Vaccines to combat the neglected tropical diseases
Identifieur interne : 003F68 ( Main/Exploration ); précédent : 003F67; suivant : 003F69Vaccines to combat the neglected tropical diseases
Auteurs : Jeffrey M. Bethony [États-Unis] ; Rhea N. Cole [États-Unis] ; Xiaoti Guo [États-Unis] ; Shaden Kamhawi [États-Unis] ; Marshall W. Lightowlers [Australie] ; Alex Loukas [Australie] ; William Petri [États-Unis] ; Steven Reed [États-Unis] ; Jesus G. Valenzuela [États-Unis] ; Peter J. Hotez [États-Unis]Source :
- Immunological Reviews [ 0105-2896 ] ; 2011-01.
Descripteurs français
- Wicri :
- topic : Adjuvant, Immunologie, Parasitologie, Vaccination, Vaccin.
English descriptors
- KwdEn :
- Acta, Adjuvant, Amebiasis, Americanus, Ancylostoma, Animal models, Antipoverty, Antipoverty vaccines, Assay, Attenuated, Bethony, Blood loss, Canine, Cercaria, Cestode, Chaga, Chagas disease, Chemotherapy, Clin, Clinical development, Clinical testing, Clinical trials, Cryptosporidiosis, Cryptosporidium, Current status, Cutaneous, Cutaneous leishmaniasis, Cyst, Cysticercosis, Cytokine, Disease burden, Echinococcosis, Endemic, Entamoeba, Enteric, Eukaryotic, Galnac, Galnac lectin, Genome, Global access, Granulosus, Haematobium, Hamster, Haque, Helminth, Helminth infections, High rates, Histolytica, Hookworm, Hookworm infection, Hookworm vaccine, Hotez, Human hookworm infection, Human host, Hydatid, Immun, Immune, Immune response, Immune responses, Immunization, Immunol, Immunology, Infection, Intermediate hosts, Intestinal, Japonicum, John wiley sons, Laboratory animal models, Lancet, Lariasis, Larva, Latin america, Lectin, Leishmania, Leishmaniasis, Leprosy, Lightowlers, Loukas, Lymphatic, Mansoni, Mebendazole, Molyneux, Morbidity, Mucosal, Necator, Necator americanus, Negl, Nematode, Neutralizing, Ntds, Oliveira, Onchocerciasis, Parasite, Parasite immunol, Parasitol, Parasitology, Pathogen, Plo, Plos negl, Poorest people, Praziquantel, Protective immunity, Putatively, Recombinant, Recombinant protein, Recombinant proteins, Reviews bethony, Sabin, Sabin vaccine institute, Saliva, Salivary, Salivary molecules, Salivary protein, Salivary proteins, Schistosoma, Schistosoma mansoni, Schistosome, Schistosomiasis, Solium, Taenia, Taenia taeniaeformis, Taeniaeformis, Taeniid, Technical challenge, Tegument, Trachoma, Tropical diseases, Trypanosomiasis, Vaccinated, Vaccination, Vaccine, Vaccine development, Vaccine formulation, Vector saliva, Visceral leishmaniasis, West africa.
- Teeft :
- Acta, Adjuvant, Amebiasis, Americanus, Ancylostoma, Animal models, Antipoverty, Antipoverty vaccines, Assay, Attenuated, Bethony, Blood loss, Canine, Cercaria, Cestode, Chaga, Chagas disease, Chemotherapy, Clin, Clinical development, Clinical testing, Clinical trials, Cryptosporidiosis, Cryptosporidium, Current status, Cutaneous, Cutaneous leishmaniasis, Cyst, Cysticercosis, Cytokine, Disease burden, Echinococcosis, Endemic, Entamoeba, Enteric, Eukaryotic, Galnac, Galnac lectin, Genome, Global access, Granulosus, Haematobium, Hamster, Haque, Helminth, Helminth infections, High rates, Histolytica, Hookworm, Hookworm infection, Hookworm vaccine, Hotez, Human hookworm infection, Human host, Hydatid, Immun, Immune, Immune response, Immune responses, Immunization, Immunol, Immunology, Infection, Intermediate hosts, Intestinal, Japonicum, John wiley sons, Laboratory animal models, Lancet, Lariasis, Larva, Latin america, Lectin, Leishmania, Leishmaniasis, Leprosy, Lightowlers, Loukas, Lymphatic, Mansoni, Mebendazole, Molyneux, Morbidity, Mucosal, Necator, Necator americanus, Negl, Nematode, Neutralizing, Ntds, Oliveira, Onchocerciasis, Parasite, Parasite immunol, Parasitol, Parasitology, Pathogen, Plo, Plos negl, Poorest people, Praziquantel, Protective immunity, Putatively, Recombinant, Recombinant protein, Recombinant proteins, Reviews bethony, Sabin, Sabin vaccine institute, Saliva, Salivary, Salivary molecules, Salivary protein, Salivary proteins, Schistosoma, Schistosoma mansoni, Schistosome, Schistosomiasis, Solium, Taenia, Taenia taeniaeformis, Taeniaeformis, Taeniid, Technical challenge, Tegument, Trachoma, Tropical diseases, Trypanosomiasis, Vaccinated, Vaccination, Vaccine, Vaccine development, Vaccine formulation, Vector saliva, Visceral leishmaniasis, West africa.
Abstract
Summary: The neglected tropical diseases (NTDs) represent a group of parasitic and related infectious diseases such as amebiasis, Chagas disease, cysticercosis, echinococcosis, hookworm, leishmaniasis, and schistosomiasis. Together, these conditions are considered the most common infections in low‐ and middle‐income countries, where they produce a level of global disability and human suffering equivalent to better known conditions such as human immunodeficiency virus/acquired immunodeficiency syndrome and malaria. Despite their global public health importance, progress on developing vaccines for NTD pathogens has lagged because of some key technical hurdles and the fact that these infections occur almost exclusively in the world’s poorest people living below the World Bank poverty line. In the absence of financial incentives for new products, the multinational pharmaceutical companies have not embarked on substantive research and development programs for the neglected tropical disease vaccines. Here, we review the current status of scientific and technical progress in the development of new neglected tropical disease vaccines, highlighting the successes that have been achieved (cysticercosis and echinococcosis) and identifying the challenges and opportunities for development of new vaccines for NTDs. Also highlighted are the contributions being made by non‐profit product development partnerships that are working to overcome some of the economic challenges in vaccine manufacture, clinical testing, and global access.
Url:
- https://api.istex.fr/document/2ED34CAFDE373E943D59C3D4653E4FF6CFA1A2AB/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438653
DOI: 10.1111/j.1600-065X.2010.00976.x
Affiliations:
- Australie, États-Unis
- District de Columbia, Maryland, Virginie, Washington (État)
- Washington (district de Columbia)
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Le document en format XML
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<term>Adjuvant</term>
<term>Amebiasis</term>
<term>Americanus</term>
<term>Ancylostoma</term>
<term>Animal models</term>
<term>Antipoverty</term>
<term>Antipoverty vaccines</term>
<term>Assay</term>
<term>Attenuated</term>
<term>Bethony</term>
<term>Blood loss</term>
<term>Canine</term>
<term>Cercaria</term>
<term>Cestode</term>
<term>Chaga</term>
<term>Chagas disease</term>
<term>Chemotherapy</term>
<term>Clin</term>
<term>Clinical development</term>
<term>Clinical testing</term>
<term>Clinical trials</term>
<term>Cryptosporidiosis</term>
<term>Cryptosporidium</term>
<term>Current status</term>
<term>Cutaneous</term>
<term>Cutaneous leishmaniasis</term>
<term>Cyst</term>
<term>Cysticercosis</term>
<term>Cytokine</term>
<term>Disease burden</term>
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<term>Vaccinated</term>
<term>Vaccination</term>
<term>Vaccine</term>
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<term>Americanus</term>
<term>Ancylostoma</term>
<term>Animal models</term>
<term>Antipoverty</term>
<term>Antipoverty vaccines</term>
<term>Assay</term>
<term>Attenuated</term>
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<term>Blood loss</term>
<term>Canine</term>
<term>Cercaria</term>
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<term>Cutaneous leishmaniasis</term>
<term>Cyst</term>
<term>Cysticercosis</term>
<term>Cytokine</term>
<term>Disease burden</term>
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<term>Entamoeba</term>
<term>Enteric</term>
<term>Eukaryotic</term>
<term>Galnac</term>
<term>Galnac lectin</term>
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<term>Global access</term>
<term>Granulosus</term>
<term>Haematobium</term>
<term>Hamster</term>
<term>Haque</term>
<term>Helminth</term>
<term>Helminth infections</term>
<term>High rates</term>
<term>Histolytica</term>
<term>Hookworm</term>
<term>Hookworm infection</term>
<term>Hookworm vaccine</term>
<term>Hotez</term>
<term>Human hookworm infection</term>
<term>Human host</term>
<term>Hydatid</term>
<term>Immun</term>
<term>Immune</term>
<term>Immune response</term>
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<term>Immunology</term>
<term>Infection</term>
<term>Intermediate hosts</term>
<term>Intestinal</term>
<term>Japonicum</term>
<term>John wiley sons</term>
<term>Laboratory animal models</term>
<term>Lancet</term>
<term>Lariasis</term>
<term>Larva</term>
<term>Latin america</term>
<term>Lectin</term>
<term>Leishmania</term>
<term>Leishmaniasis</term>
<term>Leprosy</term>
<term>Lightowlers</term>
<term>Loukas</term>
<term>Lymphatic</term>
<term>Mansoni</term>
<term>Mebendazole</term>
<term>Molyneux</term>
<term>Morbidity</term>
<term>Mucosal</term>
<term>Necator</term>
<term>Necator americanus</term>
<term>Negl</term>
<term>Nematode</term>
<term>Neutralizing</term>
<term>Ntds</term>
<term>Oliveira</term>
<term>Onchocerciasis</term>
<term>Parasite</term>
<term>Parasite immunol</term>
<term>Parasitol</term>
<term>Parasitology</term>
<term>Pathogen</term>
<term>Plo</term>
<term>Plos negl</term>
<term>Poorest people</term>
<term>Praziquantel</term>
<term>Protective immunity</term>
<term>Putatively</term>
<term>Recombinant</term>
<term>Recombinant protein</term>
<term>Recombinant proteins</term>
<term>Reviews bethony</term>
<term>Sabin</term>
<term>Sabin vaccine institute</term>
<term>Saliva</term>
<term>Salivary</term>
<term>Salivary molecules</term>
<term>Salivary protein</term>
<term>Salivary proteins</term>
<term>Schistosoma</term>
<term>Schistosoma mansoni</term>
<term>Schistosome</term>
<term>Schistosomiasis</term>
<term>Solium</term>
<term>Taenia</term>
<term>Taenia taeniaeformis</term>
<term>Taeniaeformis</term>
<term>Taeniid</term>
<term>Technical challenge</term>
<term>Tegument</term>
<term>Trachoma</term>
<term>Tropical diseases</term>
<term>Trypanosomiasis</term>
<term>Vaccinated</term>
<term>Vaccination</term>
<term>Vaccine</term>
<term>Vaccine development</term>
<term>Vaccine formulation</term>
<term>Vector saliva</term>
<term>Visceral leishmaniasis</term>
<term>West africa</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Adjuvant</term>
<term>Immunologie</term>
<term>Parasitologie</term>
<term>Vaccination</term>
<term>Vaccin</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">Summary: The neglected tropical diseases (NTDs) represent a group of parasitic and related infectious diseases such as amebiasis, Chagas disease, cysticercosis, echinococcosis, hookworm, leishmaniasis, and schistosomiasis. Together, these conditions are considered the most common infections in low‐ and middle‐income countries, where they produce a level of global disability and human suffering equivalent to better known conditions such as human immunodeficiency virus/acquired immunodeficiency syndrome and malaria. Despite their global public health importance, progress on developing vaccines for NTD pathogens has lagged because of some key technical hurdles and the fact that these infections occur almost exclusively in the world’s poorest people living below the World Bank poverty line. In the absence of financial incentives for new products, the multinational pharmaceutical companies have not embarked on substantive research and development programs for the neglected tropical disease vaccines. Here, we review the current status of scientific and technical progress in the development of new neglected tropical disease vaccines, highlighting the successes that have been achieved (cysticercosis and echinococcosis) and identifying the challenges and opportunities for development of new vaccines for NTDs. Also highlighted are the contributions being made by non‐profit product development partnerships that are working to overcome some of the economic challenges in vaccine manufacture, clinical testing, and global access.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>États-Unis</li>
</country>
<region><li>District de Columbia</li>
<li>Maryland</li>
<li>Virginie</li>
<li>Washington (État)</li>
</region>
<settlement><li>Washington (district de Columbia)</li>
</settlement>
</list>
<tree><country name="États-Unis"><region name="District de Columbia"><name sortKey="Bethony, Jeffrey M" sort="Bethony, Jeffrey M" uniqKey="Bethony J" first="Jeffrey M." last="Bethony">Jeffrey M. Bethony</name>
</region>
<name sortKey="Cole, Rhea N" sort="Cole, Rhea N" uniqKey="Cole R" first="Rhea N." last="Cole">Rhea N. Cole</name>
<name sortKey="Guo, Xiaoti" sort="Guo, Xiaoti" uniqKey="Guo X" first="Xiaoti" last="Guo">Xiaoti Guo</name>
<name sortKey="Hotez, Peter J" sort="Hotez, Peter J" uniqKey="Hotez P" first="Peter J." last="Hotez">Peter J. Hotez</name>
<name sortKey="Hotez, Peter J" sort="Hotez, Peter J" uniqKey="Hotez P" first="Peter J." last="Hotez">Peter J. Hotez</name>
<name sortKey="Kamhawi, Shaden" sort="Kamhawi, Shaden" uniqKey="Kamhawi S" first="Shaden" last="Kamhawi">Shaden Kamhawi</name>
<name sortKey="Petri, William" sort="Petri, William" uniqKey="Petri W" first="William" last="Petri">William Petri</name>
<name sortKey="Reed, Steven" sort="Reed, Steven" uniqKey="Reed S" first="Steven" last="Reed">Steven Reed</name>
<name sortKey="Valenzuela, Jesus G" sort="Valenzuela, Jesus G" uniqKey="Valenzuela J" first="Jesus G." last="Valenzuela">Jesus G. Valenzuela</name>
</country>
<country name="Australie"><noRegion><name sortKey="Lightowlers, Marshall W" sort="Lightowlers, Marshall W" uniqKey="Lightowlers M" first="Marshall W." last="Lightowlers">Marshall W. Lightowlers</name>
</noRegion>
<name sortKey="Loukas, Alex" sort="Loukas, Alex" uniqKey="Loukas A" first="Alex" last="Loukas">Alex Loukas</name>
</country>
</tree>
</affiliations>
</record>
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