SidaSubSaharaV1, Main, Exploration, bibRecordById, PMC:3071279

Human Herpesvirus 8 Infection in Children and Adults in a Population-based Study in Rural Uganda

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Human Herpesvirus 8 Infection in Children and Adults in a Population-based Study in Rural Uganda

Auteurs : Lisa M. Butler [États-Unis] ; Willy A. Were [Ouganda] ; Steven Balinandi [Ouganda] ; Robert Downing [Ouganda] ; Sheila Dollard [Géorgie (pays)] ; Torsten B. Neilands [États-Unis] ; Sundeep Gupta [Ouganda] ; George W. Rutherford [États-Unis] ; Jonathan Mermin [Géorgie (pays)]

Source :

The Journal of Infectious Diseases [ 0022-1899 ] ; 2011.

RBID : PMC:3071279

Abstract

(See the editorial commentary by Mbulaiteye an Goedert, on pages 575–7.)

Background. Human herpesvirus 8 (HHV-8) infection is endemic in sub-Saharan Africa. We examined sociodemographic, behavioral, and biological factors associated with HHV-8 infection in children and adults to determine HHV-8 seroprevalence and potential routes of transmission.

Methods. Participants were 1383 children and 1477 adults from a population-based sample in a rural community in Uganda. Serum samples were tested for HHV-8 antibodies with use of an enzyme immunoassay against K8.1.

Results. HHV-8 seroprevalence increased from 16% among children aged 1.5–2 years to 32% among children aged 10–13 years (P <.001) and from 37% among participants aged 14–19 years to 49% among adults aged ≥50 years (P <.05). HHV-8 seropositivity in children was independently associated with residing with a seropositive parent (P < .001) and residing with ≥1 other seropositive child aged <14 years (P < .001). History of sharing food and/or sauce plates was marginally associated with HHV-8 infection in children (P = .05). Among 1404 participants aged ≥15 years , there was no association between correlates of sexual behavior (eg, number of lifetime sex partners and HIV infection) and HHV-8 seropositivity (P > .10).

Conclusions. Our data suggest that HHV-8 is acquired primarily through horizontal transmission in childhood from intrafamilial contacts and that transmission continues into adulthood potentially through nonsexual routes.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071279

DOI: 10.1093/infdis/jiq092
PubMed: 21273188
PubMed Central: 3071279

Affiliations:

Le document en format XML

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<wicri:regionArea>Division of Viral Diseases, CDC, Atlanta</wicri:regionArea>
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<author><name sortKey="Neilands, Torsten B" sort="Neilands, Torsten B" uniqKey="Neilands T" first="Torsten B." last="Neilands">Torsten B. Neilands</name>
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<country>États-Unis</country>
<placeName><settlement type="city">San Francisco</settlement>
<region type="state">Californie</region>
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<country>États-Unis</country>
<placeName><settlement type="city">San Francisco</settlement>
<region type="state">Californie</region>
</placeName>
<wicri:orgArea>Department of Epidemiology and Biostatistics & Global Health Sciences, University of California</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Mermin, Jonathan" sort="Mermin, Jonathan" uniqKey="Mermin J" first="Jonathan" last="Mermin">Jonathan Mermin</name>
<affiliation wicri:level="1"><nlm:aff id="aff5">Division of HIV/AIDS Prevention, CDC, Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Division of HIV/AIDS Prevention, CDC, Atlanta</wicri:regionArea>
<wicri:noRegion>Atlanta</wicri:noRegion>
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<series><title level="j">The Journal of Infectious Diseases</title>
<idno type="ISSN">0022-1899</idno>
<idno type="eISSN">1537-6613</idno>
<imprint><date when="2011">2011</date>
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<front><div type="abstract" xml:lang="en"><p>(See the editorial commentary by Mbulaiteye an Goedert, on pages <related-article xlink:href="10.1093/infdis/jiq094" ext-link-type="doi" related-article-type="article-reference" id="d32e173">575–7</related-article>
.)</p>
<p><bold><italic>Background</italic>
.</bold>
 Human herpesvirus 8 (HHV-8) infection is endemic in sub-Saharan Africa. We examined sociodemographic, behavioral, and biological factors associated with HHV-8 infection in children and adults to determine HHV-8 seroprevalence and potential routes of transmission.</p>
<p><bold><italic>Methods</italic>
.</bold>
 Participants were 1383 children and 1477 adults from a population-based sample in a rural community in Uganda. Serum samples were tested for HHV-8 antibodies with use of an enzyme immunoassay against K8.1.</p>
<p><bold><italic>Results</italic>
.</bold>
 HHV-8 seroprevalence increased from 16% among children aged 1.5–2 years to 32% among children aged 10–13 years (<italic>P</italic>
 <.001) and from 37% among participants aged 14–19 years to 49% among adults aged ≥50 years (<italic>P</italic>
 <.05). HHV-8 seropositivity in children was independently associated with residing with a seropositive parent (<italic>P</italic>
 < .001) and residing with ≥1 other seropositive child aged <14 years (<italic>P</italic>
 < .001). History of sharing food and/or sauce plates was marginally associated with HHV-8 infection in children (<italic>P</italic>
 = .05). Among 1404 participants aged ≥15 years , there was no association between correlates of sexual behavior (eg, number of lifetime sex partners and HIV infection) and HHV-8 seropositivity (<italic>P</italic>
 > .10).</p>
<p><bold><italic>Conclusions</italic>
.</bold>
 Our data suggest that HHV-8 is acquired primarily through horizontal transmission in childhood from intrafamilial contacts and that transmission continues into adulthood potentially through nonsexual routes.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Géorgie (pays)</li>
<li>Ouganda</li>
<li>États-Unis</li>
</country>
<region><li>Californie</li>
</region>
<settlement><li>San Francisco</li>
</settlement>
</list>
<tree><country name="États-Unis"><region name="Californie"><name sortKey="Butler, Lisa M" sort="Butler, Lisa M" uniqKey="Butler L" first="Lisa M." last="Butler">Lisa M. Butler</name>
</region>
<name sortKey="Neilands, Torsten B" sort="Neilands, Torsten B" uniqKey="Neilands T" first="Torsten B." last="Neilands">Torsten B. Neilands</name>
<name sortKey="Rutherford, George W" sort="Rutherford, George W" uniqKey="Rutherford G" first="George W." last="Rutherford">George W. Rutherford</name>
</country>
<country name="Ouganda"><noRegion><name sortKey="Were, Willy A" sort="Were, Willy A" uniqKey="Were W" first="Willy A." last="Were">Willy A. Were</name>
</noRegion>
<name sortKey="Balinandi, Steven" sort="Balinandi, Steven" uniqKey="Balinandi S" first="Steven" last="Balinandi">Steven Balinandi</name>
<name sortKey="Downing, Robert" sort="Downing, Robert" uniqKey="Downing R" first="Robert" last="Downing">Robert Downing</name>
<name sortKey="Gupta, Sundeep" sort="Gupta, Sundeep" uniqKey="Gupta S" first="Sundeep" last="Gupta">Sundeep Gupta</name>
</country>
<country name="Géorgie (pays)"><noRegion><name sortKey="Dollard, Sheila" sort="Dollard, Sheila" uniqKey="Dollard S" first="Sheila" last="Dollard">Sheila Dollard</name>
</noRegion>
<name sortKey="Mermin, Jonathan" sort="Mermin, Jonathan" uniqKey="Mermin J" first="Jonathan" last="Mermin">Jonathan Mermin</name>
</country>
</tree>
</affiliations>
</record>

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Le SIDA en Afrique subsaharienne (serveur d'exploration)

Human Herpesvirus 8 Infection in Children and Adults in a Population-based Study in Rural Uganda

Human Herpesvirus 8 Infection in Children and Adults in a Population-based Study in Rural Uganda

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