Prevalence of latent rheumatic heart disease among HIV-infected children in Kampala, Uganda
Identifieur interne : 003349 ( Ncbi/Checkpoint ); précédent : 003348; suivant : 003350Prevalence of latent rheumatic heart disease among HIV-infected children in Kampala, Uganda
Auteurs : Brigette Gleason [États-Unis] ; Grace Mirembe [Ouganda] ; Judith Namuyonga [Ouganda] ; Emmy Okello [Ouganda] ; Peter Lwabi [Ouganda] ; Irene Lubega [Ouganda] ; Sulaiman Lubega [Ouganda] ; Victor Musiime [Ouganda] ; Cissy Kityo [Ouganda] ; Robert A. Salata [États-Unis] ; Chris T. Longenecker [États-Unis]Source :
- Journal of acquired immune deficiency syndromes (1999) [ 1525-4135 ] ; 2016.
Abstract
Rheumatic heart disease (RHD) remains highly prevalent in resource-constrained settings around the world, including countries with high rates of HIV/AIDS. Although both are immune-mediated diseases, it is unknown whether HIV modifies the risk or progression of RHD. We performed screening echocardiography to determine the prevalence of latent rheumatic heart disease in 488 HIV-infected children aged 5-18 in Kampala, Uganda. The overall prevalence of borderline/definite RHD was 0.82% (95% CI 0.26% to 2.23%) which is lower than the published prevalence rates of 1.5-4% among Ugandan children. There may be protective factors that decrease the risk of RHD in HIV-infected children.
Url:
DOI: 10.1097/QAI.0000000000000827
PubMed: 26413847
PubMed Central: 4712089
Affiliations:
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PMC:4712089Le document en format XML
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<front><div type="abstract" xml:lang="en"><p id="P2">Rheumatic heart disease (RHD) remains highly prevalent in resource-constrained settings around the world, including countries with high rates of HIV/AIDS. Although both are immune-mediated diseases, it is unknown whether HIV modifies the risk or progression of RHD. We performed screening echocardiography to determine the prevalence of latent rheumatic heart disease in 488 HIV-infected children aged 5-18 in Kampala, Uganda. The overall prevalence of borderline/definite RHD was 0.82% (95% CI 0.26% to 2.23%) which is lower than the published prevalence rates of 1.5-4% among Ugandan children. There may be protective factors that decrease the risk of RHD in HIV-infected children.</p>
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<name sortKey="Longenecker, Chris T" sort="Longenecker, Chris T" uniqKey="Longenecker C" first="Chris T." last="Longenecker">Chris T. Longenecker</name>
<name sortKey="Salata, Robert A" sort="Salata, Robert A" uniqKey="Salata R" first="Robert A." last="Salata">Robert A. Salata</name>
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<country name="Ouganda"><noRegion><name sortKey="Mirembe, Grace" sort="Mirembe, Grace" uniqKey="Mirembe G" first="Grace" last="Mirembe">Grace Mirembe</name>
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<name sortKey="Musiime, Victor" sort="Musiime, Victor" uniqKey="Musiime V" first="Victor" last="Musiime">Victor Musiime</name>
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