hydroxyvitamin D (25(OH)D) level was assessed at antiretroviral therapy (ART) initiation for 1103 HIV-infected adults enrolled in a trial of multivitamins (not including vitamin D) in Tanzania. Participants were prospectively followed at monthly visits at which trained physicians performed a clinical examination and nurses took anthropometric measurements and assessed self-reported symptoms. Cox proportional hazards models estimated hazard ratios (HRs) of morbidity outcomes.</p>
<p><bold><italic>Results.</italic>
</bold>
After multivariate adjustment, vitamin D deficiency (defined as a concentration of <20 ng/mL) had a significantly greater association with incident pulmonary tuberculosis, compared with vitamin D sufficiency (HR, 2.89; 95% confidence interval [CI], 1.31–7.41; <italic>P</italic>
= .027), but no association was found for vitamin D insufficiency (defined as a concentration of 20–30 ng/mL; <italic>P</italic>
= .687). Deficiency was also significantly associated with incident oral thrush (HR, 1.96; 95% CI, 1.01–3.81; <italic>P</italic>
= .046), wasting (HR, 3.10; 95% CI, 1.33–7.24; <italic>P</italic>
= .009), and >10% weight loss (HR, 2.10; 95% CI, 1.13–3.91; <italic>P</italic>
= .019). Wasting results were robust to exclusion of individuals experiencing pulmonary tuberculosis. Vitamin D status was not associated with incident malaria, pneumonia, or anemia.</p>
<p><bold><italic>Conclusions.</italic>
</bold>
Vitamin D supplementation trials for adults receiving ART appear to be warranted.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Infect Dis</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Infect. Dis</journal-id>
<journal-id journal-id-type="publisher-id">jid</journal-id>
<journal-id journal-id-type="hwp">jinfdis</journal-id>
<journal-title-group><journal-title>The Journal of Infectious Diseases</journal-title>
</journal-title-group>
<issn pub-type="ppub">0022-1899</issn>
<issn pub-type="epub">1537-6613</issn>
<publisher><publisher-name>Oxford University Press</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">23162137</article-id>
<article-id pub-id-type="pmc">3537448</article-id>
<article-id pub-id-type="doi">10.1093/infdis/jis693</article-id>
<article-id pub-id-type="publisher-id">jis693</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Major Articles and Brief Reports</subject>
<subj-group subj-group-type="heading"><subject>HIV/AIDS</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Vitamin D Status and Incidence of Pulmonary Tuberculosis, Opportunistic Infections, and Wasting Among HIV-Infected Tanzanian Adults Initiating Antiretroviral Therapy</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Sudfeld</surname>
<given-names>Christopher R.</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Giovannucci</surname>
<given-names>Edward L.</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
<xref ref-type="aff" rid="af3">3</xref>
<xref ref-type="aff" rid="af5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Isanaka</surname>
<given-names>Sheila</given-names>
</name>
<xref ref-type="aff" rid="af3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Aboud</surname>
<given-names>Said</given-names>
</name>
<xref ref-type="aff" rid="af6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mugusi</surname>
<given-names>Ferdinand M.</given-names>
</name>
<xref ref-type="aff" rid="af7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Molin</given-names>
</name>
<xref ref-type="aff" rid="af2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chalamilla</surname>
<given-names>Guerino</given-names>
</name>
<xref ref-type="aff" rid="af8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fawzi</surname>
<given-names>Wafaie W.</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
<xref ref-type="aff" rid="af3">3</xref>
<xref ref-type="aff" rid="af4">4</xref>
</contrib>
</contrib-group>
<aff id="af1"><label>1</label>
<addr-line>Department of Epidemiology</addr-line>
</aff>
<aff id="af2"><label>2</label>
<addr-line>Department of Biostatistics</addr-line>
</aff>
<aff id="af3"><label>3</label>
<addr-line>Department of Nutrition</addr-line>
</aff>
<aff id="af4"><label>4</label>
<addr-line>Department of Global Health and Population</addr-line>
,<institution>Harvard School of Public Health</institution>
</aff>
<aff id="af5"><label>5</label>
<addr-line>Channing Laboratory, Department of Medicine</addr-line>
,<institution>Brigham and Women's Hospital</institution>
,<addr-line>Boston, Massachusetts</addr-line>
</aff>
<aff id="af6"><label>6</label>
<addr-line>Department of Microbiology and Immunology</addr-line>
</aff>
<aff id="af7"><label>7</label>
<addr-line>Department of Internal Medicine</addr-line>
,<institution>Muhimbili University of Health and Allied Sciences</institution>
</aff>
<aff id="af8"><label>8</label>
<addr-line>Management and Development for Health, Dar es Salaam</addr-line>
,<country>Tanzania</country>
</aff>
<author-notes><corresp>Correspondence: Christopher R. Sudfeld, ScM, Department of Epidemiology, Harvard School of Public Health, 667 Huntington Ave, Bldg 1, Rm 1102, Boston, MA 02115 (<email>csudfeld@hsph.harvard.edu</email>
).</corresp>
</author-notes>
<pub-date pub-type="ppub"><day>1</day>
<month>2</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="epub"><day>16</day>
<month>11</month>
<year>2012</year>
</pub-date>
<volume>207</volume>
<issue>3</issue>
<fpage>378</fpage>
<lpage>385</lpage>
<history><date date-type="received"><day>13</day>
<month>6</month>
<year>2012</year>
</date>
<date date-type="accepted"><day>4</day>
<month>9</month>
<year>2012</year>
</date>
</history>
<permissions><copyright-statement>© The Author 2012. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: <email>journals.permissions@oup.com</email>
.</copyright-statement>
<copyright-year>2012</copyright-year>
</permissions>
<self-uri content-type="pdf" xlink:type="simple" xlink:href="jis693.pdf"></self-uri>
<abstract><p><bold><italic>Background.</italic>
</bold>
Maintaining vitamin D sufficiency may decrease the incidence of pulmonary tuberculosis and other infectious diseases. We present the first prospective study of vitamin D among human immunodeficiency virus (HIV)–infected adults receiving antiretrovirals in sub-Saharan Africa.</p>
<p><bold><italic>Methods.</italic>
</bold>
Serum 25-hydroxyvitamin D (25(OH)D) level was assessed at antiretroviral therapy (ART) initiation for 1103 HIV-infected adults enrolled in a trial of multivitamins (not including vitamin D) in Tanzania. Participants were prospectively followed at monthly visits at which trained physicians performed a clinical examination and nurses took anthropometric measurements and assessed self-reported symptoms. Cox proportional hazards models estimated hazard ratios (HRs) of morbidity outcomes.</p>
<p><bold><italic>Results.</italic>
</bold>
After multivariate adjustment, vitamin D deficiency (defined as a concentration of <20 ng/mL) had a significantly greater association with incident pulmonary tuberculosis, compared with vitamin D sufficiency (HR, 2.89; 95% confidence interval [CI], 1.31–7.41; <italic>P</italic>
= .027), but no association was found for vitamin D insufficiency (defined as a concentration of 20–30 ng/mL; <italic>P</italic>
= .687). Deficiency was also significantly associated with incident oral thrush (HR, 1.96; 95% CI, 1.01–3.81; <italic>P</italic>
= .046), wasting (HR, 3.10; 95% CI, 1.33–7.24; <italic>P</italic>
= .009), and >10% weight loss (HR, 2.10; 95% CI, 1.13–3.91; <italic>P</italic>
= .019). Wasting results were robust to exclusion of individuals experiencing pulmonary tuberculosis. Vitamin D status was not associated with incident malaria, pneumonia, or anemia.</p>
<p><bold><italic>Conclusions.</italic>
</bold>
Vitamin D supplementation trials for adults receiving ART appear to be warranted.</p>
</abstract>
<kwd-group><kwd>Vitamin D</kwd>
<kwd>micronutrient</kwd>
<kwd>HIV</kwd>
<kwd>tuberculosis</kwd>
<kwd>wasting</kwd>
<kwd>malaria</kwd>
<kwd>pneumonia</kwd>
<kwd>morbidity</kwd>
<kwd>ART</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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