Vaccines to combat the neglected tropical diseases
Identifieur interne : 001110 ( Ncbi/Merge ); précédent : 001109; suivant : 001111Vaccines to combat the neglected tropical diseases
Auteurs : Jeffrey M. Bethony [États-Unis] ; Rhea N. Cole [États-Unis] ; Xiaoti Guo [États-Unis] ; Shaden Kamhawi [États-Unis] ; Marshall W. Lightowlers [Australie] ; Alex Loukas [Australie] ; William Petri [États-Unis] ; Steven Reed [États-Unis] ; Jesus G. Valenzuela [États-Unis] ; Peter J. Hotez [États-Unis]Source :
- Immunological reviews [ 0105-2896 ] ; 2011.
Abstract
The neglected tropical diseases (NTDs) represent a group of parasitic and related infectious diseases such as amebiasis, Chagas disease, cysticercosis, echinococcosis, hookworm, leishmaniasis, and schistosomiasis. Together, these conditions are considered the most common infections in low- and middle-income countries, where they produce a level of global disability and human suffering equivalent to better known conditions such as human immunodeficiency virus/acquired immunodeficiency syndrome and malaria. Despite their global public health importance, progress on developing vaccines for NTD pathogens has lagged because of some key technical hurdles and the fact that these infections occur almost exclusively in the world’s poorest people living below the World Bank poverty line. In the absence of financial incentives for new products, the multinational pharmaceutical companies have not embarked on substantive research and development programs for the neglected tropical disease vaccines. Here, we review the current status of scientific and technical progress in the development of new neglected tropical disease vaccines, highlighting the successes that have been achieved (cysticercosis and echinococcosis) and identifying the challenges and opportunities for development of new vaccines for NTDs. Also highlighted are the contributions being made by non-profit product development partnerships that are working to overcome some of the economic challenges in vaccine manufacture, clinical testing, and global access.
Url:
DOI: 10.1111/j.1600-065X.2010.00976.x
PubMed: 21198676
PubMed Central: 3438653
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<front><div type="abstract" xml:lang="en"><title>Summary</title>
<p id="P1">The neglected tropical diseases (NTDs) represent a group of parasitic and related infectious diseases such as amebiasis, Chagas disease, cysticercosis, echinococcosis, hookworm, leishmaniasis, and schistosomiasis. Together, these conditions are considered the most common infections in low- and middle-income countries, where they produce a level of global disability and human suffering equivalent to better known conditions such as human immunodeficiency virus/acquired immunodeficiency syndrome and malaria. Despite their global public health importance, progress on developing vaccines for NTD pathogens has lagged because of some key technical hurdles and the fact that these infections occur almost exclusively in the world’s poorest people living below the World Bank poverty line. In the absence of financial incentives for new products, the multinational pharmaceutical companies have not embarked on substantive research and development programs for the neglected tropical disease vaccines. Here, we review the current status of scientific and technical progress in the development of new neglected tropical disease vaccines, highlighting the successes that have been achieved (cysticercosis and echinococcosis) and identifying the challenges and opportunities for development of new vaccines for NTDs. Also highlighted are the contributions being made by non-profit product development partnerships that are working to overcome some of the economic challenges in vaccine manufacture, clinical testing, and global access.</p>
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<contrib-group><contrib contrib-type="author"><name><surname>Bethony</surname>
<given-names>Jeffrey M.</given-names>
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<contrib contrib-type="author"><name><surname>Cole</surname>
<given-names>Rhea N.</given-names>
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<contrib contrib-type="author"><name><surname>Guo</surname>
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<contrib contrib-type="author"><name><surname>Kamhawi</surname>
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<given-names>Alex</given-names>
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<contrib contrib-type="author"><name><surname>Valenzuela</surname>
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<given-names>Peter J.</given-names>
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<aff id="A1"><label>1</label>
Microbiology, Immunology, and Tropical Medicine, George Washington University Medical Center, Washington DC, USA</aff>
<aff id="A2"><label>2</label>
Infectious Diseases Research Institute, Seattle, WA, USA</aff>
<aff id="A3"><label>3</label>
Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA</aff>
<aff id="A4"><label>4</label>
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA</aff>
<aff id="A5"><label>5</label>
University of Melbourne, Melbourne, Australia</aff>
<aff id="A6"><label>6</label>
James Cook University, Cairns, Australia</aff>
<aff id="A7"><label>7</label>
University of Virginia, Charlottesville, VA, USA</aff>
<aff id="A8"><label>8</label>
Sabin Vaccine Institute, Washington DC, USA</aff>
<author-notes><corresp id="FN1">Correspondence to: Jeffrey M. Bethony, Associate Professor, Immunology & Tropical Medicine, The George Washington University, Ross Hall 727, 2300 Eye Street NW, Washington DC 20037, USA, Tel.: +1 202 994 3535, Fax: +1 202 994 2913, <email>mtmjmb@gwumc.edu</email>
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<abstract><title>Summary</title>
<p id="P1">The neglected tropical diseases (NTDs) represent a group of parasitic and related infectious diseases such as amebiasis, Chagas disease, cysticercosis, echinococcosis, hookworm, leishmaniasis, and schistosomiasis. Together, these conditions are considered the most common infections in low- and middle-income countries, where they produce a level of global disability and human suffering equivalent to better known conditions such as human immunodeficiency virus/acquired immunodeficiency syndrome and malaria. Despite their global public health importance, progress on developing vaccines for NTD pathogens has lagged because of some key technical hurdles and the fact that these infections occur almost exclusively in the world’s poorest people living below the World Bank poverty line. In the absence of financial incentives for new products, the multinational pharmaceutical companies have not embarked on substantive research and development programs for the neglected tropical disease vaccines. Here, we review the current status of scientific and technical progress in the development of new neglected tropical disease vaccines, highlighting the successes that have been achieved (cysticercosis and echinococcosis) and identifying the challenges and opportunities for development of new vaccines for NTDs. Also highlighted are the contributions being made by non-profit product development partnerships that are working to overcome some of the economic challenges in vaccine manufacture, clinical testing, and global access.</p>
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<name sortKey="Valenzuela, Jesus G" sort="Valenzuela, Jesus G" uniqKey="Valenzuela J" first="Jesus G." last="Valenzuela">Jesus G. Valenzuela</name>
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<country name="Australie"><noRegion><name sortKey="Lightowlers, Marshall W" sort="Lightowlers, Marshall W" uniqKey="Lightowlers M" first="Marshall W." last="Lightowlers">Marshall W. Lightowlers</name>
</noRegion>
<name sortKey="Loukas, Alex" sort="Loukas, Alex" uniqKey="Loukas A" first="Alex" last="Loukas">Alex Loukas</name>
</country>
</tree>
</affiliations>
</record>
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