Prevalence of hepatitis B surface antigen seropositivity among HIV-infected and non-infected individuals in Nnewi, Nigeria
Identifieur interne : 001C93 ( Pmc/Checkpoint ); précédent : 001C92; suivant : 001C94Prevalence of hepatitis B surface antigen seropositivity among HIV-infected and non-infected individuals in Nnewi, Nigeria
Auteurs : E. C. Okocha [Nigeria] ; O. C. Oguejiofor [Nigeria] ; C. U. Odenigbo [Nigeria] ; U. C. Okonkwo [Nigeria] ; L. Asomugha [Nigeria]Source :
- Nigerian Medical Journal : Journal of the Nigeria Medical Association [ 0300-1652 ] ; 2012.
Abstract
Co-infection of human immunodeficiency virus (HIV) and hepatitis B virus (HBV) is common as both viruses share common routes of transmission. HIV significantly affects the natural history of HBV, hence the need to determine the prevalence of co-infection.
This was a retrospective study between 2005 and 2009, in which is a total of 2018 subjects who reported at our University Teaching Hospital blood bank and human immunodeficiency virus clinic were studied. Hepatitis B surface antigen (HBsAg) was tested for using a one step lateral flow rapid chromatographic immunoassay (Acumen labs and diagnostic centre, Bangalore, India) and HIV 1/2 was tested using two kits, Determine (made by Abbot, Japan for Inverness Medical, Japan).
A total of 2018 subjects were studied out of which 1176 were HIV positive (964 males and 212 females) and 842 (334 males and 508 females) were negative. The prevalence of HBsAg positivity in the study population was 5.9%. It was 6.3% and 5.6% in the HIV-infected and un-infected population, respectively. Although the prevalence was higher in those who are HIV infected, the difference was not statistically significant (
This study showed that in south-eastern Nigeria, infection with HBV is relatively common in both HIV-infected and un-infected individuals. Routine screening for HBV should be done for all HIV positive individuals.
Url:
DOI: 10.4103/0300-1652.107605
PubMed: 23661888
PubMed Central: 3640249
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Prevalence of hepatitis B surface antigen seropositivity among HIV-infected and non-infected individuals in Nnewi, Nigeria</title><author><name sortKey="Okocha, E C" sort="Okocha, E C" uniqKey="Okocha E" first="E. C." last="Okocha">E. C. Okocha</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Haematology, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, Nigeria</nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Haematology, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi</wicri:regionArea><wicri:noRegion>Nnewi</wicri:noRegion></affiliation></author><author><name sortKey="Oguejiofor, O C" sort="Oguejiofor, O C" uniqKey="Oguejiofor O" first="O. C." last="Oguejiofor">O. C. Oguejiofor</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Medicine, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, Nigeria</nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Medicine, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi</wicri:regionArea><wicri:noRegion>Nnewi</wicri:noRegion></affiliation></author><author><name sortKey="Odenigbo, C U" sort="Odenigbo, C U" uniqKey="Odenigbo C" first="C. U." last="Odenigbo">C. U. Odenigbo</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Medicine, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, Nigeria</nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Medicine, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi</wicri:regionArea><wicri:noRegion>Nnewi</wicri:noRegion></affiliation></author><author><name sortKey="Okonkwo, U C" sort="Okonkwo, U C" uniqKey="Okonkwo U" first="U. C." last="Okonkwo">U. C. Okonkwo</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Medicine, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, Nigeria</nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Medicine, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi</wicri:regionArea><wicri:noRegion>Nnewi</wicri:noRegion></affiliation></author><author><name sortKey="Asomugha, L" sort="Asomugha, L" uniqKey="Asomugha L" first="L." last="Asomugha">L. Asomugha</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Medicine, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, Nigeria</nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Medicine, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi</wicri:regionArea><wicri:noRegion>Nnewi</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23661888</idno><idno type="pmc">3640249</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640249</idno><idno type="RBID">PMC:3640249</idno><idno type="doi">10.4103/0300-1652.107605</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">002796</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002796</idno><idno type="wicri:Area/Pmc/Curation">002795</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002795</idno><idno type="wicri:Area/Pmc/Checkpoint">001C93</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001C93</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Prevalence of hepatitis B surface antigen seropositivity among HIV-infected and non-infected individuals in Nnewi, Nigeria</title><author><name sortKey="Okocha, E C" sort="Okocha, E C" uniqKey="Okocha E" first="E. C." last="Okocha">E. C. Okocha</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Haematology, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, Nigeria</nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Haematology, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi</wicri:regionArea><wicri:noRegion>Nnewi</wicri:noRegion></affiliation></author><author><name sortKey="Oguejiofor, O C" sort="Oguejiofor, O C" uniqKey="Oguejiofor O" first="O. C." last="Oguejiofor">O. C. Oguejiofor</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Medicine, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, Nigeria</nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Medicine, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi</wicri:regionArea><wicri:noRegion>Nnewi</wicri:noRegion></affiliation></author><author><name sortKey="Odenigbo, C U" sort="Odenigbo, C U" uniqKey="Odenigbo C" first="C. U." last="Odenigbo">C. U. Odenigbo</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Medicine, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, Nigeria</nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Medicine, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi</wicri:regionArea><wicri:noRegion>Nnewi</wicri:noRegion></affiliation></author><author><name sortKey="Okonkwo, U C" sort="Okonkwo, U C" uniqKey="Okonkwo U" first="U. C." last="Okonkwo">U. C. Okonkwo</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Medicine, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, Nigeria</nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Medicine, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi</wicri:regionArea><wicri:noRegion>Nnewi</wicri:noRegion></affiliation></author><author><name sortKey="Asomugha, L" sort="Asomugha, L" uniqKey="Asomugha L" first="L." last="Asomugha">L. Asomugha</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Medicine, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, Nigeria</nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Medicine, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi</wicri:regionArea><wicri:noRegion>Nnewi</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nigerian Medical Journal : Journal of the Nigeria Medical Association</title><idno type="ISSN">0300-1652</idno><idno type="eISSN">2229-774X</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Background:</title><p>Co-infection of human immunodeficiency virus (HIV) and hepatitis B virus (HBV) is common as both viruses share common routes of transmission. HIV significantly affects the natural history of HBV, hence the need to determine the prevalence of co-infection.</p></sec><sec id="st2"><title>Materials and Methods:</title><p>This was a retrospective study between 2005 and 2009, in which is a total of 2018 subjects who reported at our University Teaching Hospital blood bank and human immunodeficiency virus clinic were studied. Hepatitis B surface antigen (HBsAg) was tested for using a one step lateral flow rapid chromatographic immunoassay (Acumen labs and diagnostic centre, Bangalore, India) and HIV 1/2 was tested using two kits, Determine (made by Abbot, Japan for Inverness Medical, Japan).</p></sec><sec id="st3"><title>Results:</title><p>A total of 2018 subjects were studied out of which 1176 were HIV positive (964 males and 212 females) and 842 (334 males and 508 females) were negative. The prevalence of HBsAg positivity in the study population was 5.9%. It was 6.3% and 5.6% in the HIV-infected and un-infected population, respectively. Although the prevalence was higher in those who are HIV infected, the difference was not statistically significant (<italic>P</italic>=0.52). Males who were HIV positive were found to be more likely to have co-infection than females (8.7% vs. 4.2%, <italic>P</italic>=0.02, OR=1.917).</p></sec><sec id="st4"><title>Conclusion:</title><p>This study showed that in south-eastern Nigeria, infection with HBV is relatively common in both HIV-infected and un-infected individuals. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Niger Med J</journal-id><journal-id journal-id-type="iso-abbrev">Niger Med J</journal-id><journal-id journal-id-type="publisher-id">NMJ</journal-id><journal-title-group><journal-title>Nigerian Medical Journal : Journal of the Nigeria Medical Association</journal-title></journal-title-group><issn pub-type="ppub">0300-1652</issn><issn pub-type="epub">2229-774X</issn><publisher><publisher-name>Medknow Publications & Media Pvt Ltd</publisher-name><publisher-loc>India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23661888</article-id><article-id pub-id-type="pmc">3640249</article-id><article-id pub-id-type="publisher-id">NMJ-53-249</article-id><article-id pub-id-type="doi">10.4103/0300-1652.107605</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Prevalence of hepatitis B surface antigen seropositivity among HIV-infected and non-infected individuals in Nnewi, Nigeria</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Okocha</surname><given-names>E. C.</given-names></name><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Oguejiofor</surname><given-names>O. C.</given-names></name><xref ref-type="aff" rid="aff2">1</xref></contrib><contrib contrib-type="author"><name><surname>Odenigbo</surname><given-names>C. U.</given-names></name><xref ref-type="aff" rid="aff2">1</xref></contrib><contrib contrib-type="author"><name><surname>Okonkwo</surname><given-names>U. C.</given-names></name><xref ref-type="aff" rid="aff2">1</xref></contrib><contrib contrib-type="author"><name><surname>Asomugha</surname><given-names>L.</given-names></name><xref ref-type="aff" rid="aff2">1</xref></contrib></contrib-group><aff id="aff1">Department of Haematology, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, Nigeria</aff><aff id="aff2"><label>1</label>Department of Medicine, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, Nigeria</aff><author-notes><corresp id="cor1"><bold>Address for correspondence:</bold> Dr. E. C. Okocha, Department of Haematology, Nnamdi Azikiwe University Teaching Hospital, P.O. Box 910, Nnewi, Anambra State, Nigeria. E-mail: <email xlink:href="onyichideokocha@yahoo.com">onyichideokocha@yahoo.com</email></corresp></author-notes><pub-date pub-type="ppub"><season>Oct-Dec</season><year>2012</year></pub-date><volume>53</volume><issue>4</issue><fpage>249</fpage><lpage>253</lpage><permissions><copyright-statement>Copyright: © Nigerian Medical Journal</copyright-statement><copyright-year>2012</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec id="st1"><title>Background:</title><p>Co-infection of human immunodeficiency virus (HIV) and hepatitis B virus (HBV) is common as both viruses share common routes of transmission. HIV significantly affects the natural history of HBV, hence the need to determine the prevalence of co-infection.</p></sec><sec id="st2"><title>Materials and Methods:</title><p>This was a retrospective study between 2005 and 2009, in which is a total of 2018 subjects who reported at our University Teaching Hospital blood bank and human immunodeficiency virus clinic were studied. Hepatitis B surface antigen (HBsAg) was tested for using a one step lateral flow rapid chromatographic immunoassay (Acumen labs and diagnostic centre, Bangalore, India) and HIV 1/2 was tested using two kits, Determine (made by Abbot, Japan for Inverness Medical, Japan).</p></sec><sec id="st3"><title>Results:</title><p>A total of 2018 subjects were studied out of which 1176 were HIV positive (964 males and 212 females) and 842 (334 males and 508 females) were negative. The prevalence of HBsAg positivity in the study population was 5.9%. It was 6.3% and 5.6% in the HIV-infected and un-infected population, respectively. Although the prevalence was higher in those who are HIV infected, the difference was not statistically significant (<italic>P</italic>=0.52). Males who were HIV positive were found to be more likely to have co-infection than females (8.7% vs. 4.2%, <italic>P</italic>=0.02, OR=1.917).</p></sec><sec id="st4"><title>Conclusion:</title><p>This study showed that in south-eastern Nigeria, infection with HBV is relatively common in both HIV-infected and un-infected individuals. Routine screening for HBV should be done for all HIV positive individuals.</p></sec></abstract><kwd-group><kwd>Hepatitis B virus</kwd><kwd>human immunodeficiency virus</kwd><kwd>Nnewi</kwd><kwd>south-eastern Nigeria</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Nigeria</li></country></list><tree><country name="Nigeria"><noRegion><name sortKey="Okocha, E C" sort="Okocha, E C" uniqKey="Okocha E" first="E. C." last="Okocha">E. C. Okocha</name></noRegion><name sortKey="Asomugha, L" sort="Asomugha, L" uniqKey="Asomugha L" first="L." last="Asomugha">L. Asomugha</name><name sortKey="Odenigbo, C U" sort="Odenigbo, C U" uniqKey="Odenigbo C" first="C. U." last="Odenigbo">C. U. Odenigbo</name><name sortKey="Oguejiofor, O C" sort="Oguejiofor, O C" uniqKey="Oguejiofor O" first="O. C." last="Oguejiofor">O. C. Oguejiofor</name><name sortKey="Okonkwo, U C" sort="Okonkwo, U C" uniqKey="Okonkwo U" first="U. C." last="Okonkwo">U. C. Okonkwo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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