EFFECT OF DEPOT MEDOXYPROGESTERONE ACETATE ON IMMUNE FUNCTIONS AND INFLAMMATORY MARKERS OF HIV-INFECTED WOMEN
Identifieur interne : 003350 ( Ncbi/Checkpoint ); précédent : 003349; suivant : 003351EFFECT OF DEPOT MEDOXYPROGESTERONE ACETATE ON IMMUNE FUNCTIONS AND INFLAMMATORY MARKERS OF HIV-INFECTED WOMEN
Auteurs : Adriana Weinberg [États-Unis] ; Jeong-Gun Park [États-Unis] ; Ronald Bosch [États-Unis] ; Alice Cho [États-Unis] ; Elizabeth Livingston [États-Unis] ; Fran Aweeka [États-Unis] ; Yoninah Cramer [États-Unis] ; D. Heather Watts [États-Unis] ; Amneris E. Luque [États-Unis] ; Susan E. Cohn [États-Unis]Source :
- Journal of acquired immune deficiency syndromes (1999) [ 1525-4135 ] ; 2016.
Abstract
Depot medroxyprogesterone acetate (DMPA) was associated with increased HIV transmission and accelerated disease progression in untreated women. The potential underlying mechanisms include immune-modulation. We evaluated the effect of a single DMPA injection on cell-mediated immunity (CMI), T cell activation (Tact), regulation (Treg) and inflammation in HIV-infected women on cART.
Women with HIV plasma RNA ≤400 c/mL on stable cART received DMPA and had immunologic and MPA measurements at baseline, 4 weeks [peak MPA concentration (Cmax)] and 12 weeks [highest MPA area under the concentration curve (AUC)].
At baseline, among 24 women with median 32 years of age and 622 CD4+ cells/μL, ≥68% had HIV, VZV, PHA and CD3/CD28 CMI measured by lymphocyte proliferation and/or IFNγ/IL2 dual-color fluorospot. CMI did not significantly change after DMPA administration except for a 1.4-fold increase in IL2/IFNγ VZV fluorospot at week 12. Tact decreased after DMPA administration, reaching statistical significance at week 12 for CD4+CD25+%. Treg behaved heterogeneously with an increase in CD8+FOXP3+% at week 4 and a decrease in CD4+IL35+% at week 12. There was a decrease in TGFβ at week 12 and no other changes in plasma biomarkers. Correlation analyses showed that high MPA Cmax and/or AUC were significantly associated with increases of IFNγ HIV ELISPOT, CD4+IL35+% and CD4+TGFβ+% Treg and decreases of plasma IL10 from baseline to weeks 4 and/or 12.
A single dose of DMPA did not have immune-suppressive or pro-inflammatory effects in HIV-infected women on cART. Additional studies need to assess the effect of multiple doses.
Url:
DOI: 10.1097/QAI.0000000000000850
PubMed: 26413850
PubMed Central: 4712075
Affiliations:
- États-Unis
- Californie, Caroline du Nord, Colorado, District de Columbia, Illinois, Massachusetts, État de New York
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001946
- to stream Pmc, to step Curation: 001945
- to stream Pmc, to step Checkpoint: 000771
- to stream Ncbi, to step Merge: 003350
- to stream Ncbi, to step Curation: 003350
Links to Exploration step
PMC:4712075Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">EFFECT OF DEPOT MEDOXYPROGESTERONE ACETATE ON IMMUNE FUNCTIONS AND INFLAMMATORY MARKERS OF HIV-INFECTED WOMEN</title>
<author><name sortKey="Weinberg, Adriana" sort="Weinberg, Adriana" uniqKey="Weinberg A" first="Adriana" last="Weinberg">Adriana Weinberg</name>
<affiliation wicri:level="2"><nlm:aff id="A1">University of Colorado Denver Anschutz Medical Center, Aurora, CO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Colorado</region>
</placeName>
<wicri:cityArea>University of Colorado Denver Anschutz Medical Center, Aurora</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Park, Jeong Gun" sort="Park, Jeong Gun" uniqKey="Park J" first="Jeong-Gun" last="Park">Jeong-Gun Park</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Statistical and Data Analysis Center, Harvard School of Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Statistical and Data Analysis Center, Harvard School of Public Health, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bosch, Ronald" sort="Bosch, Ronald" uniqKey="Bosch R" first="Ronald" last="Bosch">Ronald Bosch</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Statistical and Data Analysis Center, Harvard School of Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Statistical and Data Analysis Center, Harvard School of Public Health, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cho, Alice" sort="Cho, Alice" uniqKey="Cho A" first="Alice" last="Cho">Alice Cho</name>
<affiliation wicri:level="2"><nlm:aff id="A1">University of Colorado Denver Anschutz Medical Center, Aurora, CO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Colorado</region>
</placeName>
<wicri:cityArea>University of Colorado Denver Anschutz Medical Center, Aurora</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Livingston, Elizabeth" sort="Livingston, Elizabeth" uniqKey="Livingston E" first="Elizabeth" last="Livingston">Elizabeth Livingston</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Duke University Medical Center, Durham, NC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Duke University Medical Center, Durham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Aweeka, Fran" sort="Aweeka, Fran" uniqKey="Aweeka F" first="Fran" last="Aweeka">Fran Aweeka</name>
<affiliation wicri:level="2"><nlm:aff id="A4">University of California, San Francisco, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>University of California, San Francisco</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cramer, Yoninah" sort="Cramer, Yoninah" uniqKey="Cramer Y" first="Yoninah" last="Cramer">Yoninah Cramer</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Statistical and Data Analysis Center, Harvard School of Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Statistical and Data Analysis Center, Harvard School of Public Health, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Watts, D Heather" sort="Watts, D Heather" uniqKey="Watts D" first="D. Heather" last="Watts">D. Heather Watts</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Office of the Global AIDS Coordinator and Health Diplomacy, U.S. Department of State, Washington, DC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">District de Columbia</region>
</placeName>
<wicri:cityArea>Office of the Global AIDS Coordinator and Health Diplomacy, U.S. Department of State, Washington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Luque, Amneris E" sort="Luque, Amneris E" uniqKey="Luque A" first="Amneris E." last="Luque">Amneris E. Luque</name>
<affiliation wicri:level="2"><nlm:aff id="A6">University of Rochester School of Medicine and Dentistry, Rochester, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>University of Rochester School of Medicine and Dentistry, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cohn, Susan E" sort="Cohn, Susan E" uniqKey="Cohn S" first="Susan E." last="Cohn">Susan E. Cohn</name>
<affiliation wicri:level="2"><nlm:aff id="A7">Northwestern University Feinberg School of Medicine, Chicago, IL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Northwestern University Feinberg School of Medicine, Chicago</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26413850</idno>
<idno type="pmc">4712075</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712075</idno>
<idno type="RBID">PMC:4712075</idno>
<idno type="doi">10.1097/QAI.0000000000000850</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">001946</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001946</idno>
<idno type="wicri:Area/Pmc/Curation">001945</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001945</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000771</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000771</idno>
<idno type="wicri:Area/Ncbi/Merge">003350</idno>
<idno type="wicri:Area/Ncbi/Curation">003350</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003350</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">EFFECT OF DEPOT MEDOXYPROGESTERONE ACETATE ON IMMUNE FUNCTIONS AND INFLAMMATORY MARKERS OF HIV-INFECTED WOMEN</title>
<author><name sortKey="Weinberg, Adriana" sort="Weinberg, Adriana" uniqKey="Weinberg A" first="Adriana" last="Weinberg">Adriana Weinberg</name>
<affiliation wicri:level="2"><nlm:aff id="A1">University of Colorado Denver Anschutz Medical Center, Aurora, CO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Colorado</region>
</placeName>
<wicri:cityArea>University of Colorado Denver Anschutz Medical Center, Aurora</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Park, Jeong Gun" sort="Park, Jeong Gun" uniqKey="Park J" first="Jeong-Gun" last="Park">Jeong-Gun Park</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Statistical and Data Analysis Center, Harvard School of Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Statistical and Data Analysis Center, Harvard School of Public Health, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bosch, Ronald" sort="Bosch, Ronald" uniqKey="Bosch R" first="Ronald" last="Bosch">Ronald Bosch</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Statistical and Data Analysis Center, Harvard School of Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Statistical and Data Analysis Center, Harvard School of Public Health, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cho, Alice" sort="Cho, Alice" uniqKey="Cho A" first="Alice" last="Cho">Alice Cho</name>
<affiliation wicri:level="2"><nlm:aff id="A1">University of Colorado Denver Anschutz Medical Center, Aurora, CO</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Colorado</region>
</placeName>
<wicri:cityArea>University of Colorado Denver Anschutz Medical Center, Aurora</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Livingston, Elizabeth" sort="Livingston, Elizabeth" uniqKey="Livingston E" first="Elizabeth" last="Livingston">Elizabeth Livingston</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Duke University Medical Center, Durham, NC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Duke University Medical Center, Durham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Aweeka, Fran" sort="Aweeka, Fran" uniqKey="Aweeka F" first="Fran" last="Aweeka">Fran Aweeka</name>
<affiliation wicri:level="2"><nlm:aff id="A4">University of California, San Francisco, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>University of California, San Francisco</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cramer, Yoninah" sort="Cramer, Yoninah" uniqKey="Cramer Y" first="Yoninah" last="Cramer">Yoninah Cramer</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Statistical and Data Analysis Center, Harvard School of Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Statistical and Data Analysis Center, Harvard School of Public Health, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Watts, D Heather" sort="Watts, D Heather" uniqKey="Watts D" first="D. Heather" last="Watts">D. Heather Watts</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Office of the Global AIDS Coordinator and Health Diplomacy, U.S. Department of State, Washington, DC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">District de Columbia</region>
</placeName>
<wicri:cityArea>Office of the Global AIDS Coordinator and Health Diplomacy, U.S. Department of State, Washington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Luque, Amneris E" sort="Luque, Amneris E" uniqKey="Luque A" first="Amneris E." last="Luque">Amneris E. Luque</name>
<affiliation wicri:level="2"><nlm:aff id="A6">University of Rochester School of Medicine and Dentistry, Rochester, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>University of Rochester School of Medicine and Dentistry, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cohn, Susan E" sort="Cohn, Susan E" uniqKey="Cohn S" first="Susan E." last="Cohn">Susan E. Cohn</name>
<affiliation wicri:level="2"><nlm:aff id="A7">Northwestern University Feinberg School of Medicine, Chicago, IL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Northwestern University Feinberg School of Medicine, Chicago</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of acquired immune deficiency syndromes (1999)</title>
<idno type="ISSN">1525-4135</idno>
<idno type="eISSN">1944-7884</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objectives</title>
<p id="P1">Depot medroxyprogesterone acetate (DMPA) was associated with increased HIV transmission and accelerated disease progression in untreated women. The potential underlying mechanisms include immune-modulation. We evaluated the effect of a single DMPA injection on cell-mediated immunity (CMI), T cell activation (Tact), regulation (Treg) and inflammation in HIV-infected women on cART.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Women with HIV plasma RNA ≤400 c/mL on stable cART received DMPA and had immunologic and MPA measurements at baseline, 4 weeks [peak MPA concentration (Cmax)] and 12 weeks [highest MPA area under the concentration curve (AUC)].</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">At baseline, among 24 women with median 32 years of age and 622 CD4+ cells/μL, ≥68% had HIV, VZV, PHA and CD3/CD28 CMI measured by lymphocyte proliferation and/or IFNγ/IL2 dual-color fluorospot. CMI did not significantly change after DMPA administration except for a 1.4-fold increase in IL2/IFNγ VZV fluorospot at week 12. Tact decreased after DMPA administration, reaching statistical significance at week 12 for CD4+CD25+%. Treg behaved heterogeneously with an increase in CD8+FOXP3+% at week 4 and a decrease in CD4+IL35+% at week 12. There was a decrease in TGFβ at week 12 and no other changes in plasma biomarkers. Correlation analyses showed that high MPA Cmax and/or AUC were significantly associated with increases of IFNγ HIV ELISPOT, CD4+IL35+% and CD4+TGFβ+% Treg and decreases of plasma IL10 from baseline to weeks 4 and/or 12.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">A single dose of DMPA did not have immune-suppressive or pro-inflammatory effects in HIV-infected women on cART. Additional studies need to assess the effect of multiple doses.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Caroline du Nord</li>
<li>Colorado</li>
<li>District de Columbia</li>
<li>Illinois</li>
<li>Massachusetts</li>
<li>État de New York</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Colorado"><name sortKey="Weinberg, Adriana" sort="Weinberg, Adriana" uniqKey="Weinberg A" first="Adriana" last="Weinberg">Adriana Weinberg</name>
</region>
<name sortKey="Aweeka, Fran" sort="Aweeka, Fran" uniqKey="Aweeka F" first="Fran" last="Aweeka">Fran Aweeka</name>
<name sortKey="Bosch, Ronald" sort="Bosch, Ronald" uniqKey="Bosch R" first="Ronald" last="Bosch">Ronald Bosch</name>
<name sortKey="Cho, Alice" sort="Cho, Alice" uniqKey="Cho A" first="Alice" last="Cho">Alice Cho</name>
<name sortKey="Cohn, Susan E" sort="Cohn, Susan E" uniqKey="Cohn S" first="Susan E." last="Cohn">Susan E. Cohn</name>
<name sortKey="Cramer, Yoninah" sort="Cramer, Yoninah" uniqKey="Cramer Y" first="Yoninah" last="Cramer">Yoninah Cramer</name>
<name sortKey="Livingston, Elizabeth" sort="Livingston, Elizabeth" uniqKey="Livingston E" first="Elizabeth" last="Livingston">Elizabeth Livingston</name>
<name sortKey="Luque, Amneris E" sort="Luque, Amneris E" uniqKey="Luque A" first="Amneris E." last="Luque">Amneris E. Luque</name>
<name sortKey="Park, Jeong Gun" sort="Park, Jeong Gun" uniqKey="Park J" first="Jeong-Gun" last="Park">Jeong-Gun Park</name>
<name sortKey="Watts, D Heather" sort="Watts, D Heather" uniqKey="Watts D" first="D. Heather" last="Watts">D. Heather Watts</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaSubSaharaV1/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003350 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 003350 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= SidaSubSaharaV1 |flux= Ncbi |étape= Checkpoint |type= RBID |clé= PMC:4712075 |texte= EFFECT OF DEPOT MEDOXYPROGESTERONE ACETATE ON IMMUNE FUNCTIONS AND INFLAMMATORY MARKERS OF HIV-INFECTED WOMEN }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:26413850" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a SidaSubSaharaV1
![]() | This area was generated with Dilib version V0.6.32. | ![]() |