SidaSubSaharaV1, Pmc, Corpus, bibRecord, 001695

Human Herpesvirus 8 Infection in Children and Adults in a Population-based Study in Rural Uganda

Identifieur interne : 001695 ( Pmc/Corpus ); précédent : 001694; suivant : 001696

Human Herpesvirus 8 Infection in Children and Adults in a Population-based Study in Rural Uganda

Auteurs : Lisa M. Butler ; Willy A. Were ; Steven Balinandi ; Robert Downing ; Sheila Dollard ; Torsten B. Neilands ; Sundeep Gupta ; George W. Rutherford ; Jonathan Mermin

Source :

The Journal of Infectious Diseases [ 0022-1899 ] ; 2011.

RBID : PMC:3071279

Abstract

(See the editorial commentary by Mbulaiteye an Goedert, on pages 575–7.)

Background. Human herpesvirus 8 (HHV-8) infection is endemic in sub-Saharan Africa. We examined sociodemographic, behavioral, and biological factors associated with HHV-8 infection in children and adults to determine HHV-8 seroprevalence and potential routes of transmission.

Methods. Participants were 1383 children and 1477 adults from a population-based sample in a rural community in Uganda. Serum samples were tested for HHV-8 antibodies with use of an enzyme immunoassay against K8.1.

Results. HHV-8 seroprevalence increased from 16% among children aged 1.5–2 years to 32% among children aged 10–13 years (P <.001) and from 37% among participants aged 14–19 years to 49% among adults aged ≥50 years (P <.05). HHV-8 seropositivity in children was independently associated with residing with a seropositive parent (P < .001) and residing with ≥1 other seropositive child aged <14 years (P < .001). History of sharing food and/or sauce plates was marginally associated with HHV-8 infection in children (P = .05). Among 1404 participants aged ≥15 years , there was no association between correlates of sexual behavior (eg, number of lifetime sex partners and HIV infection) and HHV-8 seropositivity (P > .10).

Conclusions. Our data suggest that HHV-8 is acquired primarily through horizontal transmission in childhood from intrafamilial contacts and that transmission continues into adulthood potentially through nonsexual routes.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071279

DOI: 10.1093/infdis/jiq092
PubMed: 21273188
PubMed Central: 3071279

Links to Exploration step

PMC:3071279

Le document en format XML

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<author><name sortKey="Butler, Lisa M" sort="Butler, Lisa M" uniqKey="Butler L" first="Lisa M." last="Butler">Lisa M. Butler</name>
<affiliation><nlm:aff id="aff1">Department of Epidemiology and Biostatistics & Global Health Sciences, University of California, San Francisco</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Were, Willy A" sort="Were, Willy A" uniqKey="Were W" first="Willy A." last="Were">Willy A. Were</name>
<affiliation><nlm:aff id="aff2">Global AIDS Program, Centers for Disease Control and Prevention (CDC)–Uganda, Entebbe, Uganda</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Balinandi, Steven" sort="Balinandi, Steven" uniqKey="Balinandi S" first="Steven" last="Balinandi">Steven Balinandi</name>
<affiliation><nlm:aff id="aff2">Global AIDS Program, Centers for Disease Control and Prevention (CDC)–Uganda, Entebbe, Uganda</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Downing, Robert" sort="Downing, Robert" uniqKey="Downing R" first="Robert" last="Downing">Robert Downing</name>
<affiliation><nlm:aff id="aff2">Global AIDS Program, Centers for Disease Control and Prevention (CDC)–Uganda, Entebbe, Uganda</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dollard, Sheila" sort="Dollard, Sheila" uniqKey="Dollard S" first="Sheila" last="Dollard">Sheila Dollard</name>
<affiliation><nlm:aff id="aff3">Division of Viral Diseases, CDC, Atlanta, Georgia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Neilands, Torsten B" sort="Neilands, Torsten B" uniqKey="Neilands T" first="Torsten B." last="Neilands">Torsten B. Neilands</name>
<affiliation><nlm:aff id="aff4">Center for AIDS Prevention Studies, University of California, San Francisco</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gupta, Sundeep" sort="Gupta, Sundeep" uniqKey="Gupta S" first="Sundeep" last="Gupta">Sundeep Gupta</name>
<affiliation><nlm:aff id="aff2">Global AIDS Program, Centers for Disease Control and Prevention (CDC)–Uganda, Entebbe, Uganda</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rutherford, George W" sort="Rutherford, George W" uniqKey="Rutherford G" first="George W." last="Rutherford">George W. Rutherford</name>
<affiliation><nlm:aff id="aff1">Department of Epidemiology and Biostatistics & Global Health Sciences, University of California, San Francisco</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mermin, Jonathan" sort="Mermin, Jonathan" uniqKey="Mermin J" first="Jonathan" last="Mermin">Jonathan Mermin</name>
<affiliation><nlm:aff id="aff5">Division of HIV/AIDS Prevention, CDC, Atlanta, Georgia</nlm:aff>
</affiliation>
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<idno type="pmc">3071279</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071279</idno>
<idno type="RBID">PMC:3071279</idno>
<idno type="doi">10.1093/infdis/jiq092</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Pmc/Corpus">001695</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Human Herpesvirus 8 Infection in Children and Adults in a Population-based Study in Rural Uganda</title>
<author><name sortKey="Butler, Lisa M" sort="Butler, Lisa M" uniqKey="Butler L" first="Lisa M." last="Butler">Lisa M. Butler</name>
<affiliation><nlm:aff id="aff1">Department of Epidemiology and Biostatistics & Global Health Sciences, University of California, San Francisco</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Were, Willy A" sort="Were, Willy A" uniqKey="Were W" first="Willy A." last="Were">Willy A. Were</name>
<affiliation><nlm:aff id="aff2">Global AIDS Program, Centers for Disease Control and Prevention (CDC)–Uganda, Entebbe, Uganda</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Balinandi, Steven" sort="Balinandi, Steven" uniqKey="Balinandi S" first="Steven" last="Balinandi">Steven Balinandi</name>
<affiliation><nlm:aff id="aff2">Global AIDS Program, Centers for Disease Control and Prevention (CDC)–Uganda, Entebbe, Uganda</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Downing, Robert" sort="Downing, Robert" uniqKey="Downing R" first="Robert" last="Downing">Robert Downing</name>
<affiliation><nlm:aff id="aff2">Global AIDS Program, Centers for Disease Control and Prevention (CDC)–Uganda, Entebbe, Uganda</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dollard, Sheila" sort="Dollard, Sheila" uniqKey="Dollard S" first="Sheila" last="Dollard">Sheila Dollard</name>
<affiliation><nlm:aff id="aff3">Division of Viral Diseases, CDC, Atlanta, Georgia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Neilands, Torsten B" sort="Neilands, Torsten B" uniqKey="Neilands T" first="Torsten B." last="Neilands">Torsten B. Neilands</name>
<affiliation><nlm:aff id="aff4">Center for AIDS Prevention Studies, University of California, San Francisco</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gupta, Sundeep" sort="Gupta, Sundeep" uniqKey="Gupta S" first="Sundeep" last="Gupta">Sundeep Gupta</name>
<affiliation><nlm:aff id="aff2">Global AIDS Program, Centers for Disease Control and Prevention (CDC)–Uganda, Entebbe, Uganda</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rutherford, George W" sort="Rutherford, George W" uniqKey="Rutherford G" first="George W." last="Rutherford">George W. Rutherford</name>
<affiliation><nlm:aff id="aff1">Department of Epidemiology and Biostatistics & Global Health Sciences, University of California, San Francisco</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mermin, Jonathan" sort="Mermin, Jonathan" uniqKey="Mermin J" first="Jonathan" last="Mermin">Jonathan Mermin</name>
<affiliation><nlm:aff id="aff5">Division of HIV/AIDS Prevention, CDC, Atlanta, Georgia</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of Infectious Diseases</title>
<idno type="ISSN">0022-1899</idno>
<idno type="eISSN">1537-6613</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en"><p>(See the editorial commentary by Mbulaiteye an Goedert, on pages <related-article xlink:href="10.1093/infdis/jiq094" ext-link-type="doi" related-article-type="article-reference" id="d32e173">575–7</related-article>
.)</p>
<p><bold><italic>Background</italic>
.</bold>
 Human herpesvirus 8 (HHV-8) infection is endemic in sub-Saharan Africa. We examined sociodemographic, behavioral, and biological factors associated with HHV-8 infection in children and adults to determine HHV-8 seroprevalence and potential routes of transmission.</p>
<p><bold><italic>Methods</italic>
.</bold>
 Participants were 1383 children and 1477 adults from a population-based sample in a rural community in Uganda. Serum samples were tested for HHV-8 antibodies with use of an enzyme immunoassay against K8.1.</p>
<p><bold><italic>Results</italic>
.</bold>
 HHV-8 seroprevalence increased from 16% among children aged 1.5–2 years to 32% among children aged 10–13 years (<italic>P</italic>
 <.001) and from 37% among participants aged 14–19 years to 49% among adults aged ≥50 years (<italic>P</italic>
 <.05). HHV-8 seropositivity in children was independently associated with residing with a seropositive parent (<italic>P</italic>
 < .001) and residing with ≥1 other seropositive child aged <14 years (<italic>P</italic>
 < .001). History of sharing food and/or sauce plates was marginally associated with HHV-8 infection in children (<italic>P</italic>
 = .05). Among 1404 participants aged ≥15 years , there was no association between correlates of sexual behavior (eg, number of lifetime sex partners and HIV infection) and HHV-8 seropositivity (<italic>P</italic>
 > .10).</p>
<p><bold><italic>Conclusions</italic>
.</bold>
 Our data suggest that HHV-8 is acquired primarily through horizontal transmission in childhood from intrafamilial contacts and that transmission continues into adulthood potentially through nonsexual routes.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">J Infect Dis</journal-id>
<journal-id journal-id-type="hwp">jinfdis</journal-id>
<journal-id journal-id-type="publisher-id">jinfdis</journal-id>
<journal-title-group><journal-title>The Journal of Infectious Diseases</journal-title>
</journal-title-group>
<issn pub-type="ppub">0022-1899</issn>
<issn pub-type="epub">1537-6613</issn>
<publisher><publisher-name>Oxford University Press</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21273188</article-id>
<article-id pub-id-type="pmc">3071279</article-id>
<article-id pub-id-type="doi">10.1093/infdis/jiq092</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Major Articles and Brief Reports</subject>
<subj-group><subject>Viruses</subject>
</subj-group>
</subj-group>
<series-title>Editor's Choice</series-title>
</article-categories>
<title-group><article-title>Human Herpesvirus 8 Infection in Children and Adults in a Population-based Study in Rural Uganda</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Butler</surname>
<given-names>Lisa M.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Were</surname>
<given-names>Willy A.</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Balinandi</surname>
<given-names>Steven</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Downing</surname>
<given-names>Robert</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dollard</surname>
<given-names>Sheila</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Neilands</surname>
<given-names>Torsten B.</given-names>
</name>
<xref ref-type="aff" rid="aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gupta</surname>
<given-names>Sundeep</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rutherford</surname>
<given-names>George W.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mermin</surname>
<given-names>Jonathan</given-names>
</name>
<xref ref-type="aff" rid="aff5">5</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
Department of Epidemiology and Biostatistics & Global Health Sciences, University of California, San Francisco</aff>
<aff id="aff2"><label>2</label>
Global AIDS Program, Centers for Disease Control and Prevention (CDC)–Uganda, Entebbe, Uganda</aff>
<aff id="aff3"><label>3</label>
Division of Viral Diseases, CDC, Atlanta, Georgia</aff>
<aff id="aff4"><label>4</label>
Center for AIDS Prevention Studies, University of California, San Francisco</aff>
<aff id="aff5"><label>5</label>
Division of HIV/AIDS Prevention, CDC, Atlanta, Georgia</aff>
<author-notes><corresp>Reprints or correspondence: Lisa M. Butler, PhD, MPH, Global Health Sciences, University of California, San Francisco, 50 Beale St, Ste 1200, San Francisco, CA 94105 (<email>lbutler@psg.ucsf.edu</email>
).</corresp>
<fn><p>Potential conflicts of interest: none reported.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><day>01</day>
<month>3</month>
<year>2011</year>
</pub-date>
<volume>203</volume>
<issue>5</issue>
<fpage>625</fpage>
<lpage>634</lpage>
<history><date date-type="received"><day>04</day>
<month>6</month>
<year>2010</year>
</date>
<date date-type="accepted"><day>19</day>
<month>11</month>
<year>2010</year>
</date>
</history>
<permissions><copyright-statement>© The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com</copyright-statement>
<copyright-year>2011</copyright-year>
</permissions>
<abstract><p>(See the editorial commentary by Mbulaiteye an Goedert, on pages <related-article xlink:href="10.1093/infdis/jiq094" ext-link-type="doi" related-article-type="article-reference" id="d32e173">575–7</related-article>
.)</p>
<p><bold><italic>Background</italic>
.</bold>
 Human herpesvirus 8 (HHV-8) infection is endemic in sub-Saharan Africa. We examined sociodemographic, behavioral, and biological factors associated with HHV-8 infection in children and adults to determine HHV-8 seroprevalence and potential routes of transmission.</p>
<p><bold><italic>Methods</italic>
.</bold>
 Participants were 1383 children and 1477 adults from a population-based sample in a rural community in Uganda. Serum samples were tested for HHV-8 antibodies with use of an enzyme immunoassay against K8.1.</p>
<p><bold><italic>Results</italic>
.</bold>
 HHV-8 seroprevalence increased from 16% among children aged 1.5–2 years to 32% among children aged 10–13 years (<italic>P</italic>
 <.001) and from 37% among participants aged 14–19 years to 49% among adults aged ≥50 years (<italic>P</italic>
 <.05). HHV-8 seropositivity in children was independently associated with residing with a seropositive parent (<italic>P</italic>
 < .001) and residing with ≥1 other seropositive child aged <14 years (<italic>P</italic>
 < .001). History of sharing food and/or sauce plates was marginally associated with HHV-8 infection in children (<italic>P</italic>
 = .05). Among 1404 participants aged ≥15 years , there was no association between correlates of sexual behavior (eg, number of lifetime sex partners and HIV infection) and HHV-8 seropositivity (<italic>P</italic>
 > .10).</p>
<p><bold><italic>Conclusions</italic>
.</bold>
 Our data suggest that HHV-8 is acquired primarily through horizontal transmission in childhood from intrafamilial contacts and that transmission continues into adulthood potentially through nonsexual routes.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>

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Human Herpesvirus 8 Infection in Children and Adults in a Population-based Study in Rural Uganda

Human Herpesvirus 8 Infection in Children and Adults in a Population-based Study in Rural Uganda

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Abstract

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