Morbidity in relation to feeding mode in African HIV-exposed, uninfected infants during the first 6 mo of life: the Kesho Bora study123456
Identifieur interne : 001C28 ( Main/Merge ); précédent : 001C27; suivant : 001C29Morbidity in relation to feeding mode in African HIV-exposed, uninfected infants during the first 6 mo of life: the Kesho Bora study123456
Auteurs : Kirsten A. Bork ; Amandine Cournil ; Jennifer S. Read ; Marie-Louise Newell ; Cécile Cames ; Nicolas Meda ; Stanley Luchters ; Grace Mbatia ; Kevindra Naidu ; Philippe Gaillard ; Isabelle De VincenziSource :
- The American Journal of Clinical Nutrition [ 0002-9165 ] ; 2014.
Descripteurs français
- KwdFr :
- Allaitement maternel, Facteurs de risque, Facteurs socioéconomiques, Femelle, Grossesse, Humains, Infections à VIH (épidémiologie), Morbidité, Mâle, Nourrisson, Population d'origine africaine, Préparation pour nourrissons (administration et posologie), Prévalence, République d'Afrique du Sud (épidémiologie), Transmission verticale de maladie infectieuse ().
- MESH :
- administration et posologie : Préparation pour nourrissons.
- épidémiologie : Infections à VIH, République d'Afrique du Sud.
- Allaitement maternel, Facteurs de risque, Facteurs socioéconomiques, Femelle, Grossesse, Humains, Morbidité, Mâle, Nourrisson, Population d'origine africaine, Prévalence, Transmission verticale de maladie infectieuse.
- Wicri :
- geographic : Afrique du Sud.
English descriptors
- KwdEn :
- African Continental Ancestry Group, Breast Feeding, Female, HIV Infections (epidemiology), Humans, Infant, Infant Formula (administration & dosage), Infectious Disease Transmission, Vertical (prevention & control), Male, Morbidity, Pregnancy, Prevalence, Risk Factors, Socioeconomic Factors, South Africa (epidemiology).
- MESH :
- geographic , epidemiology : South Africa.
- administration & dosage : Infant Formula.
- epidemiology : HIV Infections.
- prevention & control : Infectious Disease Transmission, Vertical.
- African Continental Ancestry Group, Breast Feeding, Female, Humans, Infant, Male, Morbidity, Pregnancy, Prevalence, Risk Factors, Socioeconomic Factors.
Abstract
Url:
DOI: 10.3945/ajcn.113.082149
PubMed: 25411291
PubMed Central: 4232020
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001576
- to stream Pmc, to step Curation: 001575
- to stream Pmc, to step Checkpoint: 001226
- to stream PubMed, to step Corpus: 001B64
- to stream PubMed, to step Curation: 001B64
- to stream PubMed, to step Checkpoint: 001B64
- to stream Ncbi, to step Merge: 002D05
- to stream Ncbi, to step Curation: 002D05
- to stream Ncbi, to step Checkpoint: 002D05
Links to Exploration step
PMC:4232020Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Morbidity in relation to feeding mode in African HIV-exposed, uninfected infants during the first 6 mo of life: the Kesho Bora study<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="author-notes" rid="fn1"><sup>2</sup>
</xref>
<xref ref-type="author-notes" rid="fn2"><sup>3</sup>
</xref>
<xref ref-type="author-notes" rid="fn3"><sup>4</sup>
</xref>
<xref ref-type="author-notes" rid="fn4"><sup>5</sup>
</xref>
<xref ref-type="corresp" rid="cor1"><sup>6</sup>
</xref>
</title>
<author><name sortKey="Bork, Kirsten A" sort="Bork, Kirsten A" uniqKey="Bork K" first="Kirsten A" last="Bork">Kirsten A. Bork</name>
</author>
<author><name sortKey="Cournil, Amandine" sort="Cournil, Amandine" uniqKey="Cournil A" first="Amandine" last="Cournil">Amandine Cournil</name>
</author>
<author><name sortKey="Read, Jennifer S" sort="Read, Jennifer S" uniqKey="Read J" first="Jennifer S" last="Read">Jennifer S. Read</name>
</author>
<author><name sortKey="Newell, Marie Louise" sort="Newell, Marie Louise" uniqKey="Newell M" first="Marie-Louise" last="Newell">Marie-Louise Newell</name>
</author>
<author><name sortKey="Cames, Cecile" sort="Cames, Cecile" uniqKey="Cames C" first="Cécile" last="Cames">Cécile Cames</name>
</author>
<author><name sortKey="Meda, Nicolas" sort="Meda, Nicolas" uniqKey="Meda N" first="Nicolas" last="Meda">Nicolas Meda</name>
</author>
<author><name sortKey="Luchters, Stanley" sort="Luchters, Stanley" uniqKey="Luchters S" first="Stanley" last="Luchters">Stanley Luchters</name>
</author>
<author><name sortKey="Mbatia, Grace" sort="Mbatia, Grace" uniqKey="Mbatia G" first="Grace" last="Mbatia">Grace Mbatia</name>
</author>
<author><name sortKey="Naidu, Kevindra" sort="Naidu, Kevindra" uniqKey="Naidu K" first="Kevindra" last="Naidu">Kevindra Naidu</name>
</author>
<author><name sortKey="Gaillard, Philippe" sort="Gaillard, Philippe" uniqKey="Gaillard P" first="Philippe" last="Gaillard">Philippe Gaillard</name>
</author>
<author><name sortKey="De Vincenzi, Isabelle" sort="De Vincenzi, Isabelle" uniqKey="De Vincenzi I" first="Isabelle" last="De Vincenzi">Isabelle De Vincenzi</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25411291</idno>
<idno type="pmc">4232020</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232020</idno>
<idno type="RBID">PMC:4232020</idno>
<idno type="doi">10.3945/ajcn.113.082149</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">001576</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001576</idno>
<idno type="wicri:Area/Pmc/Curation">001575</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001575</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001226</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001226</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">001B64</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001B64</idno>
<idno type="wicri:Area/PubMed/Curation">001B64</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001B64</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001B64</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001B64</idno>
<idno type="wicri:Area/Ncbi/Merge">002D05</idno>
<idno type="wicri:Area/Ncbi/Curation">002D05</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002D05</idno>
<idno type="wicri:doubleKey">0002-9165:2014:Bork K:morbidity:in:relation</idno>
<idno type="wicri:Area/Main/Merge">001C28</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Morbidity in relation to feeding mode in African HIV-exposed, uninfected infants during the first 6 mo of life: the Kesho Bora study<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="author-notes" rid="fn1"><sup>2</sup>
</xref>
<xref ref-type="author-notes" rid="fn2"><sup>3</sup>
</xref>
<xref ref-type="author-notes" rid="fn3"><sup>4</sup>
</xref>
<xref ref-type="author-notes" rid="fn4"><sup>5</sup>
</xref>
<xref ref-type="corresp" rid="cor1"><sup>6</sup>
</xref>
</title>
<author><name sortKey="Bork, Kirsten A" sort="Bork, Kirsten A" uniqKey="Bork K" first="Kirsten A" last="Bork">Kirsten A. Bork</name>
</author>
<author><name sortKey="Cournil, Amandine" sort="Cournil, Amandine" uniqKey="Cournil A" first="Amandine" last="Cournil">Amandine Cournil</name>
</author>
<author><name sortKey="Read, Jennifer S" sort="Read, Jennifer S" uniqKey="Read J" first="Jennifer S" last="Read">Jennifer S. Read</name>
</author>
<author><name sortKey="Newell, Marie Louise" sort="Newell, Marie Louise" uniqKey="Newell M" first="Marie-Louise" last="Newell">Marie-Louise Newell</name>
</author>
<author><name sortKey="Cames, Cecile" sort="Cames, Cecile" uniqKey="Cames C" first="Cécile" last="Cames">Cécile Cames</name>
</author>
<author><name sortKey="Meda, Nicolas" sort="Meda, Nicolas" uniqKey="Meda N" first="Nicolas" last="Meda">Nicolas Meda</name>
</author>
<author><name sortKey="Luchters, Stanley" sort="Luchters, Stanley" uniqKey="Luchters S" first="Stanley" last="Luchters">Stanley Luchters</name>
</author>
<author><name sortKey="Mbatia, Grace" sort="Mbatia, Grace" uniqKey="Mbatia G" first="Grace" last="Mbatia">Grace Mbatia</name>
</author>
<author><name sortKey="Naidu, Kevindra" sort="Naidu, Kevindra" uniqKey="Naidu K" first="Kevindra" last="Naidu">Kevindra Naidu</name>
</author>
<author><name sortKey="Gaillard, Philippe" sort="Gaillard, Philippe" uniqKey="Gaillard P" first="Philippe" last="Gaillard">Philippe Gaillard</name>
</author>
<author><name sortKey="De Vincenzi, Isabelle" sort="De Vincenzi, Isabelle" uniqKey="De Vincenzi I" first="Isabelle" last="De Vincenzi">Isabelle De Vincenzi</name>
</author>
</analytic>
<series><title level="j">The American Journal of Clinical Nutrition</title>
<idno type="ISSN">0002-9165</idno>
<idno type="eISSN">1938-3207</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>African Continental Ancestry Group</term>
<term>Breast Feeding</term>
<term>Female</term>
<term>HIV Infections (epidemiology)</term>
<term>Humans</term>
<term>Infant</term>
<term>Infant Formula (administration & dosage)</term>
<term>Infectious Disease Transmission, Vertical (prevention & control)</term>
<term>Male</term>
<term>Morbidity</term>
<term>Pregnancy</term>
<term>Prevalence</term>
<term>Risk Factors</term>
<term>Socioeconomic Factors</term>
<term>South Africa (epidemiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Allaitement maternel</term>
<term>Facteurs de risque</term>
<term>Facteurs socioéconomiques</term>
<term>Femelle</term>
<term>Grossesse</term>
<term>Humains</term>
<term>Infections à VIH (épidémiologie)</term>
<term>Morbidité</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Population d'origine africaine</term>
<term>Préparation pour nourrissons (administration et posologie)</term>
<term>Prévalence</term>
<term>République d'Afrique du Sud (épidémiologie)</term>
<term>Transmission verticale de maladie infectieuse ()</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>South Africa</term>
</keywords>
<keywords scheme="MESH" qualifier="administration & dosage" xml:lang="en"><term>Infant Formula</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Préparation pour nourrissons</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>HIV Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Infectious Disease Transmission, Vertical</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à VIH</term>
<term>République d'Afrique du Sud</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>African Continental Ancestry Group</term>
<term>Breast Feeding</term>
<term>Female</term>
<term>Humans</term>
<term>Infant</term>
<term>Male</term>
<term>Morbidity</term>
<term>Pregnancy</term>
<term>Prevalence</term>
<term>Risk Factors</term>
<term>Socioeconomic Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Allaitement maternel</term>
<term>Facteurs de risque</term>
<term>Facteurs socioéconomiques</term>
<term>Femelle</term>
<term>Grossesse</term>
<term>Humains</term>
<term>Morbidité</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Population d'origine africaine</term>
<term>Prévalence</term>
<term>Transmission verticale de maladie infectieuse</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Afrique du Sud</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
Refraining from breastfeeding to prevent HIV transmission has been associated with increased morbidity and mortality in HIV-exposed African infants.</p>
<p><bold>Objective:</bold>
The objective was to assess risks of common and serious infectious morbidity by feeding mode in HIV-exposed, uninfected infants ≤6 mo of age with special attention to the issue of reverse causality.</p>
<p><bold>Design:</bold>
HIV-infected pregnant women from 5 sites in Burkina Faso, Kenya, and South Africa were enrolled in the prevention of mother-to-child transmission Kesho Bora trial and counseled to either breastfeed exclusively and cease by 6 mo postpartum or formula feed exclusively. Maternal-reported morbidity (fever, diarrhea, and vomiting) and serious infectious events (SIEs) (gastroenteritis and lower respiratory tract infections) were investigated for 751 infants for 2 age periods (0–2.9 and 3–6 mo) by using generalized linear mixed models with breastfeeding as a time-dependent variable and adjustment for study site, maternal education, economic level, and cotrimoxazole prophylaxis.</p>
<p><bold>Results:</bold>
Reported morbidity was not significantly higher in nonbreastfed compared with breastfed infants [OR: 1.31 (95% CI: 0.97, 1.75) and 1.21 (0.90, 1.62) at 0–2.9 and 3–6 mo of age, respectively]. Between 0 and 2.9 mo of age, never-breastfed infants had increased risks of morbidity compared with those of infants who were exclusively breastfed (OR: 1.49; 95% CI: 1.01, 2.2; <italic>P</italic>
= 0.042). The adjusted excess risk of SIEs in nonbreastfed infants was large between 0 and 2.9 mo (OR: 6.0; 95% CI: 2.2, 16.4; <italic>P</italic>
= 0.001). Between 3 and 6 mo, the OR for SIEs was sensitive to the timing of breastfeeding status, i.e., 4.3 (95% CI: 1.2, 15.3; <italic>P</italic>
= 0.02) when defined at end of monthly intervals and 2.0 (95% CI: 0.8, 5.0; <italic>P</italic>
= 0.13) when defined at the beginning of intervals. Of 52 SIEs, 3 mothers reported changes in feeding mode during the SIE although none of the mothers ceased breastfeeding completely.</p>
<p><bold>Conclusions:</bold>
Not breastfeeding was associated with increased risk of serious infections especially between 0 and 2.9 mo of age. The randomized controlled trial component of the Kesho Bora study was registered at Current Controlled Trials (<ext-link ext-link-type="uri" xlink:href="www.controlled-trials.com">www.controlled-trials.com</ext-link>
) as ISRCTN71468401.</p>
</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaSubSaharaV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001C28 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 001C28 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= SidaSubSaharaV1 |flux= Main |étape= Merge |type= RBID |clé= PMC:4232020 |texte= Morbidity in relation to feeding mode in African HIV-exposed, uninfected infants during the first 6 mo of life: the Kesho Bora study123456 }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:25411291" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \ | NlmPubMed2Wicri -a SidaSubSaharaV1
![]() | This area was generated with Dilib version V0.6.32. | ![]() |