SidaSubSaharaV1, Ncbi, Curation, bibRecord, 002307

Screening for HIV-Associated Peripheral Neuropathy in Resource-Limited Settings

Identifieur interne : 002307 ( Ncbi/Curation ); précédent : 002306; suivant : 002308

Screening for HIV-Associated Peripheral Neuropathy in Resource-Limited Settings

Auteurs : Deanna Cettomai [États-Unis] ; Judith K. Kwasa [Kenya] ; Gretchen L. Birbeck [Zambie] ; Richard W. Price [États-Unis] ; Craig R. Cohen [États-Unis] ; Elizabeth A. Bukusi ; Mmed Ob Gyn [Kenya] ; Caroline Kendi [Kenya] ; Ana-Claire L. Meyer [États-Unis]

Source :

Muscle & nerve [ 0148-639X ] ; 2013.

RBID : PMC:4019398

Abstract

INTRODUCTION

Peripheral neuropathy is the most common neurological complication of HIV but is widely under-diagnosed in resource-limited settings. We investigated the utility of screening tools administered by non-physician health care workers (HCW) and quantitative sensory testing (QST) administered by trained individuals for identification of moderate/severe neuropathy.

METHODS

We enrolled 240 HIV-infected outpatients using two-stage cluster randomized sampling. HCWs administered the several screening tools. Trained study staff performed QST. Tools were validated against a clinical diagnosis of neuropathy.

RESULTS

Participants were 65% women, mean age 36.4 years, median CD4 324 cells/μL. 65% were taking antiretrovirals, and 18% had moderate/severe neuropathy. The screening tests were 76% sensitive in diagnosing moderate/severe neuropathy with negative predictive values of 84–92%. QST was less sensitive but more specific.

DISCUSSION

Screening tests administered by HCW have excellent negative predictive values and are promising tools for scale-up in resource-limited settings. QST shows promise for research use.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019398

DOI: 10.1002/mus.23795
PubMed: 24037693
PubMed Central: 4019398

Links toward previous steps (curation, corpus...)

to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001C02
to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :001C01
to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001714
to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :002307

Links to Exploration step

PMC:4019398

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Screening for HIV-Associated Peripheral Neuropathy in Resource-Limited Settings</title>
<author><name sortKey="Cettomai, Deanna" sort="Cettomai, Deanna" uniqKey="Cettomai D" first="Deanna" last="Cettomai">Deanna Cettomai</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, University of California San Francisco; San Francisco, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of California San Francisco; San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kwasa, Judith K" sort="Kwasa, Judith K" uniqKey="Kwasa J" first="Judith K." last="Kwasa">Judith K. Kwasa</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Center for Microbiology Research, Kenya Medical Research Institute; Nairobi, Kenya</nlm:aff>
<country xml:lang="fr">Kenya</country>
<wicri:regionArea>Center for Microbiology Research, Kenya Medical Research Institute; Nairobi</wicri:regionArea>
<wicri:noRegion>Kenya Medical Research Institute; Nairobi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Birbeck, Gretchen L" sort="Birbeck, Gretchen L" uniqKey="Birbeck G" first="Gretchen L." last="Birbeck">Gretchen L. Birbeck</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Chikankata Hospital, Mazabuka, Zambia</nlm:aff>
<country xml:lang="fr">Zambie</country>
<wicri:regionArea>Chikankata Hospital, Mazabuka</wicri:regionArea>
<wicri:noRegion>Mazabuka</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Price, Richard W" sort="Price, Richard W" uniqKey="Price R" first="Richard W." last="Price">Richard W. Price</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, University of California San Francisco; San Francisco, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of California San Francisco; San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cohen, Craig R" sort="Cohen, Craig R" uniqKey="Cohen C" first="Craig R." last="Cohen">Craig R. Cohen</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Obstetrics and Gynecology, University of California San Francisco, San Francisco, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Obstetrics and Gynecology, University of California San Francisco, San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bukusi, Elizabeth A" sort="Bukusi, Elizabeth A" uniqKey="Bukusi E" first="Elizabeth A." last="Bukusi">Elizabeth A. Bukusi</name>
</author>
<author><name sortKey=" Ob Gyn, Mmed" sort=" Ob Gyn, Mmed" uniqKey=" Ob Gyn M" first="Mmed" last=" Ob Gyn">Mmed  Ob Gyn</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Center for Microbiology Research, Kenya Medical Research Institute; Nairobi, Kenya</nlm:aff>
<country xml:lang="fr">Kenya</country>
<wicri:regionArea>Center for Microbiology Research, Kenya Medical Research Institute; Nairobi</wicri:regionArea>
<wicri:noRegion>Kenya Medical Research Institute; Nairobi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kendi, Caroline" sort="Kendi, Caroline" uniqKey="Kendi C" first="Caroline" last="Kendi">Caroline Kendi</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Center for Microbiology Research, Kenya Medical Research Institute; Nairobi, Kenya</nlm:aff>
<country xml:lang="fr">Kenya</country>
<wicri:regionArea>Center for Microbiology Research, Kenya Medical Research Institute; Nairobi</wicri:regionArea>
<wicri:noRegion>Kenya Medical Research Institute; Nairobi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Meyer, Ana Claire L" sort="Meyer, Ana Claire L" uniqKey="Meyer A" first="Ana-Claire L." last="Meyer">Ana-Claire L. Meyer</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, University of California San Francisco; San Francisco, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of California San Francisco; San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24037693</idno>
<idno type="pmc">4019398</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019398</idno>
<idno type="RBID">PMC:4019398</idno>
<idno type="doi">10.1002/mus.23795</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">001C02</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001C02</idno>
<idno type="wicri:Area/Pmc/Curation">001C01</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001C01</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001714</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001714</idno>
<idno type="wicri:Area/Ncbi/Merge">002307</idno>
<idno type="wicri:Area/Ncbi/Curation">002307</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Screening for HIV-Associated Peripheral Neuropathy in Resource-Limited Settings</title>
<author><name sortKey="Cettomai, Deanna" sort="Cettomai, Deanna" uniqKey="Cettomai D" first="Deanna" last="Cettomai">Deanna Cettomai</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, University of California San Francisco; San Francisco, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of California San Francisco; San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kwasa, Judith K" sort="Kwasa, Judith K" uniqKey="Kwasa J" first="Judith K." last="Kwasa">Judith K. Kwasa</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Center for Microbiology Research, Kenya Medical Research Institute; Nairobi, Kenya</nlm:aff>
<country xml:lang="fr">Kenya</country>
<wicri:regionArea>Center for Microbiology Research, Kenya Medical Research Institute; Nairobi</wicri:regionArea>
<wicri:noRegion>Kenya Medical Research Institute; Nairobi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Birbeck, Gretchen L" sort="Birbeck, Gretchen L" uniqKey="Birbeck G" first="Gretchen L." last="Birbeck">Gretchen L. Birbeck</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Chikankata Hospital, Mazabuka, Zambia</nlm:aff>
<country xml:lang="fr">Zambie</country>
<wicri:regionArea>Chikankata Hospital, Mazabuka</wicri:regionArea>
<wicri:noRegion>Mazabuka</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Price, Richard W" sort="Price, Richard W" uniqKey="Price R" first="Richard W." last="Price">Richard W. Price</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, University of California San Francisco; San Francisco, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of California San Francisco; San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cohen, Craig R" sort="Cohen, Craig R" uniqKey="Cohen C" first="Craig R." last="Cohen">Craig R. Cohen</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Obstetrics and Gynecology, University of California San Francisco, San Francisco, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Obstetrics and Gynecology, University of California San Francisco, San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bukusi, Elizabeth A" sort="Bukusi, Elizabeth A" uniqKey="Bukusi E" first="Elizabeth A." last="Bukusi">Elizabeth A. Bukusi</name>
</author>
<author><name sortKey=" Ob Gyn, Mmed" sort=" Ob Gyn, Mmed" uniqKey=" Ob Gyn M" first="Mmed" last=" Ob Gyn">Mmed  Ob Gyn</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Center for Microbiology Research, Kenya Medical Research Institute; Nairobi, Kenya</nlm:aff>
<country xml:lang="fr">Kenya</country>
<wicri:regionArea>Center for Microbiology Research, Kenya Medical Research Institute; Nairobi</wicri:regionArea>
<wicri:noRegion>Kenya Medical Research Institute; Nairobi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kendi, Caroline" sort="Kendi, Caroline" uniqKey="Kendi C" first="Caroline" last="Kendi">Caroline Kendi</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Center for Microbiology Research, Kenya Medical Research Institute; Nairobi, Kenya</nlm:aff>
<country xml:lang="fr">Kenya</country>
<wicri:regionArea>Center for Microbiology Research, Kenya Medical Research Institute; Nairobi</wicri:regionArea>
<wicri:noRegion>Kenya Medical Research Institute; Nairobi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Meyer, Ana Claire L" sort="Meyer, Ana Claire L" uniqKey="Meyer A" first="Ana-Claire L." last="Meyer">Ana-Claire L. Meyer</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, University of California San Francisco; San Francisco, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of California San Francisco; San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Muscle & nerve</title>
<idno type="ISSN">0148-639X</idno>
<idno type="eISSN">1097-4598</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>INTRODUCTION</title>
<p id="P1">Peripheral neuropathy is the most common neurological complication of HIV but is widely under-diagnosed in resource-limited settings. We investigated the utility of screening tools administered by non-physician health care workers (HCW) and quantitative sensory testing (QST) administered by trained individuals for identification of moderate/severe neuropathy.</p>
</sec>
<sec id="S2"><title>METHODS</title>
<p id="P2">We enrolled 240 HIV-infected outpatients using two-stage cluster randomized sampling. HCWs administered the several screening tools. Trained study staff performed QST. Tools were validated against a clinical diagnosis of neuropathy.</p>
</sec>
<sec id="S3"><title>RESULTS</title>
<p id="P3">Participants were 65% women, mean age 36.4 years, median CD4 324 cells/μL. 65% were taking antiretrovirals, and 18% had moderate/severe neuropathy. The screening tests were 76% sensitive in diagnosing moderate/severe neuropathy with negative predictive values of 84–92%. QST was less sensitive but more specific.</p>
</sec>
<sec id="S4"><title>DISCUSSION</title>
<p id="P4">Screening tests administered by HCW have excellent negative predictive values and are promising tools for scale-up in resource-limited settings. QST shows promise for research use.</p>
</sec>
</div>
</front>
</TEI>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaSubSaharaV1/Data/Ncbi/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002307 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 002307 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    SidaSubSaharaV1
   |flux=    Ncbi
   |étape=   Curation
   |type=    RBID
   |clé=     PMC:4019398
   |texte=   Screening for HIV-Associated Peripheral Neuropathy in Resource-Limited Settings
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i   -Sk "pubmed:24037693" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd   \
       | NlmPubMed2Wicri -a SidaSubSaharaV1

This area was generated with Dilib version V0.6.32.
Data generation: Mon Nov 13 19:31:10 2017. Site generation: Wed Mar 6 19:14:32 2024

	Le SIDA en Afrique subsaharienne (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Le SIDA en Afrique subsaharienne (serveur d'exploration)

Screening for HIV-Associated Peripheral Neuropathy in Resource-Limited Settings

Screening for HIV-Associated Peripheral Neuropathy in Resource-Limited Settings

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki