Le SIDA en Afrique subsaharienne (serveur d'exploration)

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Correlates of Syphilis Seroreactivity Among Pregnant Women: The HIVNET 024 Trial in Malawi, Tanzania, and Zambia

Identifieur interne : 001047 ( Pmc/Corpus ); précédent : 001046; suivant : 001048

Correlates of Syphilis Seroreactivity Among Pregnant Women: The HIVNET 024 Trial in Malawi, Tanzania, and Zambia

Auteurs : Dara Potter ; Robert L. Goldenberg ; Jennifer S. Read ; Jing Wang ; Irving F. Hoffman ; Elmar Saathoff ; George Kafulafula ; Said Aboud ; Francis E. A. Martinson ; Maysoon Dahab ; Sten H. Vermund

Source :

RBID : PMC:2743105

Abstract

Objective

The objectives of this cross-sectional study were to determine correlates of syphilis seroprevalence among HIV-infected and -uninfected antenatal attendees in an African multisite clinical trial, and to improve strategies for maternal syphilis prevention.

Results

A total of 2270 (86%) women were HIV-infected and 366 (14%) were HIV-uninfected. One hundred seventy-five (6.6%) were syphilis-seropositive (7.3% among HIV-infected and 2.6% HIV-uninfected women). Statistically significant correlates included geographic site (odds ratio [OR] = 4.5, Blantyre; OR = 3.2, Lilongwe; OR = 9.0, Lusaka vs. Dar es Salaam referent); HIV infection (OR = 3.3); age 20 to 24 years (OR = 2.5); being divorced, widowed, or separated (OR = 2.9); genital ulcer treatment in the last year (OR = 2.9); history of stillbirth (OR = 2.8, one stillbirth; OR = 4.3, 2–5 stillbirths); and history of preterm delivery (OR = 2.7, one preterm delivery).

Conclusion

Many women without identified risk factors were syphilis-seropositive. Younger HIV-infected women were at highest risk. Universal integrated antenatal HIV and syphilis screening and treatment is essential in sub-Saharan African settings.


Url:
DOI: 10.1097/01.olq.0000216029.00424.ae
PubMed: 16601659
PubMed Central: 2743105

Links to Exploration step

PMC:2743105

Le document en format XML

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<title xml:lang="en" level="a" type="main">Correlates of Syphilis Seroreactivity Among Pregnant Women: The HIVNET 024 Trial in Malawi, Tanzania, and Zambia</title>
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<name sortKey="Dahab, Maysoon" sort="Dahab, Maysoon" uniqKey="Dahab M" first="Maysoon" last="Dahab">Maysoon Dahab</name>
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<title>Objective</title>
<p id="P2">The objectives of this cross-sectional study were to determine correlates of syphilis seroprevalence among HIV-infected and -uninfected antenatal attendees in an African multisite clinical trial, and to improve strategies for maternal syphilis prevention.</p>
</sec>
<sec id="S2">
<title>Results</title>
<p id="P3">A total of 2270 (86%) women were HIV-infected and 366 (14%) were HIV-uninfected. One hundred seventy-five (6.6%) were syphilis-seropositive (7.3% among HIV-infected and 2.6% HIV-uninfected women). Statistically significant correlates included geographic site (odds ratio [OR] = 4.5, Blantyre; OR = 3.2, Lilongwe; OR = 9.0, Lusaka vs. Dar es Salaam referent); HIV infection (OR = 3.3); age 20 to 24 years (OR = 2.5); being divorced, widowed, or separated (OR = 2.9); genital ulcer treatment in the last year (OR = 2.9); history of stillbirth (OR = 2.8, one stillbirth; OR = 4.3, 2–5 stillbirths); and history of preterm delivery (OR = 2.7, one preterm delivery).</p>
</sec>
<sec id="S3">
<title>Conclusion</title>
<p id="P4">Many women without identified risk factors were syphilis-seropositive. Younger HIV-infected women were at highest risk. Universal integrated antenatal HIV and syphilis screening and treatment is essential in sub-Saharan African settings.</p>
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<journal-id journal-id-type="pubmed-jr-id">7382</journal-id>
<journal-id journal-id-type="nlm-ta">Sex Transm Dis</journal-id>
<journal-title>Sexually transmitted diseases</journal-title>
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<issn pub-type="epub">1537-4521</issn>
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<article-id pub-id-type="pmc">2743105</article-id>
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<subject>Article</subject>
</subj-group>
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<title-group>
<article-title>Correlates of Syphilis Seroreactivity Among Pregnant Women: The HIVNET 024 Trial in Malawi, Tanzania, and Zambia</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Potter</surname>
<given-names>Dara</given-names>
</name>
<degrees>MBA</degrees>
<xref ref-type="aff" rid="A1">*</xref>
<xref ref-type="aff" rid="A2"></xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Goldenberg</surname>
<given-names>Robert L.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">*</xref>
<xref ref-type="aff" rid="A2"></xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Read</surname>
<given-names>Jennifer S.</given-names>
</name>
<degrees>MD, MPH</degrees>
<xref ref-type="aff" rid="A3"></xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Wang</surname>
<given-names>Jing</given-names>
</name>
<degrees>MA</degrees>
<xref ref-type="aff" rid="A4">§</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hoffman</surname>
<given-names>Irving F.</given-names>
</name>
<degrees>PA, MPH</degrees>
<xref ref-type="aff" rid="A5"></xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Saathoff</surname>
<given-names>Elmar</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A6"></xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kafulafula</surname>
<given-names>George</given-names>
</name>
<degrees>MBBS, MMed</degrees>
<xref ref-type="aff" rid="A7">**</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Aboud</surname>
<given-names>Said</given-names>
</name>
<degrees>MD, MMed</degrees>
<xref ref-type="aff" rid="A8">††</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Martinson</surname>
<given-names>Francis E. A.</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A5"></xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Dahab</surname>
<given-names>Maysoon</given-names>
</name>
<degrees>MHS</degrees>
<xref ref-type="aff" rid="A9">‡‡</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Vermund</surname>
<given-names>Sten H.</given-names>
</name>
<degrees>MD, PHD</degrees>
<xref ref-type="aff" rid="A1">*</xref>
<xref ref-type="aff" rid="A10">§§</xref>
</contrib>
</contrib-group>
<aff id="A1">
<label>*</label>
Schools of Public Health and Medicine, University of Alabama at Birmingham, Birmingham, Alabama</aff>
<aff id="A2">
<label></label>
Centre for Infectious Disease Research in Zambia, Lusaka, Zambia</aff>
<aff id="A3">
<label></label>
Pediatric, Adolescent, and Maternal AIDS Branch, National Institute of Child Health and Development, National Institutes of Health, Bethesda, Maryland</aff>
<aff id="A4">
<label>§</label>
Statistical Center for HIV/AIDS Research & Prevention, FHCRC, Seattle, Washington</aff>
<aff id="A5">
<label></label>
University of North Carolina, Chapel Hill, North Carolina, and the UNC Project, Lilongwe, Malawi</aff>
<aff id="A6">
<label></label>
Harvard School of Public Health, Boston, Massachusetts</aff>
<aff id="A7">
<label>**</label>
College of Medicine, University of Malawi, Blantyre, Malawi</aff>
<aff id="A8">
<label>††</label>
Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania</aff>
<aff id="A9">
<label>‡‡</label>
Johns Hopkins College of Medicine Research Project, Blantyre, Malawi</aff>
<aff id="A10">
<label>§§</label>
Vanderbilt University School of Medicine, Nashville, Tennessee</aff>
<author-notes>
<corresp id="cor1">Correspondence: Dara Potter, MBA, Centre for Infectious Disease Research in Zambia, Box 34681, 5977 Benekale & Mwembeshi Roads, Northmead, Lusaka, Zambia. E-mail:
<email>dara@cidrz.org</email>
</corresp>
<fn id="FN1">
<p id="P1">
<bold>HIVNET 024 Team</bold>
:
<italic>Protocol Cochairs</italic>
: Taha E. Taha, MD, PhD (Johns Hopkins University Bloomberg School of Public Health); Robert Goldenberg,MD (University of Alabama at Birmingham);
<italic>In-Country Cochairs/Investigators of Record</italic>
: Newton Kumwenda, PhD, George Kafulafula, MBBS, FCOG (Blantyre, Malawi); Francis Martinson, MD, PhD (Lilongwe, Malawi); Gernard Msamanga, MD, ScD (Dar es Salaam, Tanzania); Moses Sinkala, MD, MPH (Lusaka, Zambia);
<italic>US Cochairs</italic>
: Irving Hoffman, PA, MPH (University of North Carolina, Chapel Hill); Wafaie Fawzi, MD, DrPH (Harvard School of Public Health);
<italic>In-Country Investigators, Consultants, and Key Site Personnel</italic>
: Robin Broadhead, MBBS, FRCP, George Liomba, MBBS, FRCPath, Johnstone Kumwenda, MBChB, MRCP, Tsedal Mebrahtu, ScM, Pauline Katunda, MHS, Maysoon Dahab, MHS (Blantyre, Malawi); Peter Kazembe, MBChB, David Chilongozi CO, MPH, Charles Chasela, CO, MPH, George Joaki, MD, Willard Dzinyemba, Sam Kamanga (Lilongwe, Malawi); Elgius Lyamuya, MD, PhD, Charles Kilewo, MD, MMed, Karim Manji, MD, MMed, Sylvia Kaaya, MD, MS, Said Aboud, MD, MMed, Muhsin Sheriff, MD, MPH, Elmar Saathoff, PhD, Priya Satow, MPH, Illuminata Ballonzi, SRN, Gretchen Antelman, ScD, Edgar Basheka, BPharm (Dar es Salaam, Tanzania); Victor Mudenda, MD, Christine Kaseba, MD, Maureen Njobvu, MD, Makungu Kabaso, MD, Muzala Kapina, MD, Anthony Yeta, MD, Seraphine Kaminsa, MD, MPH, Constantine Malama, MD, Dara Potter, MBA, Maclean Ukwimi, RN, Alison Taylor, BSc, Patrick Chipaila, MSc, Bernice Mwale, BPharm (Lusaka, Zambia);
<italic>U.S. Investigators, Consultants, and Key Site Personnel</italic>
: Priya Joshi, BS, Ada Cachafeiro, BS, Shermalyn Greene, PhD, Marker Turner, BS, Melissa Kerkau, BS, Paul Alabanza, BS, Amy James, BS, Som Siharath, BS, Tiffany Tribull, MS (UNC-CH); Saidi Kapiga, MD, ScD, George Seage, PhD (HSPH); Sten Vermund, MD, PhD, William Andrews, PhD, MD, Deedee Lyon, BS, MT(ASCP), Jeffrey Stringer, MD (UAB);
<italic>NIAID Medical Officer</italic>
: Samuel Adeniyi-Jones, MD;
<italic>NICHD Medical Officer</italic>
: Jennifer S. Read, MD, MS, MPH, DTM&H;
<italic>NIAID Protocol Pharmacist</italic>
: Scharla Estep, RPh, MS;
<italic>Protocol Statisticians</italic>
: Elizabeth R. Brown, ScD, Thomas R. Fleming, PhD, Anthony Mwatha, MS, Lei Wang, PhD, Ying Q. Chen, PhD (University of Washington and Fred Hutchinson Cancer Research Center [FHCRC]);
<italic>Protocol Virologist</italic>
: Susan Fiscus, PhD (UNC-CH);
<italic>Protocol Operations Coordinator</italic>
: Lynda Emel, PhD (Statistical Center for HIV/AIDS Prevention [SCHARP], FHCRC);
<italic>Data Coordinators</italic>
: Debra J. Lands, EdM, Ceceilia J. Dominique;
<italic>Systems Analyst Programmers</italic>
: Alice H. Fisher, BA, Martha Doyle (SCHARP, FHCRC);
<italic>Protocol Specialist</italic>
: Megan Valentine, PA-C, MS (Family Health International).</p>
</fn>
</author-notes>
<pub-date pub-type="nihms-submitted">
<day>15</day>
<month>7</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="ppub">
<month>10</month>
<year>2006</year>
</pub-date>
<pub-date pub-type="pmc-release">
<day>14</day>
<month>9</month>
<year>2009</year>
</pub-date>
<volume>33</volume>
<issue>10</issue>
<fpage>604</fpage>
<lpage>609</lpage>
<permissions>
<copyright-statement>Copyright © 2006, American Sexually Transmitted Diseases Association All rights reserved.</copyright-statement>
<copyright-year>2006</copyright-year>
</permissions>
<abstract>
<sec id="S1">
<title>Objective</title>
<p id="P2">The objectives of this cross-sectional study were to determine correlates of syphilis seroprevalence among HIV-infected and -uninfected antenatal attendees in an African multisite clinical trial, and to improve strategies for maternal syphilis prevention.</p>
</sec>
<sec id="S2">
<title>Results</title>
<p id="P3">A total of 2270 (86%) women were HIV-infected and 366 (14%) were HIV-uninfected. One hundred seventy-five (6.6%) were syphilis-seropositive (7.3% among HIV-infected and 2.6% HIV-uninfected women). Statistically significant correlates included geographic site (odds ratio [OR] = 4.5, Blantyre; OR = 3.2, Lilongwe; OR = 9.0, Lusaka vs. Dar es Salaam referent); HIV infection (OR = 3.3); age 20 to 24 years (OR = 2.5); being divorced, widowed, or separated (OR = 2.9); genital ulcer treatment in the last year (OR = 2.9); history of stillbirth (OR = 2.8, one stillbirth; OR = 4.3, 2–5 stillbirths); and history of preterm delivery (OR = 2.7, one preterm delivery).</p>
</sec>
<sec id="S3">
<title>Conclusion</title>
<p id="P4">Many women without identified risk factors were syphilis-seropositive. Younger HIV-infected women were at highest risk. Universal integrated antenatal HIV and syphilis screening and treatment is essential in sub-Saharan African settings.</p>
</sec>
</abstract>
<contract-num rid="AI1">U01 AI048006-01</contract-num>
<contract-num rid="AI1">U01 AI048005-01</contract-num>
<contract-num rid="AI1">U01 AI047972-04</contract-num>
<contract-num rid="AI1">N01 AI045200</contract-num>
<contract-num rid="AI1">N01 AI035173</contract-num>
<contract-num rid="HD1">F31 HD046415-01</contract-num>
<contract-num rid="TW1">D43 TW001035-07</contract-num>
<contract-sponsor id="AI1">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</contract-sponsor>
<contract-sponsor id="HD1">National Institute of Child Health & Human Development : NICHD</contract-sponsor>
<contract-sponsor id="TW1">Fogarty International Center : FIC</contract-sponsor>
</article-meta>
</front>
</pmc>
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