Environmental and host-related determinants of tuberculosis in Metema district, north-west Ethiopia
Identifieur interne : 001718 ( Main/Exploration ); précédent : 001717; suivant : 001719Environmental and host-related determinants of tuberculosis in Metema district, north-west Ethiopia
Auteurs : Cheru Tesema [Éthiopie] ; Takele Tadesse [Éthiopie] ; Mulat Gebrehiwot [Éthiopie] ; Azanaw Tsegaw [Éthiopie] ; Fitsum Weldegebreal [Éthiopie]Source :
- Drug, Healthcare and Patient Safety [ 1179-1365 ] ; 2015.
Abstract
Each year, one third of the world’s population is estimated to be infected with tuberculosis (TB). Globally in 2011, there were an estimated 8.7 million TB cases that resulted in 1.4 million deaths. In Ethiopia, TB is the leading cause of morbidity and the third most common cause of hospital admission. The aim of this study is to assess environmental and host-related determinants of TB in Metema district, north-west Ethiopia.
A community-based unmatched case-control study was conducted from March 12 to April 5, 2013. The study population included 655 subjects (218 cases and 437 controls in a ratio of 1:2). Cases were TB patients selected from a total of 475 cases registered and treated from March 2012 to February 2013 at the Metema District Hospital DOTS (direct observation therapy, short-course) clinic and selected randomly using a lottery method. Controls were people who had had no productive cough for at least 2 weeks previously and were selected from the community.
A total of 655 respondents (218 cases and 437 controls) participated in the study. In multivariate analysis, being illiterate (adjusted odds ratio [AOR] 3.65, 95% confidence interval [CI] 2.31–5.76), households containing more than four family members (AOR 3.09, 95% CI 2.07–4.61), living space <4 m2 per person (AOR 3.11, 95% CI 2.09–4.63), a nonseparated kitchen (AOR 3.27, 95% CI 1.99–5.35), history of contact with a TB patient (AOR 2.05, 95% CI 1.35–3.12), a house with no ceiling (AOR 1.46, 95% CI 1.07–2.21), and absence of windows (AOR 4.42, 95% CI 2.46–7.95) were independently associated with the development of TB.
This study identified that the number of family members in the household, educational status, room space per person, history of contact with a TB patient, availability and number of windows, location of kitchen facilities within the house, and whether or not the house had a ceiling were independently associated with contracting TB. Every community should construct houses with the kitchen separated from the main living room, and include a ceiling and more than one window. Cigarette smoking should be avoided since this also contributed to the risk of transmission of TB. Further research focusing on coinfection with human immunodeficiency virus, helminth burden, and malnutrition is important for the control and prevention of TB.
Url:
DOI: 10.2147/DHPS.S82070
PubMed: 26064069
PubMed Central: 4455843
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000073
- to stream Pmc, to step Curation: 000073
- to stream Pmc, to step Checkpoint: 000D60
- to stream Ncbi, to step Merge: 003126
- to stream Ncbi, to step Curation: 003126
- to stream Ncbi, to step Checkpoint: 003126
- to stream Main, to step Merge: 001719
- to stream Main, to step Curation: 001718
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Environmental and host-related determinants of tuberculosis in Metema district, north-west Ethiopia</title><author><name sortKey="Tesema, Cheru" sort="Tesema, Cheru" uniqKey="Tesema C" first="Cheru" last="Tesema">Cheru Tesema</name><affiliation wicri:level="1"><nlm:aff id="af1-dhps-7-087">College of Medical and Health Science, Debre Markos University, Debremarkos, Ethiopia</nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea>College of Medical and Health Science, Debre Markos University, Debremarkos</wicri:regionArea><wicri:noRegion>Debremarkos</wicri:noRegion></affiliation></author><author><name sortKey="Tadesse, Takele" sort="Tadesse, Takele" uniqKey="Tadesse T" first="Takele" last="Tadesse">Takele Tadesse</name><affiliation wicri:level="1"><nlm:aff id="af2-dhps-7-087">Institute of Public Health, College of Medical and Health Sciences, University of Gondar, Gondar, Ethiopia</nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea>Institute of Public Health, College of Medical and Health Sciences, University of Gondar, Gondar</wicri:regionArea><wicri:noRegion>Gondar</wicri:noRegion></affiliation></author><author><name sortKey="Gebrehiwot, Mulat" sort="Gebrehiwot, Mulat" uniqKey="Gebrehiwot M" first="Mulat" last="Gebrehiwot">Mulat Gebrehiwot</name><affiliation wicri:level="1"><nlm:aff id="af2-dhps-7-087">Institute of Public Health, College of Medical and Health Sciences, University of Gondar, Gondar, Ethiopia</nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea>Institute of Public Health, College of Medical and Health Sciences, University of Gondar, Gondar</wicri:regionArea><wicri:noRegion>Gondar</wicri:noRegion></affiliation></author><author><name sortKey="Tsegaw, Azanaw" sort="Tsegaw, Azanaw" uniqKey="Tsegaw A" first="Azanaw" last="Tsegaw">Azanaw Tsegaw</name><affiliation wicri:level="1"><nlm:aff id="af3-dhps-7-087">College of Health and Medical Sciences, University of Gondar, Gondar, Ethiopia</nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea>College of Health and Medical Sciences, University of Gondar, Gondar</wicri:regionArea><wicri:noRegion>Gondar</wicri:noRegion></affiliation></author><author><name sortKey="Weldegebreal, Fitsum" sort="Weldegebreal, Fitsum" uniqKey="Weldegebreal F" first="Fitsum" last="Weldegebreal">Fitsum Weldegebreal</name><affiliation wicri:level="1"><nlm:aff id="af4-dhps-7-087">Haramaya University, College of Health and Medical Sciences, Department of Medical Laboratory Science, Harar, Ethiopia</nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea>Haramaya University, College of Health and Medical Sciences, Department of Medical Laboratory Science, Harar</wicri:regionArea><wicri:noRegion>Harar</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26064069</idno><idno type="pmc">4455843</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455843</idno><idno type="RBID">PMC:4455843</idno><idno type="doi">10.2147/DHPS.S82070</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000073</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000073</idno><idno type="wicri:Area/Pmc/Curation">000073</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000073</idno><idno type="wicri:Area/Pmc/Checkpoint">000D60</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000D60</idno><idno type="wicri:Area/Ncbi/Merge">003126</idno><idno type="wicri:Area/Ncbi/Curation">003126</idno><idno type="wicri:Area/Ncbi/Checkpoint">003126</idno><idno type="wicri:Area/Main/Merge">001719</idno><idno type="wicri:Area/Main/Curation">001718</idno><idno type="wicri:Area/Main/Exploration">001718</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Environmental and host-related determinants of tuberculosis in Metema district, north-west Ethiopia</title><author><name sortKey="Tesema, Cheru" sort="Tesema, Cheru" uniqKey="Tesema C" first="Cheru" last="Tesema">Cheru Tesema</name><affiliation wicri:level="1"><nlm:aff id="af1-dhps-7-087">College of Medical and Health Science, Debre Markos University, Debremarkos, Ethiopia</nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea>College of Medical and Health Science, Debre Markos University, Debremarkos</wicri:regionArea><wicri:noRegion>Debremarkos</wicri:noRegion></affiliation></author><author><name sortKey="Tadesse, Takele" sort="Tadesse, Takele" uniqKey="Tadesse T" first="Takele" last="Tadesse">Takele Tadesse</name><affiliation wicri:level="1"><nlm:aff id="af2-dhps-7-087">Institute of Public Health, College of Medical and Health Sciences, University of Gondar, Gondar, Ethiopia</nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea>Institute of Public Health, College of Medical and Health Sciences, University of Gondar, Gondar</wicri:regionArea><wicri:noRegion>Gondar</wicri:noRegion></affiliation></author><author><name sortKey="Gebrehiwot, Mulat" sort="Gebrehiwot, Mulat" uniqKey="Gebrehiwot M" first="Mulat" last="Gebrehiwot">Mulat Gebrehiwot</name><affiliation wicri:level="1"><nlm:aff id="af2-dhps-7-087">Institute of Public Health, College of Medical and Health Sciences, University of Gondar, Gondar, Ethiopia</nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea>Institute of Public Health, College of Medical and Health Sciences, University of Gondar, Gondar</wicri:regionArea><wicri:noRegion>Gondar</wicri:noRegion></affiliation></author><author><name sortKey="Tsegaw, Azanaw" sort="Tsegaw, Azanaw" uniqKey="Tsegaw A" first="Azanaw" last="Tsegaw">Azanaw Tsegaw</name><affiliation wicri:level="1"><nlm:aff id="af3-dhps-7-087">College of Health and Medical Sciences, University of Gondar, Gondar, Ethiopia</nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea>College of Health and Medical Sciences, University of Gondar, Gondar</wicri:regionArea><wicri:noRegion>Gondar</wicri:noRegion></affiliation></author><author><name sortKey="Weldegebreal, Fitsum" sort="Weldegebreal, Fitsum" uniqKey="Weldegebreal F" first="Fitsum" last="Weldegebreal">Fitsum Weldegebreal</name><affiliation wicri:level="1"><nlm:aff id="af4-dhps-7-087">Haramaya University, College of Health and Medical Sciences, Department of Medical Laboratory Science, Harar, Ethiopia</nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea>Haramaya University, College of Health and Medical Sciences, Department of Medical Laboratory Science, Harar</wicri:regionArea><wicri:noRegion>Harar</wicri:noRegion></affiliation></author></analytic><series><title level="j">Drug, Healthcare and Patient Safety</title><idno type="eISSN">1179-1365</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Each year, one third of the world’s population is estimated to be infected with tuberculosis (TB). Globally in 2011, there were an estimated 8.7 million TB cases that resulted in 1.4 million deaths. In Ethiopia, TB is the leading cause of morbidity and the third most common cause of hospital admission. The aim of this study is to assess environmental and host-related determinants of TB in Metema district, north-west Ethiopia.</p></sec><sec><title>Methods</title><p>A community-based unmatched case-control study was conducted from March 12 to April 5, 2013. The study population included 655 subjects (218 cases and 437 controls in a ratio of 1:2). Cases were TB patients selected from a total of 475 cases registered and treated from March 2012 to February 2013 at the Metema District Hospital DOTS (direct observation therapy, short-course) clinic and selected randomly using a lottery method. Controls were people who had had no productive cough for at least 2 weeks previously and were selected from the community.</p></sec><sec><title>Results</title><p>A total of 655 respondents (218 cases and 437 controls) participated in the study. In multivariate analysis, being illiterate (adjusted odds ratio [AOR] 3.65, 95% confidence interval [CI] 2.31–5.76), households containing more than four family members (AOR 3.09, 95% CI 2.07–4.61), living space <4 m<sup>2</sup> per person (AOR 3.11, 95% CI 2.09–4.63), a nonseparated kitchen (AOR 3.27, 95% CI 1.99–5.35), history of contact with a TB patient (AOR 2.05, 95% CI 1.35–3.12), a house with no ceiling (AOR 1.46, 95% CI 1.07–2.21), and absence of windows (AOR 4.42, 95% CI 2.46–7.95) were independently associated with the development of TB.</p></sec><sec><title>Conclusion</title><p>This study identified that the number of family members in the household, educational status, room space per person, history of contact with a TB patient, availability and number of windows, location of kitchen facilities within the house, and whether or not the house had a ceiling were independently associated with contracting TB. Every community should construct houses with the kitchen separated from the main living room, and include a ceiling and more than one window. Cigarette smoking should be avoided since this also contributed to the risk of transmission of TB. Further research focusing on coinfection with human immunodeficiency virus, helminth burden, and malnutrition is important for the control and prevention of TB.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Tadesse, T" uniqKey="Tadesse T">T Tadesse</name></author><author><name sortKey="Tadesse, S" uniqKey="Tadesse S">S Tadesse</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Taha, M" uniqKey="Taha M">M Taha</name></author><author><name sortKey="Deribew, A" uniqKey="Deribew A">A Deribew</name></author><author><name sortKey="Tessema, F" uniqKey="Tessema F">F Tessema</name></author><author><name sortKey="Assegid, S" uniqKey="Assegid S">S Assegid</name></author><author><name sortKey="Duchateau, L" uniqKey="Duchateau L">L Duchateau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shetty, N" uniqKey="Shetty N">N Shetty</name></author><author><name sortKey="Shemko, M" uniqKey="Shemko M">M Shemko</name></author><author><name sortKey="Vaz, M" uniqKey="Vaz M">M Vaz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karima, Mr" uniqKey="Karima M">MR Karima</name></author><author><name sortKey="Rahmana, Ma" uniqKey="Rahmana M">MA Rahmana</name></author><author><name sortKey="Mamunb, Saa" uniqKey="Mamunb S">SAA Mamunb</name></author><author><name sortKey="Alama, Ma" uniqKey="Alama M">MA Alama</name></author><author><name sortKey="Akhterc, S" uniqKey="Akhterc S">S Akhterc</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gustafson, P" uniqKey="Gustafson P">P Gustafson</name></author><author><name sortKey="Victor, F" uniqKey="Victor F">F Victor</name></author><author><name sortKey="Cesaltina, S" uniqKey="Cesaltina S">S Cesaltina</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lienhardt, C" uniqKey="Lienhardt C">C Lienhardt</name></author><author><name sortKey="Fielding, K" uniqKey="Fielding K">K Fielding</name></author><author><name sortKey="Sillah, Js" uniqKey="Sillah J">JS Sillah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hill, Pc" uniqKey="Hill P">PC Hill</name></author><author><name sortKey="Jackson Sillah, D" uniqKey="Jackson Sillah D">D Jackson-Sillah</name></author><author><name sortKey="Donkor, Sa" uniqKey="Donkor S">SA Donkor</name></author><author><name sortKey="Otu, J" uniqKey="Otu J">J Otu</name></author><author><name sortKey="Adegbola, Ra" uniqKey="Adegbola R">RA Adegbola</name></author><author><name sortKey="Lienhardt, C" uniqKey="Lienhardt C">C Lienhardt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tornee, S" uniqKey="Tornee S">S Tornee</name></author><author><name sortKey="Kaewkungwal, J" uniqKey="Kaewkungwal J">J Kaewkungwal</name></author><author><name sortKey="Fungladda, W" uniqKey="Fungladda W">W Fungladda</name></author><author><name sortKey="Silachamroon, U" uniqKey="Silachamroon U">U Silachamroon</name></author><author><name sortKey="Akarasewi, P" uniqKey="Akarasewi P">P Akarasewi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lienhardt, C" uniqKey="Lienhardt C">C Lienhardt</name></author><author><name sortKey="Fielding, K" uniqKey="Fielding K">K Fielding</name></author><author><name sortKey="Sillah, J" uniqKey="Sillah J">J Sillah</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Éthiopie</li></country></list><tree><country name="Éthiopie"><noRegion><name sortKey="Tesema, Cheru" sort="Tesema, Cheru" uniqKey="Tesema C" first="Cheru" last="Tesema">Cheru Tesema</name></noRegion><name sortKey="Gebrehiwot, Mulat" sort="Gebrehiwot, Mulat" uniqKey="Gebrehiwot M" first="Mulat" last="Gebrehiwot">Mulat Gebrehiwot</name><name sortKey="Tadesse, Takele" sort="Tadesse, Takele" uniqKey="Tadesse T" first="Takele" last="Tadesse">Takele Tadesse</name><name sortKey="Tsegaw, Azanaw" sort="Tsegaw, Azanaw" uniqKey="Tsegaw A" first="Azanaw" last="Tsegaw">Azanaw Tsegaw</name><name sortKey="Weldegebreal, Fitsum" sort="Weldegebreal, Fitsum" uniqKey="Weldegebreal F" first="Fitsum" last="Weldegebreal">Fitsum Weldegebreal</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaSubSaharaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001718 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001718 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= SidaSubSaharaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4455843
|texte= Environmental and host-related determinants of tuberculosis in Metema district, north-west Ethiopia
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26064069" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a SidaSubSaharaV1
| This area was generated with Dilib version V0.6.32. |  |