SidaSubSaharaV1, Pmc, Corpus, bibRecord, 001C02

Screening for HIV-Associated Peripheral Neuropathy in Resource-Limited Settings

Identifieur interne : 001C02 ( Pmc/Corpus ); précédent : 001C01; suivant : 001C03

Screening for HIV-Associated Peripheral Neuropathy in Resource-Limited Settings

Auteurs : Deanna Cettomai ; Judith K. Kwasa ; Gretchen L. Birbeck ; Richard W. Price ; Craig R. Cohen ; Elizabeth A. Bukusi ; Mmed Ob Gyn ; Caroline Kendi ; Ana-Claire L. Meyer

Source :

Muscle & nerve [ 0148-639X ] ; 2013.

RBID : PMC:4019398

Abstract

INTRODUCTION

Peripheral neuropathy is the most common neurological complication of HIV but is widely under-diagnosed in resource-limited settings. We investigated the utility of screening tools administered by non-physician health care workers (HCW) and quantitative sensory testing (QST) administered by trained individuals for identification of moderate/severe neuropathy.

METHODS

We enrolled 240 HIV-infected outpatients using two-stage cluster randomized sampling. HCWs administered the several screening tools. Trained study staff performed QST. Tools were validated against a clinical diagnosis of neuropathy.

RESULTS

Participants were 65% women, mean age 36.4 years, median CD4 324 cells/μL. 65% were taking antiretrovirals, and 18% had moderate/severe neuropathy. The screening tests were 76% sensitive in diagnosing moderate/severe neuropathy with negative predictive values of 84–92%. QST was less sensitive but more specific.

DISCUSSION

Screening tests administered by HCW have excellent negative predictive values and are promising tools for scale-up in resource-limited settings. QST shows promise for research use.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019398

DOI: 10.1002/mus.23795
PubMed: 24037693
PubMed Central: 4019398

Links to Exploration step

PMC:4019398

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Screening for HIV-Associated Peripheral Neuropathy in Resource-Limited Settings</title>
<author><name sortKey="Cettomai, Deanna" sort="Cettomai, Deanna" uniqKey="Cettomai D" first="Deanna" last="Cettomai">Deanna Cettomai</name>
<affiliation><nlm:aff id="A1">Department of Neurology, University of California San Francisco; San Francisco, CA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kwasa, Judith K" sort="Kwasa, Judith K" uniqKey="Kwasa J" first="Judith K." last="Kwasa">Judith K. Kwasa</name>
<affiliation><nlm:aff id="A2">Center for Microbiology Research, Kenya Medical Research Institute; Nairobi, Kenya</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Birbeck, Gretchen L" sort="Birbeck, Gretchen L" uniqKey="Birbeck G" first="Gretchen L." last="Birbeck">Gretchen L. Birbeck</name>
<affiliation><nlm:aff id="A3">Chikankata Hospital, Mazabuka, Zambia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Price, Richard W" sort="Price, Richard W" uniqKey="Price R" first="Richard W." last="Price">Richard W. Price</name>
<affiliation><nlm:aff id="A1">Department of Neurology, University of California San Francisco; San Francisco, CA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cohen, Craig R" sort="Cohen, Craig R" uniqKey="Cohen C" first="Craig R." last="Cohen">Craig R. Cohen</name>
<affiliation><nlm:aff id="A4">Department of Obstetrics and Gynecology, University of California San Francisco, San Francisco, CA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bukusi, Elizabeth A" sort="Bukusi, Elizabeth A" uniqKey="Bukusi E" first="Elizabeth A." last="Bukusi">Elizabeth A. Bukusi</name>
</author>
<author><name sortKey=" Ob Gyn, Mmed" sort=" Ob Gyn, Mmed" uniqKey=" Ob Gyn M" first="Mmed" last=" Ob Gyn">Mmed  Ob Gyn</name>
<affiliation><nlm:aff id="A2">Center for Microbiology Research, Kenya Medical Research Institute; Nairobi, Kenya</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kendi, Caroline" sort="Kendi, Caroline" uniqKey="Kendi C" first="Caroline" last="Kendi">Caroline Kendi</name>
<affiliation><nlm:aff id="A2">Center for Microbiology Research, Kenya Medical Research Institute; Nairobi, Kenya</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Meyer, Ana Claire L" sort="Meyer, Ana Claire L" uniqKey="Meyer A" first="Ana-Claire L." last="Meyer">Ana-Claire L. Meyer</name>
<affiliation><nlm:aff id="A1">Department of Neurology, University of California San Francisco; San Francisco, CA, USA</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24037693</idno>
<idno type="pmc">4019398</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019398</idno>
<idno type="RBID">PMC:4019398</idno>
<idno type="doi">10.1002/mus.23795</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">001C02</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001C02</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Screening for HIV-Associated Peripheral Neuropathy in Resource-Limited Settings</title>
<author><name sortKey="Cettomai, Deanna" sort="Cettomai, Deanna" uniqKey="Cettomai D" first="Deanna" last="Cettomai">Deanna Cettomai</name>
<affiliation><nlm:aff id="A1">Department of Neurology, University of California San Francisco; San Francisco, CA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kwasa, Judith K" sort="Kwasa, Judith K" uniqKey="Kwasa J" first="Judith K." last="Kwasa">Judith K. Kwasa</name>
<affiliation><nlm:aff id="A2">Center for Microbiology Research, Kenya Medical Research Institute; Nairobi, Kenya</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Birbeck, Gretchen L" sort="Birbeck, Gretchen L" uniqKey="Birbeck G" first="Gretchen L." last="Birbeck">Gretchen L. Birbeck</name>
<affiliation><nlm:aff id="A3">Chikankata Hospital, Mazabuka, Zambia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Price, Richard W" sort="Price, Richard W" uniqKey="Price R" first="Richard W." last="Price">Richard W. Price</name>
<affiliation><nlm:aff id="A1">Department of Neurology, University of California San Francisco; San Francisco, CA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cohen, Craig R" sort="Cohen, Craig R" uniqKey="Cohen C" first="Craig R." last="Cohen">Craig R. Cohen</name>
<affiliation><nlm:aff id="A4">Department of Obstetrics and Gynecology, University of California San Francisco, San Francisco, CA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bukusi, Elizabeth A" sort="Bukusi, Elizabeth A" uniqKey="Bukusi E" first="Elizabeth A." last="Bukusi">Elizabeth A. Bukusi</name>
</author>
<author><name sortKey=" Ob Gyn, Mmed" sort=" Ob Gyn, Mmed" uniqKey=" Ob Gyn M" first="Mmed" last=" Ob Gyn">Mmed  Ob Gyn</name>
<affiliation><nlm:aff id="A2">Center for Microbiology Research, Kenya Medical Research Institute; Nairobi, Kenya</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kendi, Caroline" sort="Kendi, Caroline" uniqKey="Kendi C" first="Caroline" last="Kendi">Caroline Kendi</name>
<affiliation><nlm:aff id="A2">Center for Microbiology Research, Kenya Medical Research Institute; Nairobi, Kenya</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Meyer, Ana Claire L" sort="Meyer, Ana Claire L" uniqKey="Meyer A" first="Ana-Claire L." last="Meyer">Ana-Claire L. Meyer</name>
<affiliation><nlm:aff id="A1">Department of Neurology, University of California San Francisco; San Francisco, CA, USA</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Muscle & nerve</title>
<idno type="ISSN">0148-639X</idno>
<idno type="eISSN">1097-4598</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>INTRODUCTION</title>
<p id="P1">Peripheral neuropathy is the most common neurological complication of HIV but is widely under-diagnosed in resource-limited settings. We investigated the utility of screening tools administered by non-physician health care workers (HCW) and quantitative sensory testing (QST) administered by trained individuals for identification of moderate/severe neuropathy.</p>
</sec>
<sec id="S2"><title>METHODS</title>
<p id="P2">We enrolled 240 HIV-infected outpatients using two-stage cluster randomized sampling. HCWs administered the several screening tools. Trained study staff performed QST. Tools were validated against a clinical diagnosis of neuropathy.</p>
</sec>
<sec id="S3"><title>RESULTS</title>
<p id="P3">Participants were 65% women, mean age 36.4 years, median CD4 324 cells/μL. 65% were taking antiretrovirals, and 18% had moderate/severe neuropathy. The screening tests were 76% sensitive in diagnosing moderate/severe neuropathy with negative predictive values of 84–92%. QST was less sensitive but more specific.</p>
</sec>
<sec id="S4"><title>DISCUSSION</title>
<p id="P4">Screening tests administered by HCW have excellent negative predictive values and are promising tools for scale-up in resource-limited settings. QST shows promise for research use.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">7803146</journal-id>
<journal-id journal-id-type="pubmed-jr-id">5975</journal-id>
<journal-id journal-id-type="nlm-ta">Muscle Nerve</journal-id>
<journal-id journal-id-type="iso-abbrev">Muscle Nerve</journal-id>
<journal-title-group><journal-title>Muscle & nerve</journal-title>
</journal-title-group>
<issn pub-type="ppub">0148-639X</issn>
<issn pub-type="epub">1097-4598</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">24037693</article-id>
<article-id pub-id-type="pmc">4019398</article-id>
<article-id pub-id-type="doi">10.1002/mus.23795</article-id>
<article-id pub-id-type="manuscript">NIHMS559920</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Screening for HIV-Associated Peripheral Neuropathy in Resource-Limited Settings</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Cettomai</surname>
<given-names>Deanna</given-names>
</name>
<degrees>MD, MHS</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kwasa</surname>
<given-names>Judith K.</given-names>
</name>
<degrees>MBChB, MMed</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Birbeck</surname>
<given-names>Gretchen L.</given-names>
</name>
<degrees>MD, MPH</degrees>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Price</surname>
<given-names>Richard W.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cohen</surname>
<given-names>Craig R.</given-names>
</name>
<degrees>MD, MPH</degrees>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bukusi</surname>
<given-names>Elizabeth A.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>(OB/Gyn)</surname>
<given-names>MMed</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kendi</surname>
<given-names>Caroline</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Meyer</surname>
<given-names>Ana-Claire L.</given-names>
</name>
<degrees>MD, MSHS</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Neurology, University of California San Francisco; San Francisco, CA, USA</aff>
<aff id="A2"><label>2</label>
Center for Microbiology Research, Kenya Medical Research Institute; Nairobi, Kenya</aff>
<aff id="A3"><label>3</label>
Chikankata Hospital, Mazabuka, Zambia</aff>
<aff id="A4"><label>4</label>
Department of Obstetrics and Gynecology, University of California San Francisco, San Francisco, CA, USA</aff>
<author-notes><corresp id="FN1">Corresponding Author: Ana-Claire Meyer, MD, MSHS, Assistant Professor, Neurology, University of California, San Francisco, Visiting Scientist, Center for Microbiology Research, Kenya Medical Research Institute, San Francisco General Hospital, 1001 Potrero Ave, 4M62, Box 0870, San Francisco, CA 94110, Phone: +1-415-206-6182, FAX: +1-415-476-3382, <email>meyerac@sfgh.ucsf.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>10</day>
<month>3</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>27</day>
<month>8</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="ppub"><month>10</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>10</month>
<year>2014</year>
</pub-date>
<volume>48</volume>
<issue>4</issue>
<fpage>516</fpage>
<lpage>524</lpage>
<pmc-comment>elocation-id from pubmed: 10.1002/mus.23795</pmc-comment>
      <abstract><sec id="S1"><title>INTRODUCTION</title>
<p id="P1">Peripheral neuropathy is the most common neurological complication of HIV but is widely under-diagnosed in resource-limited settings. We investigated the utility of screening tools administered by non-physician health care workers (HCW) and quantitative sensory testing (QST) administered by trained individuals for identification of moderate/severe neuropathy.</p>
</sec>
<sec id="S2"><title>METHODS</title>
<p id="P2">We enrolled 240 HIV-infected outpatients using two-stage cluster randomized sampling. HCWs administered the several screening tools. Trained study staff performed QST. Tools were validated against a clinical diagnosis of neuropathy.</p>
</sec>
<sec id="S3"><title>RESULTS</title>
<p id="P3">Participants were 65% women, mean age 36.4 years, median CD4 324 cells/μL. 65% were taking antiretrovirals, and 18% had moderate/severe neuropathy. The screening tests were 76% sensitive in diagnosing moderate/severe neuropathy with negative predictive values of 84–92%. QST was less sensitive but more specific.</p>
</sec>
<sec id="S4"><title>DISCUSSION</title>
<p id="P4">Screening tests administered by HCW have excellent negative predictive values and are promising tools for scale-up in resource-limited settings. QST shows promise for research use.</p>
</sec>
</abstract>
<kwd-group><kwd>sensitivity and specificity</kwd>
<kwd>HIV</kwd>
<kwd>peripheral nervous system diseases</kwd>
<kwd>developing countries</kwd>
<kwd>screening tools</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaSubSaharaV1/Data/Pmc/Corpus

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001C02 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 001C02 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    SidaSubSaharaV1
   |flux=    Pmc
   |étape=   Corpus
   |type=    RBID
   |clé=     PMC:4019398
   |texte=   Screening for HIV-Associated Peripheral Neuropathy in Resource-Limited Settings
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i   -Sk "pubmed:24037693" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd   \
       | NlmPubMed2Wicri -a SidaSubSaharaV1

This area was generated with Dilib version V0.6.32.
Data generation: Mon Nov 13 19:31:10 2017. Site generation: Wed Mar 6 19:14:32 2024

	Le SIDA en Afrique subsaharienne (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Le SIDA en Afrique subsaharienne (serveur d'exploration)

Screening for HIV-Associated Peripheral Neuropathy in Resource-Limited Settings

Screening for HIV-Associated Peripheral Neuropathy in Resource-Limited Settings

Source :

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki