Prevalence of Pulmonary tuberculosis and immunological profile of HIV co-infected patients in Northwest Ethiopia
Identifieur interne : 001C94 ( Pmc/Checkpoint ); précédent : 001C93; suivant : 001C95Prevalence of Pulmonary tuberculosis and immunological profile of HIV co-infected patients in Northwest Ethiopia
Auteurs : Yitayih Wondimeneh [Éthiopie] ; Dagnachew Muluye [Éthiopie] ; Yeshambel Belyhun [Éthiopie]Source :
- BMC Research Notes [ 1756-0500 ] ; 2012.
Abstract
In sub-Saharan Africa, as high as 2/3 of tuberculosis patients are HIV/AIDS co-infected and tuberculosis is the most common cause of death among HIV/AIDS patients worldwide. Tuberculosis and HIV co-infections are associated with special diagnostic and therapeutic challenges and constitute an immense burden on healthcare systems of heavily infected countries like Ethiopia. The aim of the study was to determine the prevalence of pulmonary tuberculosis and their immunologic profiles among HIV positive patients.
A cross sectional study was conducted among adult HIV-positive patients attending HIV/AIDS clinic of Gondar University Hospital. Clinical and laboratory investigations including chest x-ray and acid fast staining were used to identify tuberculosis cases. Blood samples were collected to determine CD4+ lymphocyte count. A structured questionnaire was used to collect socio-demographic characteristics of study subjects. The data was entered and analyzed using SPSS version 16 software.
A total of 400 HIV positive study participants were enrolled. Thirty (7.5%, 95%CI: 5.2-10.6%) of the study participants were found to have pulmonary tuberculosis. In multivariate analysis, only CD4+ lymphocyte count (AOR = 2.9; 95% CI: 1.002-8.368) was found to be independently associated with tuberculosis-HIV co-infection. Individuals who had advanced WHO clinical stage were also statistically significant for co-infection. The mean CD4+ lymphocyte count of HIV mono-infected participants were 296 ± 192 Cells/mm3 and tuberculosis-HIV co-infected patients had mean CD4+ lymphocyte count of 199 ± 149 Cells/mm3 with p value of 0.007.
We found high prevalence of tuberculosis-HIV co-infection. Lower CD4+ lymphocyte count was found to be the only predicting factor for co-infection. Early detection of co-infection is very necessary to prolong their ART initiation time and by then strengthening their immune status.
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DOI: 10.1186/1756-0500-5-331
PubMed: 22738361
PubMed Central: 3434071
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Prevalence of Pulmonary tuberculosis and immunological profile of HIV co-infected patients in Northwest Ethiopia</title><author><name sortKey="Wondimeneh, Yitayih" sort="Wondimeneh, Yitayih" uniqKey="Wondimeneh Y" first="Yitayih" last="Wondimeneh">Yitayih Wondimeneh</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Parasitology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, P.O. Box 196, Gondar, Ethiopia</nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea>Department of Parasitology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, P.O. Box 196, Gondar</wicri:regionArea><wicri:noRegion>Gondar</wicri:noRegion></affiliation></author><author><name sortKey="Muluye, Dagnachew" sort="Muluye, Dagnachew" uniqKey="Muluye D" first="Dagnachew" last="Muluye">Dagnachew Muluye</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, P.O. Box 196, Gondar, Ethiopia</nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea>Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, P.O. Box 196, Gondar</wicri:regionArea><wicri:noRegion>Gondar</wicri:noRegion></affiliation></author><author><name sortKey="Belyhun, Yeshambel" sort="Belyhun, Yeshambel" uniqKey="Belyhun Y" first="Yeshambel" last="Belyhun">Yeshambel Belyhun</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Immunology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, P.O. Box 196, Gondar, Ethiopia</nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea>Department of Immunology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, P.O. 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Box 196, Gondar, Ethiopia</nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea>Department of Parasitology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, P.O. Box 196, Gondar</wicri:regionArea><wicri:noRegion>Gondar</wicri:noRegion></affiliation></author><author><name sortKey="Muluye, Dagnachew" sort="Muluye, Dagnachew" uniqKey="Muluye D" first="Dagnachew" last="Muluye">Dagnachew Muluye</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, P.O. Box 196, Gondar, Ethiopia</nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea>Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, P.O. Box 196, Gondar</wicri:regionArea><wicri:noRegion>Gondar</wicri:noRegion></affiliation></author><author><name sortKey="Belyhun, Yeshambel" sort="Belyhun, Yeshambel" uniqKey="Belyhun Y" first="Yeshambel" last="Belyhun">Yeshambel Belyhun</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Immunology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, P.O. Box 196, Gondar, Ethiopia</nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea>Department of Immunology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, P.O. Box 196, Gondar</wicri:regionArea><wicri:noRegion>Gondar</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC Research Notes</title><idno type="eISSN">1756-0500</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>In sub-Saharan Africa, as high as 2/3 of tuberculosis patients are HIV/AIDS co-infected and tuberculosis is the most common cause of death among HIV/AIDS patients worldwide. Tuberculosis and HIV co-infections are associated with special diagnostic and therapeutic challenges and constitute an immense burden on healthcare systems of heavily infected countries like Ethiopia. The aim of the study was to determine the prevalence of pulmonary tuberculosis and their immunologic profiles among HIV positive patients.</p></sec><sec><title>Methods</title><p>A cross sectional study was conducted among adult HIV-positive patients attending HIV/AIDS clinic of Gondar University Hospital. Clinical and laboratory investigations including chest x-ray and acid fast staining were used to identify tuberculosis cases. Blood samples were collected to determine CD4+ lymphocyte count. A structured questionnaire was used to collect socio-demographic characteristics of study subjects. The data was entered and analyzed using SPSS version 16 software.</p></sec><sec><title>Results</title><p>A total of 400 HIV positive study participants were enrolled. Thirty (7.5%, 95%CI: 5.2-10.6%) of the study participants were found to have pulmonary tuberculosis. In multivariate analysis, only CD4+ lymphocyte count (AOR = 2.9; 95% CI: 1.002-8.368) was found to be independently associated with tuberculosis-HIV co-infection. Individuals who had advanced WHO clinical stage were also statistically significant for co-infection. The mean CD4+ lymphocyte count of HIV mono-infected participants were 296 ± 192 Cells/mm3 and tuberculosis-HIV co-infected patients had mean CD4+ lymphocyte count of 199 ± 149 Cells/mm3 with p value of 0.007.</p></sec><sec><title>Conclusions</title><p>We found high prevalence of tuberculosis-HIV co-infection. Lower CD4+ lymphocyte count was found to be the only predicting factor for co-infection. Early detection of co-infection is very necessary to prolong their ART initiation time and by then strengthening their immune status.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Harrington, M" uniqKey="Harrington M">M Harrington</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Friedland, G" uniqKey="Friedland G">G Friedland</name></author><author><name sortKey="Churchyard, Gj" uniqKey="Churchyard G">GJ Churchyard</name></author><author><name sortKey="Nardell, E" uniqKey="Nardell E">E Nardell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meya, Db" uniqKey="Meya D">DB Meya</name></author><author><name sortKey="Mcadam, Kp" uniqKey="Mcadam K">KP McAdam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Girardi, E" uniqKey="Girardi E">E Girardi</name></author><author><name sortKey="Raviglione, Mc" 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uniqKey="Sudre P">P Sudre</name></author><author><name sortKey="Naef, M" uniqKey="Naef M">M Naef</name></author><author><name sortKey="Sendi, P" uniqKey="Sendi P">P Sendi</name></author><author><name sortKey="Battegay, M" uniqKey="Battegay M">M Battegay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Selwyn, Pa" uniqKey="Selwyn P">PA Selwyn</name></author><author><name sortKey="Hartel, D" uniqKey="Hartel D">D Hartel</name></author><author><name sortKey="Lewis, Va" uniqKey="Lewis V">VA Lewis</name></author><author><name sortKey="Schoenbaum, Ee" uniqKey="Schoenbaum E">EE Schoenbaum</name></author><author><name sortKey="Vermund, St" uniqKey="Vermund S">ST Vermund</name></author><author><name sortKey="Klein, Rs" uniqKey="Klein R">RS Klein</name></author><author><name sortKey="Walker, At" uniqKey="Walker A">AT Walker</name></author><author><name sortKey="Friedland, Gh" uniqKey="Friedland G">GH 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<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Res Notes</journal-id><journal-id journal-id-type="iso-abbrev">BMC Res Notes</journal-id><journal-title-group><journal-title>BMC Research Notes</journal-title></journal-title-group><issn pub-type="epub">1756-0500</issn><publisher><publisher-name>BioMed Central</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22738361</article-id><article-id pub-id-type="pmc">3434071</article-id><article-id pub-id-type="publisher-id">1756-0500-5-331</article-id><article-id pub-id-type="doi">10.1186/1756-0500-5-331</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Prevalence of Pulmonary tuberculosis and immunological profile of HIV co-infected patients in Northwest Ethiopia</article-title></title-group><contrib-group><contrib contrib-type="author" id="A1"><name><surname>Wondimeneh</surname><given-names>Yitayih</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>yitayihlab@gmail.com</email></contrib><contrib contrib-type="author" corresp="yes" id="A2"><name><surname>Muluye</surname><given-names>Dagnachew</given-names></name><xref ref-type="aff" rid="I2">2</xref><email>fetenemulu24@gmail.com</email></contrib><contrib contrib-type="author" id="A3"><name><surname>Belyhun</surname><given-names>Yeshambel</given-names></name><xref ref-type="aff" rid="I3">3</xref><email>yeshi4s@yahoo.com</email></contrib></contrib-group><aff id="I1"><label>1</label>Department of Parasitology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, P.O. Box 196, Gondar, Ethiopia</aff><aff id="I2"><label>2</label>Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, P.O. Box 196, Gondar, Ethiopia</aff><aff id="I3"><label>3</label>Department of Immunology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, P.O. Box 196, Gondar, Ethiopia</aff><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>27</day><month>6</month><year>2012</year></pub-date><volume>5</volume><fpage>331</fpage><lpage>331</lpage><history><date date-type="received"><day>27</day><month>3</month><year>2012</year></date><date date-type="accepted"><day>14</day><month>6</month><year>2012</year></date></history><permissions><copyright-statement>Copyright ©2012 Wondimeneh et al.; licensee BioMed Central Ltd.</copyright-statement><copyright-year>2012</copyright-year><copyright-holder>Wondimeneh et al.; licensee BioMed Central Ltd.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><self-uri xlink:href="http://www.biomedcentral.com/1756-0500/5/331"></self-uri><abstract><sec><title>Background</title><p>In sub-Saharan Africa, as high as 2/3 of tuberculosis patients are HIV/AIDS co-infected and tuberculosis is the most common cause of death among HIV/AIDS patients worldwide. Tuberculosis and HIV co-infections are associated with special diagnostic and therapeutic challenges and constitute an immense burden on healthcare systems of heavily infected countries like Ethiopia. The aim of the study was to determine the prevalence of pulmonary tuberculosis and their immunologic profiles among HIV positive patients.</p></sec><sec><title>Methods</title><p>A cross sectional study was conducted among adult HIV-positive patients attending HIV/AIDS clinic of Gondar University Hospital. Clinical and laboratory investigations including chest x-ray and acid fast staining were used to identify tuberculosis cases. Blood samples were collected to determine CD4+ lymphocyte count. A structured questionnaire was used to collect socio-demographic characteristics of study subjects. The data was entered and analyzed using SPSS version 16 software.</p></sec><sec><title>Results</title><p>A total of 400 HIV positive study participants were enrolled. Thirty (7.5%, 95%CI: 5.2-10.6%) of the study participants were found to have pulmonary tuberculosis. In multivariate analysis, only CD4+ lymphocyte count (AOR = 2.9; 95% CI: 1.002-8.368) was found to be independently associated with tuberculosis-HIV co-infection. Individuals who had advanced WHO clinical stage were also statistically significant for co-infection. The mean CD4+ lymphocyte count of HIV mono-infected participants were 296 ± 192 Cells/mm3 and tuberculosis-HIV co-infected patients had mean CD4+ lymphocyte count of 199 ± 149 Cells/mm3 with p value of 0.007.</p></sec><sec><title>Conclusions</title><p>We found high prevalence of tuberculosis-HIV co-infection. Lower CD4+ lymphocyte count was found to be the only predicting factor for co-infection. Early detection of co-infection is very necessary to prolong their ART initiation time and by then strengthening their immune status.</p></sec></abstract></article-meta></front></pmc><affiliations><list><country><li>Éthiopie</li></country></list><tree><country name="Éthiopie"><noRegion><name sortKey="Wondimeneh, Yitayih" sort="Wondimeneh, Yitayih" uniqKey="Wondimeneh Y" first="Yitayih" last="Wondimeneh">Yitayih Wondimeneh</name></noRegion><name sortKey="Belyhun, Yeshambel" sort="Belyhun, Yeshambel" uniqKey="Belyhun Y" first="Yeshambel" last="Belyhun">Yeshambel Belyhun</name><name sortKey="Muluye, Dagnachew" sort="Muluye, Dagnachew" uniqKey="Muluye D" first="Dagnachew" last="Muluye">Dagnachew Muluye</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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