Seroprevalence of hepatitis B and C infection among the HIV-positive population in Abuja, Nigeria
Identifieur interne : 001C60 ( Pmc/Checkpoint ); précédent : 001C59; suivant : 001C61Seroprevalence of hepatitis B and C infection among the HIV-positive population in Abuja, Nigeria
Auteurs : A. Tremeau-Bravard ; Ic Ogbukagu ; Cj Ticao ; Jj AbubakarSource :
- African Health Sciences [ 1680-6905 ] ; 2012.
Abstract
In Nigeria, it is estimated that 3.6% of the population were living with Human immunodeficiency virus in 2009, and the country had the world's second highest number of HIV/AIDS related deaths after South Africa. Viral hepatitis is also a major public health concern as hepatitis B virus (HBV) afflicts an estimated 350 million people, and hepatitis C virus (HCV) affects 150 million people worldwide.
We conducted a retrospective study of HBV and HCV seroprevalence among Nigerian population coming to our clinic in Abuja and receiving HIV/AIDS treatment.
In this cohort study, we collected medical data from 443 HIV-positive patients between September 2010 and May 2011. Standard enzyme immunoassays were used to determine the serological prevalence of hepatitis B (HBsAg) and C (anti-HCV antibody) among HIV-positive individuals.
Among the HIV/AIDS positive individuals, we found that 35 patients were infected with hepatitis B virus (7.9%), 10 with hepatitis C virus (2.3%) and 3 with both hepatitis B and C viruses (0.7%). The overall hepatitis-HIV prevalence is 10.8%. The majority of the population infected was under 39 years of age (55%) and the same proportion of males and females was observed in all the studied categories (HIV, HIV + hepatitis B and/or C). Remarkably, an overall lower CD4 count was seen in the co-infected population (205 cells/µl versus 243 cells/µl), with the lowest seen for the triply infected individuals (97 cells/µl).
Our findings underscore the importance of screening for hepatitis B and hepatitis C viruses in the HIV-infected population in developing countries, and particularly in sub-Saharan Africa, where the epidemics are still growing.
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PubMed: 23382745
PubMed Central: 3557671
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Afr Health Sci</journal-id><journal-id journal-id-type="iso-abbrev">Afr Health Sci</journal-id><journal-title-group><journal-title>African Health Sciences</journal-title></journal-title-group><issn pub-type="ppub">1680-6905</issn><issn pub-type="epub">1729-0503</issn><publisher><publisher-name>Makerere Medical School</publisher-name><publisher-loc>Kampala, Uganda</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23382745</article-id><article-id pub-id-type="pmc">3557671</article-id><article-id pub-id-type="publisher-id">jAFHS.v12.i3.pg312</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Seroprevalence of hepatitis B and C infection among the HIV-positive population in Abuja, Nigeria</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Tremeau-Bravard</surname><given-names>A</given-names></name></contrib><contrib contrib-type="author"><name><surname>Ogbukagu</surname><given-names>IC</given-names></name></contrib><contrib contrib-type="author"><name><surname>Ticao</surname><given-names>CJ</given-names></name></contrib><contrib contrib-type="author"><name><surname>Abubakar</surname><given-names>JJ</given-names></name></contrib></contrib-group><aff>Gede Foundation, 13 Danube Street, Abuja, Nigeria</aff><author-notes><corresp><bold>*Corresponding author:</bold> Alexandre Tremeau-Bravard Gede AIDS & Infectious Diseases Research Institute 13 Danube Street Abuja, Nigeria Email: <email>a_tremeau_bravard@hotmail.com</email></corresp></author-notes><pub-date pub-type="ppub"><month>9</month><year>2012</year></pub-date><volume>12</volume><issue>3</issue><fpage>312</fpage><lpage>317</lpage><permissions><copyright-statement>Copyright © Makerere Medical School, Uganda 2012</copyright-statement><copyright-year>2012</copyright-year></permissions><abstract abstract-type="executive-summary"><sec><title>Background</title><p>In Nigeria, it is estimated that 3.6% of the population were living with Human immunodeficiency virus in 2009, and the country had the world's second highest number of HIV/AIDS related deaths after South Africa. Viral hepatitis is also a major public health concern as hepatitis B virus (HBV) afflicts an estimated 350 million people, and hepatitis C virus (HCV) affects 150 million people worldwide.</p></sec><sec><title>Objectives</title><p>We conducted a retrospective study of HBV and HCV seroprevalence among Nigerian population coming to our clinic in Abuja and receiving HIV/AIDS treatment.</p></sec><sec sec-type="methods"><title>Methods</title><p>In this cohort study, we collected medical data from 443 HIV-positive patients between September 2010 and May 2011. Standard enzyme immunoassays were used to determine the serological prevalence of hepatitis B (HBsAg) and C (anti-HCV antibody) among HIV-positive individuals.</p></sec><sec sec-type="results"><title>Results</title><p>Among the HIV/AIDS positive individuals, we found that 35 patients were infected with hepatitis B virus (7.9%), 10 with hepatitis C virus (2.3%) and 3 with both hepatitis B and C viruses (0.7%). The overall hepatitis-HIV prevalence is 10.8%. The majority of the population infected was under 39 years of age (55%) and the same proportion of males and females was observed in all the studied categories (HIV, HIV + hepatitis B and/or C). Remarkably, an overall lower CD4 count was seen in the co-infected population (205 cells/µl versus 243 cells/µl), with the lowest seen for the triply infected individuals (97 cells/µl).</p></sec><sec sec-type="conclusions"><title>Conclusions</title><p>Our findings underscore the importance of screening for hepatitis B and hepatitis C viruses in the HIV-infected population in developing countries, and particularly in sub-Saharan Africa, where the epidemics are still growing.</p></sec></abstract><kwd-group><kwd>Human Immunodeficiency Virus</kwd><kwd>Hepatitis B virus</kwd><kwd>Hepatitis C virus</kwd><kwd>cohort study</kwd><kwd>Nigeria</kwd></kwd-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Abubakar, Jj" sort="Abubakar, Jj" uniqKey="Abubakar J" first="Jj" last="Abubakar">Jj Abubakar</name><name sortKey="Ogbukagu, Ic" sort="Ogbukagu, Ic" uniqKey="Ogbukagu I" first="Ic" last="Ogbukagu">Ic Ogbukagu</name><name sortKey="Ticao, Cj" sort="Ticao, Cj" uniqKey="Ticao C" first="Cj" last="Ticao">Cj Ticao</name><name sortKey="Tremeau Bravard, A" sort="Tremeau Bravard, A" uniqKey="Tremeau Bravard A" first="A" last="Tremeau-Bravard">A. Tremeau-Bravard</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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